AFAP1L2 (actin filament associated protein 1 like 2)

Gene

• Entrez ID: 84632
• Gene name: Actin filament associated protein 1 like 2
• Gene symbol: AFAP1L2
• Synonyms (NCBI Gene): CTB-1144G6.4, KIAA1914, XB130
• Chromosome: 10
• Chromosome location: 10q25.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT025412	hsa-miR-34a-5p	Proteomics	21566225
MIRT025412	hsa-miR-34a-5p	Proteomics	21566225
MIRT025412	hsa-miR-34a-5p	Proteomics	21566225
MIRT770903	hsa-miR-1270	CLIP-seq
MIRT770904	hsa-miR-146a	CLIP-seq
MIRT770905	hsa-miR-146b-5p	CLIP-seq
MIRT770906	hsa-miR-185	CLIP-seq
MIRT770907	hsa-miR-2392	CLIP-seq
MIRT770908	hsa-miR-3925-5p	CLIP-seq
MIRT770909	hsa-miR-4306	CLIP-seq
MIRT770910	hsa-miR-4459	CLIP-seq
MIRT770911	hsa-miR-4493	CLIP-seq
MIRT770912	hsa-miR-4531	CLIP-seq
MIRT770913	hsa-miR-4644	CLIP-seq
MIRT770914	hsa-miR-5096	CLIP-seq
MIRT770915	hsa-miR-620	CLIP-seq
MIRT770916	hsa-miR-1264	CLIP-seq
MIRT770917	hsa-miR-1269	CLIP-seq
MIRT770918	hsa-miR-1269b	CLIP-seq
MIRT770919	hsa-miR-1288	CLIP-seq
MIRT770920	hsa-miR-3978	CLIP-seq
MIRT770921	hsa-miR-4312	CLIP-seq
MIRT770922	hsa-miR-4515	CLIP-seq
MIRT770923	hsa-miR-4529-3p	CLIP-seq
MIRT770924	hsa-miR-4740-5p	CLIP-seq
MIRT770925	hsa-miR-875-3p	CLIP-seq
MIRT1927408	hsa-miR-3120-3p	CLIP-seq
MIRT2168172	hsa-miR-143	CLIP-seq
MIRT2168173	hsa-miR-4433	CLIP-seq
MIRT2168174	hsa-miR-4435	CLIP-seq
MIRT2168175	hsa-miR-4770	CLIP-seq
MIRT2168176	hsa-miR-665	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IDA	17412687
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0006954	Process	Inflammatory response	IBA	21873635
GO:0006954	Process	Inflammatory response	IDA	17412687
GO:0007346	Process	Regulation of mitotic cell cycle	IBA	21873635
GO:0007346	Process	Regulation of mitotic cell cycle	IDA	17412687
GO:0017124	Function	SH3 domain binding	IBA	21873635
GO:0017124	Function	SH3 domain binding	IPI	17412687
GO:0030296	Function	Protein tyrosine kinase activator activity	IDA	17412687
GO:0032675	Process	Regulation of interleukin-6 production	IBA	21873635
GO:0032675	Process	Regulation of interleukin-6 production	IDA	17412687
GO:0032757	Process	Positive regulation of interleukin-8 production	IBA	21873635
GO:0032757	Process	Positive regulation of interleukin-8 production	IDA	17412687
GO:0035591	Function	Signaling adaptor activity	IEA
GO:0042169	Function	SH2 domain binding	IBA	21873635
GO:0042169	Function	SH2 domain binding	IPI	17412687
GO:0045742	Process	Positive regulation of epidermal growth factor receptor signaling pathway	IBA	21873635
GO:0045742	Process	Positive regulation of epidermal growth factor receptor signaling pathway	IDA	17412687
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IBA	21873635
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IDA	17412687
GO:0061098	Process	Positive regulation of protein tyrosine kinase activity	IEA

Other IDs

• MIM: 612420
• HGNC: 25901
• e!Ensembl: ENSG00000169129

Protein

• UniProt ID: Q8N4X5
• Protein name: Actin filament-associated protein 1-like 2 (AFAP1-like protein 2)
• Protein function: May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation.
• PDB: 2COF
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00169	PH	169 → 271	PH domain	Domain
  PF00169	PH	338 → 445	PH domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected in spleen and thyroid, and at lower levels in kidney, brain, lung and pancreas. {ECO:0000269|PubMed:17412687}.
• Sequence:

  MERYKALEQLLTELDDFLKILDQENLSSTALVKKSCLAELLRLYTKSSSSDEEYIYMNKV
  TINKQQNAESQGKAPEEQGLLPNGEPSQHSSAPQKSLPDLPPPKMIPERKQLAIPKTESP
  EGYYEEAEPYDTSLNEDGEAVSSSYESYDEEDGSKGKSAPYQWPSPEAGIELMRDARICA
  FLWRKKWLGQWAKQLCVIKDNRLLCYKSSKDHSPQLDVNLLGSSVIHKEKQVRKKEHKLK
  ITPMNADVIVLGLQSKDQAEQWLRVIQEVSGLPSEGASEGNQYTPDAQRFNCQKPDIAEK
  YLSASEYGSSVDGHPEVPETKDVKKKCSAGLKLSNLMNLGRKKSTSLEPVERSLETSSYL
  NVLVNSQWKSRWCSVRDNHLHFYQDRNRSKVAQQPLSLVGCEVVPDPSPDHLYSFRILHK
  GEELAKLEAKSSEEMGHWLGLLLSESGSKTDPEEFTYDYVDADRVSCIVSAAKNSLLLMQ
  RKFSEPNTYIDGLPSQDRQEELYDDVDLSELTAAVEPTEEATPVADDPNERESDRVYLDL
  TPVKSFLHGPSSAQAQASSPTLSCLDNATEALPADSGPGPTPDEPCIKCPENLGEQQLES
  LEPEDPSLRITTVKIQTEQQRISFPPSCPDAVVATPPGASPPVKDRLRVTSAEIKLGKNR
  TEAEVKRYTEEKERLEKKKEEIRGHLAQLRKEKRELKETLLKCTDKEVLASLEQKLKEID
  EECRGEESRRVDLELSIMEVKDNLKKAEAGPVTLGTTVDTTHLENVSPRPKAVTPASAPD
  CTPVNSATTLKNRPLSVVVTGKGTVLQKAKEWEKKGAS

• Sequence length: 818

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Carcinoma	Squamous cell carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	29059373

Unknown
Disease term	Disease name	Evidence	References	Source
Coronary artery disease	Coronary artery disease			GWAS
Myocardial Infarction	Myocardial Infarction			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Associate	26191231
Carcinogenesis	Associate	24581082, 26191231
Carcinoma Hepatocellular	Associate	22190283, 34094815, 37733919
Carcinoma Pancreatic Ductal	Stimulate	24581082
Carcinoma Renal Cell	Associate	37729738
Carcinoma Squamous Cell	Associate	29059373
Cholangiocarcinoma	Associate	34780466
Lung Neoplasms	Associate	25980441
Lymphatic Metastasis	Stimulate	24581082, 34780466
Melanoma	Associate	25892537
Necrosis	Associate	26191231
Neoplasm Metastasis	Stimulate	24581082, 37729738
Neoplasms	Associate	22927913, 22928011, 23527086, 24581082, 26191231, 27509056
Prostatic Neoplasms	Stimulate	27509056
Pulmonary Disease Chronic Obstructive	Associate	25980441
Stomach Neoplasms	Associate	22927913
Thyroid Neoplasms	Stimulate	22927913
Thyroid Neoplasms	Associate	22928011, 23527086