Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	84735
Gene name Gene Name - the full gene name approved by the HGNC.	Carnosine dipeptidase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CNDP1
Synonyms (NCBI Gene) Gene synonyms aliases	CN1, CPGL2, HsT2308
Chromosome Chromosome number	18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	18q22.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the M20 metalloprotease family. The encoded protein is specifically expressed in the brain, is a homodimeric dipeptidase which was identified as human carnosinase. This gene contains trinucleotide (CTG) repeat length polymorp

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018796	hsa-miR-335-5p	Microarray	18185580
MIRT688748	hsa-miR-4485-5p	HITS-CLIP	23313552
MIRT688747	hsa-miR-660-3p	HITS-CLIP	23313552
MIRT688746	hsa-miR-4722-3p	HITS-CLIP	23313552
MIRT688745	hsa-miR-6727-3p	HITS-CLIP	23313552
MIRT688744	hsa-miR-6747-3p	HITS-CLIP	23313552
MIRT688743	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT688742	hsa-miR-6852-5p	HITS-CLIP	23313552
MIRT688741	hsa-miR-6742-3p	HITS-CLIP	23313552
MIRT688740	hsa-miR-1281	HITS-CLIP	23313552
MIRT688739	hsa-miR-3653-5p	HITS-CLIP	23313552
MIRT688738	hsa-miR-1976	HITS-CLIP	23313552
MIRT688737	hsa-miR-4772-3p	HITS-CLIP	23313552
MIRT688736	hsa-miR-891b	HITS-CLIP	23313552
MIRT688735	hsa-miR-6791-3p	HITS-CLIP	23313552
MIRT688734	hsa-miR-6829-3p	HITS-CLIP	23313552
MIRT688733	hsa-miR-23a-5p	HITS-CLIP	23313552
MIRT688732	hsa-miR-23b-5p	HITS-CLIP	23313552
MIRT688731	hsa-miR-6084	HITS-CLIP	23313552
MIRT688730	hsa-miR-1343-3p	HITS-CLIP	23313552
MIRT688729	hsa-miR-6783-3p	HITS-CLIP	23313552
MIRT688728	hsa-miR-4279	HITS-CLIP	23313552
MIRT688727	hsa-miR-498	HITS-CLIP	23313552
MIRT688726	hsa-miR-718	HITS-CLIP	23313552
MIRT669782	hsa-miR-5693	HITS-CLIP	23824327
MIRT669781	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT669780	hsa-miR-3135b	HITS-CLIP	23824327
MIRT669779	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT669778	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT669777	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT669776	hsa-miR-3652	HITS-CLIP	23824327
MIRT669775	hsa-miR-4430	HITS-CLIP	23824327
MIRT669774	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT669769	hsa-miR-5698	HITS-CLIP	23824327
MIRT669782	hsa-miR-5693	HITS-CLIP	23824327
MIRT669781	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT669780	hsa-miR-3135b	HITS-CLIP	23824327
MIRT669779	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT669778	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT669777	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT669776	hsa-miR-3652	HITS-CLIP	23824327
MIRT669775	hsa-miR-4430	HITS-CLIP	23824327
MIRT669774	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT669773	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT669772	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT669771	hsa-miR-4420	HITS-CLIP	23824327
MIRT669770	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT669769	hsa-miR-5698	HITS-CLIP	23824327
MIRT688748	hsa-miR-4485-5p	HITS-CLIP	23313552
MIRT688747	hsa-miR-660-3p	HITS-CLIP	23313552
MIRT688746	hsa-miR-4722-3p	HITS-CLIP	23313552
MIRT688745	hsa-miR-6727-3p	HITS-CLIP	23313552
MIRT688744	hsa-miR-6747-3p	HITS-CLIP	23313552
MIRT688743	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT688742	hsa-miR-6852-5p	HITS-CLIP	23313552
MIRT688741	hsa-miR-6742-3p	HITS-CLIP	23313552
MIRT688740	hsa-miR-1281	HITS-CLIP	23313552
MIRT688739	hsa-miR-3653-5p	HITS-CLIP	23313552
MIRT688738	hsa-miR-1976	HITS-CLIP	23313552
MIRT688737	hsa-miR-4772-3p	HITS-CLIP	23313552
MIRT688736	hsa-miR-891b	HITS-CLIP	23313552
MIRT688735	hsa-miR-6791-3p	HITS-CLIP	23313552
MIRT688734	hsa-miR-6829-3p	HITS-CLIP	23313552
MIRT688733	hsa-miR-23a-5p	HITS-CLIP	23313552
MIRT688732	hsa-miR-23b-5p	HITS-CLIP	23313552
MIRT688731	hsa-miR-6084	HITS-CLIP	23313552
MIRT688730	hsa-miR-1343-3p	HITS-CLIP	23313552
MIRT688729	hsa-miR-6783-3p	HITS-CLIP	23313552
MIRT688728	hsa-miR-4279	HITS-CLIP	23313552
MIRT688727	hsa-miR-498	HITS-CLIP	23313552
MIRT688726	hsa-miR-718	HITS-CLIP	23313552
MIRT669782	hsa-miR-5693	HITS-CLIP	23824327
MIRT669781	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT669780	hsa-miR-3135b	HITS-CLIP	23824327
MIRT669779	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT669778	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT669777	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT669776	hsa-miR-3652	HITS-CLIP	23824327
MIRT669775	hsa-miR-4430	HITS-CLIP	23824327
MIRT669774	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT669769	hsa-miR-5698	HITS-CLIP	23824327
MIRT669782	hsa-miR-5693	HITS-CLIP	23824327
MIRT669781	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT669780	hsa-miR-3135b	HITS-CLIP	23824327
MIRT669779	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT669778	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT669777	hsa-miR-3622b-5p	HITS-CLIP	23824327
MIRT669776	hsa-miR-3652	HITS-CLIP	23824327
MIRT669775	hsa-miR-4430	HITS-CLIP	23824327
MIRT669774	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT669773	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT669772	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT669771	hsa-miR-4420	HITS-CLIP	23824327
MIRT669770	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT669769	hsa-miR-5698	HITS-CLIP	23824327
MIRT899363	hsa-miR-1343	CLIP-seq
MIRT899364	hsa-miR-25	CLIP-seq
MIRT899365	hsa-miR-32	CLIP-seq
MIRT899366	hsa-miR-363	CLIP-seq
MIRT899367	hsa-miR-367	CLIP-seq
MIRT899368	hsa-miR-4283	CLIP-seq
MIRT899369	hsa-miR-4489	CLIP-seq
MIRT899370	hsa-miR-4700-3p	CLIP-seq
MIRT899371	hsa-miR-92a	CLIP-seq
MIRT899372	hsa-miR-92b	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004180	Function	Carboxypeptidase activity	IEA
GO:0005515	Function	Protein binding	IPI	33961781
GO:0005576	Component	Extracellular region	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	24891507
GO:0006508	Process	Proteolysis	IBA
GO:0006508	Process	Proteolysis	IDA	24891507
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016805	Function	Dipeptidase activity	IBA
GO:0016805	Function	Dipeptidase activity	IDA	24891507
GO:0046872	Function	Metal ion binding	IEA
GO:0051246	Process	Regulation of protein metabolic process	IDA	24891507
GO:0070573	Function	Metallodipeptidase activity	IEA

MIM	HGNC	e!Ensembl
609064	20675	ENSG00000150656

Protein

UniProt ID

Q96KN2

Protein name

Beta-Ala-His dipeptidase (EC 3.4.13.20) (CNDP dipeptidase 1) (Carnosine dipeptidase 1) (Glutamate carboxypeptidase-like protein 2) (Serum carnosinase)

Protein function

Catalyzes the peptide bond hydrolysis in Xaa-His dipeptides, displaying the highest activity toward carnosine (beta-alanyl-L-histidine) and anserine (beta-alanyl-3-methyl-histidine).

PDB

3DLJ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01546	Peptidase_M20	128 → 502	Peptidase family M20/M25/M40	Family
PF07687	M20_dimer	241 → 402	Peptidase dimerisation domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Found in serum and adult nervous central system. Absent in serum from patients with homocarnosinosis. {ECO:0000269|PubMed:12473676, ECO:0000269|PubMed:6616870}.

Sequence

MDPKLGRMAASLLAVLLLLLERGMFSSPSPPPALLEKVFQYIDLHQDEFVQTLKEWVAIE
SDSVQPVPRFRQELFRMMAVAADTLQRLGARVASVDMGPQQLPDGQSLPIPPIILAELGS
DPTKGTVCFYGHLDVQPADRGDGWLTDPYVLTEVDGKLYGRGATDNKGPVLAWINAVSAF
RALEQDLPVNIKFIIEGMEEAGSVALEELVEKEKDRFFSGVDYIVISDNLWISQRKPAIT
YGTRGNSYFMVEVKCRDQDFHSGTFGGILHEPMADLVALLGSLVDSSGHILVPGIYDEVV
PLTEEEINTYKAIHLDLEEYRNSSRVEKFLFDTKEEILMHLWRYPSLSIHGIEGAFDEPG
TKTVIPGRVIGKFSIRLVPHMNVSAVEKQVTRHLEDVFSKRNSSNKMVVSMTLGLHPWIA
NIDDTQYLAAKRAIRTVFGTEPDMIRDGSTIPIAKMFQEIVHKSVVLIPLGAVDDGEHSQ
NEKINRWNYIEGTKLFAAFFLEMAQLH

Sequence length

507

Interactions

View interactions

	KEGG
	Arginine and proline metabolism Histidine metabolism beta-Alanine metabolism Metabolic pathways

CNDP1 (carnosine dipeptidase 1)