Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	84624
Gene name Gene Name - the full gene name approved by the HGNC.	Fibronectin type III domain containing 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	FNDC1
Synonyms (NCBI Gene) Gene synonyms aliases	AGS8, FNDC2, MEL4B3, bA243O10.1, dJ322A24.1
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6q25.3

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017697	hsa-miR-335-5p	Microarray	18185580
MIRT1000273	hsa-miR-1297	CLIP-seq
MIRT1000274	hsa-miR-1343	CLIP-seq
MIRT1000275	hsa-miR-26a	CLIP-seq
MIRT1000276	hsa-miR-26b	CLIP-seq
MIRT1000277	hsa-miR-3123	CLIP-seq
MIRT1000278	hsa-miR-3925-5p	CLIP-seq
MIRT1000279	hsa-miR-4436b-3p	CLIP-seq
MIRT1000280	hsa-miR-4465	CLIP-seq
MIRT1000281	hsa-miR-4508	CLIP-seq
MIRT1000282	hsa-miR-4656	CLIP-seq
MIRT1000283	hsa-miR-4761-3p	CLIP-seq
MIRT1000284	hsa-miR-4781-5p	CLIP-seq
MIRT1000285	hsa-miR-498	CLIP-seq
MIRT1000286	hsa-miR-513a-3p	CLIP-seq
MIRT1000287	hsa-miR-548n	CLIP-seq
MIRT1000288	hsa-miR-744	CLIP-seq
MIRT1000289	hsa-miR-885-3p	CLIP-seq
MIRT1548856	hsa-miR-103a	CLIP-seq
MIRT1548857	hsa-miR-107	CLIP-seq
MIRT1548858	hsa-miR-1179	CLIP-seq
MIRT1548859	hsa-miR-1207-5p	CLIP-seq
MIRT1548860	hsa-miR-1285	CLIP-seq
MIRT1548861	hsa-miR-1301	CLIP-seq
MIRT1548862	hsa-miR-1914	CLIP-seq
MIRT1548863	hsa-miR-3151	CLIP-seq
MIRT1548864	hsa-miR-3187-5p	CLIP-seq
MIRT1548865	hsa-miR-4283	CLIP-seq
MIRT1548866	hsa-miR-4327	CLIP-seq
MIRT1548867	hsa-miR-4422	CLIP-seq
MIRT1548868	hsa-miR-4489	CLIP-seq
MIRT1548869	hsa-miR-4492	CLIP-seq
MIRT1548870	hsa-miR-4498	CLIP-seq
MIRT1548871	hsa-miR-4505	CLIP-seq
MIRT1548872	hsa-miR-4763-3p	CLIP-seq
MIRT1548873	hsa-miR-5047	CLIP-seq
MIRT1548874	hsa-miR-612	CLIP-seq
MIRT1548875	hsa-miR-762	CLIP-seq
MIRT1548858	hsa-miR-1179	CLIP-seq
MIRT2230451	hsa-miR-1972	CLIP-seq
MIRT2230452	hsa-miR-3199	CLIP-seq
MIRT2230453	hsa-miR-451b	CLIP-seq
MIRT2230454	hsa-miR-4648	CLIP-seq
MIRT2230455	hsa-miR-4682	CLIP-seq
MIRT2230456	hsa-miR-4740-5p	CLIP-seq
MIRT2230457	hsa-miR-4795-5p	CLIP-seq
MIRT2449836	hsa-miR-3074-3p	CLIP-seq
MIRT2449837	hsa-miR-4461	CLIP-seq
MIRT2449838	hsa-miR-4698	CLIP-seq
MIRT2449839	hsa-miR-580	CLIP-seq
MIRT2449836	hsa-miR-3074-3p	CLIP-seq
MIRT2449837	hsa-miR-4461	CLIP-seq
MIRT2449838	hsa-miR-4698	CLIP-seq
MIRT2449839	hsa-miR-580	CLIP-seq
MIRT2681074	hsa-miR-1178	CLIP-seq
MIRT1548860	hsa-miR-1285	CLIP-seq
MIRT2681075	hsa-miR-3064-5p	CLIP-seq
MIRT1548863	hsa-miR-3151	CLIP-seq
MIRT1548864	hsa-miR-3187-5p	CLIP-seq
MIRT2681076	hsa-miR-3663-3p	CLIP-seq
MIRT2681077	hsa-miR-4259	CLIP-seq
MIRT1548865	hsa-miR-4283	CLIP-seq
MIRT1000279	hsa-miR-4436b-3p	CLIP-seq
MIRT1548868	hsa-miR-4489	CLIP-seq
MIRT1548869	hsa-miR-4492	CLIP-seq
MIRT1548870	hsa-miR-4498	CLIP-seq
MIRT1548871	hsa-miR-4505	CLIP-seq
MIRT1000281	hsa-miR-4508	CLIP-seq
MIRT1000282	hsa-miR-4656	CLIP-seq
MIRT2681078	hsa-miR-4663	CLIP-seq
MIRT2681079	hsa-miR-4687-3p	CLIP-seq
MIRT2681080	hsa-miR-4715-5p	CLIP-seq
MIRT1000283	hsa-miR-4761-3p	CLIP-seq
MIRT1000284	hsa-miR-4781-5p	CLIP-seq
MIRT2681081	hsa-miR-511	CLIP-seq
MIRT2681082	hsa-miR-541	CLIP-seq
MIRT1548874	hsa-miR-612	CLIP-seq
MIRT2681083	hsa-miR-626	CLIP-seq
MIRT2681084	hsa-miR-654-5p	CLIP-seq
MIRT1000288	hsa-miR-744	CLIP-seq
MIRT1548875	hsa-miR-762	CLIP-seq
MIRT1000289	hsa-miR-885-3p	CLIP-seq

Show/Hide all(1)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005576	Component	Extracellular region	IEA

MIM	HGNC	e!Ensembl
609991	21184	ENSG00000164694

Protein

UniProt ID

Q4ZHG4

Protein name

Fibronectin type III domain-containing protein 1 (Activation-associated cDNA protein) (Expressed in synovial lining protein)

Protein function

May be an activator of G protein signaling.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00041	fn3	41 → 122	Fibronectin type III domain	Domain
PF00041	fn3	261 → 347	Fibronectin type III domain	Domain
PF00041	fn3	361 → 447	Fibronectin type III domain	Domain
PF00041	fn3	1657 → 1742	Fibronectin type III domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Almost absent from healthy skin; especially in epidermal keratinocytes, skin fibroblasts or endothelial cells and is barely detectable in benign melanocytic naevi. Expressed in the stroma close to skin tumors, in the tumor cells themse

Sequence

MAPEAGATLRAPRRLSWAALLLLAALLPVASSAAASVDHPLKPRHVKLLSTKMGLKVTWD
PPKDATSRPVEHYNIAYGKSLKSLKYIKVNAETYSFLIEDVEPGVVYFVLLTAENHSGVS
RPVYRAESPPGGEWIEIDGFPIKGPGPFNETVTEKEVPNKPLRVRVRSSDDRLSVAWKAP
RLSGAKSPRRSRGFLLGYGESGRKMNYVPLTRDERTHEIKKLASESVYVVSLQSMNSQGR
SQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSVLVSWVDPVLEKQKKVVASRQYTVR
YREKGELARWDYKQIANRRVLIENLIPDTVYEFAVRISQGERDGKWSTSVFQRTPESAPT
TAPENLNVWPVNGKPTVVAASWDALPETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSA
LVDGLQPGERYLFKIRATNRRGLGPHSKAFIVAMPTTSKADVEQNTEDNGKPEKPEPSSP
SPRAPASSQHPSVPASPQGRNAKDLLLDLKNKILANGGAPRKPQLRAKKAEELDLQSTEI
TGEEELGSREDSPMSPSDTQDQKRTLRPPSRHGHSVVAPGRTAVRARMPALPRREGVDKP
GFSLATQPRPGAPPSASASPAHHASTQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPK
GAFAQPRPALSPSRQSPSSVLRDRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLS
PPHGGSSRLLPTQPHLSSPLSKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEG
AEASDGESHGDGDREDGGRQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRG
PRLQPSSSPQSTVPSRAHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQ
PISRGWEDLRRSPQRGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADT
EGHSPKAQPGSTDRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQ
SRDAGRSPSQPRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYD
DDSTEVEAQDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSR
PGGPQSRARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSV
PKWPSSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSR
LPPRSAATVSPVAGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSY
RQGYNGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHGNP
LRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVGLEVI
KKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTTTRTTTT
TTPTPTTPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAVPTEEAYVI
YDEDYEFETSRPPTTTEPSTTATTPRVIPEEGAISSFPEEEFDLAGRKRFVAPYVTYLNK
DPSAPCSLTDALDHFQVDSLDEIIPNDLKKSDLPPQHAPRNITVVAVEGCHSFVIVDWDK
ATPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNTRYYFKVQAQNPHGYGP
ISPSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPSYTDCHGRQYVKRTWYRKFVGVVL
CNSLRYKIYLSDNLKDTFYSIGDSWGRGEDHCQFVDSHLDGRTGPQSYVEALPTIQGYYR
QYRQEPVRFGNIGFGTPYYYVGWYECGVSIPGKW

Sequence length

1894

Interactions

View interactions

Show/Hide Unknown Diseases (4)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Coronary artery disease	Coronary artery disease	N/A	N/A	GWAS
Coronary Heart Disease	Coronary heart disease	N/A	N/A	GWAS
Multiple Sclerosis	Multiple sclerosis	N/A	N/A	GWAS
Psoriasis	Psoriasis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (10)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Breast Neoplasms	Associate	33899120
Carcinogenesis	Associate	33899120
Colorectal Neoplasms	Associate	35255438
Lymphoma	Associate	21088137
Neoplasms	Associate	26762409, 36190948, 36420274
Neoplasms	Stimulate	34968391
Pancreatic Neoplasms	Stimulate	36420274
Prostatic Neoplasms	Associate	27693493
Squamous Cell Carcinoma of Head and Neck	Associate	37232821
Stomach Neoplasms	Associate	31530096, 34968391

FNDC1 (fibronectin type III domain containing 1)