ABLIM2 (actin binding LIM protein family member 2)

Gene

• Entrez ID: 84448
• Gene name: Actin binding LIM protein family member 2
• Gene symbol: ABLIM2
• Synonyms (NCBI Gene): -
• Chromosome: 4
• Chromosome location: 4p16.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT760922	hsa-miR-1255a	CLIP-seq
MIRT760923	hsa-miR-1255b	CLIP-seq
MIRT760924	hsa-miR-1291	CLIP-seq
MIRT760925	hsa-miR-2467-5p	CLIP-seq
MIRT760926	hsa-miR-3188	CLIP-seq
MIRT760927	hsa-miR-3194-3p	CLIP-seq
MIRT760928	hsa-miR-3975	CLIP-seq
MIRT760929	hsa-miR-4293	CLIP-seq
MIRT760930	hsa-miR-4649-3p	CLIP-seq
MIRT760931	hsa-miR-4732-3p	CLIP-seq
MIRT760932	hsa-miR-485-5p	CLIP-seq
MIRT760933	hsa-miR-5096	CLIP-seq
MIRT760934	hsa-miR-513a-5p	CLIP-seq
MIRT760935	hsa-miR-516b	CLIP-seq
MIRT760936	hsa-miR-544b	CLIP-seq
MIRT760937	hsa-miR-550a	CLIP-seq
MIRT760938	hsa-miR-3155	CLIP-seq
MIRT760939	hsa-miR-3155b	CLIP-seq
MIRT760940	hsa-miR-3180-5p	CLIP-seq
MIRT760941	hsa-miR-3929	CLIP-seq
MIRT760942	hsa-miR-4307	CLIP-seq
MIRT760943	hsa-miR-4329	CLIP-seq
MIRT760944	hsa-miR-4419b	CLIP-seq
MIRT760945	hsa-miR-4478	CLIP-seq
MIRT760946	hsa-miR-484	CLIP-seq
MIRT760938	hsa-miR-3155	CLIP-seq
MIRT760939	hsa-miR-3155b	CLIP-seq
MIRT760940	hsa-miR-3180-5p	CLIP-seq
MIRT760946	hsa-miR-484	CLIP-seq
MIRT2383778	hsa-miR-146b-3p	CLIP-seq
MIRT760938	hsa-miR-3155	CLIP-seq
MIRT760939	hsa-miR-3155b	CLIP-seq
MIRT2383779	hsa-miR-339-5p	CLIP-seq
MIRT2383780	hsa-miR-3655	CLIP-seq
MIRT2383781	hsa-miR-431	CLIP-seq
MIRT2383782	hsa-miR-4421	CLIP-seq
MIRT2383783	hsa-miR-4646-3p	CLIP-seq
MIRT2383784	hsa-miR-4780	CLIP-seq
MIRT760946	hsa-miR-484	CLIP-seq
MIRT2383785	hsa-miR-489	CLIP-seq
MIRT2383786	hsa-miR-623	CLIP-seq
MIRT2383787	hsa-miR-653	CLIP-seq
MIRT2468005	hsa-miR-1231	CLIP-seq
MIRT2468006	hsa-miR-1273g	CLIP-seq
MIRT2468007	hsa-miR-3127-5p	CLIP-seq
MIRT2468008	hsa-miR-323b-5p	CLIP-seq
MIRT2468009	hsa-miR-4270	CLIP-seq
MIRT2468010	hsa-miR-4288	CLIP-seq
MIRT2468011	hsa-miR-4441	CLIP-seq
MIRT2468012	hsa-miR-632	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IEA
GO:0006351	Process	Transcription, DNA-templated	IEA
GO:0015629	Component	Actin cytoskeleton	IBA	21873635
GO:0015629	Component	Actin cytoskeleton	IDA	17194709
GO:0030032	Process	Lamellipodium assembly	IBA	21873635
GO:0030036	Process	Actin cytoskeleton organization	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051015	Function	Actin filament binding	IBA	21873635

Other IDs

• MIM: 612544
• HGNC: 19195
• e!Ensembl: ENSG00000163995

Protein

• UniProt ID: Q6H8Q1
• Protein name: Actin-binding LIM protein 2 (abLIM-2) (Actin-binding LIM protein family member 2)
• Protein function: May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity.
• PDB: 1V6G, 1WIG, 2L3X
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00412	LIM	24 → 79	LIM domain	Domain
  PF00412	LIM	83 → 137	LIM domain	Domain
  PF00412	LIM	153 → 208	LIM domain	Domain
  PF00412	LIM	212 → 266	LIM domain	Domain
  PF16182	AbLIM_anchor	276 → 453	Putative adherens-junction anchoring region of AbLIM	Family
  PF16182	AbLIM_anchor	442 → 575	Putative adherens-junction anchoring region of AbLIM	Family
  PF02209	VHP	576 → 611	Villin headpiece domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in skeletal muscle. {ECO:0000269|PubMed:17194709}.
• Sequence:

  MSAVSQPQAAPSPLEKSPSTAILCNTCGNVCKGEVLRVQDKYFHIKCFVCKACGCDLAEG
  GFFVRQGEYICTLDYQRLYGTRCFSCDQFIEGEVVSALGKTYHPDCFVCAVCRLPFPPGD
  RVTFNGKECMCQKCSLPVSVGSSAHLSQGLRSCGGCGTEIKNGQALVALDKHWHLGCFKC
  KSCGKLLNAEYISKDGLPYCEADYHAKFGIRCDSCEKYITGRVLEAGEKHYHPSCALCVR
  CGQMFAEGEEMYLQGSSIWHPACRQAARTEDRNKETRTSSESIISVPASSTSGSPSRVIY
  AKLGGEILDYRDLAALPKSKAIYDIDRPDMISYSPYISHSAGDRQSYGEGDQDDRSYKQC
  RTSSPSSTGSVSLGRYTPTSRSPQHYSRPGSESGRSTPSLSVLSDSKPPPSTYQQAPRHF
  HVPDTGVKDNIYRKPPIYRQHAARRSDGEDGSLDQDNRKKSSWLMLKGDADTRTNSPDLD
  TQSLSHSSGTDRDPLQRMAGDSFHSRFPYSKSDPLPGHGKNGLDQRNANLAPCGADPDAS
  WGMREYKIYPYDSLIVTNRIRVKLPKDVDRTRLERHLSPEEFQEVFGMSIEEFDRLALWK
  RNDLKKKALLF

• Sequence length: 611

Pathways

KEGG:

Axon guidance

Associated diseases

Unknown
Disease term	Disease name	Evidence	References	Source
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease		26634245	ClinVar
Pancreatic adenocarcinoma	Pancreatic Ductal Adenocarcinoma	PDAC patients with high expression of PSMA6 having a significantly shorter overall survival rate.		ClinVar, CBGDA
Irritable Bowel Syndrome	Irritable Bowel Syndrome			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Alzheimer Disease	Associate	31755389
Neurodegenerative Diseases	Associate	31755389
Osteoporosis	Associate	29924424