Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	84665
Gene name	Myopalladin
Gene symbol	MYPN
Synonyms (NCBI Gene)	CMD1DDCMH22CMYO24CMYP24MYOPNEM11RCM4
Chromosome	10
Chromosome location	10q21.3
Summary	Striated muscle in vertebrates comprises large proteins which must be organized properly to contract efficiently. Z-lines in striated muscle are a sign of this organization, representing the ends of actin thin filaments, titin, nebulin or nebulette and ac

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SNP ID	Visualize variation	Clinical significance	Consequence
rs2673793	C>G,T	Conflicting-interpretations-of-pathogenicity, benign	Non coding transcript variant, coding sequence variant, synonymous variant
rs71534278	C>A,T	Likely-benign, conflicting-interpretations-of-pathogenicity, pathogenic, uncertain-significance, benign-likely-benign, benign	Missense variant, coding sequence variant, non coding transcript variant
rs71534280	G>A	Conflicting-interpretations-of-pathogenicity, uncertain-significance, likely-benign	Missense variant, coding sequence variant, non coding transcript variant
rs71584501	G>A	Uncertain-significance, pathogenic	Missense variant, coding sequence variant, non coding transcript variant
rs138313730	C>A	Benign-likely-benign, benign, likely-benign, conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, non coding transcript variant, coding sequence variant
rs140148105	A>G	Conflicting-interpretations-of-pathogenicity, pathogenic, likely-benign	5 prime UTR variant, missense variant, non coding transcript variant, coding sequence variant, intron variant
rs142354704	C>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, non coding transcript variant, coding sequence variant
rs145142157	C>G	Conflicting-interpretations-of-pathogenicity, likely-benign	5 prime UTR variant, missense variant, non coding transcript variant, coding sequence variant, intron variant
rs149887823	C>G,T	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant, non coding transcript variant
rs150911078	G>A	Conflicting-interpretations-of-pathogenicity, likely-benign	Coding sequence variant, missense variant, non coding transcript variant
rs151282801	C>A,T	Uncertain-significance, conflicting-interpretations-of-pathogenicity	Coding sequence variant, missense variant, non coding transcript variant
rs199476401	A>C,G	Likely-pathogenic, uncertain-significance, not-provided	5 prime UTR variant, missense variant, non coding transcript variant, intron variant, coding sequence variant
rs199476408	C>G,T	Pathogenic, not-provided	Coding sequence variant, stop gained, non coding transcript variant, missense variant
rs199853307	G>C,T	Conflicting-interpretations-of-pathogenicity, likely-benign	5 prime UTR variant, missense variant, non coding transcript variant, intron variant, coding sequence variant
rs201245117	A>C	Conflicting-interpretations-of-pathogenicity, likely-benign	Coding sequence variant, non coding transcript variant, missense variant
rs786205457	C>T	Uncertain-significance, likely-pathogenic	Non coding transcript variant, coding sequence variant, 5 prime UTR variant, missense variant
rs864621995	C>T	Conflicting-interpretations-of-pathogenicity	Non coding transcript variant, coding sequence variant, missense variant
rs865921466	G>A	Likely-pathogenic	Splice acceptor variant
rs1057519570	A>-	Pathogenic	Frameshift variant, non coding transcript variant, coding sequence variant
rs1057519571	A>C	Pathogenic	Splice acceptor variant
rs1057519572	C>T	Uncertain-significance, pathogenic	Stop gained, non coding transcript variant, coding sequence variant
rs1057519573	C>T	Pathogenic	Stop gained, non coding transcript variant, coding sequence variant
rs1589608098	A>-	Pathogenic	Frameshift variant, coding sequence variant, non coding transcript variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017101	hsa-miR-335-5p	Microarray	18185580
MIRT021986	hsa-miR-128-3p	Microarray	17612493
MIRT022358	hsa-miR-124-3p	Microarray	18668037
MIRT701615	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT701614	hsa-miR-3163	HITS-CLIP	23313552
MIRT701613	hsa-miR-340-3p	HITS-CLIP	23313552
MIRT701612	hsa-miR-6827-3p	HITS-CLIP	23313552
MIRT701611	hsa-miR-340-5p	HITS-CLIP	23313552
MIRT701610	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT701609	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT701608	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT667295	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT667294	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT701607	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT667293	hsa-miR-1285-3p	HITS-CLIP	23313552
MIRT667292	hsa-miR-3187-5p	HITS-CLIP	23313552
MIRT667290	hsa-miR-5189-5p	HITS-CLIP	23313552
MIRT667291	hsa-miR-612	HITS-CLIP	23313552
MIRT667289	hsa-miR-6860	HITS-CLIP	23313552
MIRT701606	hsa-miR-5186	HITS-CLIP	23313552
MIRT701605	hsa-miR-4252	HITS-CLIP	23313552
MIRT667288	hsa-miR-661	HITS-CLIP	23313552
MIRT701604	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT701603	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT701602	hsa-miR-7703	HITS-CLIP	23313552
MIRT701601	hsa-miR-3609	HITS-CLIP	23313552
MIRT701600	hsa-miR-548ah-5p	HITS-CLIP	23313552
MIRT701599	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT701598	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT701597	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT701596	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT701595	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT701594	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT701593	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT701592	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT701591	hsa-miR-4796-3p	HITS-CLIP	23313552
MIRT701590	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT701589	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT701588	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT701587	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT701586	hsa-miR-302e	HITS-CLIP	23313552
MIRT701585	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT701584	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT701583	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT701582	hsa-miR-520b	HITS-CLIP	23313552
MIRT701581	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT701580	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT701579	hsa-miR-520e	HITS-CLIP	23313552
MIRT701578	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT701577	hsa-miR-5009-3p	HITS-CLIP	23313552
MIRT701576	hsa-miR-6747-3p	HITS-CLIP	23313552
MIRT701574	hsa-miR-1234-3p	HITS-CLIP	23313552
MIRT701575	hsa-miR-7107-5p	HITS-CLIP	23313552
MIRT701573	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT701571	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT701572	hsa-miR-6791-3p	HITS-CLIP	23313552
MIRT701570	hsa-miR-6829-3p	HITS-CLIP	23313552
MIRT701569	hsa-miR-4763-5p	HITS-CLIP	23313552
MIRT701568	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT701567	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT701566	hsa-miR-6511b-5p	HITS-CLIP	23313552
MIRT701565	hsa-miR-6811-5p	HITS-CLIP	23313552
MIRT701564	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT681190	hsa-miR-4756-3p	HITS-CLIP	23706177
MIRT681189	hsa-miR-143-3p	HITS-CLIP	23706177
MIRT681188	hsa-miR-4770	HITS-CLIP	23706177
MIRT681187	hsa-miR-6088	HITS-CLIP	23706177
MIRT681186	hsa-miR-4468	HITS-CLIP	23706177
MIRT681185	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT681184	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT681183	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT678409	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT678408	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT678407	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT678405	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT678406	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT678404	hsa-miR-221-5p	HITS-CLIP	23824327
MIRT678403	hsa-miR-8073	HITS-CLIP	23824327
MIRT678402	hsa-miR-1281	HITS-CLIP	23824327
MIRT678401	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678400	hsa-miR-149-5p	HITS-CLIP	23824327
MIRT678399	hsa-miR-4284	HITS-CLIP	23824327
MIRT678398	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT678397	hsa-miR-4279	HITS-CLIP	23824327
MIRT667295	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT667294	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT667293	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT667292	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT667290	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT667291	hsa-miR-612	HITS-CLIP	23824327
MIRT667289	hsa-miR-6860	HITS-CLIP	23824327
MIRT667288	hsa-miR-661	HITS-CLIP	23824327
MIRT656019	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT656018	hsa-miR-3183	HITS-CLIP	23824327
MIRT656016	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT656017	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT656015	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT656014	hsa-miR-4504	HITS-CLIP	23824327
MIRT656013	hsa-miR-8068	HITS-CLIP	23824327
MIRT656012	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT656011	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT656010	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT656009	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT656007	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT535734	hsa-miR-302f	PAR-CLIP	22012620
MIRT535733	hsa-miR-3977	PAR-CLIP	22012620
MIRT535732	hsa-miR-133a-3p	PAR-CLIP	22012620
MIRT535732	hsa-miR-133a-3p	PAR-CLIP	22012620
MIRT535731	hsa-miR-133b	PAR-CLIP	22012620
MIRT516731	hsa-miR-3681-5p	PAR-CLIP	23446348
MIRT516732	hsa-miR-6849-5p	PAR-CLIP	23446348
MIRT516730	hsa-miR-6890-5p	PAR-CLIP	23446348
MIRT516729	hsa-miR-1273f	PAR-CLIP	23446348
MIRT516728	hsa-miR-4683	PAR-CLIP	23446348
MIRT516727	hsa-miR-193b-5p	PAR-CLIP	23446348
MIRT516726	hsa-miR-4727-3p	PAR-CLIP	23446348
MIRT516725	hsa-miR-4460	PAR-CLIP	23446348
MIRT516724	hsa-miR-6788-3p	PAR-CLIP	23446348
MIRT516723	hsa-miR-1270	PAR-CLIP	23446348
MIRT516722	hsa-miR-620	PAR-CLIP	23446348
MIRT516721	hsa-miR-3170	PAR-CLIP	23446348
MIRT516720	hsa-miR-6855-5p	PAR-CLIP	23446348
MIRT516719	hsa-miR-3591-5p	PAR-CLIP	23446348
MIRT443397	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT443396	hsa-miR-3156-5p	PAR-CLIP	22100165
MIRT443395	hsa-miR-4802-3p	PAR-CLIP	22100165
MIRT443394	hsa-miR-490-5p	PAR-CLIP	22100165
MIRT443392	hsa-miR-3928-3p	PAR-CLIP	22100165
MIRT443393	hsa-miR-1261	PAR-CLIP	22100165
MIRT681189	hsa-miR-143-3p	PAR-CLIP	26701625
MIRT681189	hsa-miR-143-3p	PAR-CLIP	26701625
MIRT681186	hsa-miR-4468	PAR-CLIP	26701625
MIRT681186	hsa-miR-4468	PAR-CLIP	26701625
MIRT681184	hsa-miR-455-3p	PAR-CLIP	26701625
MIRT681184	hsa-miR-455-3p	PAR-CLIP	26701625
MIRT681190	hsa-miR-4756-3p	PAR-CLIP	26701625
MIRT681190	hsa-miR-4756-3p	PAR-CLIP	26701625
MIRT681188	hsa-miR-4770	PAR-CLIP	26701625
MIRT681188	hsa-miR-4770	PAR-CLIP	26701625
MIRT681187	hsa-miR-6088	PAR-CLIP	26701625
MIRT681187	hsa-miR-6088	PAR-CLIP	26701625
MIRT681185	hsa-miR-6499-3p	PAR-CLIP	26701625
MIRT681185	hsa-miR-6499-3p	PAR-CLIP	26701625
MIRT681183	hsa-miR-6516-5p	PAR-CLIP	26701625
MIRT681183	hsa-miR-6516-5p	PAR-CLIP	26701625
MIRT667288	hsa-miR-661	PAR-CLIP	26701625
MIRT667288	hsa-miR-661	PAR-CLIP	26701625
MIRT701615	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT701614	hsa-miR-3163	HITS-CLIP	23313552
MIRT701613	hsa-miR-340-3p	HITS-CLIP	23313552
MIRT701612	hsa-miR-6827-3p	HITS-CLIP	23313552
MIRT701611	hsa-miR-340-5p	HITS-CLIP	23313552
MIRT701610	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT701609	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT701608	hsa-miR-1273g-3p	HITS-CLIP	23313552
MIRT667295	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT667294	hsa-miR-939-3p	HITS-CLIP	23313552
MIRT701607	hsa-miR-4793-3p	HITS-CLIP	23313552
MIRT667293	hsa-miR-1285-3p	HITS-CLIP	23313552
MIRT667292	hsa-miR-3187-5p	HITS-CLIP	23313552
MIRT667290	hsa-miR-5189-5p	HITS-CLIP	23313552
MIRT667291	hsa-miR-612	HITS-CLIP	23313552
MIRT667289	hsa-miR-6860	HITS-CLIP	23313552
MIRT701606	hsa-miR-5186	HITS-CLIP	23313552
MIRT701605	hsa-miR-4252	HITS-CLIP	23313552
MIRT667288	hsa-miR-661	HITS-CLIP	23313552
MIRT701604	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT701603	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT701602	hsa-miR-7703	HITS-CLIP	23313552
MIRT701601	hsa-miR-3609	HITS-CLIP	23313552
MIRT701600	hsa-miR-548ah-5p	HITS-CLIP	23313552
MIRT701599	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT701598	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT701597	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT701596	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT701595	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT701594	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT701593	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT701592	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT701591	hsa-miR-4796-3p	HITS-CLIP	23313552
MIRT701590	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT701589	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT701588	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT701587	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT701586	hsa-miR-302e	HITS-CLIP	23313552
MIRT701585	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT701584	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT701583	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT701582	hsa-miR-520b	HITS-CLIP	23313552
MIRT701581	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT701580	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT701579	hsa-miR-520e	HITS-CLIP	23313552
MIRT701578	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT701577	hsa-miR-5009-3p	HITS-CLIP	23313552
MIRT701576	hsa-miR-6747-3p	HITS-CLIP	23313552
MIRT701574	hsa-miR-1234-3p	HITS-CLIP	23313552
MIRT701575	hsa-miR-7107-5p	HITS-CLIP	23313552
MIRT701573	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT701571	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT701572	hsa-miR-6791-3p	HITS-CLIP	23313552
MIRT701570	hsa-miR-6829-3p	HITS-CLIP	23313552
MIRT701569	hsa-miR-4763-5p	HITS-CLIP	23313552
MIRT701568	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT701567	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT701566	hsa-miR-6511b-5p	HITS-CLIP	23313552
MIRT701565	hsa-miR-6811-5p	HITS-CLIP	23313552
MIRT701564	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT681190	hsa-miR-4756-3p	HITS-CLIP	23706177
MIRT681189	hsa-miR-143-3p	HITS-CLIP	23706177
MIRT681188	hsa-miR-4770	HITS-CLIP	23706177
MIRT681187	hsa-miR-6088	HITS-CLIP	23706177
MIRT681186	hsa-miR-4468	HITS-CLIP	23706177
MIRT681185	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT681184	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT681183	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT678409	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT678408	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT678407	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT678405	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT678406	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT678404	hsa-miR-221-5p	HITS-CLIP	23824327
MIRT678403	hsa-miR-8073	HITS-CLIP	23824327
MIRT678402	hsa-miR-1281	HITS-CLIP	23824327
MIRT678401	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678400	hsa-miR-149-5p	HITS-CLIP	23824327
MIRT678399	hsa-miR-4284	HITS-CLIP	23824327
MIRT678398	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT678397	hsa-miR-4279	HITS-CLIP	23824327
MIRT667295	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT667294	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT667293	hsa-miR-1285-3p	HITS-CLIP	23824327
MIRT667292	hsa-miR-3187-5p	HITS-CLIP	23824327
MIRT667290	hsa-miR-5189-5p	HITS-CLIP	23824327
MIRT667291	hsa-miR-612	HITS-CLIP	23824327
MIRT667289	hsa-miR-6860	HITS-CLIP	23824327
MIRT667288	hsa-miR-661	HITS-CLIP	23824327
MIRT656019	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT656018	hsa-miR-3183	HITS-CLIP	23824327
MIRT656016	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT656017	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT656015	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT656014	hsa-miR-4504	HITS-CLIP	23824327
MIRT656013	hsa-miR-8068	HITS-CLIP	23824327
MIRT656012	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT656011	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT656010	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT656009	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT656007	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT535734	hsa-miR-302f	PAR-CLIP	22012620
MIRT535733	hsa-miR-3977	PAR-CLIP	22012620
MIRT535732	hsa-miR-133a-3p	PAR-CLIP	22012620
MIRT535732	hsa-miR-133a-3p	PAR-CLIP	22012620
MIRT535731	hsa-miR-133b	PAR-CLIP	22012620
MIRT516731	hsa-miR-3681-5p	PAR-CLIP	23446348
MIRT516732	hsa-miR-6849-5p	PAR-CLIP	23446348
MIRT516730	hsa-miR-6890-5p	PAR-CLIP	23446348
MIRT516729	hsa-miR-1273f	PAR-CLIP	23446348
MIRT516728	hsa-miR-4683	PAR-CLIP	23446348
MIRT516727	hsa-miR-193b-5p	PAR-CLIP	23446348
MIRT516726	hsa-miR-4727-3p	PAR-CLIP	23446348
MIRT516725	hsa-miR-4460	PAR-CLIP	23446348
MIRT516724	hsa-miR-6788-3p	PAR-CLIP	23446348
MIRT516723	hsa-miR-1270	PAR-CLIP	23446348
MIRT516722	hsa-miR-620	PAR-CLIP	23446348
MIRT516721	hsa-miR-3170	PAR-CLIP	23446348
MIRT516720	hsa-miR-6855-5p	PAR-CLIP	23446348
MIRT516719	hsa-miR-3591-5p	PAR-CLIP	23446348
MIRT443397	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT443396	hsa-miR-3156-5p	PAR-CLIP	22100165
MIRT443395	hsa-miR-4802-3p	PAR-CLIP	22100165
MIRT443394	hsa-miR-490-5p	PAR-CLIP	22100165
MIRT443392	hsa-miR-3928-3p	PAR-CLIP	22100165
MIRT443393	hsa-miR-1261	PAR-CLIP	22100165
MIRT2049091	hsa-miR-150	CLIP-seq
MIRT2049092	hsa-miR-214	CLIP-seq
MIRT2049093	hsa-miR-216a	CLIP-seq
MIRT2049094	hsa-miR-3127-3p	CLIP-seq
MIRT2049095	hsa-miR-3619-5p	CLIP-seq
MIRT2049096	hsa-miR-3692	CLIP-seq
MIRT2049097	hsa-miR-3938	CLIP-seq
MIRT2049098	hsa-miR-3941	CLIP-seq
MIRT2049099	hsa-miR-4272	CLIP-seq
MIRT2049100	hsa-miR-4305	CLIP-seq
MIRT2049101	hsa-miR-4519	CLIP-seq
MIRT2049102	hsa-miR-466	CLIP-seq
MIRT2049103	hsa-miR-4672	CLIP-seq
MIRT2049104	hsa-miR-4713-5p	CLIP-seq
MIRT2049105	hsa-miR-532-3p	CLIP-seq
MIRT2049106	hsa-miR-600	CLIP-seq
MIRT2049107	hsa-miR-761	CLIP-seq
MIRT2278169	hsa-miR-1271	CLIP-seq
MIRT2278170	hsa-miR-1324	CLIP-seq
MIRT2049091	hsa-miR-150	CLIP-seq
MIRT2278171	hsa-miR-218	CLIP-seq
MIRT2278172	hsa-miR-29a	CLIP-seq
MIRT2278173	hsa-miR-29b	CLIP-seq
MIRT2278174	hsa-miR-29c	CLIP-seq
MIRT2278175	hsa-miR-3065-3p	CLIP-seq
MIRT2049094	hsa-miR-3127-3p	CLIP-seq
MIRT2278176	hsa-miR-330-3p	CLIP-seq
MIRT2049096	hsa-miR-3692	CLIP-seq
MIRT2049097	hsa-miR-3938	CLIP-seq
MIRT2278177	hsa-miR-4263	CLIP-seq
MIRT2049104	hsa-miR-4713-5p	CLIP-seq
MIRT2049105	hsa-miR-532-3p	CLIP-seq
MIRT2278178	hsa-miR-636	CLIP-seq
MIRT2278179	hsa-miR-96	CLIP-seq
MIRT2454746	hsa-miR-1238	CLIP-seq
MIRT2049091	hsa-miR-150	CLIP-seq
MIRT2049094	hsa-miR-3127-3p	CLIP-seq
MIRT2049096	hsa-miR-3692	CLIP-seq
MIRT2049097	hsa-miR-3938	CLIP-seq
MIRT2049104	hsa-miR-4713-5p	CLIP-seq
MIRT2049105	hsa-miR-532-3p	CLIP-seq
MIRT2049091	hsa-miR-150	CLIP-seq
MIRT2049094	hsa-miR-3127-3p	CLIP-seq
MIRT2049096	hsa-miR-3692	CLIP-seq
MIRT2049097	hsa-miR-3938	CLIP-seq
MIRT2049104	hsa-miR-4713-5p	CLIP-seq
MIRT2049105	hsa-miR-532-3p	CLIP-seq

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IEA
GO:0005515	Function	Protein binding	IPI	11309420, 12482578
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IBA
GO:0007411	Process	Axon guidance	IBA
GO:0008092	Function	Cytoskeletal protein binding	IPI	11309420
GO:0017124	Function	SH3 domain binding	IPI	11309420
GO:0030017	Component	Sarcomere	IEA
GO:0030018	Component	Z disc	IBA
GO:0030018	Component	Z disc	IDA	11309420
GO:0030018	Component	Z disc	IDA	28017374
GO:0030018	Component	Z disc	IEA
GO:0030018	Component	Z disc	IEA
GO:0030424	Component	Axon	IBA
GO:0031674	Component	I band	IDA	11309420
GO:0031674	Component	I band	IEA
GO:0045214	Process	Sarcomere organization	IMP	11309420
GO:0051371	Function	Muscle alpha-actinin binding	IEA
GO:0051371	Function	Muscle alpha-actinin binding	IPI	11309420
GO:0070593	Process	Dendrite self-avoidance	IBA
GO:0098632	Function	Cell-cell adhesion mediator activity	IBA

MIM	HGNC	e!Ensembl
608517	23246	ENSG00000138347

Q86TC9

Protein name

Myopalladin (145 kDa sarcomeric protein)

Protein function

Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07679	I-set	269 → 358	Immunoglobulin I-set domain	Domain
PF07679	I-set	435 → 532	Immunoglobulin I-set domain	Domain
PF07679	I-set	945 → 1036	Immunoglobulin I-set domain	Domain
PF07679	I-set	1073 → 1163	Immunoglobulin I-set domain	Domain
PF07679	I-set	1172 → 1263	Immunoglobulin I-set domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in adult skeletal muscle and fetal heart. {ECO:0000269|PubMed:11309420}.

Sequence

MQDDSIEASTSISQLLRESYLAETRHRGNNERSRAEPSSNPCHFGSPSGAAEGGGGQDDL
PDLSAFLSQEELDESVNLARLAINYDPLEKADETQARKRLSPDQMKHSPNLSFEPNFCQD
NPRSPTSSKESPQEAKRPQYCSETQSKKVFLNKAADFIEELSSLFKSHSSKRIRPRACKN
HKSKLESQNKVMQENSSSFSDLSERRERSSVPIPIPADTRDNEVNHALEQQEAKRREAEQ
AASEAAGGDTTPGSSPSSLYYEEPLGQPPRFTQKLRSREVPEGTRVQLDCIVVGIPPPQV
RWYCEGKELENSPDIHIVQAGNLHSLTIAEAFEEDTGRYSCFASNIYGTDSTSAEIYIEG
VSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSAVIPPAVPQAQHLVAQPRVATIQQCQSPT
NYLQGLDGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKVEWYREGTLIEDSPD
FRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLHVRGNEDLSN
NGSLHSANSTTNLAAIEPQPSPPHSEPPSVEQPPKPKLEGVLVNHNEPRSSSRIGLRVHF
NLPEDDKGSEASSEAGVVTTRQTRPDSFQERFNGQATKTPEPSSPVKEPPPVLAKPKLDS
TQLQQLHNQVLLEQHQLQNPPPSSPKEFPFSMTVLNSNAPPAVTTSSKQVKAPSSQTFSL
ARPKYFFPSTNTTAATVAPSSSPVFTLSSTPQTIQRTVSKESLLVSHPSVQTKSPGGLSI
QNEPLPPGPTEPTPPPFTFSIPSGNQFQPRCVSPIPVSPTSRIQNPVAFLSSVLPSLPAI
PPTNAMGLPRSAPSMPSQGLAKKNTKSPQPVNDDNIRETKNAVIRDLGKKITFSDVRPNQ
QEYKISSFEQRLMNEIEFRLERTPVDESDDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGS
PVTFTCKIVGIPVPKVYWFKDGKQISKRNEHCKMRREGDGTCSLHIESTTSDDDGNYTIM
AANPQGRISCSGHLMVQSLPIRSRLTSAGQSHRGRSRVQERDKEPLQERFFRPHFLQAPG
DMVAHEGRLCRLDCKVSGLPPPELTWLLNGQPVLPDASHKMLVRETGVHSLLIDPLTQRD
AGTYKCIATNKTGQNSFSLELSVVAKEVKKAPVILEKLQNCGVPEGHPVRLECRVIGMPP
PVFYWKKDNETIPCTRERISMHQDTTGYACLLIQPAKKSDAGWYTLSAKNEAGIVSCTAR
LDIYAQWHHQIPPPMSVRPSGSRYGSLTSKGLDIFSAFSSMESTMVYSCSSRSVVESDEL

Sequence length

1320

Interactions

View interactions

	KEGG
	Cytoskeleton in muscle cells

2219

Show/Hide Causal Diseases (8)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Cardiomyopathy, familial restrictive, 4	Pathogenic	rs199476408	RCV000043547
Cardiovascular phenotype	Pathogenic; Likely pathogenic	rs2495676595, rs772657844, rs753094063, rs2495701378, rs2495590778, rs2495728963, rs2495796729, rs781261060	RCV002389410 RCV002437430 RCV002442257 RCV004068824 RCV003306298 RCV003306304 RCV004519870 RCV004649146
Congenital myopathy	Likely pathogenic	rs766502564	RCV004774613
Dilated cardiomyopathy 1KK	Likely pathogenic; Pathogenic	rs746850858, rs2134300034, rs2134198422, rs766502564, rs2134278222, rs2134204980, rs2134169413, rs2134168183, rs2133995502, rs2495465932, rs753094063, rs2495701378, rs2495461148, rs2495804503, rs2495467126 View all (15 more)	RCV002050379 RCV001932273 RCV001997111 RCV002023592 RCV001946555 RCV001958638 RCV001879410 RCV001887724 RCV002052192 RCV002288287 RCV003102947 RCV002610555 RCV002643086 RCV002863132 RCV002848214 RCV002893968 RCV002877431 RCV003034262 RCV003034623 RCV003054060 RCV003581130 RCV003582952 RCV003583016 RCV003741693 RCV003848463 RCV003874997 RCV001389633 RCV000710036 RCV000818659 RCV001204026
Melanoma	Likely pathogenic	rs865921466	RCV005901766
MYPN-related disorder	Likely pathogenic	rs2495675414, rs2495951071, rs1298376008	RCV003404288 RCV003421158 RCV003901535
MYPN-related myopathy	Likely pathogenic; Pathogenic	rs2495459534, rs2495701378, rs2134168183, rs2495738570, rs2495790637, rs1057519570, rs1057519571, rs781261060, rs1057519573	RCV002471296 RCV005409906 RCV004820914 RCV003319294 RCV003319295 RCV000417052 RCV000417065 RCV000417047 RCV000417040
Nemaline myopathy	Pathogenic	rs778885362	RCV004587629

Show/Hide Unknown Diseases (32)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs56006628	RCV005904168
Adrenocortical carcinoma, hereditary	Benign; Likely benign	rs62620248	RCV005888671
Arrhythmogenic right ventricular cardiomyopathy	Conflicting classifications of pathogenicity	rs777446804	RCV000852606
Cap myopathy	Conflicting classifications of pathogenicity	rs199476412	RCV004586025
Cardiomyopathy	Conflicting classifications of pathogenicity; Benign; Uncertain significance	rs147596628, rs150911078, rs794729069, rs11279655, rs71534278, rs138313730, rs201975081, rs765931465, rs1589614570	RCV000852609 RCV000852610 RCV000183571 RCV000183573 RCV000852613 RCV000852614 RCV000852612 RCV000852608 RCV000852430
Cardiomyopathy, familial restrictive, 1	Uncertain significance	rs146336815	RCV005863028
Cervical cancer	Benign	rs61857180	RCV005903969
Clear cell carcinoma of kidney	Benign	rs74143030	RCV005888673
Colon adenocarcinoma	Benign; Likely benign	rs62620248	RCV005888669
Dilated cardiomyopathy 1A	Conflicting classifications of pathogenicity; Uncertain significance	rs750655311, rs555527385, rs546434497	RCV001256744 RCV001256882 RCV001256745
Familial hypertrophic cardiomyopathy 22	Conflicting classifications of pathogenicity	rs71534278, rs140148105	RCV000043542 RCV000043545
Gastric cancer	Benign; Likely benign	rs56006628, rs117144583, rs61854651, rs17458319	RCV005904170 RCV005903958 RCV005903961 RCV005904173
Heart failure	Conflicting classifications of pathogenicity	rs138313730	RCV000852614
Hepatocellular carcinoma	Benign; Likely benign	rs62620248	RCV005888670
Hypertrophic cardiomyopathy	Uncertain significance; Conflicting classifications of pathogenicity; Benign; Likely benign	rs2043722325, rs759400657, rs786205457, rs150404143, rs764775347, rs573684358, rs71534278, rs373101027, rs373040567, rs1321971649	RCV004765355 RCV001823425 RCV001293106 RCV004765320 RCV000857226 RCV004765328 RCV000852613 RCV001293105 RCV000768523 RCV000768524
Hypertrophic cardiomyopathy 1	Uncertain significance	rs749935442	RCV004785728
Left ventricular hypertrophy	Uncertain significance	rs140037748	RCV000678726
Left ventricular noncompaction 1	Uncertain significance	rs372903698	RCV001256746
Left ventricular noncompaction cardiomyopathy	Uncertain significance	rs140037748, rs201983087	RCV000678727 RCV000208333
Long QT syndrome	Conflicting classifications of pathogenicity	rs377389861	RCV000852607
Lung cancer	Benign; Likely benign	rs62620248, rs17458319	RCV005888672 RCV005904174
Malignant tumor of esophagus	Benign; Likely benign	rs61857180, rs17458319	RCV005903968 RCV005904172
Primary dilated cardiomyopathy	Uncertain significance; Conflicting classifications of pathogenicity	rs730880169, rs199585352, rs730880170, rs71534278, rs142354704, rs140148105, rs199476401, rs138313730, rs376945733, rs141276802, rs181848049, rs754064567, rs754707304, rs758026056	RCV000157385 RCV000157386 RCV000157387 RCV000172079 RCV003319183 RCV000157384 RCV000157381 RCV000512643 RCV000852614 RCV000853143 RCV000853120 RCV003319211 RCV000852611 RCV001293061 RCV001257940
Primary familial dilated cardiomyopathy	Conflicting classifications of pathogenicity; Uncertain significance	rs138313730, rs181848049, rs1048512621, rs958954733	RCV000624690 RCV000845562 RCV000845528 RCV000845330
Primary familial hypertrophic cardiomyopathy	Conflicting classifications of pathogenicity; Likely benign; Uncertain significance	rs151282801, rs587782969, rs730880168, rs149412051, rs146336815, rs869025490, rs786205348, rs71584493, rs768471574, rs1589550119	RCV000143934 RCV000143935 RCV000157382 RCV006252578 RCV005863028 RCV000208248 RCV000208046 RCV000157383 RCV000845328 RCV000853171
Restrictive cardiomyopathy	Conflicting classifications of pathogenicity	rs201454261	RCV000513324
Sarcoma	Benign	rs74143030, rs56006628	RCV005888674 RCV005904169
See cases	Benign; Likely benign; Conflicting classifications of pathogenicity	rs147287437, rs778574912	RCV002252026 RCV003128473
Sudden unexplained death	Uncertain significance	rs778178863	RCV000999613
Thymoma	Benign	rs117144583, rs61854651	RCV005903960 RCV005903963
Uterine carcinosarcoma	Benign	rs56006628, rs117144583, rs61854651	RCV005904171 RCV005903959 RCV005903962
Uterine corpus endometrial carcinoma	Benign; Likely benign	rs61854651, rs17458319	RCV005903964 RCV005904175

Show/Hide Text Mining Associations (17)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Atrioventricular Block	Associate	31524317
Cap Myopathy	Associate	31133047
Carcinoma Pancreatic Ductal	Associate	33048956
Cardiomyopathies	Associate	31133047
Cardiomyopathy Dilated	Associate	22892539, 26458567, 30764827, 31524317
Cardiomyopathy Hypertrophic	Associate	28427417
Cardiomyopathy Restrictive	Associate	30953456, 31133047
Contracture	Associate	31133047
Coronary Disease	Associate	31524317
Glioma	Associate	37192718
Heart Failure	Associate	31524317
Hirschsprung Disease with Ulnar Polydactyly Polysyndactyly of Big Toes and Ventricular Septal Defect	Associate	31133047
Muscular Diseases	Associate	31133047
Myopathies Nemaline	Associate	31133047
Myotonia Congenita	Associate	31133047
Pancreatic Neoplasms	Associate	33048956
Short QT Syndrome 1	Associate	28427417

MYPN (myopalladin)