MGARP (mitochondria localized glutamic acid rich protein)

Gene

• Entrez ID: 84709
• Gene name: Mitochondria localized glutamic acid rich protein
• Gene symbol: MGARP
• Synonyms (NCBI Gene): C4orf49, CESP-1, HUMMR, OSAP
• Chromosome: 4
• Chromosome location: 4q31.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT527383	hsa-miR-548ac	PAR-CLIP	22012620
MIRT527382	hsa-miR-548bb-3p	PAR-CLIP	22012620
MIRT527381	hsa-miR-548d-3p	PAR-CLIP	22012620
MIRT527380	hsa-miR-548h-3p	PAR-CLIP	22012620
MIRT527379	hsa-miR-548z	PAR-CLIP	22012620
MIRT527378	hsa-miR-548ae-3p	PAR-CLIP	22012620
MIRT527377	hsa-miR-548ah-3p	PAR-CLIP	22012620
MIRT527376	hsa-miR-548aj-3p	PAR-CLIP	22012620
MIRT527375	hsa-miR-548am-3p	PAR-CLIP	22012620
MIRT527374	hsa-miR-548aq-3p	PAR-CLIP	22012620
MIRT527373	hsa-miR-548j-3p	PAR-CLIP	22012620
MIRT527372	hsa-miR-548x-3p	PAR-CLIP	22012620
MIRT527371	hsa-miR-548e-5p	PAR-CLIP	22012620
MIRT527369	hsa-miR-6835-3p	PAR-CLIP	22012620
MIRT527370	hsa-miR-2115-3p	PAR-CLIP	22012620
MIRT527368	hsa-miR-361-5p	PAR-CLIP	22012620
MIRT527367	hsa-miR-374a-3p	PAR-CLIP	22012620
MIRT527383	hsa-miR-548ac	PAR-CLIP	22012620
MIRT527382	hsa-miR-548bb-3p	PAR-CLIP	22012620
MIRT527381	hsa-miR-548d-3p	PAR-CLIP	22012620
MIRT527380	hsa-miR-548h-3p	PAR-CLIP	22012620
MIRT527379	hsa-miR-548z	PAR-CLIP	22012620
MIRT527378	hsa-miR-548ae-3p	PAR-CLIP	22012620
MIRT527377	hsa-miR-548ah-3p	PAR-CLIP	22012620
MIRT527376	hsa-miR-548aj-3p	PAR-CLIP	22012620
MIRT527375	hsa-miR-548am-3p	PAR-CLIP	22012620
MIRT527374	hsa-miR-548aq-3p	PAR-CLIP	22012620
MIRT527373	hsa-miR-548j-3p	PAR-CLIP	22012620
MIRT527372	hsa-miR-548x-3p	PAR-CLIP	22012620
MIRT527371	hsa-miR-548e-5p	PAR-CLIP	22012620
MIRT527369	hsa-miR-6835-3p	PAR-CLIP	22012620
MIRT527370	hsa-miR-2115-3p	PAR-CLIP	22012620
MIRT527368	hsa-miR-361-5p	PAR-CLIP	22012620
MIRT527367	hsa-miR-374a-3p	PAR-CLIP	22012620

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	19528298, 32814053
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA	16565373, 21447634
GO:0005739	Component	Mitochondrion	IEA
GO:0005741	Component	Mitochondrial outer membrane	IBA
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005741	Component	Mitochondrial outer membrane	ISS
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	ISS
GO:0006626	Process	Protein targeting to mitochondrion	ISS
GO:0008089	Process	Anterograde axonal transport	IEA
GO:0008089	Process	Anterograde axonal transport	ISS
GO:0008090	Process	Retrograde axonal transport	ISS
GO:0010821	Process	Regulation of mitochondrion organization	ISS
GO:0016020	Component	Membrane	IEA
GO:0019896	Process	Axonal transport of mitochondrion	ISS
GO:0021987	Process	Cerebral cortex development	ISS
GO:0061564	Process	Axon development	ISS
GO:0071383	Process	Cellular response to steroid hormone stimulus	ISS
GO:0071456	Process	Cellular response to hypoxia	ISS
GO:0097211	Process	Cellular response to gonadotropin-releasing hormone	ISS
GO:1904115	Component	Axon cytoplasm	IEA
GO:2000171	Process	Negative regulation of dendrite development	ISS

Other IDs

• MIM: 619684
• HGNC: 29969
• e!Ensembl: ENSG00000137463

Protein

• UniProt ID: Q8TDB4
• Protein name: Protein MGARP (Corneal endothelium-specific protein 1) (CESP-1) (Hypoxia up-regulated mitochondrial movement regulator protein) (Mitochondria-localized glutamic acid-rich protein) (Ovary-specific acidic protein)
• Protein function: Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the c
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF14962	AIF-MLS	1 → 191	Mitochondria Localisation Sequence	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in the brain, adrenal gland and corneal endothelium (CE). Expressed in steroid-producing cells of the ovary and testis (at protein level). Expressed in steroid-producing cells of the ovary and testis. Weakly expressed in plac
• Sequence:

  MYLRRAVSKTLALPLRAPPNPAPLGKDASLRRMSSNRFPGSSGSNMIYYLVVGVTVSAGG
  YYAYKTVTSDQAKHTEHKTNLKEKTKAEIHPFQGEKENVAETEKASSEAPEELIVEAEVV
  DAEESPSATVVVIKEASACPGHVEAAPETTAVSAETGPEVTDAAARETTEVNPETTPEVT
  NAALDEAVTIDNDKDTTKNETSDEYAELEEENSPAESESSAGDDLQEEASVGSEAASAQG
  

• Sequence length: 240