Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	84750
Gene name Gene Name - the full gene name approved by the HGNC.	Protein O-fucosyltransferase 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	POFUT3
Synonyms (NCBI Gene) Gene synonyms aliases	FUCTX, FUT10
Chromosome Chromosome number	8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	8p12

Show/Hide all(265)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025374	hsa-miR-34a-5p	Sequencing	20371350
MIRT051863	hsa-let-7c-5p	CLASH	23622248
MIRT458299	hsa-miR-548m	PAR-CLIP	23592263
MIRT458298	hsa-miR-3609	PAR-CLIP	23592263
MIRT458297	hsa-miR-548ah-5p	PAR-CLIP	23592263
MIRT458296	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT458295	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT458294	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT458293	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT458292	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT458291	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT458290	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT458289	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT458288	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT458287	hsa-miR-183-5p	PAR-CLIP	23592263
MIRT458286	hsa-miR-4698	PAR-CLIP	23592263
MIRT458285	hsa-miR-5681a	PAR-CLIP	23592263
MIRT458284	hsa-miR-6730-5p	PAR-CLIP	23592263
MIRT458283	hsa-miR-4524a-3p	PAR-CLIP	23592263
MIRT458282	hsa-let-7a-5p	PAR-CLIP	23592263
MIRT458281	hsa-let-7b-5p	PAR-CLIP	23592263
MIRT051863	hsa-let-7c-5p	PAR-CLIP	23592263
MIRT458280	hsa-let-7d-5p	PAR-CLIP	23592263
MIRT458279	hsa-let-7e-5p	PAR-CLIP	23592263
MIRT458278	hsa-let-7f-5p	PAR-CLIP	23592263
MIRT458277	hsa-let-7g-5p	PAR-CLIP	23592263
MIRT458276	hsa-let-7i-5p	PAR-CLIP	23592263
MIRT458274	hsa-miR-4458	PAR-CLIP	23592263
MIRT458275	hsa-miR-4500	PAR-CLIP	23592263
MIRT458273	hsa-miR-98-5p	PAR-CLIP	23592263
MIRT458272	hsa-miR-202-3p	PAR-CLIP	23592263
MIRT458271	hsa-miR-1468-3p	PAR-CLIP	23592263
MIRT458269	hsa-miR-4470	PAR-CLIP	23592263
MIRT458270	hsa-miR-4713-3p	PAR-CLIP	23592263
MIRT458268	hsa-miR-638	PAR-CLIP	23592263
MIRT458267	hsa-miR-505-3p	PAR-CLIP	23592263
MIRT458266	hsa-miR-488-3p	PAR-CLIP	23592263
MIRT458265	hsa-miR-450b-3p	PAR-CLIP	23592263
MIRT458264	hsa-miR-769-3p	PAR-CLIP	23592263
MIRT458263	hsa-miR-3138	PAR-CLIP	23592263
MIRT446715	hsa-miR-548at-5p	PAR-CLIP	22100165
MIRT446714	hsa-miR-561-3p	PAR-CLIP	22100165
MIRT446713	hsa-miR-148a-5p	PAR-CLIP	22100165
MIRT446712	hsa-miR-5584-3p	PAR-CLIP	22100165
MIRT446711	hsa-miR-142-5p	PAR-CLIP	22100165
MIRT446710	hsa-miR-5590-3p	PAR-CLIP	22100165
MIRT446709	hsa-miR-3613-3p	PAR-CLIP	22100165
MIRT446708	hsa-miR-371b-5p	PAR-CLIP	22100165
MIRT446707	hsa-miR-373-5p	PAR-CLIP	22100165
MIRT446706	hsa-miR-616-5p	PAR-CLIP	22100165
MIRT450007	hsa-miR-371a-5p	PAR-CLIP	22100165
MIRT450006	hsa-miR-372-5p	PAR-CLIP	22100165
MIRT446705	hsa-miR-4635	PAR-CLIP	22100165
MIRT446704	hsa-miR-570-3p	PAR-CLIP	22100165
MIRT446703	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT446715	hsa-miR-548at-5p	PAR-CLIP	22100165
MIRT446714	hsa-miR-561-3p	PAR-CLIP	22100165
MIRT446713	hsa-miR-148a-5p	PAR-CLIP	22100165
MIRT446712	hsa-miR-5584-3p	PAR-CLIP	22100165
MIRT446711	hsa-miR-142-5p	PAR-CLIP	22100165
MIRT446710	hsa-miR-5590-3p	PAR-CLIP	22100165
MIRT446709	hsa-miR-3613-3p	PAR-CLIP	22100165
MIRT446708	hsa-miR-371b-5p	PAR-CLIP	22100165
MIRT446707	hsa-miR-373-5p	PAR-CLIP	22100165
MIRT446706	hsa-miR-616-5p	PAR-CLIP	22100165
MIRT446705	hsa-miR-4635	PAR-CLIP	22100165
MIRT446704	hsa-miR-570-3p	PAR-CLIP	22100165
MIRT446703	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT727631	hsa-miR-92a-3p	HITS-CLIP	22473208
MIRT727630	hsa-miR-92b-3p	HITS-CLIP	22473208
MIRT727629	hsa-miR-32-5p	HITS-CLIP	22473208
MIRT458282	hsa-let-7a-5p	PAR-CLIP	26701625
MIRT458282	hsa-let-7a-5p	PAR-CLIP	26701625
MIRT458281	hsa-let-7b-5p	PAR-CLIP	26701625
MIRT458281	hsa-let-7b-5p	PAR-CLIP	26701625
MIRT051863	hsa-let-7c-5p	PAR-CLIP	26701625
MIRT051863	hsa-let-7c-5p	PAR-CLIP	26701625
MIRT458280	hsa-let-7d-5p	PAR-CLIP	26701625
MIRT458280	hsa-let-7d-5p	PAR-CLIP	26701625
MIRT458279	hsa-let-7e-5p	PAR-CLIP	26701625
MIRT458279	hsa-let-7e-5p	PAR-CLIP	26701625
MIRT458278	hsa-let-7f-5p	PAR-CLIP	26701625
MIRT458278	hsa-let-7f-5p	PAR-CLIP	26701625
MIRT458277	hsa-let-7g-5p	PAR-CLIP	26701625
MIRT458277	hsa-let-7g-5p	PAR-CLIP	26701625
MIRT458276	hsa-let-7i-5p	PAR-CLIP	26701625
MIRT458276	hsa-let-7i-5p	PAR-CLIP	26701625
MIRT458296	hsa-miR-106a-5p	PAR-CLIP	26701625
MIRT458296	hsa-miR-106a-5p	PAR-CLIP	26701625
MIRT458295	hsa-miR-106b-5p	PAR-CLIP	26701625
MIRT458295	hsa-miR-106b-5p	PAR-CLIP	26701625
MIRT458271	hsa-miR-1468-3p	PAR-CLIP	26701625
MIRT458271	hsa-miR-1468-3p	PAR-CLIP	26701625
MIRT458294	hsa-miR-17-5p	PAR-CLIP	26701625
MIRT458294	hsa-miR-17-5p	PAR-CLIP	26701625
MIRT458287	hsa-miR-183-5p	PAR-CLIP	26701625
MIRT458287	hsa-miR-183-5p	PAR-CLIP	26701625
MIRT458272	hsa-miR-202-3p	PAR-CLIP	26701625
MIRT458272	hsa-miR-202-3p	PAR-CLIP	26701625
MIRT458293	hsa-miR-20a-5p	PAR-CLIP	26701625
MIRT458293	hsa-miR-20a-5p	PAR-CLIP	26701625
MIRT458292	hsa-miR-20b-5p	PAR-CLIP	26701625
MIRT458292	hsa-miR-20b-5p	PAR-CLIP	26701625
MIRT458263	hsa-miR-3138	PAR-CLIP	26701625
MIRT458263	hsa-miR-3138	PAR-CLIP	26701625
MIRT458298	hsa-miR-3609	PAR-CLIP	26701625
MIRT458298	hsa-miR-3609	PAR-CLIP	26701625
MIRT458274	hsa-miR-4458	PAR-CLIP	26701625
MIRT458274	hsa-miR-4458	PAR-CLIP	26701625
MIRT458269	hsa-miR-4470	PAR-CLIP	26701625
MIRT458269	hsa-miR-4470	PAR-CLIP	26701625
MIRT458275	hsa-miR-4500	PAR-CLIP	26701625
MIRT458275	hsa-miR-4500	PAR-CLIP	26701625
MIRT458283	hsa-miR-4524a-3p	PAR-CLIP	26701625
MIRT458283	hsa-miR-4524a-3p	PAR-CLIP	26701625
MIRT458288	hsa-miR-4796-3p	PAR-CLIP	26701625
MIRT458288	hsa-miR-4796-3p	PAR-CLIP	26701625
MIRT458266	hsa-miR-488-3p	PAR-CLIP	26701625
MIRT458266	hsa-miR-488-3p	PAR-CLIP	26701625
MIRT458291	hsa-miR-519d-3p	PAR-CLIP	26701625
MIRT458291	hsa-miR-519d-3p	PAR-CLIP	26701625
MIRT458290	hsa-miR-526b-3p	PAR-CLIP	26701625
MIRT458290	hsa-miR-526b-3p	PAR-CLIP	26701625
MIRT458297	hsa-miR-548ah-5p	PAR-CLIP	26701625
MIRT458297	hsa-miR-548ah-5p	PAR-CLIP	26701625
MIRT458299	hsa-miR-548m	PAR-CLIP	26701625
MIRT458299	hsa-miR-548m	PAR-CLIP	26701625
MIRT458285	hsa-miR-5681a	PAR-CLIP	26701625
MIRT458285	hsa-miR-5681a	PAR-CLIP	26701625
MIRT458284	hsa-miR-6730-5p	PAR-CLIP	26701625
MIRT458284	hsa-miR-6730-5p	PAR-CLIP	26701625
MIRT458289	hsa-miR-93-5p	PAR-CLIP	26701625
MIRT458289	hsa-miR-93-5p	PAR-CLIP	26701625
MIRT458273	hsa-miR-98-5p	PAR-CLIP	26701625
MIRT458273	hsa-miR-98-5p	PAR-CLIP	26701625
MIRT458299	hsa-miR-548m	PAR-CLIP	23592263
MIRT458298	hsa-miR-3609	PAR-CLIP	23592263
MIRT458297	hsa-miR-548ah-5p	PAR-CLIP	23592263
MIRT458296	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT458295	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT458294	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT458293	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT458292	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT458291	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT458290	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT458289	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT458288	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT458287	hsa-miR-183-5p	PAR-CLIP	23592263
MIRT458286	hsa-miR-4698	PAR-CLIP	23592263
MIRT458285	hsa-miR-5681a	PAR-CLIP	23592263
MIRT458284	hsa-miR-6730-5p	PAR-CLIP	23592263
MIRT458283	hsa-miR-4524a-3p	PAR-CLIP	23592263
MIRT458282	hsa-let-7a-5p	PAR-CLIP	23592263
MIRT458281	hsa-let-7b-5p	PAR-CLIP	23592263
MIRT051863	hsa-let-7c-5p	PAR-CLIP	23592263
MIRT458280	hsa-let-7d-5p	PAR-CLIP	23592263
MIRT458279	hsa-let-7e-5p	PAR-CLIP	23592263
MIRT458278	hsa-let-7f-5p	PAR-CLIP	23592263
MIRT458277	hsa-let-7g-5p	PAR-CLIP	23592263
MIRT458276	hsa-let-7i-5p	PAR-CLIP	23592263
MIRT458274	hsa-miR-4458	PAR-CLIP	23592263
MIRT458275	hsa-miR-4500	PAR-CLIP	23592263
MIRT458273	hsa-miR-98-5p	PAR-CLIP	23592263
MIRT458272	hsa-miR-202-3p	PAR-CLIP	23592263
MIRT458271	hsa-miR-1468-3p	PAR-CLIP	23592263
MIRT458269	hsa-miR-4470	PAR-CLIP	23592263
MIRT458270	hsa-miR-4713-3p	PAR-CLIP	23592263
MIRT458268	hsa-miR-638	PAR-CLIP	23592263
MIRT458267	hsa-miR-505-3p	PAR-CLIP	23592263
MIRT458266	hsa-miR-488-3p	PAR-CLIP	23592263
MIRT458265	hsa-miR-450b-3p	PAR-CLIP	23592263
MIRT458264	hsa-miR-769-3p	PAR-CLIP	23592263
MIRT458263	hsa-miR-3138	PAR-CLIP	23592263
MIRT446715	hsa-miR-548at-5p	PAR-CLIP	22100165
MIRT446714	hsa-miR-561-3p	PAR-CLIP	22100165
MIRT446713	hsa-miR-148a-5p	PAR-CLIP	22100165
MIRT446712	hsa-miR-5584-3p	PAR-CLIP	22100165
MIRT446711	hsa-miR-142-5p	PAR-CLIP	22100165
MIRT446710	hsa-miR-5590-3p	PAR-CLIP	22100165
MIRT446709	hsa-miR-3613-3p	PAR-CLIP	22100165
MIRT446708	hsa-miR-371b-5p	PAR-CLIP	22100165
MIRT446707	hsa-miR-373-5p	PAR-CLIP	22100165
MIRT446706	hsa-miR-616-5p	PAR-CLIP	22100165
MIRT450007	hsa-miR-371a-5p	PAR-CLIP	22100165
MIRT450006	hsa-miR-372-5p	PAR-CLIP	22100165
MIRT446705	hsa-miR-4635	PAR-CLIP	22100165
MIRT446704	hsa-miR-570-3p	PAR-CLIP	22100165
MIRT446703	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT446715	hsa-miR-548at-5p	PAR-CLIP	22100165
MIRT446714	hsa-miR-561-3p	PAR-CLIP	22100165
MIRT446713	hsa-miR-148a-5p	PAR-CLIP	22100165
MIRT446712	hsa-miR-5584-3p	PAR-CLIP	22100165
MIRT446711	hsa-miR-142-5p	PAR-CLIP	22100165
MIRT446710	hsa-miR-5590-3p	PAR-CLIP	22100165
MIRT446709	hsa-miR-3613-3p	PAR-CLIP	22100165
MIRT446708	hsa-miR-371b-5p	PAR-CLIP	22100165
MIRT446707	hsa-miR-373-5p	PAR-CLIP	22100165
MIRT446706	hsa-miR-616-5p	PAR-CLIP	22100165
MIRT446705	hsa-miR-4635	PAR-CLIP	22100165
MIRT446704	hsa-miR-570-3p	PAR-CLIP	22100165
MIRT446703	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT1006429	hsa-miR-103a	CLIP-seq
MIRT1006430	hsa-miR-107	CLIP-seq
MIRT1006431	hsa-miR-1184	CLIP-seq
MIRT1006432	hsa-miR-1229	CLIP-seq
MIRT1006433	hsa-miR-1253	CLIP-seq
MIRT1006434	hsa-miR-1266	CLIP-seq
MIRT1006435	hsa-miR-1278	CLIP-seq
MIRT1006436	hsa-miR-186	CLIP-seq
MIRT1006437	hsa-miR-1911	CLIP-seq
MIRT1006438	hsa-miR-217	CLIP-seq
MIRT1006439	hsa-miR-2682	CLIP-seq
MIRT1006440	hsa-miR-299-3p	CLIP-seq
MIRT1006441	hsa-miR-3129-3p	CLIP-seq
MIRT1006442	hsa-miR-3133	CLIP-seq
MIRT1006443	hsa-miR-3185	CLIP-seq
MIRT1006444	hsa-miR-342-3p	CLIP-seq
MIRT1006445	hsa-miR-3529	CLIP-seq
MIRT1006446	hsa-miR-365	CLIP-seq
MIRT1006447	hsa-miR-3692	CLIP-seq
MIRT1006448	hsa-miR-3714	CLIP-seq
MIRT1006449	hsa-miR-379	CLIP-seq
MIRT1006450	hsa-miR-3927	CLIP-seq
MIRT1006451	hsa-miR-425	CLIP-seq
MIRT1006452	hsa-miR-4279	CLIP-seq
MIRT1006453	hsa-miR-4418	CLIP-seq
MIRT1006454	hsa-miR-4434	CLIP-seq
MIRT1006455	hsa-miR-4491	CLIP-seq
MIRT1006456	hsa-miR-449c	CLIP-seq
MIRT1006457	hsa-miR-4516	CLIP-seq
MIRT1006458	hsa-miR-4518	CLIP-seq
MIRT1006459	hsa-miR-4531	CLIP-seq
MIRT1006460	hsa-miR-4657	CLIP-seq
MIRT1006461	hsa-miR-4744	CLIP-seq
MIRT1006462	hsa-miR-4789-3p	CLIP-seq
MIRT1006463	hsa-miR-4802-5p	CLIP-seq
MIRT1006464	hsa-miR-509-3-5p	CLIP-seq
MIRT1006465	hsa-miR-509-5p	CLIP-seq
MIRT1006466	hsa-miR-548ah	CLIP-seq
MIRT1006467	hsa-miR-548an	CLIP-seq
MIRT1006468	hsa-miR-642b	CLIP-seq
MIRT1006469	hsa-miR-659	CLIP-seq
MIRT1006470	hsa-miR-944	CLIP-seq
MIRT1998240	hsa-miR-3671	CLIP-seq
MIRT1998241	hsa-miR-3688-3p	CLIP-seq
MIRT1998242	hsa-miR-4303	CLIP-seq
MIRT1998243	hsa-miR-4649-3p	CLIP-seq
MIRT1998244	hsa-miR-656	CLIP-seq
MIRT1998245	hsa-miR-889	CLIP-seq
MIRT2231835	hsa-miR-3065-3p	CLIP-seq
MIRT2231836	hsa-miR-3198	CLIP-seq
MIRT2231837	hsa-miR-4291	CLIP-seq
MIRT2231838	hsa-miR-4309	CLIP-seq
MIRT2231839	hsa-miR-4653-3p	CLIP-seq
MIRT2388250	hsa-miR-4438	CLIP-seq
MIRT2535863	hsa-miR-199a-5p	CLIP-seq
MIRT2535864	hsa-miR-199b-5p	CLIP-seq
MIRT2535865	hsa-miR-4462	CLIP-seq
MIRT2535866	hsa-miR-4802-3p	CLIP-seq
MIRT2535867	hsa-miR-554	CLIP-seq
MIRT2535868	hsa-miR-7	CLIP-seq
MIRT2535863	hsa-miR-199a-5p	CLIP-seq
MIRT2535864	hsa-miR-199b-5p	CLIP-seq
MIRT2535866	hsa-miR-4802-3p	CLIP-seq
MIRT2535867	hsa-miR-554	CLIP-seq

Show/Hide all(18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005654	Component	Nucleoplasm	IDA
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005794	Component	Golgi apparatus	TAS	11698403
GO:0006457	Process	Protein folding	NAS	11698403
GO:0006486	Process	Protein glycosylation	IEA
GO:0006486	Process	Protein glycosylation	TAS	11698403
GO:0006605	Process	Protein targeting	NAS	11698403
GO:0007399	Process	Nervous system development	NAS	11698403
GO:0009566	Process	Fertilization	NAS	11698403
GO:0016021	Component	Integral component of membrane	IEA
GO:0030097	Process	Hemopoiesis	NAS	11698403
GO:0032580	Component	Golgi cisterna membrane	IEA
GO:0036065	Process	Fucosylation	IBA	21873635
GO:0042060	Process	Wound healing	NAS	11698403
GO:0042355	Process	L-fucose catabolic process	NAS	11698403
GO:0046920	Function	Alpha-(1->3)-fucosyltransferase activity	IBA	21873635
GO:0046920	Function	Alpha-(1->3)-fucosyltransferase activity	TAS	11698403

MIM	HGNC	e!Ensembl
616931	19234	ENSG00000172728

Protein

UniProt ID

Q6P4F1

Protein name

GDP-fucose protein O-fucosyltransferase 3 (EC 2.4.1.221) (Alpha-(1,3)-fucosyltransferase 10) (EC 2.4.1.-) (Fucosyltransferase X) (Fuc-TX) (FucT-X) (Galactoside 3-L-fucosyltransferase 10) (Fucosyltransferase 10)

Protein function

Protein O-fucosyltransferase that specifically catalyzes O-fucosylation of serine or threonine residues in EMI domains of target proteins, such as MMRN1, MMRN2 and EMID1 (PubMed:39775168). Attaches fucose through an O-glycosidic linkage (PubMed:

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF17039	Glyco_tran_10_N	79 → 185	Fucosyltransferase, N-terminal	Domain
PF00852	Glyco_transf_10	209 → 405	Glycosyltransferase family 10 (fucosyltransferase) C-term	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in lung, digestive tract, gall bladder, placenta, kidney, uterus and brain. Not detected in spleen, heart, muscle, liver and pancreas. {ECO:0000269|PubMed:19088067}.

Sequence

MVRIQRRKLLASCLCVTATVFLLVTLQVMVELGKFERKEFKSSSLQDGHTKMEEAPTHLN
SFLKKEGLTFNRKRKWELDSYPIMLWWSPLTGETGRLGQCGADACFFTINRTYLHHHMTK
AFLFYGTDFNIDSLPLPRKAHHDWAVFHEESPKNNYKLFHKPVITLFNYTATFSRHSHLP
LTTQYLESIEVLKSLRYLVPLQSKNKLRKRLAPLVYVQSDCDPPSDRDSYVRELMTYIEV
DSYGECLRNKDLPQQLKNPASMDADGFYRIIAQYKFILAFENAVCDDYITEKFWRPLKLG
VVPVYYGSPSITDWLPSNKSAILVSEFSHPRELASYIRRLDSDDRLYEAYVEWKLKGEIS
NQRLLTALRERKWGVQDVNQDNYIDAFECMVCTKVWANIRLQEKGLPPKRWEAEDTHLSC
PEPTVFAFSPLRTPPLSSLREMWISSFEQSKKEAQALRWLVDRNQNFSSQEFWGLVFKD

Sequence length

479

Interactions

View interactions

	Reactome
			Lewis blood group biosynthesis

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Frontotemporal dementia	Frontotemporal dementia	rs63751273, rs63750376, rs63750424, rs63750972, rs1568327531, rs63750570, rs63750756, rs63751165, rs63750512, rs63751438, rs63750912, rs63750711, rs63750635, rs63750349, rs63750092 View all (31 more)	29724592

POFUT3 (protein O-fucosyltransferase 3)