Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8477
Gene name Gene Name - the full gene name approved by the HGNC.
G protein-coupled receptor 65
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GPR65
Synonyms (NCBI Gene) Gene synonyms aliases
TDAG8, hTDAG8
Chromosome Chromosome number
14
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
14q31.3
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT1031648 hsa-miR-106a CLIP-seq
MIRT1031649 hsa-miR-106b CLIP-seq
MIRT1031650 hsa-miR-1202 CLIP-seq
MIRT1031651 hsa-miR-1251 CLIP-seq
MIRT1031652 hsa-miR-1261 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004930 Function G protein-coupled receptor activity IBA
GO:0004930 Function G protein-coupled receptor activity IDA 15326175, 15618224, 20855608, 33478938, 39753132
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0005768 Component Endosome IEA
GO:0005886 Component Plasma membrane IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604620 4517 ENSG00000140030
Protein
UniProt ID Q8IYL9
Protein name G-protein coupled receptor 65 (Psychosine receptor) (T-cell death-associated gene 8 protein)
Protein function Proton-sensing G-protein coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions (PubMed:15326175, PubMed:15618224, PubMed:20855608, PubMed:33478938, PubMed:37722051, PubMed:3975313
PDB 9BHL
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 31 290 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Predominantly expressed in thymus, spleen, lymph nodes, small intestine, lung, placenta and peripheral blood leukocytes. {ECO:0000269|PubMed:11309421, ECO:0000269|PubMed:9655242}.
Sequence
Sequence length 337
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Crohn Disease Crohn's disease N/A N/A GWAS
Inflammatory Bowel Disease Inflammatory bowel disease N/A N/A GWAS
Parkinson Disease Parkinson's disease N/A N/A GWAS
Ulcerative colitis Ulcerative colitis N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acidosis Associate 24152439
Adenocarcinoma of Lung Associate 36311801, 40519919
Asthma Associate 24876173, 30532529
Celiac Disease Stimulate 40650227
Crohn Disease Stimulate 40650227
Emphysema Associate 30532529
Glioblastoma Associate 30356407
Idiopathic Pulmonary Fibrosis Associate 36233248
Inflammation Associate 30616622, 33431967, 35218908, 40650227
Inflammatory Bowel Diseases Associate 30616622, 35218908