Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	84620
Gene name Gene Name - the full gene name approved by the HGNC.	ST6 beta-galactoside alpha-2,6-sialyltransferase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ST6GAL2
Synonyms (NCBI Gene) Gene synonyms aliases	SIAT2, ST6GalII
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q12.3
Summary Summary of gene provided in NCBI Entrez Gene.	This locus encodes a sialyltransferase. The encoded type II transmembrane protein catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate. Polymorphisms at this locus may be associated with variations in risperidone response in schi

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miRTarBase ID	miRNA	Experiments	Reference
MIRT446147	hsa-miR-548ae-3p	PAR-CLIP	22100165
MIRT446146	hsa-miR-548ah-3p	PAR-CLIP	22100165
MIRT446145	hsa-miR-548aj-3p	PAR-CLIP	22100165
MIRT446144	hsa-miR-548am-3p	PAR-CLIP	22100165
MIRT446143	hsa-miR-548aq-3p	PAR-CLIP	22100165
MIRT446142	hsa-miR-548j-3p	PAR-CLIP	22100165
MIRT446141	hsa-miR-548x-3p	PAR-CLIP	22100165
MIRT446140	hsa-miR-548a-3p	PAR-CLIP	22100165
MIRT446139	hsa-miR-548ar-3p	PAR-CLIP	22100165
MIRT446138	hsa-miR-548az-3p	PAR-CLIP	22100165
MIRT446137	hsa-miR-548e-3p	PAR-CLIP	22100165
MIRT446136	hsa-miR-548f-3p	PAR-CLIP	22100165
MIRT446134	hsa-miR-3925-5p	PAR-CLIP	22100165
MIRT446135	hsa-miR-15b-3p	PAR-CLIP	22100165
MIRT446133	hsa-miR-146a-5p	PAR-CLIP	22100165
MIRT446132	hsa-miR-146b-5p	PAR-CLIP	22100165
MIRT446130	hsa-miR-7153-5p	PAR-CLIP	22100165
MIRT446131	hsa-miR-185-5p	PAR-CLIP	22100165
MIRT446129	hsa-miR-4306	PAR-CLIP	22100165
MIRT446128	hsa-miR-4644	PAR-CLIP	22100165
MIRT446127	hsa-miR-5192	PAR-CLIP	22100165
MIRT446147	hsa-miR-548ae-3p	PAR-CLIP	22100165
MIRT446146	hsa-miR-548ah-3p	PAR-CLIP	22100165
MIRT446145	hsa-miR-548aj-3p	PAR-CLIP	22100165
MIRT446144	hsa-miR-548am-3p	PAR-CLIP	22100165
MIRT446143	hsa-miR-548aq-3p	PAR-CLIP	22100165
MIRT446142	hsa-miR-548j-3p	PAR-CLIP	22100165
MIRT446141	hsa-miR-548x-3p	PAR-CLIP	22100165
MIRT446140	hsa-miR-548a-3p	PAR-CLIP	22100165
MIRT446139	hsa-miR-548ar-3p	PAR-CLIP	22100165
MIRT446138	hsa-miR-548az-3p	PAR-CLIP	22100165
MIRT446137	hsa-miR-548e-3p	PAR-CLIP	22100165
MIRT446136	hsa-miR-548f-3p	PAR-CLIP	22100165
MIRT446134	hsa-miR-3925-5p	PAR-CLIP	22100165
MIRT446135	hsa-miR-15b-3p	PAR-CLIP	22100165
MIRT446133	hsa-miR-146a-5p	PAR-CLIP	22100165
MIRT446132	hsa-miR-146b-5p	PAR-CLIP	22100165
MIRT446130	hsa-miR-7153-5p	PAR-CLIP	22100165
MIRT446131	hsa-miR-185-5p	PAR-CLIP	22100165
MIRT446129	hsa-miR-4306	PAR-CLIP	22100165
MIRT446128	hsa-miR-4644	PAR-CLIP	22100165
MIRT446127	hsa-miR-5192	PAR-CLIP	22100165
MIRT446147	hsa-miR-548ae-3p	PAR-CLIP	22100165
MIRT446146	hsa-miR-548ah-3p	PAR-CLIP	22100165
MIRT446145	hsa-miR-548aj-3p	PAR-CLIP	22100165
MIRT446144	hsa-miR-548am-3p	PAR-CLIP	22100165
MIRT446143	hsa-miR-548aq-3p	PAR-CLIP	22100165
MIRT446142	hsa-miR-548j-3p	PAR-CLIP	22100165
MIRT446141	hsa-miR-548x-3p	PAR-CLIP	22100165
MIRT446140	hsa-miR-548a-3p	PAR-CLIP	22100165
MIRT446139	hsa-miR-548ar-3p	PAR-CLIP	22100165
MIRT446138	hsa-miR-548az-3p	PAR-CLIP	22100165
MIRT446137	hsa-miR-548e-3p	PAR-CLIP	22100165
MIRT446136	hsa-miR-548f-3p	PAR-CLIP	22100165
MIRT446134	hsa-miR-3925-5p	PAR-CLIP	22100165
MIRT446135	hsa-miR-15b-3p	PAR-CLIP	22100165
MIRT446133	hsa-miR-146a-5p	PAR-CLIP	22100165
MIRT446132	hsa-miR-146b-5p	PAR-CLIP	22100165
MIRT446130	hsa-miR-7153-5p	PAR-CLIP	22100165
MIRT446131	hsa-miR-185-5p	PAR-CLIP	22100165
MIRT446129	hsa-miR-4306	PAR-CLIP	22100165
MIRT446128	hsa-miR-4644	PAR-CLIP	22100165
MIRT446127	hsa-miR-5192	PAR-CLIP	22100165
MIRT446147	hsa-miR-548ae-3p	PAR-CLIP	22100165
MIRT446146	hsa-miR-548ah-3p	PAR-CLIP	22100165
MIRT446145	hsa-miR-548aj-3p	PAR-CLIP	22100165
MIRT446144	hsa-miR-548am-3p	PAR-CLIP	22100165
MIRT446143	hsa-miR-548aq-3p	PAR-CLIP	22100165
MIRT446142	hsa-miR-548j-3p	PAR-CLIP	22100165
MIRT446141	hsa-miR-548x-3p	PAR-CLIP	22100165
MIRT446140	hsa-miR-548a-3p	PAR-CLIP	22100165
MIRT446139	hsa-miR-548ar-3p	PAR-CLIP	22100165
MIRT446138	hsa-miR-548az-3p	PAR-CLIP	22100165
MIRT446137	hsa-miR-548e-3p	PAR-CLIP	22100165
MIRT446136	hsa-miR-548f-3p	PAR-CLIP	22100165
MIRT446134	hsa-miR-3925-5p	PAR-CLIP	22100165
MIRT446135	hsa-miR-15b-3p	PAR-CLIP	22100165
MIRT446133	hsa-miR-146a-5p	PAR-CLIP	22100165
MIRT446132	hsa-miR-146b-5p	PAR-CLIP	22100165
MIRT446130	hsa-miR-7153-5p	PAR-CLIP	22100165
MIRT446131	hsa-miR-185-5p	PAR-CLIP	22100165
MIRT446129	hsa-miR-4306	PAR-CLIP	22100165
MIRT446128	hsa-miR-4644	PAR-CLIP	22100165
MIRT446127	hsa-miR-5192	PAR-CLIP	22100165
MIRT1393691	hsa-miR-103b	CLIP-seq
MIRT1393692	hsa-miR-1305	CLIP-seq
MIRT1393693	hsa-miR-194	CLIP-seq
MIRT1393694	hsa-miR-2964a-5p	CLIP-seq
MIRT1393695	hsa-miR-3607-3p	CLIP-seq
MIRT1393696	hsa-miR-3646	CLIP-seq
MIRT1393697	hsa-miR-376a	CLIP-seq
MIRT1393698	hsa-miR-376b	CLIP-seq
MIRT1393699	hsa-miR-4282	CLIP-seq
MIRT1393700	hsa-miR-4292	CLIP-seq
MIRT1393701	hsa-miR-4308	CLIP-seq
MIRT1393702	hsa-miR-4718	CLIP-seq
MIRT1393703	hsa-miR-548p	CLIP-seq
MIRT1393704	hsa-miR-552	CLIP-seq
MIRT1393705	hsa-miR-603	CLIP-seq
MIRT1393706	hsa-miR-664	CLIP-seq
MIRT1393707	hsa-miR-4328	CLIP-seq
MIRT1393708	hsa-miR-4435	CLIP-seq
MIRT1393691	hsa-miR-103b	CLIP-seq
MIRT1393709	hsa-miR-1231	CLIP-seq
MIRT1393710	hsa-miR-1273	CLIP-seq
MIRT1393692	hsa-miR-1305	CLIP-seq
MIRT1393693	hsa-miR-194	CLIP-seq
MIRT1393711	hsa-miR-3128	CLIP-seq
MIRT1393697	hsa-miR-376a	CLIP-seq
MIRT1393698	hsa-miR-376b	CLIP-seq
MIRT1393712	hsa-miR-3978	CLIP-seq
MIRT1393713	hsa-miR-410	CLIP-seq
MIRT1393699	hsa-miR-4282	CLIP-seq
MIRT1393714	hsa-miR-4470	CLIP-seq
MIRT1393715	hsa-miR-4486	CLIP-seq
MIRT1393716	hsa-miR-4649-5p	CLIP-seq
MIRT1393717	hsa-miR-4666-5p	CLIP-seq
MIRT1393718	hsa-miR-4698	CLIP-seq
MIRT1393719	hsa-miR-4720-5p	CLIP-seq
MIRT1393720	hsa-miR-4799-3p	CLIP-seq
MIRT1393721	hsa-miR-511	CLIP-seq
MIRT1393703	hsa-miR-548p	CLIP-seq
MIRT1393704	hsa-miR-552	CLIP-seq
MIRT1393722	hsa-miR-616	CLIP-seq
MIRT1393723	hsa-miR-654-3p	CLIP-seq
MIRT1393706	hsa-miR-664	CLIP-seq
MIRT1393724	hsa-miR-891a	CLIP-seq
MIRT1554189	hsa-miR-1184	CLIP-seq
MIRT1554190	hsa-miR-198	CLIP-seq
MIRT1554191	hsa-miR-4685-5p	CLIP-seq
MIRT1554192	hsa-miR-4688	CLIP-seq
MIRT1393709	hsa-miR-1231	CLIP-seq
MIRT2118136	hsa-miR-2681	CLIP-seq
MIRT2118137	hsa-miR-3159	CLIP-seq
MIRT2118138	hsa-miR-4534	CLIP-seq
MIRT2340144	hsa-miR-1251	CLIP-seq
MIRT2340145	hsa-miR-1266	CLIP-seq
MIRT1393710	hsa-miR-1273	CLIP-seq
MIRT2340146	hsa-miR-1827	CLIP-seq
MIRT2340147	hsa-miR-2114	CLIP-seq
MIRT1393694	hsa-miR-2964a-5p	CLIP-seq
MIRT2340148	hsa-miR-3180-5p	CLIP-seq
MIRT1393695	hsa-miR-3607-3p	CLIP-seq
MIRT2340149	hsa-miR-3612	CLIP-seq
MIRT1393696	hsa-miR-3646	CLIP-seq
MIRT2340150	hsa-miR-3650	CLIP-seq
MIRT2340151	hsa-miR-3664-3p	CLIP-seq
MIRT2340152	hsa-miR-3689a-3p	CLIP-seq
MIRT2340153	hsa-miR-3689c	CLIP-seq
MIRT2340154	hsa-miR-3929	CLIP-seq
MIRT2340155	hsa-miR-4270	CLIP-seq
MIRT2340156	hsa-miR-4293	CLIP-seq
MIRT2340157	hsa-miR-4312	CLIP-seq
MIRT2340158	hsa-miR-4318	CLIP-seq
MIRT2340159	hsa-miR-4419b	CLIP-seq
MIRT2340160	hsa-miR-4423-5p	CLIP-seq
MIRT2340161	hsa-miR-4433	CLIP-seq
MIRT2340162	hsa-miR-4441	CLIP-seq
MIRT2340163	hsa-miR-4459	CLIP-seq
MIRT2340164	hsa-miR-4478	CLIP-seq
MIRT1393715	hsa-miR-4486	CLIP-seq
MIRT2340165	hsa-miR-4487	CLIP-seq
MIRT2340166	hsa-miR-4518	CLIP-seq
MIRT2118138	hsa-miR-4534	CLIP-seq
MIRT2340167	hsa-miR-4649-3p	CLIP-seq
MIRT1393716	hsa-miR-4649-5p	CLIP-seq
MIRT2340168	hsa-miR-4653-3p	CLIP-seq
MIRT2340169	hsa-miR-4695-5p	CLIP-seq
MIRT1393702	hsa-miR-4718	CLIP-seq
MIRT2340170	hsa-miR-4722-5p	CLIP-seq
MIRT2340171	hsa-miR-4728-5p	CLIP-seq
MIRT2340172	hsa-miR-4768-3p	CLIP-seq
MIRT2340173	hsa-miR-4775	CLIP-seq
MIRT2340174	hsa-miR-4790-3p	CLIP-seq
MIRT2340175	hsa-miR-4793-3p	CLIP-seq
MIRT2340176	hsa-miR-485-5p	CLIP-seq
MIRT2340177	hsa-miR-510	CLIP-seq
MIRT2340178	hsa-miR-520a-5p	CLIP-seq
MIRT2340179	hsa-miR-525-5p	CLIP-seq
MIRT2340180	hsa-miR-596	CLIP-seq
MIRT1393705	hsa-miR-603	CLIP-seq
MIRT2340181	hsa-miR-642b	CLIP-seq
MIRT2340182	hsa-miR-650	CLIP-seq
MIRT2340183	hsa-miR-661	CLIP-seq
MIRT2340184	hsa-miR-940	CLIP-seq
MIRT2460615	hsa-miR-10a	CLIP-seq
MIRT2460616	hsa-miR-10b	CLIP-seq
MIRT2340144	hsa-miR-1251	CLIP-seq
MIRT2460617	hsa-miR-1268	CLIP-seq
MIRT2460618	hsa-miR-1268b	CLIP-seq
MIRT1393710	hsa-miR-1273	CLIP-seq
MIRT2460619	hsa-miR-1908	CLIP-seq
MIRT2460620	hsa-miR-339-5p	CLIP-seq
MIRT2460621	hsa-miR-3613-3p	CLIP-seq
MIRT2460622	hsa-miR-3656	CLIP-seq
MIRT2340156	hsa-miR-4293	CLIP-seq
MIRT2460623	hsa-miR-4421	CLIP-seq
MIRT1393715	hsa-miR-4486	CLIP-seq
MIRT1393716	hsa-miR-4649-5p	CLIP-seq
MIRT2460624	hsa-miR-4684-5p	CLIP-seq
MIRT2460625	hsa-miR-548c-3p	CLIP-seq
MIRT2460626	hsa-miR-550a	CLIP-seq
MIRT2460627	hsa-miR-585	CLIP-seq
MIRT2460628	hsa-miR-593	CLIP-seq
MIRT2340180	hsa-miR-596	CLIP-seq
MIRT2340183	hsa-miR-661	CLIP-seq
MIRT2460629	hsa-miR-663	CLIP-seq
MIRT2460615	hsa-miR-10a	CLIP-seq
MIRT2460616	hsa-miR-10b	CLIP-seq
MIRT2340144	hsa-miR-1251	CLIP-seq
MIRT2460617	hsa-miR-1268	CLIP-seq
MIRT2460618	hsa-miR-1268b	CLIP-seq
MIRT1393710	hsa-miR-1273	CLIP-seq
MIRT2634059	hsa-miR-146a	CLIP-seq
MIRT2460619	hsa-miR-1908	CLIP-seq
MIRT2634060	hsa-miR-298	CLIP-seq
MIRT2634061	hsa-miR-3184	CLIP-seq
MIRT2460620	hsa-miR-339-5p	CLIP-seq
MIRT2634062	hsa-miR-3591-3p	CLIP-seq
MIRT2460621	hsa-miR-3613-3p	CLIP-seq
MIRT2460622	hsa-miR-3656	CLIP-seq
MIRT2634063	hsa-miR-423-5p	CLIP-seq
MIRT2340156	hsa-miR-4293	CLIP-seq
MIRT2460623	hsa-miR-4421	CLIP-seq
MIRT1393715	hsa-miR-4486	CLIP-seq
MIRT2634064	hsa-miR-4502	CLIP-seq
MIRT1393716	hsa-miR-4649-5p	CLIP-seq
MIRT2460624	hsa-miR-4684-5p	CLIP-seq
MIRT2634065	hsa-miR-4733-3p	CLIP-seq
MIRT2340175	hsa-miR-4793-3p	CLIP-seq
MIRT2460625	hsa-miR-548c-3p	CLIP-seq
MIRT2460626	hsa-miR-550a	CLIP-seq
MIRT2460627	hsa-miR-585	CLIP-seq
MIRT2634066	hsa-miR-589	CLIP-seq
MIRT2460628	hsa-miR-593	CLIP-seq
MIRT2340180	hsa-miR-596	CLIP-seq
MIRT2340183	hsa-miR-661	CLIP-seq
MIRT2460629	hsa-miR-663	CLIP-seq
MIRT2460615	hsa-miR-10a	CLIP-seq
MIRT2460616	hsa-miR-10b	CLIP-seq
MIRT2340144	hsa-miR-1251	CLIP-seq
MIRT2460617	hsa-miR-1268	CLIP-seq
MIRT2460618	hsa-miR-1268b	CLIP-seq
MIRT1393710	hsa-miR-1273	CLIP-seq
MIRT2634059	hsa-miR-146a	CLIP-seq
MIRT2460619	hsa-miR-1908	CLIP-seq
MIRT2634060	hsa-miR-298	CLIP-seq
MIRT2634061	hsa-miR-3184	CLIP-seq
MIRT2460620	hsa-miR-339-5p	CLIP-seq
MIRT2634062	hsa-miR-3591-3p	CLIP-seq
MIRT2460621	hsa-miR-3613-3p	CLIP-seq
MIRT2460622	hsa-miR-3656	CLIP-seq
MIRT2692114	hsa-miR-371-5p	CLIP-seq
MIRT2692115	hsa-miR-371b-5p	CLIP-seq
MIRT2634063	hsa-miR-423-5p	CLIP-seq
MIRT2340156	hsa-miR-4293	CLIP-seq
MIRT2460623	hsa-miR-4421	CLIP-seq
MIRT1393715	hsa-miR-4486	CLIP-seq
MIRT2634064	hsa-miR-4502	CLIP-seq
MIRT1393716	hsa-miR-4649-5p	CLIP-seq
MIRT2460624	hsa-miR-4684-5p	CLIP-seq
MIRT2634065	hsa-miR-4733-3p	CLIP-seq
MIRT2340175	hsa-miR-4793-3p	CLIP-seq
MIRT2460625	hsa-miR-548c-3p	CLIP-seq
MIRT2460626	hsa-miR-550a	CLIP-seq
MIRT2460627	hsa-miR-585	CLIP-seq
MIRT2634066	hsa-miR-589	CLIP-seq
MIRT2460628	hsa-miR-593	CLIP-seq
MIRT2340180	hsa-miR-596	CLIP-seq
MIRT2340183	hsa-miR-661	CLIP-seq
MIRT2460629	hsa-miR-663	CLIP-seq

Show/Hide all(8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	TAS
GO:0003835	Function	Beta-galactoside alpha-2,6-sialyltransferase activity	IBA	21873635
GO:0003835	Function	Beta-galactoside alpha-2,6-sialyltransferase activity	IDA	12235148
GO:0006486	Process	Protein glycosylation	IEA
GO:0009311	Process	Oligosaccharide metabolic process	IDA	12235148
GO:0016021	Component	Integral component of membrane	IEA
GO:0032580	Component	Golgi cisterna membrane	IEA
GO:0097503	Process	Sialylation	IEA

MIM	HGNC	e!Ensembl
608472	10861	ENSG00000144057

Protein

UniProt ID

Q96JF0

Protein name

Beta-galactoside alpha-2,6-sialyltransferase 2 (Alpha 2,6-ST 2) (EC 2.4.3.1) (CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2) (ST6Gal II) (ST6GalII) (hST6Gal II) (Sialyltransferase 2)

Protein function

Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00777	Glyco_transf_29	275 → 504	Glycosyltransferase family 29 (sialyltransferase)	Family

Tissue specificity

TISSUE SPECIFICITY: Weakly expressed in some tissues, such as small intestine, colon and fetal brain. {ECO:0000269|PubMed:12235148, ECO:0000269|PubMed:12603328}.

Sequence

MKPHLKQWRQRMLFGIFAWGLLFLLIFIYFTDSNPAEPVPSSLSFLETRRLLPVQGKQRA
IMGAAHEPSPPGGLDARQALPRAHPAGSFHAGPGDLQKWAQSQDGFEHKEFFSSQVGRKS
QSAFYPEDDDYFFAAGQPGWHSHTQGTLGFPSPGEPGPREGAFPAAQVQRRRVKKRHRRQ
RRSHVLEEGDDGDRLYSSMSRAFLYRLWKGNVSSKMLNPRLQKAMKDYLTANKHGVRFRG
KREAGLSRAQLLCQLRSRARVRTLDGTEAPFSALGWRRLVPAVPLSQLHPRGLRSCAVVM
SAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQILTNPSHHFIDSS
LYKDVILVAWDPAPYSANLNLWYKKPDYNLFTPYIQHRQRNPNQPFYILHPKFIWQLWDI
IQENTKEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTELCHYHELYYDAACTLG
AYHPLLYEKLLVQRLNMGTQGDLHRKGKVVLPGFQAVHCPAPSPVIPHS

Sequence length

529

Interactions

View interactions

	KEGG		Reactome
	N-Glycan biosynthesis Other types of O-glycan biosynthesis Metabolic pathways		Sialic acid metabolism

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Esophagus neoplasm	Esophageal Neoplasms	rs28934578, rs121918714, rs1567556006, rs1575166666	22960999

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Alzheimer disease	Alzheimer disease			GWAS

Show/Hide Text Mining Associations (14)

Disease Name	Relationship Type	References
Associations from Text Mining
Atherosclerosis	Associate	11781157
Autism Spectrum Disorder	Associate	28281572
Breast Neoplasms	Associate	12841680, 28032858, 33260650
Calcinosis Cutis	Associate	1544942
Carcinoma Pancreatic Ductal	Associate	39260693
Coronary Disease	Associate	24399302
Glaucoma Open Angle	Associate	36727359
Inflammation	Stimulate	39260693
Meningioma	Associate	34943806
Multiple Myeloma	Associate	35294519
Neoplasms	Associate	24606438, 28154177, 31702036, 34943806, 37227919
Neuralgia	Associate	8757818
Pancreatic Neoplasms	Associate	39260693
Urinary Bladder Neoplasms	Associate	19811634

ST6GAL2 (ST6 beta-galactoside alpha-2,6-sialyltransferase 2)