Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	84524
Gene name	Zinc finger CCCH-type containing 8
Gene symbol	ZC3H8
Synonyms (NCBI Gene)	Fliz1ZC3HDC8
Chromosome	2
Chromosome location	2q14.1

156

Show/Hide all (156)

miRTarBase ID	miRNA	Experiments	Reference
MIRT044954	hsa-miR-186-5p	CLASH	23622248
MIRT662145	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT662144	hsa-miR-1910-3p	HITS-CLIP	23824327
MIRT662143	hsa-miR-6511a-5p	HITS-CLIP	23824327
MIRT662142	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT662141	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT662140	hsa-miR-940	HITS-CLIP	23824327
MIRT662139	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT662138	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT662137	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT662136	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT662135	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT662134	hsa-miR-1827	HITS-CLIP	23824327
MIRT662133	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT662132	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT662131	hsa-miR-4327	HITS-CLIP	23824327
MIRT662130	hsa-miR-3612	HITS-CLIP	23824327
MIRT662129	hsa-miR-650	HITS-CLIP	23824327
MIRT662128	hsa-miR-455-3p	HITS-CLIP	23824327
MIRT662127	hsa-miR-6516-5p	HITS-CLIP	23824327
MIRT439251	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439251	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT662136	hsa-miR-1247-3p	PAR-CLIP	27292025
MIRT662134	hsa-miR-1827	PAR-CLIP	27292025
MIRT662144	hsa-miR-1910-3p	PAR-CLIP	27292025
MIRT662145	hsa-miR-34b-3p	PAR-CLIP	27292025
MIRT662130	hsa-miR-3612	PAR-CLIP	27292025
MIRT662139	hsa-miR-3614-5p	PAR-CLIP	27292025
MIRT662131	hsa-miR-4327	PAR-CLIP	27292025
MIRT662128	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT662135	hsa-miR-4649-3p	PAR-CLIP	27292025
MIRT662133	hsa-miR-4722-5p	PAR-CLIP	27292025
MIRT662132	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT662138	hsa-miR-6500-3p	PAR-CLIP	27292025
MIRT662129	hsa-miR-650	PAR-CLIP	27292025
MIRT662143	hsa-miR-6511a-5p	PAR-CLIP	27292025
MIRT662127	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT662142	hsa-miR-6808-5p	PAR-CLIP	27292025
MIRT662141	hsa-miR-6893-5p	PAR-CLIP	27292025
MIRT662140	hsa-miR-940	PAR-CLIP	27292025
MIRT662145	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT662144	hsa-miR-1910-3p	HITS-CLIP	23824327
MIRT662143	hsa-miR-6511a-5p	HITS-CLIP	23824327
MIRT662142	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT662141	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT662140	hsa-miR-940	HITS-CLIP	23824327
MIRT662139	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT662138	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT662137	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT662136	hsa-miR-1247-3p	HITS-CLIP	23824327
MIRT662135	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT662134	hsa-miR-1827	HITS-CLIP	23824327
MIRT662133	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT662132	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT662131	hsa-miR-4327	HITS-CLIP	23824327
MIRT662130	hsa-miR-3612	HITS-CLIP	23824327
MIRT662129	hsa-miR-650	HITS-CLIP	23824327
MIRT662128	hsa-miR-455-3p	HITS-CLIP	23824327
MIRT662127	hsa-miR-6516-5p	HITS-CLIP	23824327
MIRT1506260	hsa-miR-1268	CLIP-seq
MIRT1506261	hsa-miR-1268b	CLIP-seq
MIRT1506262	hsa-miR-132	CLIP-seq
MIRT1506263	hsa-miR-212	CLIP-seq
MIRT1506264	hsa-miR-4635	CLIP-seq
MIRT1506265	hsa-miR-548a-5p	CLIP-seq
MIRT1506266	hsa-miR-548ab	CLIP-seq
MIRT1506267	hsa-miR-548ak	CLIP-seq
MIRT1506268	hsa-miR-548b-5p	CLIP-seq
MIRT1506269	hsa-miR-548c-5p	CLIP-seq
MIRT1506270	hsa-miR-548d-5p	CLIP-seq
MIRT1506271	hsa-miR-548h	CLIP-seq
MIRT1506272	hsa-miR-548i	CLIP-seq
MIRT1506273	hsa-miR-548j	CLIP-seq
MIRT1506274	hsa-miR-548k	CLIP-seq
MIRT1506275	hsa-miR-548l	CLIP-seq
MIRT1506276	hsa-miR-548w	CLIP-seq
MIRT1506277	hsa-miR-548y	CLIP-seq
MIRT1506278	hsa-miR-559	CLIP-seq
MIRT1506279	hsa-miR-585	CLIP-seq
MIRT2152508	hsa-miR-1226	CLIP-seq
MIRT1506260	hsa-miR-1268	CLIP-seq
MIRT1506261	hsa-miR-1268b	CLIP-seq
MIRT1506262	hsa-miR-132	CLIP-seq
MIRT1506263	hsa-miR-212	CLIP-seq
MIRT2152509	hsa-miR-30a	CLIP-seq
MIRT2152510	hsa-miR-30b	CLIP-seq
MIRT2152511	hsa-miR-30c	CLIP-seq
MIRT2152512	hsa-miR-30d	CLIP-seq
MIRT2152513	hsa-miR-30e	CLIP-seq
MIRT2152514	hsa-miR-3145-5p	CLIP-seq
MIRT2152515	hsa-miR-3688-3p	CLIP-seq
MIRT2152516	hsa-miR-3915	CLIP-seq
MIRT2152517	hsa-miR-3928	CLIP-seq
MIRT2152518	hsa-miR-4427	CLIP-seq
MIRT1506264	hsa-miR-4635	CLIP-seq
MIRT2152519	hsa-miR-4680-3p	CLIP-seq
MIRT2152520	hsa-miR-4733-3p	CLIP-seq
MIRT2152521	hsa-miR-4796-5p	CLIP-seq
MIRT2152522	hsa-miR-508-5p	CLIP-seq
MIRT1506265	hsa-miR-548a-5p	CLIP-seq
MIRT1506266	hsa-miR-548ab	CLIP-seq
MIRT1506267	hsa-miR-548ak	CLIP-seq
MIRT1506268	hsa-miR-548b-5p	CLIP-seq
MIRT1506269	hsa-miR-548c-5p	CLIP-seq
MIRT1506270	hsa-miR-548d-5p	CLIP-seq
MIRT1506271	hsa-miR-548h	CLIP-seq
MIRT1506272	hsa-miR-548i	CLIP-seq
MIRT1506273	hsa-miR-548j	CLIP-seq
MIRT1506274	hsa-miR-548k	CLIP-seq
MIRT1506275	hsa-miR-548l	CLIP-seq
MIRT1506276	hsa-miR-548w	CLIP-seq
MIRT1506277	hsa-miR-548y	CLIP-seq
MIRT1506278	hsa-miR-559	CLIP-seq
MIRT1506279	hsa-miR-585	CLIP-seq
MIRT2152523	hsa-miR-606	CLIP-seq
MIRT2152524	hsa-miR-643	CLIP-seq
MIRT2152525	hsa-miR-654-3p	CLIP-seq
MIRT2152526	hsa-miR-885-5p	CLIP-seq
MIRT2372815	hsa-miR-1	CLIP-seq
MIRT2152508	hsa-miR-1226	CLIP-seq
MIRT2372816	hsa-miR-1266	CLIP-seq
MIRT2372817	hsa-miR-1283	CLIP-seq
MIRT1506262	hsa-miR-132	CLIP-seq
MIRT2372818	hsa-miR-206	CLIP-seq
MIRT1506263	hsa-miR-212	CLIP-seq
MIRT2372819	hsa-miR-3652	CLIP-seq
MIRT2372820	hsa-miR-3664-3p	CLIP-seq
MIRT2372821	hsa-miR-3673	CLIP-seq
MIRT2152515	hsa-miR-3688-3p	CLIP-seq
MIRT2152516	hsa-miR-3915	CLIP-seq
MIRT2152517	hsa-miR-3928	CLIP-seq
MIRT2372822	hsa-miR-4270	CLIP-seq
MIRT2152518	hsa-miR-4427	CLIP-seq
MIRT2372823	hsa-miR-4430	CLIP-seq
MIRT2372824	hsa-miR-4441	CLIP-seq
MIRT2372825	hsa-miR-4505	CLIP-seq
MIRT2372826	hsa-miR-4518	CLIP-seq
MIRT1506264	hsa-miR-4635	CLIP-seq
MIRT2152519	hsa-miR-4680-3p	CLIP-seq
MIRT2372827	hsa-miR-4699-3p	CLIP-seq
MIRT2372828	hsa-miR-4705	CLIP-seq
MIRT2372829	hsa-miR-4714-5p	CLIP-seq
MIRT2152520	hsa-miR-4733-3p	CLIP-seq
MIRT2372830	hsa-miR-613	CLIP-seq
MIRT2152524	hsa-miR-643	CLIP-seq
MIRT2372831	hsa-miR-7	CLIP-seq
MIRT2152526	hsa-miR-885-5p	CLIP-seq
MIRT2152515	hsa-miR-3688-3p	CLIP-seq
MIRT2152526	hsa-miR-885-5p	CLIP-seq
MIRT2665646	hsa-miR-2115	CLIP-seq
MIRT2665647	hsa-miR-3200-3p	CLIP-seq
MIRT2665648	hsa-miR-3620	CLIP-seq
MIRT2665649	hsa-miR-3977	CLIP-seq
MIRT2665650	hsa-miR-4477a	CLIP-seq
MIRT2665651	hsa-miR-512-5p	CLIP-seq
MIRT2665652	hsa-miR-516a-3p	CLIP-seq

Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000785	Component	Chromatin	ISA
GO:0000791	Component	Euchromatin	IDA	23932780
GO:0001162	Function	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	IEA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	23932780
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0008023	Component	Transcription elongation factor complex	IDA	23932780
GO:0008270	Function	Zinc ion binding	IEA
GO:0015030	Component	Cajal body	IDA	23932780
GO:0016604	Component	Nuclear body	IDA
GO:0033085	Process	Negative regulation of T cell differentiation in thymus	IMP	12153508
GO:0035363	Component	Histone locus body	IDA	23932780
GO:0042795	Process	SnRNA transcription by RNA polymerase II	IMP	23932780
GO:0042796	Process	SnRNA transcription by RNA polymerase III	IMP	23932780
GO:0043029	Process	T cell homeostasis	IMP	12153508
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	12077251
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	ISS
GO:0045945	Process	Positive regulation of transcription by RNA polymerase III	IMP	23932780
GO:0046677	Process	Response to antibiotic	IDA	12153508
GO:0046872	Function	Metal ion binding	IEA
GO:0070245	Process	Positive regulation of thymocyte apoptotic process	IMP	12153508

MIM	HGNC	e!Ensembl
621273	30941	ENSG00000144161

Q8N5P1

Protein name

Zinc finger CCCH domain-containing protein 8

Protein function

Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). C

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00642	zf-CCCH	192 → 217	Zinc finger C-x8-C-x5-C-x3-H type (and similar)	Family
PF18345	zf_CCCH_4	226 → 244		Domain
PF14608	zf-CCCH_2	248 → 269		Domain

Sequence

MDFENLFSKPPNPALGKTATDSDERIDDEIDTEVEETQEEKIKLECEQIPKKFRHSAISP
KSSLHRKSRSKDYDVYSDNDICSQESEDNFAKELQQYIQAREMANAAQPEESTKKEGVKD
TPQAAKQKNKNLKAGHKNGKQKKMKRKWPGPGNKGSNALLRNSGSQEEDGKPKEKQQHLS
QAFINQHTVERKGKQICKYFLERKCIKGDQCKFDHDAEIEKKKEMCKFYVQGYCTRGENC
LYLHNEYPCKFYHTGTKCYQGEYCKFSHAPLTPETQELLAKVLDTEKKSCK

Sequence length

291

Interactions

View interactions

	Reactome
			RNA polymerase II transcribes snRNA genes

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
NEUROTIC DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Glioma	Associate	34482648	★★★★★ ★☆☆☆☆ Found in Text Mining only

ZC3H8 (zinc finger CCCH-type containing 8)