Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8454
Gene name Gene Name - the full gene name approved by the HGNC.	Cullin 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CUL1
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q36.1

Show/Hide all(246)

miRTarBase ID	miRNA	Experiments	Reference
MIRT032428	hsa-let-7b-5p	Proteomics	18668040
MIRT050028	hsa-miR-27a-3p	CLASH	23622248
MIRT048506	hsa-miR-100-5p	CLASH	23622248
MIRT046199	hsa-miR-27b-3p	CLASH	23622248
MIRT738305	hsa-miR-520a-3p	HITS-CLIP	33718276
MIRT738311	hsa-miR-302e	HITS-CLIP	33718276
MIRT738312	hsa-miR-106a	CLIP-seq
MIRT738315	hsa-miR-106b	CLIP-seq
MIRT916378	hsa-miR-1200	CLIP-seq
MIRT916379	hsa-miR-1284	CLIP-seq
MIRT738313	hsa-miR-17	CLIP-seq
MIRT916380	hsa-miR-1910	CLIP-seq
MIRT916381	hsa-miR-203	CLIP-seq
MIRT738314	hsa-miR-20a	CLIP-seq
MIRT738317	hsa-miR-20b	CLIP-seq
MIRT916382	hsa-miR-2116	CLIP-seq
MIRT916383	hsa-miR-300	CLIP-seq
MIRT738310	hsa-miR-302a	CLIP-seq
MIRT738301	hsa-miR-302b	CLIP-seq
MIRT738303	hsa-miR-302c	CLIP-seq
MIRT738304	hsa-miR-302d	CLIP-seq
MIRT916384	hsa-miR-3646	CLIP-seq
MIRT916385	hsa-miR-3662	CLIP-seq
MIRT738322	hsa-miR-371-5p	CLIP-seq
MIRT738323	hsa-miR-371b-5p	CLIP-seq
MIRT738302	hsa-miR-372	CLIP-seq
MIRT738307	hsa-miR-373	CLIP-seq
MIRT916386	hsa-miR-377	CLIP-seq
MIRT916387	hsa-miR-381	CLIP-seq
MIRT738321	hsa-miR-3973	CLIP-seq
MIRT916388	hsa-miR-4324	CLIP-seq
MIRT916389	hsa-miR-4468	CLIP-seq
MIRT738325	hsa-miR-4494	CLIP-seq
MIRT916390	hsa-miR-4495	CLIP-seq
MIRT916391	hsa-miR-455-3p	CLIP-seq
MIRT916392	hsa-miR-4666-3p	CLIP-seq
MIRT916393	hsa-miR-4669	CLIP-seq
MIRT916394	hsa-miR-4677-5p	CLIP-seq
MIRT916395	hsa-miR-4687-5p	CLIP-seq
MIRT916396	hsa-miR-4694-3p	CLIP-seq
MIRT916397	hsa-miR-4699-3p	CLIP-seq
MIRT916398	hsa-miR-4775	CLIP-seq
MIRT916399	hsa-miR-494	CLIP-seq
MIRT738324	hsa-miR-499a-5p	CLIP-seq
MIRT916400	hsa-miR-500a	CLIP-seq
MIRT916401	hsa-miR-501-5p	CLIP-seq
MIRT916402	hsa-miR-5096	CLIP-seq
MIRT738299	hsa-miR-512-3p	CLIP-seq
MIRT738318	hsa-miR-519d	CLIP-seq
MIRT738308	hsa-miR-520b	CLIP-seq
MIRT738300	hsa-miR-520c-3p	CLIP-seq
MIRT738309	hsa-miR-520d-3p	CLIP-seq
MIRT738306	hsa-miR-520e	CLIP-seq
MIRT738320	hsa-miR-520g	CLIP-seq
MIRT738319	hsa-miR-520h	CLIP-seq
MIRT916403	hsa-miR-522	CLIP-seq
MIRT916404	hsa-miR-544b	CLIP-seq
MIRT916405	hsa-miR-564	CLIP-seq
MIRT916406	hsa-miR-590-3p	CLIP-seq
MIRT916407	hsa-miR-603	CLIP-seq
MIRT738316	hsa-miR-93	CLIP-seq
MIRT738312	hsa-miR-106a	CLIP-seq
MIRT738315	hsa-miR-106b	CLIP-seq
MIRT738313	hsa-miR-17	CLIP-seq
MIRT738314	hsa-miR-20a	CLIP-seq
MIRT738317	hsa-miR-20b	CLIP-seq
MIRT738310	hsa-miR-302a	CLIP-seq
MIRT738301	hsa-miR-302b	CLIP-seq
MIRT738303	hsa-miR-302c	CLIP-seq
MIRT738304	hsa-miR-302d	CLIP-seq
MIRT738322	hsa-miR-371-5p	CLIP-seq
MIRT738323	hsa-miR-371b-5p	CLIP-seq
MIRT738302	hsa-miR-372	CLIP-seq
MIRT738307	hsa-miR-373	CLIP-seq
MIRT738321	hsa-miR-3973	CLIP-seq
MIRT738325	hsa-miR-4494	CLIP-seq
MIRT738324	hsa-miR-499a-5p	CLIP-seq
MIRT738318	hsa-miR-519d	CLIP-seq
MIRT738308	hsa-miR-520b	CLIP-seq
MIRT738300	hsa-miR-520c-3p	CLIP-seq
MIRT738309	hsa-miR-520d-3p	CLIP-seq
MIRT738306	hsa-miR-520e	CLIP-seq
MIRT738320	hsa-miR-520g	CLIP-seq
MIRT738319	hsa-miR-520h	CLIP-seq
MIRT738316	hsa-miR-93	CLIP-seq
MIRT738312	hsa-miR-106a	CLIP-seq
MIRT738315	hsa-miR-106b	CLIP-seq
MIRT738313	hsa-miR-17	CLIP-seq
MIRT738314	hsa-miR-20a	CLIP-seq
MIRT738317	hsa-miR-20b	CLIP-seq
MIRT738310	hsa-miR-302a	CLIP-seq
MIRT738301	hsa-miR-302b	CLIP-seq
MIRT738303	hsa-miR-302c	CLIP-seq
MIRT738304	hsa-miR-302d	CLIP-seq
MIRT738322	hsa-miR-371-5p	CLIP-seq
MIRT738323	hsa-miR-371b-5p	CLIP-seq
MIRT738302	hsa-miR-372	CLIP-seq
MIRT738307	hsa-miR-373	CLIP-seq
MIRT738321	hsa-miR-3973	CLIP-seq
MIRT1971814	hsa-miR-4294	CLIP-seq
MIRT738325	hsa-miR-4494	CLIP-seq
MIRT738324	hsa-miR-499a-5p	CLIP-seq
MIRT738299	hsa-miR-512-3p	CLIP-seq
MIRT738318	hsa-miR-519d	CLIP-seq
MIRT738308	hsa-miR-520b	CLIP-seq
MIRT738300	hsa-miR-520c-3p	CLIP-seq
MIRT738309	hsa-miR-520d-3p	CLIP-seq
MIRT738306	hsa-miR-520e	CLIP-seq
MIRT738320	hsa-miR-520g	CLIP-seq
MIRT738319	hsa-miR-520h	CLIP-seq
MIRT1971815	hsa-miR-924	CLIP-seq
MIRT738316	hsa-miR-93	CLIP-seq
MIRT738312	hsa-miR-106a	CLIP-seq
MIRT738315	hsa-miR-106b	CLIP-seq
MIRT916378	hsa-miR-1200	CLIP-seq
MIRT738313	hsa-miR-17	CLIP-seq
MIRT916380	hsa-miR-1910	CLIP-seq
MIRT916381	hsa-miR-203	CLIP-seq
MIRT738314	hsa-miR-20a	CLIP-seq
MIRT738317	hsa-miR-20b	CLIP-seq
MIRT916382	hsa-miR-2116	CLIP-seq
MIRT2207490	hsa-miR-299-3p	CLIP-seq
MIRT738310	hsa-miR-302a	CLIP-seq
MIRT738301	hsa-miR-302b	CLIP-seq
MIRT738303	hsa-miR-302c	CLIP-seq
MIRT738304	hsa-miR-302d	CLIP-seq
MIRT738322	hsa-miR-371-5p	CLIP-seq
MIRT738323	hsa-miR-371b-5p	CLIP-seq
MIRT738302	hsa-miR-372	CLIP-seq
MIRT738307	hsa-miR-373	CLIP-seq
MIRT738321	hsa-miR-3973	CLIP-seq
MIRT916388	hsa-miR-4324	CLIP-seq
MIRT916389	hsa-miR-4468	CLIP-seq
MIRT738325	hsa-miR-4494	CLIP-seq
MIRT916391	hsa-miR-455-3p	CLIP-seq
MIRT2207491	hsa-miR-4666-5p	CLIP-seq
MIRT916393	hsa-miR-4669	CLIP-seq
MIRT916394	hsa-miR-4677-5p	CLIP-seq
MIRT2207492	hsa-miR-4690-5p	CLIP-seq
MIRT916396	hsa-miR-4694-3p	CLIP-seq
MIRT916397	hsa-miR-4699-3p	CLIP-seq
MIRT738324	hsa-miR-499a-5p	CLIP-seq
MIRT738299	hsa-miR-512-3p	CLIP-seq
MIRT738318	hsa-miR-519d	CLIP-seq
MIRT738308	hsa-miR-520b	CLIP-seq
MIRT738300	hsa-miR-520c-3p	CLIP-seq
MIRT738309	hsa-miR-520d-3p	CLIP-seq
MIRT738306	hsa-miR-520e	CLIP-seq
MIRT738320	hsa-miR-520g	CLIP-seq
MIRT738319	hsa-miR-520h	CLIP-seq
MIRT916403	hsa-miR-522	CLIP-seq
MIRT916404	hsa-miR-544b	CLIP-seq
MIRT2207493	hsa-miR-657	CLIP-seq
MIRT738316	hsa-miR-93	CLIP-seq
MIRT738312	hsa-miR-106a	CLIP-seq
MIRT738315	hsa-miR-106b	CLIP-seq
MIRT738313	hsa-miR-17	CLIP-seq
MIRT738314	hsa-miR-20a	CLIP-seq
MIRT738317	hsa-miR-20b	CLIP-seq
MIRT738310	hsa-miR-302a	CLIP-seq
MIRT738301	hsa-miR-302b	CLIP-seq
MIRT738303	hsa-miR-302c	CLIP-seq
MIRT738304	hsa-miR-302d	CLIP-seq
MIRT738322	hsa-miR-371-5p	CLIP-seq
MIRT738323	hsa-miR-371b-5p	CLIP-seq
MIRT738302	hsa-miR-372	CLIP-seq
MIRT738307	hsa-miR-373	CLIP-seq
MIRT738321	hsa-miR-3973	CLIP-seq
MIRT738325	hsa-miR-4494	CLIP-seq
MIRT738324	hsa-miR-499a-5p	CLIP-seq
MIRT738299	hsa-miR-512-3p	CLIP-seq
MIRT738318	hsa-miR-519d	CLIP-seq
MIRT738308	hsa-miR-520b	CLIP-seq
MIRT738300	hsa-miR-520c-3p	CLIP-seq
MIRT738309	hsa-miR-520d-3p	CLIP-seq
MIRT738306	hsa-miR-520e	CLIP-seq
MIRT738320	hsa-miR-520g	CLIP-seq
MIRT738319	hsa-miR-520h	CLIP-seq
MIRT738316	hsa-miR-93	CLIP-seq
MIRT738312	hsa-miR-106a	CLIP-seq
MIRT738315	hsa-miR-106b	CLIP-seq
MIRT738313	hsa-miR-17	CLIP-seq
MIRT738314	hsa-miR-20a	CLIP-seq
MIRT738317	hsa-miR-20b	CLIP-seq
MIRT738310	hsa-miR-302a	CLIP-seq
MIRT738301	hsa-miR-302b	CLIP-seq
MIRT738303	hsa-miR-302c	CLIP-seq
MIRT738304	hsa-miR-302d	CLIP-seq
MIRT738322	hsa-miR-371-5p	CLIP-seq
MIRT738323	hsa-miR-371b-5p	CLIP-seq
MIRT738302	hsa-miR-372	CLIP-seq
MIRT738307	hsa-miR-373	CLIP-seq
MIRT738321	hsa-miR-3973	CLIP-seq
MIRT738325	hsa-miR-4494	CLIP-seq
MIRT738324	hsa-miR-499a-5p	CLIP-seq
MIRT738299	hsa-miR-512-3p	CLIP-seq
MIRT738318	hsa-miR-519d	CLIP-seq
MIRT738308	hsa-miR-520b	CLIP-seq
MIRT738300	hsa-miR-520c-3p	CLIP-seq
MIRT738309	hsa-miR-520d-3p	CLIP-seq
MIRT738306	hsa-miR-520e	CLIP-seq
MIRT738320	hsa-miR-520g	CLIP-seq
MIRT738319	hsa-miR-520h	CLIP-seq
MIRT738316	hsa-miR-93	CLIP-seq
MIRT916380	hsa-miR-1910	CLIP-seq
MIRT738310	hsa-miR-302a	CLIP-seq
MIRT738301	hsa-miR-302b	CLIP-seq
MIRT738303	hsa-miR-302c	CLIP-seq
MIRT738304	hsa-miR-302d	CLIP-seq
MIRT738302	hsa-miR-372	CLIP-seq
MIRT738307	hsa-miR-373	CLIP-seq
MIRT2510710	hsa-miR-4473	CLIP-seq
MIRT2510711	hsa-miR-4480	CLIP-seq
MIRT916391	hsa-miR-455-3p	CLIP-seq
MIRT2510712	hsa-miR-4641	CLIP-seq
MIRT2510713	hsa-miR-4671-3p	CLIP-seq
MIRT916395	hsa-miR-4687-5p	CLIP-seq
MIRT738299	hsa-miR-512-3p	CLIP-seq
MIRT738308	hsa-miR-520b	CLIP-seq
MIRT738300	hsa-miR-520c-3p	CLIP-seq
MIRT738309	hsa-miR-520d-3p	CLIP-seq
MIRT738306	hsa-miR-520e	CLIP-seq
MIRT2510714	hsa-miR-542-5p	CLIP-seq
MIRT916405	hsa-miR-564	CLIP-seq
MIRT2510715	hsa-miR-939	CLIP-seq
MIRT916380	hsa-miR-1910	CLIP-seq
MIRT738310	hsa-miR-302a	CLIP-seq
MIRT738301	hsa-miR-302b	CLIP-seq
MIRT738303	hsa-miR-302c	CLIP-seq
MIRT738304	hsa-miR-302d	CLIP-seq
MIRT738302	hsa-miR-372	CLIP-seq
MIRT738307	hsa-miR-373	CLIP-seq
MIRT2510710	hsa-miR-4473	CLIP-seq
MIRT2510711	hsa-miR-4480	CLIP-seq
MIRT916391	hsa-miR-455-3p	CLIP-seq
MIRT2510712	hsa-miR-4641	CLIP-seq
MIRT2510713	hsa-miR-4671-3p	CLIP-seq
MIRT916395	hsa-miR-4687-5p	CLIP-seq
MIRT738299	hsa-miR-512-3p	CLIP-seq
MIRT738308	hsa-miR-520b	CLIP-seq
MIRT738300	hsa-miR-520c-3p	CLIP-seq
MIRT738309	hsa-miR-520d-3p	CLIP-seq
MIRT738306	hsa-miR-520e	CLIP-seq
MIRT2510714	hsa-miR-542-5p	CLIP-seq
MIRT916405	hsa-miR-564	CLIP-seq
MIRT2510715	hsa-miR-939	CLIP-seq

Show/Hide all(39)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000082	Process	G1/S transition of mitotic cell cycle	TAS	8681378
GO:0000086	Process	G2/M transition of mitotic cell cycle	TAS
GO:0000209	Process	Protein polyubiquitination	TAS
GO:0002223	Process	Stimulatory C-type lectin receptor signaling pathway	TAS
GO:0004842	Function	Ubiquitin-protein transferase activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	11961546, 12504025, 12504026, 12609982, 14685242, 15537541, 16051867, 16278047, 16797541, 16861300, 16880511, 17290223, 17318178, 17914462, 18203720, 18239684, 18264111, 18274552, 18354482, 18644861, 18667692, 18723677, 18775313, 18805092, 18818696, 18826954, 18929646, 19615732, 197
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA	19617556
GO:0006513	Process	Protein monoubiquitination	IEA
GO:0006879	Process	Cellular iron ion homeostasis	TAS
GO:0008283	Process	Cell population proliferation	IEA
GO:0009887	Process	Animal organ morphogenesis	IEA
GO:0010265	Process	SCF complex assembly	TAS
GO:0010972	Process	Negative regulation of G2/M transition of mitotic cell cycle	TAS
GO:0016032	Process	Viral process	IEA
GO:0016055	Process	Wnt signaling pathway	TAS
GO:0016567	Process	Protein ubiquitination	IBA	21873635
GO:0016567	Process	Protein ubiquitination	IDA	15103331
GO:0019005	Component	SCF ubiquitin ligase complex	IBA	21873635
GO:0019005	Component	SCF ubiquitin ligase complex	IDA	11956208, 15103331, 15145941, 16880511, 20596027, 21572392, 21725316, 23263282, 25585578, 28007894
GO:0019005	Component	SCF ubiquitin ligase complex	ISS
GO:0031146	Process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA	21873635
GO:0031146	Process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA	15103331
GO:0031146	Process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISS
GO:0031146	Process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	TAS
GO:0031461	Component	Cullin-RING ubiquitin ligase complex	IBA	21873635
GO:0031461	Component	Cullin-RING ubiquitin ligase complex	IDA	22405651
GO:0031625	Function	Ubiquitin protein ligase binding	IBA	21873635
GO:0038061	Process	NIK/NF-kappaB signaling	TAS
GO:0038095	Process	Fc-epsilon receptor signaling pathway	TAS
GO:0043687	Process	Post-translational protein modification	TAS
GO:0050852	Process	T cell receptor signaling pathway	TAS
GO:0051403	Process	Stress-activated MAPK cascade	TAS
GO:0070498	Process	Interleukin-1-mediated signaling pathway	TAS
GO:0070936	Process	Protein K48-linked ubiquitination	IEA
GO:0097193	Process	Intrinsic apoptotic signaling pathway	TAS	8681378
GO:1901990	Process	Regulation of mitotic cell cycle phase transition	TAS
GO:1990452	Component	Parkin-FBXW7-Cul1 ubiquitin ligase complex	IPI	12628165

MIM	HGNC	e!Ensembl
603134	2551	ENSG00000055130

Protein

UniProt ID

Q13616

Protein name

Cullin-1 (CUL-1)

Protein function

Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complex

PDB

1LDJ , 1LDK , 1U6G , 3RTR , 3TDU , 3TDZ , 4F52 , 4P5O , 5V89 , 6TTU , 6WCQ , 7B5L , 7B5M , 7B5N , 7B5R , 7B5S , 7Z8R , 7Z8T , 7Z8V , 7ZBW , 7ZBZ , 8CAF , 8CDJ , 8CDK , 8OR0 , 8OR2 , 8OR3 , 8OR4 , 8UA6 , 8UBT , 8UBU , 8VVY , 9JKB , 9KBD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00888	Cullin	21 → 670	Cullin family	Family
PF10557	Cullin_Nedd8	706 → 768	Cullin protein neddylation domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in lung fibroblasts. {ECO:0000269|PubMed:9663463}.

Sequence

MSSTRSQNPHGLKQIGLDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSN
QARGAGVPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTNLLKDGEDLMDESVLKFYT
QQWEDYRFSSKVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFRPLNKQVT
NAVLKLIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADT
ERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKHL
EIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAAL
NDPKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPE
LLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSA
SDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNSEPLDLDFSIQVL
SSGSWPFQQSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYT
LQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILLKSKLLVLEDENANVDE
VELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMK
MRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA

Sequence length

776

Interactions

View interactions

	KEGG		Reactome
	Cell cycle Oocyte meiosis Ubiquitin mediated proteolysis Protein processing in endoplasmic reticulum Wnt signaling pathway Hedgehog signaling pathway TGF-beta signaling pathway Circadian rhythm Shigellosis Human immunodeficiency virus 1 infection Pathways in cancer		Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of PLK1 Activity at G2/M Transition Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FCERI mediated NF-kB activation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Orc1 removal from chromatin Cyclin D associated events in G1 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Regulation of RUNX2 expression and activity Neddylation Interleukin-1 signaling Iron uptake and transport Antigen processing: Ubiquitination & Proteasome degradation

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Inflammatory bowel disease	Inflammatory Bowel Diseases	rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs1989014468	28067908

Show/Hide Unknown Diseases (6)

Disease term	Disease name	Evidence	References	Source
Unknown
Crohn disease	Crohn Disease		28067908	ClinVar
Diabetes	Diabetes			GWAS
Crohn Disease	Crohn Disease			GWAS
Inflammatory Bowel Disease	Inflammatory Bowel Disease			GWAS
Glioblastoma	Glioblastoma	CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587		GWAS, CBGDA
Ulcerative colitis	Ulcerative colitis			GWAS

Show/Hide Text Mining Associations (37)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenomatous Polyps	Associate	29475926
Alzheimer Disease	Stimulate	33754896
Bipolar Disorder	Associate	32871949
Breast Neoplasms	Associate	23592700, 31175550
Carcinogenesis	Associate	9736735
Carcinoid Tumor	Associate	17823919
Carcinoma Hepatocellular	Associate	26097587
Carcinoma Neuroendocrine	Associate	17823919
Carcinoma Non Small Cell Lung	Associate	17823919
Choriocarcinoma	Associate	23429288
Chromosomal Instability	Associate	33731859
Colorectal Neoplasms	Associate	28269751, 29475926, 34237211
Drug Related Side Effects and Adverse Reactions	Associate	24938872
Dysplastic Nevus Syndrome	Associate	23028750
Exostoses	Associate	34582124
Glomus vagale tumors	Associate	22748924
Hereditary Breast and Ovarian Cancer Syndrome	Associate	26598692
Hypoxia	Stimulate	34237211
Lung Neoplasms	Associate	17823919
Lymphoma B Cell Marginal Zone	Associate	24349473
Melanoma	Associate	23028750
Muscle Hypotonia	Associate	34582124
Neoplasm Metastasis	Associate	28315506
Neoplasm Metastasis	Stimulate	31175550
Neoplasms	Associate	17823919, 26097587, 26152289, 27225414, 28315506, 31175550, 32871949, 34237211, 35008511, 36245368, 37204251
Neoplasms	Inhibit	19679553
Neurologic Manifestations	Associate	34582124
Oncogene Addiction	Associate	35773268
Osteosarcoma	Associate	28315506
Ovarian Neoplasms	Associate	33731859
Pre Eclampsia	Associate	23429288
Prostatic Neoplasms	Associate	30885218
Pulmonary Disease Chronic Obstructive	Associate	32565880
Squamous Cell Carcinoma of Head and Neck	Associate	26152289
Stomach Neoplasms	Associate	23311997
Thyroid Neoplasms	Associate	32737449
Triple Negative Breast Neoplasms	Associate	31175550

CUL1 (cullin 1)