Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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8445
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Dual specificity tyrosine phosphorylation regulated kinase 2 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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DYRK2 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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- |
Chromosome
Chromosome number
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12 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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12q15 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine res |
UniProt ID |
Q92630
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Protein name |
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1) |
Protein function |
Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protei |
PDB |
3K2L
,
3KVW
,
4AZF
,
5LXC
,
5LXD
,
5ZTN
,
6HDP
,
6HDR
,
6K0J
,
7AKF
,
7AKH
,
7DG4
,
7DH3
,
7DH9
,
7DHC
,
7DHH
,
7DHK
,
7DHN
,
7DHO
,
7DHV
,
7DJO
,
7DL6
,
8HLT
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Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00069
|
Pkinase |
222 → 535 |
Protein kinase domain |
Domain |
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Tissue specificity |
TISSUE SPECIFICITY: Testis, after the onset of spermatogenesis. {ECO:0000269|PubMed:9748265}. |
Sequence |
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Sequence length |
601 |
Interactions |
View interactions
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Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Gastrointestinal stromal tumor |
Gastrointestinal Stromal Tumors, Gastrointestinal Stromal Sarcoma |
rs587776653, rs74315368, rs74315369, rs587776793, rs587776794, rs587776795, rs606231209, rs121908589, rs121913685, rs121913680, rs794726675, rs587776804, rs121913517, rs121913234, rs121913512, rs267607032, rs387906780, rs201286421, rs587778661, rs587781270, rs587782243, rs74315370, rs587782703, rs786203457, rs764575966, rs786203251, rs587782604, rs200245469, rs397516836, rs786202732, rs786201161, rs786201063, rs751000085, rs869025568, rs876660642, rs876658713, rs151170408, rs878854632, rs752360961, rs121913235, rs121913521, rs121913513, rs1057519708, rs1057519710, rs121913514, rs1057519713, rs778582853, rs1060503757, rs1060502521, rs1060502543, rs898854295, rs981049067, rs916516745, rs1553887262, rs1057520032, rs1553887960, rs775143272, rs1560395607, rs1560418178, rs751904543, rs1560420761, rs1560417385, rs1560417396, rs1560417427, rs1560417438, rs1560417535, rs1560417642, rs1560417666, rs1560417673, rs1577992594, rs1577995761, rs1578003055, rs1301704156, rs1734957331 View all (59 more) |
27793025 |
Glioblastoma |
Glioblastoma Multiforme |
rs121913500, rs886042842, rs1555138291, rs1558518449, rs1567176006, rs1558650888 |
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