Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8453
Gene name Gene Name - the full gene name approved by the HGNC.	Cullin 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CUL2
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10p11.21

Show/Hide all(251)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005927	hsa-miR-424-5p	ChIP-seq, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	20972335
MIRT007130	hsa-miR-30c-5p	qRT-PCR	23418453
MIRT052315	hsa-let-7b-5p	CLASH	23622248
MIRT048623	hsa-miR-99a-5p	CLASH	23622248
MIRT048406	hsa-miR-100-5p	CLASH	23622248
MIRT038756	hsa-miR-93-3p	CLASH	23622248
MIRT052839	hsa-miR-4326	CLASH	23622248
MIRT053490	hsa-miR-574-3p	Microarray, qRT-PCR, Western blot	22683180
MIRT126912	hsa-miR-3163	HITS-CLIP	21572407
MIRT509019	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT509018	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT509017	hsa-miR-656-3p	HITS-CLIP	21572407
MIRT558513	hsa-miR-1267	HITS-CLIP	21572407
MIRT509016	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509015	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT509018	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT509017	hsa-miR-656-3p	HITS-CLIP	21572407
MIRT509016	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509015	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT126912	hsa-miR-3163	HITS-CLIP	23313552
MIRT509019	hsa-miR-410-3p	HITS-CLIP	23313552
MIRT509015	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT126912	hsa-miR-3163	PAR-CLIP	20371350
MIRT509019	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT509018	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT509017	hsa-miR-656-3p	PAR-CLIP	20371350
MIRT509016	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT509015	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT126912	hsa-miR-3163	PAR-CLIP	21572407
MIRT509019	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT509018	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509017	hsa-miR-656-3p	PAR-CLIP	21572407
MIRT558513	hsa-miR-1267	PAR-CLIP	21572407
MIRT509016	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509015	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509015	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT126912	hsa-miR-3163	PAR-CLIP	22012620
MIRT509019	hsa-miR-410-3p	PAR-CLIP	22012620
MIRT509018	hsa-miR-5011-5p	PAR-CLIP	22012620
MIRT509017	hsa-miR-656-3p	PAR-CLIP	22012620
MIRT509016	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT126912	hsa-miR-3163	PAR-CLIP	23446348
MIRT509019	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT509018	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509017	hsa-miR-656-3p	PAR-CLIP	23446348
MIRT509016	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509015	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT126912	hsa-miR-3163	PAR-CLIP	23446348
MIRT509019	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT509018	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509017	hsa-miR-656-3p	PAR-CLIP	23446348
MIRT509016	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509015	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT727917	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT727916	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT727915	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT727914	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT733748	hsa-miR-154-5p	Luciferase reporter assay, qRT-PCR, Western blotting	32742484
MIRT733748	hsa-miR-154-5p	Western blotting, Microarray, qRT-PCR	32742484
MIRT126912	hsa-miR-3163	HITS-CLIP	21572407
MIRT509019	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT509018	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT509017	hsa-miR-656-3p	HITS-CLIP	21572407
MIRT558513	hsa-miR-1267	HITS-CLIP	21572407
MIRT509016	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509015	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT509018	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT509017	hsa-miR-656-3p	HITS-CLIP	21572407
MIRT509016	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509015	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT126912	hsa-miR-3163	HITS-CLIP	23313552
MIRT509019	hsa-miR-410-3p	HITS-CLIP	23313552
MIRT509015	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT126912	hsa-miR-3163	PAR-CLIP	20371350
MIRT509019	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT509018	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT509017	hsa-miR-656-3p	PAR-CLIP	20371350
MIRT509016	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT509015	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT126912	hsa-miR-3163	PAR-CLIP	21572407
MIRT509019	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT509018	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509017	hsa-miR-656-3p	PAR-CLIP	21572407
MIRT558513	hsa-miR-1267	PAR-CLIP	21572407
MIRT509016	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509015	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509015	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT126912	hsa-miR-3163	PAR-CLIP	22012620
MIRT509019	hsa-miR-410-3p	PAR-CLIP	22012620
MIRT509018	hsa-miR-5011-5p	PAR-CLIP	22012620
MIRT509017	hsa-miR-656-3p	PAR-CLIP	22012620
MIRT509016	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT126912	hsa-miR-3163	PAR-CLIP	23446348
MIRT509019	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT509018	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509017	hsa-miR-656-3p	PAR-CLIP	23446348
MIRT509016	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509015	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT126912	hsa-miR-3163	PAR-CLIP	23446348
MIRT509019	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT509018	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509017	hsa-miR-656-3p	PAR-CLIP	23446348
MIRT509016	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509015	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT916408	hsa-miR-1251	CLIP-seq
MIRT916409	hsa-miR-1260	CLIP-seq
MIRT916410	hsa-miR-1260b	CLIP-seq
MIRT916411	hsa-miR-1279	CLIP-seq
MIRT916412	hsa-miR-154	CLIP-seq
MIRT916413	hsa-miR-15a	CLIP-seq
MIRT916414	hsa-miR-15b	CLIP-seq
MIRT916415	hsa-miR-16	CLIP-seq
MIRT916416	hsa-miR-188-3p	CLIP-seq
MIRT916417	hsa-miR-1910	CLIP-seq
MIRT916418	hsa-miR-195	CLIP-seq
MIRT916419	hsa-miR-2681	CLIP-seq
MIRT916420	hsa-miR-3122	CLIP-seq
MIRT916421	hsa-miR-3140-3p	CLIP-seq
MIRT916422	hsa-miR-3153	CLIP-seq
MIRT916423	hsa-miR-3156-3p	CLIP-seq
MIRT916424	hsa-miR-3175	CLIP-seq
MIRT916425	hsa-miR-3179	CLIP-seq
MIRT916426	hsa-miR-3180-5p	CLIP-seq
MIRT916427	hsa-miR-338-5p	CLIP-seq
MIRT916428	hsa-miR-3675-3p	CLIP-seq
MIRT916429	hsa-miR-3689a-3p	CLIP-seq
MIRT916430	hsa-miR-3689c	CLIP-seq
MIRT916431	hsa-miR-370	CLIP-seq
MIRT916432	hsa-miR-3913-5p	CLIP-seq
MIRT916433	hsa-miR-424	CLIP-seq
MIRT916434	hsa-miR-4261	CLIP-seq
MIRT916435	hsa-miR-4293	CLIP-seq
MIRT916436	hsa-miR-4446-5p	CLIP-seq
MIRT916437	hsa-miR-4646-5p	CLIP-seq
MIRT916438	hsa-miR-4668-5p	CLIP-seq
MIRT916439	hsa-miR-4756-3p	CLIP-seq
MIRT916440	hsa-miR-4757-3p	CLIP-seq
MIRT916441	hsa-miR-494	CLIP-seq
MIRT916442	hsa-miR-497	CLIP-seq
MIRT916443	hsa-miR-514	CLIP-seq
MIRT916444	hsa-miR-514b-3p	CLIP-seq
MIRT916445	hsa-miR-520a-5p	CLIP-seq
MIRT916446	hsa-miR-525-5p	CLIP-seq
MIRT916447	hsa-miR-596	CLIP-seq
MIRT916448	hsa-miR-642b	CLIP-seq
MIRT916449	hsa-miR-645	CLIP-seq
MIRT916450	hsa-miR-661	CLIP-seq
MIRT916451	hsa-miR-873	CLIP-seq
MIRT916452	hsa-miR-944	CLIP-seq
MIRT1971816	hsa-miR-1257	CLIP-seq
MIRT916409	hsa-miR-1260	CLIP-seq
MIRT916410	hsa-miR-1260b	CLIP-seq
MIRT916416	hsa-miR-188-3p	CLIP-seq
MIRT916417	hsa-miR-1910	CLIP-seq
MIRT916419	hsa-miR-2681	CLIP-seq
MIRT1971817	hsa-miR-30a	CLIP-seq
MIRT1971818	hsa-miR-30b	CLIP-seq
MIRT1971819	hsa-miR-30c	CLIP-seq
MIRT1971820	hsa-miR-30d	CLIP-seq
MIRT1971821	hsa-miR-30e	CLIP-seq
MIRT916421	hsa-miR-3140-3p	CLIP-seq
MIRT916423	hsa-miR-3156-3p	CLIP-seq
MIRT1971822	hsa-miR-329	CLIP-seq
MIRT916427	hsa-miR-338-5p	CLIP-seq
MIRT1971823	hsa-miR-3612	CLIP-seq
MIRT1971824	hsa-miR-3613-5p	CLIP-seq
MIRT1971825	hsa-miR-362-3p	CLIP-seq
MIRT916431	hsa-miR-370	CLIP-seq
MIRT1971826	hsa-miR-4299	CLIP-seq
MIRT1971827	hsa-miR-4443	CLIP-seq
MIRT916436	hsa-miR-4446-5p	CLIP-seq
MIRT1971828	hsa-miR-4645-3p	CLIP-seq
MIRT1971829	hsa-miR-491-3p	CLIP-seq
MIRT916443	hsa-miR-514	CLIP-seq
MIRT916444	hsa-miR-514b-3p	CLIP-seq
MIRT1971830	hsa-miR-522	CLIP-seq
MIRT1971831	hsa-miR-570	CLIP-seq
MIRT1971832	hsa-miR-650	CLIP-seq
MIRT1971833	hsa-miR-656	CLIP-seq
MIRT916451	hsa-miR-873	CLIP-seq
MIRT1971834	hsa-miR-922	CLIP-seq
MIRT916409	hsa-miR-1260	CLIP-seq
MIRT916410	hsa-miR-1260b	CLIP-seq
MIRT2207494	hsa-miR-142-5p	CLIP-seq
MIRT916413	hsa-miR-15a	CLIP-seq
MIRT916414	hsa-miR-15b	CLIP-seq
MIRT916415	hsa-miR-16	CLIP-seq
MIRT916416	hsa-miR-188-3p	CLIP-seq
MIRT916418	hsa-miR-195	CLIP-seq
MIRT916419	hsa-miR-2681	CLIP-seq
MIRT1971817	hsa-miR-30a	CLIP-seq
MIRT1971818	hsa-miR-30b	CLIP-seq
MIRT1971819	hsa-miR-30c	CLIP-seq
MIRT1971820	hsa-miR-30d	CLIP-seq
MIRT1971821	hsa-miR-30e	CLIP-seq
MIRT916421	hsa-miR-3140-3p	CLIP-seq
MIRT916423	hsa-miR-3156-3p	CLIP-seq
MIRT1971822	hsa-miR-329	CLIP-seq
MIRT1971825	hsa-miR-362-3p	CLIP-seq
MIRT916433	hsa-miR-424	CLIP-seq
MIRT1971827	hsa-miR-4443	CLIP-seq
MIRT916436	hsa-miR-4446-5p	CLIP-seq
MIRT916439	hsa-miR-4756-3p	CLIP-seq
MIRT916442	hsa-miR-497	CLIP-seq
MIRT916443	hsa-miR-514	CLIP-seq
MIRT916444	hsa-miR-514b-3p	CLIP-seq
MIRT1971830	hsa-miR-522	CLIP-seq
MIRT2207495	hsa-miR-561	CLIP-seq
MIRT1971831	hsa-miR-570	CLIP-seq
MIRT916451	hsa-miR-873	CLIP-seq
MIRT1971834	hsa-miR-922	CLIP-seq
MIRT1971822	hsa-miR-329	CLIP-seq
MIRT1971825	hsa-miR-362-3p	CLIP-seq
MIRT916431	hsa-miR-370	CLIP-seq
MIRT916408	hsa-miR-1251	CLIP-seq
MIRT916411	hsa-miR-1279	CLIP-seq
MIRT916412	hsa-miR-154	CLIP-seq
MIRT916413	hsa-miR-15a	CLIP-seq
MIRT916414	hsa-miR-15b	CLIP-seq
MIRT916415	hsa-miR-16	CLIP-seq
MIRT916418	hsa-miR-195	CLIP-seq
MIRT2510716	hsa-miR-203	CLIP-seq
MIRT916419	hsa-miR-2681	CLIP-seq
MIRT1971817	hsa-miR-30a	CLIP-seq
MIRT1971818	hsa-miR-30b	CLIP-seq
MIRT1971819	hsa-miR-30c	CLIP-seq
MIRT1971820	hsa-miR-30d	CLIP-seq
MIRT1971821	hsa-miR-30e	CLIP-seq
MIRT1971824	hsa-miR-3613-5p	CLIP-seq
MIRT2510717	hsa-miR-3668	CLIP-seq
MIRT916428	hsa-miR-3675-3p	CLIP-seq
MIRT2510718	hsa-miR-3935	CLIP-seq
MIRT916433	hsa-miR-424	CLIP-seq
MIRT1971826	hsa-miR-4299	CLIP-seq
MIRT2510719	hsa-miR-4666-3p	CLIP-seq
MIRT916442	hsa-miR-497	CLIP-seq
MIRT2510720	hsa-miR-556-5p	CLIP-seq
MIRT1971831	hsa-miR-570	CLIP-seq
MIRT2510721	hsa-miR-616	CLIP-seq
MIRT916449	hsa-miR-645	CLIP-seq
MIRT1971834	hsa-miR-922	CLIP-seq
MIRT916452	hsa-miR-944	CLIP-seq
MIRT1971817	hsa-miR-30a	CLIP-seq
MIRT1971818	hsa-miR-30b	CLIP-seq
MIRT1971819	hsa-miR-30c	CLIP-seq
MIRT1971820	hsa-miR-30d	CLIP-seq
MIRT1971821	hsa-miR-30e	CLIP-seq
MIRT1971824	hsa-miR-3613-5p	CLIP-seq
MIRT1971826	hsa-miR-4299	CLIP-seq
MIRT1971831	hsa-miR-570	CLIP-seq
MIRT1971834	hsa-miR-922	CLIP-seq

Show/Hide all(32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000082	Process	G1/S transition of mitotic cell cycle	IEA
GO:0000082	Process	G1/S transition of mitotic cell cycle	TAS	8681378
GO:0004842	Function	Ubiquitin-protein transferase activity	TAS
GO:0005515	Function	Protein binding	IPI	12504026, 12609982, 15601820, 17183367, 17304241, 18323857, 18775313, 18826954, 19327355, 21145461, 21778237, 22190034, 22466964, 22939624, 23401859, 23563313, 24192928, 24402281, 25661653, 26906416, 28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0010498	Process	Proteasomal protein catabolic process	IEA
GO:0016567	Process	Protein ubiquitination	IBA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016567	Process	Protein ubiquitination	TAS
GO:0019005	Component	SCF ubiquitin ligase complex	IBA
GO:0030163	Process	Protein catabolic process	IEA
GO:0030674	Function	Protein-macromolecule adaptor activity	IBA
GO:0031146	Process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA
GO:0031461	Component	Cullin-RING ubiquitin ligase complex	IEA
GO:0031462	Component	Cul2-RING ubiquitin ligase complex	IBA
GO:0031462	Component	Cul2-RING ubiquitin ligase complex	IDA	17636018
GO:0031462	Component	Cul2-RING ubiquitin ligase complex	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IBA
GO:0031625	Function	Ubiquitin protein ligase binding	IDA	17636018
GO:0031625	Function	Ubiquitin protein ligase binding	IEA
GO:0031981	Component	Nuclear lumen	IEA
GO:0097193	Process	Intrinsic apoptotic signaling pathway	IEA
GO:0097193	Process	Intrinsic apoptotic signaling pathway	TAS	8681378
GO:0140627	Process	Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	IDA	29779948
GO:0140627	Process	Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	IDA	29779948
GO:0160072	Function	Ubiquitin ligase complex scaffold activity	IDA	29779948
GO:0160072	Function	Ubiquitin ligase complex scaffold activity	IEA

MIM	HGNC	e!Ensembl
603135	2552	ENSG00000108094

Protein

UniProt ID

Q13617

Protein name

Cullin-2 (CUL-2)

Protein function

Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins (PubMed:11384984, PubMed:26138980, PubMed:29775578, PubMed:29779948,

PDB

4WQO , 5N4W , 6R6H , 6R7F , 6R7H , 6R7I , 6R7N , 7PLO , 8IJ1 , 8JAL , 8JAQ , 8JAR , 8JAS , 8JAU , 8JAV , 8JE1 , 8JE2 , 8PQL , 8Q7R , 8QU8 , 8R5H , 8RWZ , 8RX0 , 8WDK , 8WQA , 8WQB , 8WQC , 8WQE , 8WQF , 8WQG , 8WQH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00888	Cullin	14 → 644	Cullin family	Family
PF10557	Cullin_Nedd8	675 → 737	Cullin protein neddylation domain	Domain

Sequence

MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTE
TKIFLENHVRHLHKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTE
ADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVL
GRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMANMYVL
LRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFIT
VFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDM
SVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQ
DSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKD
TPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKK
CIEVLIDKQYIERSQASADEYSYVA

Sequence length

745

Interactions

View interactions

	KEGG		Reactome
	HIF-1 signaling pathway Ubiquitin mediated proteolysis Pathways in cancer Renal cell carcinoma		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Neddylation Antigen processing: Ubiquitination & Proteasome degradation

Show/Hide Unknown Diseases (4)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Alzheimer disease	Alzheimer's disease or family history of Alzheimer's disease	N/A	N/A	GWAS
Crohn Disease	Crohn's disease	N/A	N/A	GWAS
Inflammatory Bowel Disease	Inflammatory bowel disease	N/A	N/A	GWAS
Ulcerative colitis	Ulcerative colitis	N/A	N/A	GWAS

Show/Hide Text Mining Associations (22)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenomatous Polyps	Associate	29475926
Autism Spectrum Disorder	Associate	39519104
Breast Neoplasms	Associate	31374029
Carcinogenesis	Associate	27153550
Carcinoma Hepatocellular	Associate	25540389
Carcinoma Non Small Cell Lung	Inhibit	35068326
Carcinoma Pancreatic Ductal	Associate	35650603
Cell Transformation Neoplastic	Associate	10585493
Colorectal Neoplasms	Associate	29475926
Glioblastoma	Associate	35111402, 36168628
Hypoxia	Associate	9447969
Neoplasms	Associate	14612903, 17609271, 21822215, 26152289, 27153550, 37695034
Ovarian Neoplasms	Associate	30864705
Pulmonary Disease Chronic Obstructive	Associate	40413536
Retinoblastoma	Associate	17609271
Squamous Cell Carcinoma of Head and Neck	Associate	26152289
Squamous Cell Carcinoma of Head and Neck	Stimulate	37695034
Uterine Cervical Neoplasms	Stimulate	27153550
Uterine Cervical Neoplasms	Associate	34031216
Uterine Cervicitis	Associate	27153550
Uveal melanoma	Associate	14612903
von Hippel Lindau Disease	Associate	10318914, 16669786, 21942715

CUL2 (cullin 2)