GPR65 (G protein-coupled receptor 65)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 8477 |
| Gene name | G protein-coupled receptor 65 |
| Gene symbol | GPR65 |
| Synonyms (NCBI Gene) |
TDAG8hTDAG8
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| Chromosome | 14 |
| Chromosome location | 14q31.3 |
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miRNA
miRNA information provided by mirtarbase database.
507
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q8IYL9 | ||||||||||
| Protein name | G-protein coupled receptor 65 (Psychosine receptor) (T-cell death-associated gene 8 protein) | ||||||||||
| Protein function | Proton-sensing G-protein coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions (PubMed:15326175, PubMed:15618224, PubMed:20855608, PubMed:33478938, PubMed:37722051, PubMed:3975313 | ||||||||||
| PDB | 9BHL | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Predominantly expressed in thymus, spleen, lymph nodes, small intestine, lung, placenta and peripheral blood leukocytes. {ECO:0000269|PubMed:11309421, ECO:0000269|PubMed:9655242}. | ||||||||||
| Sequence |
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| Sequence length | 337 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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