L3MBTL3 (L3MBTL histone methyl-lysine binding protein 3)

Gene

• Entrez ID: 84456
• Gene name: L3MBTL histone methyl-lysine binding protein 3
• Gene symbol: L3MBTL3
• Synonyms (NCBI Gene): MBT-1, MBT1
• Chromosome: 6
• Chromosome location: 6q23.1
• Summary: This gene encodes a member of the malignant brain tumor (MBT) family of chromatin interacting transcriptional repressors. Members of this family function as methyl-lysine readers, which recognize methylated lysine residues on histone protein tails, and ar

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1102952	hsa-miR-183	CLIP-seq
MIRT1102953	hsa-miR-203	CLIP-seq
MIRT1102954	hsa-miR-3163	CLIP-seq
MIRT1102955	hsa-miR-410	CLIP-seq
MIRT1102956	hsa-miR-4684-3p	CLIP-seq
MIRT1102957	hsa-miR-4698	CLIP-seq
MIRT1102958	hsa-miR-218	CLIP-seq
MIRT1102959	hsa-miR-3065-5p	CLIP-seq
MIRT1102960	hsa-miR-3122	CLIP-seq
MIRT1102961	hsa-miR-3153	CLIP-seq
MIRT1102962	hsa-miR-3913-5p	CLIP-seq
MIRT1102963	hsa-miR-421	CLIP-seq
MIRT1102964	hsa-miR-4272	CLIP-seq
MIRT1102965	hsa-miR-4275	CLIP-seq
MIRT1102966	hsa-miR-451	CLIP-seq
MIRT1102967	hsa-miR-4668-5p	CLIP-seq
MIRT1102957	hsa-miR-4698	CLIP-seq
MIRT1102968	hsa-miR-520d-5p	CLIP-seq
MIRT1102969	hsa-miR-524-5p	CLIP-seq
MIRT1102970	hsa-miR-636	CLIP-seq
MIRT2028172	hsa-miR-3126-3p	CLIP-seq
MIRT2028173	hsa-miR-3660	CLIP-seq
MIRT2028174	hsa-miR-4526	CLIP-seq
MIRT2259333	hsa-miR-1298	CLIP-seq
MIRT2259334	hsa-miR-1302	CLIP-seq
MIRT2259335	hsa-miR-3158-5p	CLIP-seq
MIRT2028173	hsa-miR-3660	CLIP-seq
MIRT2259336	hsa-miR-4298	CLIP-seq
MIRT2259337	hsa-miR-4418	CLIP-seq
MIRT2028174	hsa-miR-4526	CLIP-seq
MIRT2259338	hsa-miR-509-3-5p	CLIP-seq
MIRT2259339	hsa-miR-509-5p	CLIP-seq
MIRT2259340	hsa-miR-556-5p	CLIP-seq
MIRT2559617	hsa-miR-105	CLIP-seq
MIRT2559618	hsa-miR-106a	CLIP-seq
MIRT2559619	hsa-miR-106b	CLIP-seq
MIRT2559620	hsa-miR-10a	CLIP-seq
MIRT2559621	hsa-miR-10b	CLIP-seq
MIRT2559622	hsa-miR-1267	CLIP-seq
MIRT2559623	hsa-miR-1283	CLIP-seq
MIRT2559624	hsa-miR-1288	CLIP-seq
MIRT2559625	hsa-miR-132	CLIP-seq
MIRT2559626	hsa-miR-1324	CLIP-seq
MIRT2559627	hsa-miR-149	CLIP-seq
MIRT2559628	hsa-miR-17	CLIP-seq
MIRT2559629	hsa-miR-182	CLIP-seq
MIRT1102952	hsa-miR-183	CLIP-seq
MIRT2559630	hsa-miR-186	CLIP-seq
MIRT2559631	hsa-miR-1910	CLIP-seq
MIRT2559632	hsa-miR-193a-3p	CLIP-seq
MIRT2559633	hsa-miR-193b	CLIP-seq
MIRT1102953	hsa-miR-203	CLIP-seq
MIRT2559634	hsa-miR-20a	CLIP-seq
MIRT2559635	hsa-miR-20b	CLIP-seq
MIRT2559636	hsa-miR-212	CLIP-seq
MIRT2559637	hsa-miR-219-2-3p	CLIP-seq
MIRT2559638	hsa-miR-221	CLIP-seq
MIRT2559639	hsa-miR-222	CLIP-seq
MIRT2559640	hsa-miR-2277-3p	CLIP-seq
MIRT2559641	hsa-miR-2681	CLIP-seq
MIRT2559642	hsa-miR-2964a-3p	CLIP-seq
MIRT2559643	hsa-miR-299-5p	CLIP-seq
MIRT2559644	hsa-miR-3064-5p	CLIP-seq
MIRT2559645	hsa-miR-30a	CLIP-seq
MIRT2559646	hsa-miR-30b	CLIP-seq
MIRT2559647	hsa-miR-30c	CLIP-seq
MIRT2559648	hsa-miR-30d	CLIP-seq
MIRT2559649	hsa-miR-30e	CLIP-seq
MIRT2559650	hsa-miR-3121-3p	CLIP-seq
MIRT2028172	hsa-miR-3126-3p	CLIP-seq
MIRT2559651	hsa-miR-3133	CLIP-seq
MIRT2559652	hsa-miR-3152-5p	CLIP-seq
MIRT1102954	hsa-miR-3163	CLIP-seq
MIRT2559653	hsa-miR-3169	CLIP-seq
MIRT2559654	hsa-miR-3200-3p	CLIP-seq
MIRT2559655	hsa-miR-3591-5p	CLIP-seq
MIRT2559656	hsa-miR-3607-3p	CLIP-seq
MIRT2559657	hsa-miR-3609	CLIP-seq
MIRT2559658	hsa-miR-3647-3p	CLIP-seq
MIRT2559659	hsa-miR-3667-5p	CLIP-seq
MIRT2559660	hsa-miR-3670	CLIP-seq
MIRT2559661	hsa-miR-3672	CLIP-seq
MIRT2559662	hsa-miR-3686	CLIP-seq
MIRT2559663	hsa-miR-371b-5p	CLIP-seq
MIRT2559664	hsa-miR-374a	CLIP-seq
MIRT2559665	hsa-miR-374b	CLIP-seq
MIRT2559666	hsa-miR-409-3p	CLIP-seq
MIRT1102955	hsa-miR-410	CLIP-seq
MIRT2559667	hsa-miR-425	CLIP-seq
MIRT2559668	hsa-miR-4252	CLIP-seq
MIRT2559669	hsa-miR-4255	CLIP-seq
MIRT2559670	hsa-miR-4423-3p	CLIP-seq
MIRT2559671	hsa-miR-4452	CLIP-seq
MIRT2559672	hsa-miR-4470	CLIP-seq
MIRT2559673	hsa-miR-4474-5p	CLIP-seq
MIRT2559674	hsa-miR-4499	CLIP-seq
MIRT2559675	hsa-miR-4652-3p	CLIP-seq
MIRT2559676	hsa-miR-4655-5p	CLIP-seq
MIRT2559677	hsa-miR-4662a-5p	CLIP-seq
MIRT2559678	hsa-miR-4676-5p	CLIP-seq
MIRT1102956	hsa-miR-4684-3p	CLIP-seq
MIRT1102957	hsa-miR-4698	CLIP-seq
MIRT2559679	hsa-miR-4704-5p	CLIP-seq
MIRT2559680	hsa-miR-4724-3p	CLIP-seq
MIRT2559681	hsa-miR-4725-5p	CLIP-seq
MIRT2559682	hsa-miR-4729	CLIP-seq
MIRT2559683	hsa-miR-4735-5p	CLIP-seq
MIRT2559684	hsa-miR-4742-3p	CLIP-seq
MIRT2559685	hsa-miR-4744	CLIP-seq
MIRT2559686	hsa-miR-4762-3p	CLIP-seq
MIRT2559687	hsa-miR-4765	CLIP-seq
MIRT2559688	hsa-miR-4766-5p	CLIP-seq
MIRT2559689	hsa-miR-4774-3p	CLIP-seq
MIRT2559690	hsa-miR-4794	CLIP-seq
MIRT2559691	hsa-miR-4796-3p	CLIP-seq
MIRT2559692	hsa-miR-499-3p	CLIP-seq
MIRT2559693	hsa-miR-499a-3p	CLIP-seq
MIRT2559694	hsa-miR-504	CLIP-seq
MIRT2559695	hsa-miR-518a-5p	CLIP-seq
MIRT2559696	hsa-miR-519a	CLIP-seq
MIRT2559697	hsa-miR-519b-3p	CLIP-seq
MIRT2559698	hsa-miR-519c-3p	CLIP-seq
MIRT2559699	hsa-miR-519d	CLIP-seq
MIRT2559700	hsa-miR-527	CLIP-seq
MIRT2559701	hsa-miR-548ad	CLIP-seq
MIRT2559702	hsa-miR-548ah	CLIP-seq
MIRT2559703	hsa-miR-548l	CLIP-seq
MIRT2559704	hsa-miR-548v	CLIP-seq
MIRT2259340	hsa-miR-556-5p	CLIP-seq
MIRT2559705	hsa-miR-575	CLIP-seq
MIRT2559706	hsa-miR-579	CLIP-seq
MIRT2559707	hsa-miR-586	CLIP-seq
MIRT2559708	hsa-miR-593	CLIP-seq
MIRT2559709	hsa-miR-600	CLIP-seq
MIRT2559710	hsa-miR-617	CLIP-seq
MIRT2559711	hsa-miR-634	CLIP-seq
MIRT2559712	hsa-miR-643	CLIP-seq
MIRT2559713	hsa-miR-659	CLIP-seq
MIRT2559714	hsa-miR-760	CLIP-seq
MIRT2559715	hsa-miR-888	CLIP-seq
MIRT2559716	hsa-miR-892b	CLIP-seq
MIRT2559717	hsa-miR-93	CLIP-seq
MIRT2559617	hsa-miR-105	CLIP-seq
MIRT2559618	hsa-miR-106a	CLIP-seq
MIRT2559619	hsa-miR-106b	CLIP-seq
MIRT2559620	hsa-miR-10a	CLIP-seq
MIRT2559621	hsa-miR-10b	CLIP-seq
MIRT2559622	hsa-miR-1267	CLIP-seq
MIRT2559624	hsa-miR-1288	CLIP-seq
MIRT2559625	hsa-miR-132	CLIP-seq
MIRT2559626	hsa-miR-1324	CLIP-seq
MIRT2559627	hsa-miR-149	CLIP-seq
MIRT2559628	hsa-miR-17	CLIP-seq
MIRT2559629	hsa-miR-182	CLIP-seq
MIRT1102952	hsa-miR-183	CLIP-seq
MIRT2559631	hsa-miR-1910	CLIP-seq
MIRT2559632	hsa-miR-193a-3p	CLIP-seq
MIRT2559633	hsa-miR-193b	CLIP-seq
MIRT1102953	hsa-miR-203	CLIP-seq
MIRT2559634	hsa-miR-20a	CLIP-seq
MIRT2559635	hsa-miR-20b	CLIP-seq
MIRT2559636	hsa-miR-212	CLIP-seq
MIRT2559637	hsa-miR-219-2-3p	CLIP-seq
MIRT2559640	hsa-miR-2277-3p	CLIP-seq
MIRT2559641	hsa-miR-2681	CLIP-seq
MIRT2559642	hsa-miR-2964a-3p	CLIP-seq
MIRT2559643	hsa-miR-299-5p	CLIP-seq
MIRT2559644	hsa-miR-3064-5p	CLIP-seq
MIRT2559645	hsa-miR-30a	CLIP-seq
MIRT2559646	hsa-miR-30b	CLIP-seq
MIRT2559647	hsa-miR-30c	CLIP-seq
MIRT2559648	hsa-miR-30d	CLIP-seq
MIRT2559649	hsa-miR-30e	CLIP-seq
MIRT2559650	hsa-miR-3121-3p	CLIP-seq
MIRT2028172	hsa-miR-3126-3p	CLIP-seq
MIRT2559652	hsa-miR-3152-5p	CLIP-seq
MIRT1102954	hsa-miR-3163	CLIP-seq
MIRT2559653	hsa-miR-3169	CLIP-seq
MIRT2559654	hsa-miR-3200-3p	CLIP-seq
MIRT2559655	hsa-miR-3591-5p	CLIP-seq
MIRT2559656	hsa-miR-3607-3p	CLIP-seq
MIRT2559657	hsa-miR-3609	CLIP-seq
MIRT2559658	hsa-miR-3647-3p	CLIP-seq
MIRT2559660	hsa-miR-3670	CLIP-seq
MIRT2559661	hsa-miR-3672	CLIP-seq
MIRT2559662	hsa-miR-3686	CLIP-seq
MIRT2559663	hsa-miR-371b-5p	CLIP-seq
MIRT2559664	hsa-miR-374a	CLIP-seq
MIRT2559665	hsa-miR-374b	CLIP-seq
MIRT2559666	hsa-miR-409-3p	CLIP-seq
MIRT1102955	hsa-miR-410	CLIP-seq
MIRT2559667	hsa-miR-425	CLIP-seq
MIRT2559668	hsa-miR-4252	CLIP-seq
MIRT2559669	hsa-miR-4255	CLIP-seq
MIRT2683721	hsa-miR-4307	CLIP-seq
MIRT2559670	hsa-miR-4423-3p	CLIP-seq
MIRT2559671	hsa-miR-4452	CLIP-seq
MIRT2559672	hsa-miR-4470	CLIP-seq
MIRT2559673	hsa-miR-4474-5p	CLIP-seq
MIRT2559674	hsa-miR-4499	CLIP-seq
MIRT2559675	hsa-miR-4652-3p	CLIP-seq
MIRT2559676	hsa-miR-4655-5p	CLIP-seq
MIRT2559677	hsa-miR-4662a-5p	CLIP-seq
MIRT2559678	hsa-miR-4676-5p	CLIP-seq
MIRT1102956	hsa-miR-4684-3p	CLIP-seq
MIRT1102957	hsa-miR-4698	CLIP-seq
MIRT2559679	hsa-miR-4704-5p	CLIP-seq
MIRT2559680	hsa-miR-4724-3p	CLIP-seq
MIRT2559681	hsa-miR-4725-5p	CLIP-seq
MIRT2559682	hsa-miR-4729	CLIP-seq
MIRT2559683	hsa-miR-4735-5p	CLIP-seq
MIRT2559686	hsa-miR-4762-3p	CLIP-seq
MIRT2559687	hsa-miR-4765	CLIP-seq
MIRT2559689	hsa-miR-4774-3p	CLIP-seq
MIRT2559690	hsa-miR-4794	CLIP-seq
MIRT2559691	hsa-miR-4796-3p	CLIP-seq
MIRT2559694	hsa-miR-504	CLIP-seq
MIRT2559695	hsa-miR-518a-5p	CLIP-seq
MIRT2559699	hsa-miR-519d	CLIP-seq
MIRT2559700	hsa-miR-527	CLIP-seq
MIRT2559702	hsa-miR-548ah	CLIP-seq
MIRT2259340	hsa-miR-556-5p	CLIP-seq
MIRT2559705	hsa-miR-575	CLIP-seq
MIRT2559706	hsa-miR-579	CLIP-seq
MIRT2559707	hsa-miR-586	CLIP-seq
MIRT2559708	hsa-miR-593	CLIP-seq
MIRT2559711	hsa-miR-634	CLIP-seq
MIRT2559712	hsa-miR-643	CLIP-seq
MIRT2559713	hsa-miR-659	CLIP-seq
MIRT2559714	hsa-miR-760	CLIP-seq
MIRT2559715	hsa-miR-888	CLIP-seq
MIRT2559716	hsa-miR-892b	CLIP-seq
MIRT2559717	hsa-miR-93	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003682	Function	Chromatin binding	IBA
GO:0003682	Function	Chromatin binding	IDA	33980486
GO:0005515	Function	Protein binding	IPI	17517653, 21516116, 22157815, 25416956, 26871637, 29030483, 29691401, 30442713, 31515488, 32296183, 32814053, 33980486
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	33980486
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0006325	Process	Chromatin organization	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0030099	Process	Myeloid cell differentiation	IEA
GO:0030225	Process	Macrophage differentiation	IEA
GO:0030851	Process	Granulocyte differentiation	IEA
GO:0042393	Function	Histone binding	IBA
GO:0042802	Function	Identical protein binding	IPI	21516116, 25416956, 31515488, 32296183
GO:0043249	Process	Erythrocyte maturation	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IBA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IMP	29030483
GO:0046872	Function	Metal ion binding	IEA
GO:0140034	Function	Methylation-dependent protein binding	IPI	29691401
GO:0160217	Process	Negative regulation of transcription initiation-coupled chromatin remodeling	IDA	33980486
GO:2000058	Process	Regulation of ubiquitin-dependent protein catabolic process	IEA
GO:2000060	Process	Positive regulation of ubiquitin-dependent protein catabolic process	IMP	29691401

Other IDs

• MIM: 618844
• HGNC: 23035
• e!Ensembl: ENSG00000198945

Protein

• UniProt ID: Q96JM7
• Protein name: Lethal(3)malignant brain tumor-like protein 3 (H-l(3)mbt-like protein 3) (L(3)mbt-like protein 3) (L3mbt-like 3) (MBT-1)
• Protein function: Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression (PubMed:29030483). It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation (PubMed:29030483).
• PDB: 1WJQ, 1WJS, 3UT1, 4FL6, 4L59, 7RTE, 7RTI, 8Y76, 8Y77
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02820	MBT	268 → 336	mbt repeat	Domain
  PF02820	MBT	375 → 443	mbt repeat	Domain
  PF02820	MBT	479 → 545	mbt repeat	Domain
  PF00536	SAM_1	706 → 770	SAM domain (Sterile alpha motif)	Domain

• Sequence:

  MTESASSTSGQEFDVFSVMDWKDGVGTLPGSDLKFRVNEFGALEVITDENEMENVKKATA
  TTTWMVPTAQEAPTSPPSSRPVFPPAYWTSPPGCPTVFSEKTGMPFRLKDPVKVEGLQFC
  ENCCQYGNVDECLSGGNYCSQNCARHIKDKDQKEERDVEEDNEEEDPKCSRKKKPKLSLK
  ADTKEDGEERDDEMENKQDVRILRGSQRARRKRRGDSAVLKQGLPPKGKKAWCWASYLEE
  EKAVAVPAKLFKEHQSFPYNKNGFKVGMKLEGVDPEHQSVYCVLTVAEVCGYRIKLHFDG
  YSDCYDFWVNADALDIHPVGWCEKTGHKLHPPKGYKEEEFNWQTYLKTCKAQAAPKSLFE
  NQNITVIPSGFRVGMKLEAVDKKNPSFICVATVTDMVDNRFLVHFDNWDESYDYWCEASS
  PHIHPVGWCKEHRRTLITPPGYPNVKHFSWDKYLEETNSLPAPARAFKVKPPHGFQKKMK
  LEVVDKRNPMFIRVATVADTDDHRVKVHFDGWNNCYDYWIDADSPDIHPVGWCSKTGHPL
  QPPLSPLELMEASEHGGCSTPGCKGIGHFKRARHLGPHSAANCPYSEINLNKDRIFPDRL
  SGEMPPASPSFPRNKRTDANESSSSPEIRDQHADDVKEDFEERTESEMRTSHEARGAREE
  PTVQQAQRRSAVFLSFKSPIPCLPLRWEQQSKLLPTVAGIPASKVSKWSTDEVSEFIQSL
  PGCEEHGKVFKDEQIDGEAFLLMTQTDIVKIMSIKLGPALKIFNSILMFKAAEKNSHNEL
  

• Sequence length: 780

Pathways

KEGG:

Polycomb repressive complex