ZNF559 (zinc finger protein 559)

Gene

• Entrez ID: 84527
• Gene name: Zinc finger protein 559
• Gene symbol: ZNF559
• Synonyms (NCBI Gene): NBLA00121
• Chromosome: 19
• Chromosome location: 19p13.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT000922	hsa-miR-15a-5p	Microarray	18362358
MIRT000921	hsa-miR-16-5p	Microarray	18362358
MIRT295213	hsa-miR-5692a	PAR-CLIP	22100165
MIRT295213	hsa-miR-5692a	PAR-CLIP	22100165
MIRT295213	hsa-miR-5692a	PAR-CLIP	22100165
MIRT295213	hsa-miR-5692a	PAR-CLIP	22100165
MIRT1529540	hsa-miR-1260	CLIP-seq
MIRT1529541	hsa-miR-1260b	CLIP-seq
MIRT1529542	hsa-miR-140-3p	CLIP-seq
MIRT1529543	hsa-miR-181a	CLIP-seq
MIRT1529544	hsa-miR-181b	CLIP-seq
MIRT1529545	hsa-miR-181c	CLIP-seq
MIRT1529546	hsa-miR-181d	CLIP-seq
MIRT1529547	hsa-miR-188-3p	CLIP-seq
MIRT1529548	hsa-miR-1911	CLIP-seq
MIRT1529549	hsa-miR-3124-3p	CLIP-seq
MIRT1529550	hsa-miR-3156-3p	CLIP-seq
MIRT1529551	hsa-miR-3156-5p	CLIP-seq
MIRT1529552	hsa-miR-3200-5p	CLIP-seq
MIRT1529553	hsa-miR-3691-3p	CLIP-seq
MIRT1529554	hsa-miR-4251	CLIP-seq
MIRT1529555	hsa-miR-4262	CLIP-seq
MIRT1529556	hsa-miR-4329	CLIP-seq
MIRT1529557	hsa-miR-4446-5p	CLIP-seq
MIRT1529558	hsa-miR-4476	CLIP-seq
MIRT1529559	hsa-miR-4666-5p	CLIP-seq
MIRT1529560	hsa-miR-4690-3p	CLIP-seq
MIRT1529561	hsa-miR-595	CLIP-seq
MIRT1529562	hsa-miR-654-3p	CLIP-seq
MIRT1529563	hsa-miR-942	CLIP-seq
MIRT1529564	hsa-miR-3667-3p	CLIP-seq
MIRT1529565	hsa-miR-3692	CLIP-seq
MIRT1529540	hsa-miR-1260	CLIP-seq
MIRT1529541	hsa-miR-1260b	CLIP-seq
MIRT1529547	hsa-miR-188-3p	CLIP-seq
MIRT1529550	hsa-miR-3156-3p	CLIP-seq
MIRT1529540	hsa-miR-1260	CLIP-seq
MIRT1529541	hsa-miR-1260b	CLIP-seq
MIRT1529543	hsa-miR-181a	CLIP-seq
MIRT1529544	hsa-miR-181b	CLIP-seq
MIRT1529545	hsa-miR-181c	CLIP-seq
MIRT1529546	hsa-miR-181d	CLIP-seq
MIRT1529547	hsa-miR-188-3p	CLIP-seq
MIRT1529549	hsa-miR-3124-3p	CLIP-seq
MIRT1529550	hsa-miR-3156-3p	CLIP-seq
MIRT2379441	hsa-miR-3202	CLIP-seq
MIRT2379442	hsa-miR-3688-3p	CLIP-seq
MIRT1529553	hsa-miR-3691-3p	CLIP-seq
MIRT1529555	hsa-miR-4262	CLIP-seq
MIRT2379443	hsa-miR-4533	CLIP-seq
MIRT2379444	hsa-miR-4643	CLIP-seq
MIRT1529560	hsa-miR-4690-3p	CLIP-seq
MIRT2379445	hsa-miR-4753-5p	CLIP-seq
MIRT2379446	hsa-miR-642b	CLIP-seq
MIRT1529562	hsa-miR-654-3p	CLIP-seq
MIRT2464358	hsa-miR-4753-3p	CLIP-seq
MIRT2671467	hsa-miR-1236	CLIP-seq
MIRT1529540	hsa-miR-1260	CLIP-seq
MIRT1529541	hsa-miR-1260b	CLIP-seq
MIRT1529543	hsa-miR-181a	CLIP-seq
MIRT1529544	hsa-miR-181b	CLIP-seq
MIRT1529545	hsa-miR-181c	CLIP-seq
MIRT1529546	hsa-miR-181d	CLIP-seq
MIRT1529547	hsa-miR-188-3p	CLIP-seq
MIRT2671468	hsa-miR-2053	CLIP-seq
MIRT2671469	hsa-miR-219-2-3p	CLIP-seq
MIRT1529550	hsa-miR-3156-3p	CLIP-seq
MIRT1529551	hsa-miR-3156-5p	CLIP-seq
MIRT1529552	hsa-miR-3200-5p	CLIP-seq
MIRT2379441	hsa-miR-3202	CLIP-seq
MIRT2671470	hsa-miR-3673	CLIP-seq
MIRT2671471	hsa-miR-3685	CLIP-seq
MIRT2379442	hsa-miR-3688-3p	CLIP-seq
MIRT2671472	hsa-miR-384	CLIP-seq
MIRT1529554	hsa-miR-4251	CLIP-seq
MIRT1529555	hsa-miR-4262	CLIP-seq
MIRT1529556	hsa-miR-4329	CLIP-seq
MIRT2671473	hsa-miR-4426	CLIP-seq
MIRT1529557	hsa-miR-4446-5p	CLIP-seq
MIRT2379443	hsa-miR-4533	CLIP-seq
MIRT2379444	hsa-miR-4643	CLIP-seq
MIRT2671474	hsa-miR-4647	CLIP-seq
MIRT2671475	hsa-miR-4662b	CLIP-seq
MIRT2464358	hsa-miR-4753-3p	CLIP-seq
MIRT2379445	hsa-miR-4753-5p	CLIP-seq
MIRT2671476	hsa-miR-4797-3p	CLIP-seq
MIRT2379446	hsa-miR-642b	CLIP-seq
MIRT1529562	hsa-miR-654-3p	CLIP-seq
MIRT1529563	hsa-miR-942	CLIP-seq
MIRT2671467	hsa-miR-1236	CLIP-seq
MIRT1529540	hsa-miR-1260	CLIP-seq
MIRT1529541	hsa-miR-1260b	CLIP-seq
MIRT1529543	hsa-miR-181a	CLIP-seq
MIRT1529544	hsa-miR-181b	CLIP-seq
MIRT1529545	hsa-miR-181c	CLIP-seq
MIRT1529546	hsa-miR-181d	CLIP-seq
MIRT1529547	hsa-miR-188-3p	CLIP-seq
MIRT2671468	hsa-miR-2053	CLIP-seq
MIRT2671469	hsa-miR-219-2-3p	CLIP-seq
MIRT1529550	hsa-miR-3156-3p	CLIP-seq
MIRT2379441	hsa-miR-3202	CLIP-seq
MIRT2671470	hsa-miR-3673	CLIP-seq
MIRT2671471	hsa-miR-3685	CLIP-seq
MIRT2379442	hsa-miR-3688-3p	CLIP-seq
MIRT2671472	hsa-miR-384	CLIP-seq
MIRT1529555	hsa-miR-4262	CLIP-seq
MIRT2671473	hsa-miR-4426	CLIP-seq
MIRT1529557	hsa-miR-4446-5p	CLIP-seq
MIRT2379443	hsa-miR-4533	CLIP-seq
MIRT2379444	hsa-miR-4643	CLIP-seq
MIRT2671474	hsa-miR-4647	CLIP-seq
MIRT2671475	hsa-miR-4662b	CLIP-seq
MIRT2464358	hsa-miR-4753-3p	CLIP-seq
MIRT2379445	hsa-miR-4753-5p	CLIP-seq
MIRT2671476	hsa-miR-4797-3p	CLIP-seq
MIRT2379446	hsa-miR-642b	CLIP-seq
MIRT1529562	hsa-miR-654-3p	CLIP-seq
MIRT1529563	hsa-miR-942	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA	21873635
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	21873635
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA	21873635
GO:0005515	Function	Protein binding	IPI	16189514, 25416956, 29892012, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q9BR84
• Protein name: Zinc finger protein 559
• Protein function: May be involved in transcriptional regulation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01352	KRAB	13 → 54	KRAB box	Family
  PF00096	zf-C2H2	241 → 263	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	297 → 319	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	325 → 347	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	353 → 375	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	381 → 403	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	409 → 431	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	437 → 459	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	465 → 487	Zinc finger, C2H2 type	Domain
  PF00096	zf-C2H2	493 → 515	Zinc finger, C2H2 type	Domain

• Sequence:

  MVAGWLTNYSQDSVTFEDVAVDFTQEEWTLLDQTQRNLYRDVMLENYKNLVAVDWESHIN
  TKWSAPQQNFLQGKTSSVVEMERNHFGEELFDFNQCEKALSEHSCLKTHRRTYFRKKTCE
  CNQCEKAFRKPSIFTLHKKTDIGEELPNCNQCETAFSQHLHLVCKKTSQNLHLVCKKTHT
  QEKPYKCSDCEKGLPSSSHLRECVRIYGGERPYTHKEYVETFSHSTALFVHMQTQDGEKF
  YECKACGKPFTESSYLTQHLRTHSRVLPIEHKKFGKAFAFSPDLAKHIRLRTRGKHYVCN
  ECGKEFTCFSKLNIHIRVHTGEKPYECNKCGKAFTDSSGLIKHRRTHTGEKPYECKECGK
  AFANSSHLTVHMRTHTGEKPYQCKECGKAFINSSSFKSHMQTHPGVKPYDCQQCGKAFIR
  SSFLIRHLRSHSAERPFECEECGKAFRYSSHLSQHKRIHTGERPYKCQKCGQAFSISSGL
  TVHMRTHTGERPFECQECGKAFTRSTYLIRHLRSHSVEKPYKECGQTFSNSSCLTECV

• Sequence length: 538

Pathways

Reactome:

Generic Transcription Pathway

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208	16367923

Associations from Text Mining
Disease Name	Relationship Type	References
Stomach Neoplasms	Associate	16367923