ZGPAT (zinc finger CCCH-type and G-patch domain containing)

Gene

• Entrez ID: 84619
• Gene name: Zinc finger CCCH-type and G-patch domain containing
• Gene symbol: ZGPAT
• Synonyms (NCBI Gene): GPATC6, GPATCH6, KIAA1847, ZC3H9, ZC3HDC9, ZIP
• Chromosome: 20
• Chromosome location: 20q13.33

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT2374669	hsa-miR-1207-5p	CLIP-seq
MIRT2374670	hsa-miR-141	CLIP-seq
MIRT2374671	hsa-miR-200a	CLIP-seq
MIRT2374672	hsa-miR-214	CLIP-seq
MIRT2374673	hsa-miR-3120-5p	CLIP-seq
MIRT2374674	hsa-miR-3619-5p	CLIP-seq
MIRT2374675	hsa-miR-365	CLIP-seq
MIRT2374676	hsa-miR-3663-5p	CLIP-seq
MIRT2374677	hsa-miR-3665	CLIP-seq
MIRT2374678	hsa-miR-4291	CLIP-seq
MIRT2374679	hsa-miR-4480	CLIP-seq
MIRT2374680	hsa-miR-4519	CLIP-seq
MIRT2374681	hsa-miR-4660	CLIP-seq
MIRT2374682	hsa-miR-4667-3p	CLIP-seq
MIRT2374683	hsa-miR-4736	CLIP-seq
MIRT2374684	hsa-miR-4749-3p	CLIP-seq
MIRT2374685	hsa-miR-4763-3p	CLIP-seq
MIRT2374686	hsa-miR-502-5p	CLIP-seq
MIRT2374687	hsa-miR-512-5p	CLIP-seq
MIRT2374688	hsa-miR-541	CLIP-seq
MIRT2374689	hsa-miR-654-5p	CLIP-seq
MIRT2374690	hsa-miR-761	CLIP-seq
MIRT2374691	hsa-miR-922	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	19644445
GO:0000785	Component	Chromatin	ISA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	19644445
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	19644445
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IDA	19644445
GO:0005515	Function	Protein binding	IPI	19644445, 21516116, 25416956, 26871637, 28514442, 31515488, 32296183, 32814053
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	19644445
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0007175	Process	Negative regulation of epidermal growth factor-activated receptor activity	IDA	19644445
GO:0008270	Function	Zinc ion binding	IEA
GO:0043565	Function	Sequence-specific DNA binding	IDA	19644445
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	19644445
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 619577
• HGNC: 15948
• e!Ensembl: ENSG00000197114

Protein

• UniProt ID: Q8N5A5
• Protein name: Zinc finger CCCH-type with G patch domain-containing protein (G patch domain-containing protein 6) (Zinc finger CCCH domain-containing protein 9) (Zinc finger and G patch domain-containing protein)
• Protein function: Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene invol
• PDB: 4II1
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF18044	zf-CCCH_4	178 → 199	CCCH-type zinc finger	Domain
  PF01585	G-patch	333 → 376	G-patch domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:19644445}.
• Sequence:

  MDEESLESALQTYRAQLQQVELALGAGLDSSEQADLRQLQGDLKELIELTEASLVSVRKS
  SLLAALDEERPGRQEDAEYQAFREAITEAVEAPAAARGSGSETVPKAEAGPESAAGGQEE
  EEGEDEEELSGTKVSAPYYSSWGTLEYHNAMVVGTEEAEDGSAGVRVLYLYPTHKSLKPC
  PFFLEGKCRFKENCRFSHGQVVSLDELRPFQDPDLSSLQAGSACLAKHQDGLWHAARITD
  VDNGYYTVKFDSLLLREAVVEGDGILPPLRTEATESDSDSDGTGDSSYARVVGSDAVDSA
  QSSALCPSLAVVGSDAVDSGTCSSAFAGWEVHTRGIGSRLLTKMGYEFGKGLGRHAEGRV
  EPIHAVVLPRGKSLDQCVETLQKQTRVGKAGTNKPPRCRGRGARPGGRPAPRNVFDFLNE
  KLQGQAPGALEAGAAPAGRRSKDMYHASKSAKRALSLRLFQTEEKIERTQRDIRSIQEAL
  ARNAGRHSVASAQLQEKLAGAQRQLGQLRAQEAGLQQEQRKADTHKKMTEF

• Sequence length: 531