MT4 (metallothionein 4)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID 84560
Gene name Metallothionein 4
Gene symbol MT4
Synonyms (NCBI Gene)
MT-4MT-IVMTIV
Chromosome 16
Chromosome location 16q13
miRNA miRNA information provided by mirtarbase database.
2
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (2)
miRTarBase ID miRNA Experiments Reference
MIRT019458 hsa-miR-148b-3p Microarray 17612493
MIRT023368 hsa-miR-122-5p Microarray 17612493
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (10)
GO ID Ontology Definition Evidence Reference
GO:0005634 Component Nucleus IBA
GO:0005737 Component Cytoplasm IBA
GO:0006882 Process Intracellular zinc ion homeostasis IBA
GO:0010273 Process Detoxification of copper ion IBA
GO:0030003 Process Intracellular monoatomic cation homeostasis IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
606206 18705 ENSG00000102891
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P47944
Protein name Metallothionein-4 (MT-4) (Metallothionein-IV) (MT-IV)
Protein function Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00131 Metallothio 1 → 62 Metallothionein Domain
Sequence
Sequence length 62
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (1)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
KIDNEY DISEASES — CTD, Disgenet
CTD, Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (3)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Coronary Artery Disease Associate 36743388
★★★★★
★☆☆☆☆
Found in Text Mining only
Glomerulonephritis Membranous Inhibit 6332232
★★★★★
★☆☆☆☆
Found in Text Mining only
Periodontitis Associate 27531006
★★★★★
★☆☆☆☆
Found in Text Mining only