Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	8463
Gene name	TEA domain transcription factor 2
Gene symbol	TEAD2
Synonyms (NCBI Gene)	ETFTEAD-2TEF-4TEF4
Chromosome	19
Chromosome location	19q13.33

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017098	hsa-miR-335-5p	Microarray	18185580
MIRT042715	hsa-miR-346	CLASH	23622248
MIRT041334	hsa-miR-193b-3p	CLASH	23622248
MIRT1417506	hsa-miR-1245b-5p	CLIP-seq
MIRT1417507	hsa-miR-1252	CLIP-seq
MIRT1417508	hsa-miR-1255a	CLIP-seq
MIRT1417509	hsa-miR-1255b	CLIP-seq
MIRT1417510	hsa-miR-1294	CLIP-seq
MIRT1417511	hsa-miR-1295	CLIP-seq
MIRT1417512	hsa-miR-142-5p	CLIP-seq
MIRT1417513	hsa-miR-1537	CLIP-seq
MIRT1417514	hsa-miR-3142	CLIP-seq
MIRT1417515	hsa-miR-3667-5p	CLIP-seq
MIRT1417516	hsa-miR-3921	CLIP-seq
MIRT1417517	hsa-miR-3944-5p	CLIP-seq
MIRT1417518	hsa-miR-421	CLIP-seq
MIRT1417519	hsa-miR-4316	CLIP-seq
MIRT1417520	hsa-miR-4476	CLIP-seq
MIRT1417521	hsa-miR-4496	CLIP-seq
MIRT1417522	hsa-miR-4533	CLIP-seq
MIRT1417523	hsa-miR-4649-3p	CLIP-seq
MIRT1417524	hsa-miR-4653-5p	CLIP-seq
MIRT1417525	hsa-miR-4677-3p	CLIP-seq
MIRT1417526	hsa-miR-4757-5p	CLIP-seq
MIRT1417527	hsa-miR-495	CLIP-seq
MIRT1417528	hsa-miR-577	CLIP-seq
MIRT1417529	hsa-miR-603	CLIP-seq
MIRT2125356	hsa-miR-1238	CLIP-seq
MIRT1417508	hsa-miR-1255a	CLIP-seq
MIRT1417509	hsa-miR-1255b	CLIP-seq
MIRT2125357	hsa-miR-1275	CLIP-seq
MIRT1417512	hsa-miR-142-5p	CLIP-seq
MIRT2125358	hsa-miR-1910	CLIP-seq
MIRT2125359	hsa-miR-296-5p	CLIP-seq
MIRT1417515	hsa-miR-3667-5p	CLIP-seq
MIRT2125360	hsa-miR-3918	CLIP-seq
MIRT1417517	hsa-miR-3944-5p	CLIP-seq
MIRT1417518	hsa-miR-421	CLIP-seq
MIRT2125361	hsa-miR-4260	CLIP-seq
MIRT2125362	hsa-miR-4264	CLIP-seq
MIRT2125363	hsa-miR-4266	CLIP-seq
MIRT2125364	hsa-miR-4284	CLIP-seq
MIRT2125365	hsa-miR-4488	CLIP-seq
MIRT2125366	hsa-miR-4506	CLIP-seq
MIRT2125367	hsa-miR-455-3p	CLIP-seq
MIRT2125368	hsa-miR-4665-5p	CLIP-seq
MIRT2125369	hsa-miR-4697-5p	CLIP-seq
MIRT2125370	hsa-miR-4749-3p	CLIP-seq
MIRT2125371	hsa-miR-515-5p	CLIP-seq
MIRT1417528	hsa-miR-577	CLIP-seq
MIRT1417529	hsa-miR-603	CLIP-seq
MIRT1417508	hsa-miR-1255a	CLIP-seq
MIRT1417509	hsa-miR-1255b	CLIP-seq
MIRT1417510	hsa-miR-1294	CLIP-seq
MIRT2347570	hsa-miR-1324	CLIP-seq
MIRT2125358	hsa-miR-1910	CLIP-seq
MIRT2347571	hsa-miR-342-3p	CLIP-seq
MIRT2347572	hsa-miR-3942-3p	CLIP-seq
MIRT2347573	hsa-miR-412	CLIP-seq
MIRT1417518	hsa-miR-421	CLIP-seq
MIRT2125363	hsa-miR-4266	CLIP-seq
MIRT1417519	hsa-miR-4316	CLIP-seq
MIRT2125367	hsa-miR-455-3p	CLIP-seq
MIRT1417525	hsa-miR-4677-3p	CLIP-seq
MIRT2347574	hsa-miR-4695-3p	CLIP-seq
MIRT2347575	hsa-miR-513a-5p	CLIP-seq
MIRT2347576	hsa-miR-758	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001223	Function	Transcription coactivator binding	IPI	20368466
GO:0001570	Process	Vasculogenesis	IEA
GO:0001843	Process	Neural tube closure	IEA
GO:0003143	Process	Embryonic heart tube morphogenesis	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IDA	18579750, 19324877
GO:0003700	Function	DNA-binding transcription factor activity	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IMP	20368466
GO:0003700	Function	DNA-binding transcription factor activity	NAS	8702974
GO:0005515	Function	Protein binding	IPI	18579750, 19324877, 20368466, 25416956, 25751139, 32296183, 33961781, 35140242
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	8702974
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IBA
GO:0005667	Component	Transcription regulator complex	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	NAS	8702974
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006366	Process	Transcription by RNA polymerase II	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0030903	Process	Notochord development	IEA
GO:0035329	Process	Hippo signaling	IBA
GO:0035329	Process	Hippo signaling	IDA	18579750, 19324877
GO:0035329	Process	Hippo signaling	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IMP	20368466
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0048339	Process	Paraxial mesoderm development	IEA
GO:0048368	Process	Lateral mesoderm development	IEA
GO:0048568	Process	Embryonic organ development	IBA
GO:0060485	Process	Mesenchyme development	IEA
GO:0065003	Process	Protein-containing complex assembly	IMP	20368466
GO:0071300	Process	Cellular response to retinoic acid	IEA
GO:0097718	Function	Disordered domain specific binding	IMP	20368466
GO:0140552	Component	TEAD-YAP complex	IDA	20368466
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IEA
GO:2000736	Process	Regulation of stem cell differentiation	IEA

MIM	HGNC	e!Ensembl
601729	11715	ENSG00000074219

Q15562

Protein name

Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2)

Protein function

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cas

PDB

3L15 , 5DQ8 , 5DQE , 5EMV , 5HGU , 6CDY , 6E5G , 6S60 , 6S64 , 6S66 , 6S69 , 6S6J , 6UYB , 6UYC , 6VAH , 7OYJ , 7T2J , 7T2K , 7T2L , 7T2M , 7TYP , 7TYQ , 7TYU , 8CUH , 8E1O , 8P29 , 8POJ , 8POM , 8PON , 8PUX , 8PUY , 8RXL , 8RXP , 8RXQ , 8RXV , 8RYC , 8YGQ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01285	TEA	41 → 110	TEA/ATTS domain	Domain
PF17725	YBD	226 → 444	YAP binding domain	Domain

Sequence

MGEPRAGAALDDGSGWTGSEEGSEEGTGGSEGAGGDGGPDAEGVWSPDIEQSFQEALAIY
PPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSREIQSKLK
DQVSKDKAFQTMATMSSAQLISAPSLQAKLGPTGPQASELFQFWSGGSGPPWNVPDVKPF
SQTPFTLSLTPPSTDLPGYEPPQALSPLPPPTPSPPAWQARGLGTARLQLVEFSAFVEPP
DAVDSYQRHLFVHISQHCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLV
KFWADLNWGPSGEEAGAGGSISSGGFYGVSSQYESLEHMTLTCSSKVCSFGKQVVEKVET
ERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQEL
LLCTAYVFEVSTSERGAQHHIYRLVRD

Sequence length

447

Interactions

View interactions

	KEGG		Reactome
	Hippo signaling pathway Hippo signaling pathway - multiple species		YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription

TEAD2 (TEA domain transcription factor 2)