Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8463
Gene name Gene Name - the full gene name approved by the HGNC.	TEA domain transcription factor 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TEAD2
Synonyms (NCBI Gene) Gene synonyms aliases	ETF, TEAD-2, TEF-4, TEF4
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19q13.33

Show/Hide all(67)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017098	hsa-miR-335-5p	Microarray	18185580
MIRT042715	hsa-miR-346	CLASH	23622248
MIRT041334	hsa-miR-193b-3p	CLASH	23622248
MIRT1417506	hsa-miR-1245b-5p	CLIP-seq
MIRT1417507	hsa-miR-1252	CLIP-seq
MIRT1417508	hsa-miR-1255a	CLIP-seq
MIRT1417509	hsa-miR-1255b	CLIP-seq
MIRT1417510	hsa-miR-1294	CLIP-seq
MIRT1417511	hsa-miR-1295	CLIP-seq
MIRT1417512	hsa-miR-142-5p	CLIP-seq
MIRT1417513	hsa-miR-1537	CLIP-seq
MIRT1417514	hsa-miR-3142	CLIP-seq
MIRT1417515	hsa-miR-3667-5p	CLIP-seq
MIRT1417516	hsa-miR-3921	CLIP-seq
MIRT1417517	hsa-miR-3944-5p	CLIP-seq
MIRT1417518	hsa-miR-421	CLIP-seq
MIRT1417519	hsa-miR-4316	CLIP-seq
MIRT1417520	hsa-miR-4476	CLIP-seq
MIRT1417521	hsa-miR-4496	CLIP-seq
MIRT1417522	hsa-miR-4533	CLIP-seq
MIRT1417523	hsa-miR-4649-3p	CLIP-seq
MIRT1417524	hsa-miR-4653-5p	CLIP-seq
MIRT1417525	hsa-miR-4677-3p	CLIP-seq
MIRT1417526	hsa-miR-4757-5p	CLIP-seq
MIRT1417527	hsa-miR-495	CLIP-seq
MIRT1417528	hsa-miR-577	CLIP-seq
MIRT1417529	hsa-miR-603	CLIP-seq
MIRT2125356	hsa-miR-1238	CLIP-seq
MIRT1417508	hsa-miR-1255a	CLIP-seq
MIRT1417509	hsa-miR-1255b	CLIP-seq
MIRT2125357	hsa-miR-1275	CLIP-seq
MIRT1417512	hsa-miR-142-5p	CLIP-seq
MIRT2125358	hsa-miR-1910	CLIP-seq
MIRT2125359	hsa-miR-296-5p	CLIP-seq
MIRT1417515	hsa-miR-3667-5p	CLIP-seq
MIRT2125360	hsa-miR-3918	CLIP-seq
MIRT1417517	hsa-miR-3944-5p	CLIP-seq
MIRT1417518	hsa-miR-421	CLIP-seq
MIRT2125361	hsa-miR-4260	CLIP-seq
MIRT2125362	hsa-miR-4264	CLIP-seq
MIRT2125363	hsa-miR-4266	CLIP-seq
MIRT2125364	hsa-miR-4284	CLIP-seq
MIRT2125365	hsa-miR-4488	CLIP-seq
MIRT2125366	hsa-miR-4506	CLIP-seq
MIRT2125367	hsa-miR-455-3p	CLIP-seq
MIRT2125368	hsa-miR-4665-5p	CLIP-seq
MIRT2125369	hsa-miR-4697-5p	CLIP-seq
MIRT2125370	hsa-miR-4749-3p	CLIP-seq
MIRT2125371	hsa-miR-515-5p	CLIP-seq
MIRT1417528	hsa-miR-577	CLIP-seq
MIRT1417529	hsa-miR-603	CLIP-seq
MIRT1417508	hsa-miR-1255a	CLIP-seq
MIRT1417509	hsa-miR-1255b	CLIP-seq
MIRT1417510	hsa-miR-1294	CLIP-seq
MIRT2347570	hsa-miR-1324	CLIP-seq
MIRT2125358	hsa-miR-1910	CLIP-seq
MIRT2347571	hsa-miR-342-3p	CLIP-seq
MIRT2347572	hsa-miR-3942-3p	CLIP-seq
MIRT2347573	hsa-miR-412	CLIP-seq
MIRT1417518	hsa-miR-421	CLIP-seq
MIRT2125363	hsa-miR-4266	CLIP-seq
MIRT1417519	hsa-miR-4316	CLIP-seq
MIRT2125367	hsa-miR-455-3p	CLIP-seq
MIRT1417525	hsa-miR-4677-3p	CLIP-seq
MIRT2347574	hsa-miR-4695-3p	CLIP-seq
MIRT2347575	hsa-miR-513a-5p	CLIP-seq
MIRT2347576	hsa-miR-758	CLIP-seq

Show/Hide all(36)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001223	Function	Transcription coactivator binding	IPI	20368466
GO:0001570	Process	Vasculogenesis	IEA
GO:0001843	Process	Neural tube closure	IEA
GO:0003143	Process	Embryonic heart tube morphogenesis	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IDA	18579750, 19324877
GO:0003700	Function	DNA-binding transcription factor activity	IMP	20368466
GO:0003700	Function	DNA-binding transcription factor activity	NAS	8702974
GO:0005515	Function	Protein binding	IPI	18579750, 19324877, 20368466, 25416956, 25751139
GO:0005634	Component	Nucleus	NAS	8702974
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0006355	Process	Regulation of transcription, DNA-templated	NAS	8702974
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0006367	Process	Transcription initiation from RNA polymerase II promoter	TAS
GO:0030903	Process	Notochord development	IEA
GO:0035329	Process	Hippo signaling	IBA	21873635
GO:0035329	Process	Hippo signaling	IDA	18579750, 19324877
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IMP	20368466
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0048339	Process	Paraxial mesoderm development	IEA
GO:0048368	Process	Lateral mesoderm development	IEA
GO:0048568	Process	Embryonic organ development	IBA	21873635
GO:0060548	Process	Negative regulation of cell death	IEA
GO:0065003	Process	Protein-containing complex assembly	IMP	20368466
GO:0071300	Process	Cellular response to retinoic acid	IEA
GO:0097718	Function	Disordered domain specific binding	IMP	20368466
GO:0140552	Component	TEAD-YAP complex	IDA	20368466
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536
GO:2000736	Process	Regulation of stem cell differentiation	IEA

MIM	HGNC	e!Ensembl
601729	11715	ENSG00000074219

Protein

UniProt ID

Q15562

Protein name

Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2)

Protein function

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cas

PDB

3L15 , 5DQ8 , 5DQE , 5EMV , 5HGU , 6CDY , 6E5G , 6S60 , 6S64 , 6S66 , 6S69 , 6S6J , 6UYB , 6UYC , 6VAH , 7OYJ , 7T2J , 7T2K , 7T2L , 7T2M , 7TYP , 7TYQ , 7TYU , 8CUH , 8E1O , 8P29 , 8POJ , 8POM , 8PON , 8PUX , 8PUY , 8RXL , 8RXP , 8RXQ , 8RXV , 8RYC , 8YGQ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01285	TEA	41 → 110	TEA/ATTS domain	Domain
PF17725	YBD	226 → 444	YAP binding domain	Domain

Sequence

MGEPRAGAALDDGSGWTGSEEGSEEGTGGSEGAGGDGGPDAEGVWSPDIEQSFQEALAIY
PPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSREIQSKLK
DQVSKDKAFQTMATMSSAQLISAPSLQAKLGPTGPQASELFQFWSGGSGPPWNVPDVKPF
SQTPFTLSLTPPSTDLPGYEPPQALSPLPPPTPSPPAWQARGLGTARLQLVEFSAFVEPP
DAVDSYQRHLFVHISQHCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLV
KFWADLNWGPSGEEAGAGGSISSGGFYGVSSQYESLEHMTLTCSSKVCSFGKQVVEKVET
ERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQEL
LLCTAYVFEVSTSERGAQHHIYRLVRD

Sequence length

447

Interactions

View interactions

	KEGG		Reactome
	Hippo signaling pathway Hippo signaling pathway - multiple species		YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Systemic lupus erythematosus	Systemic lupus erythematosus			GWAS

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References
Associations from Text Mining
Carcinoma Hepatocellular	Associate	32323824
Carcinoma Hepatocellular	Stimulate	35077390
Carcinoma Non Small Cell Lung	Associate	31485614
Carcinoma Pancreatic Ductal	Associate	36907523
Developmental Disabilities	Associate	33509776
Multiple Acyl Coenzyme A Dehydrogenase Deficiency	Associate	22013910
Neoplasms	Associate	32323824, 36907523
Pancreatic Neoplasms	Associate	36907523
Trisomy 18 Syndrome	Associate	33509776

TEAD2 (TEA domain transcription factor 2)