LZTS2 (leucine zipper tumor suppressor 2)

Gene

• Entrez ID: 84445
• Gene name: Leucine zipper tumor suppressor 2
• Gene symbol: LZTS2
• Synonyms (NCBI Gene): LAPSER1
• Chromosome: 10
• Chromosome location: 10q24.31
• Summary: The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017535	hsa-miR-335-5p	Microarray	18185580
MIRT1124530	hsa-miR-1203	CLIP-seq
MIRT1124531	hsa-miR-1207-3p	CLIP-seq
MIRT1124532	hsa-miR-1262	CLIP-seq
MIRT1124533	hsa-miR-138	CLIP-seq
MIRT1124534	hsa-miR-149	CLIP-seq
MIRT1124535	hsa-miR-1587	CLIP-seq
MIRT1124536	hsa-miR-299-3p	CLIP-seq
MIRT1124537	hsa-miR-300	CLIP-seq
MIRT1124538	hsa-miR-3064-5p	CLIP-seq
MIRT1124539	hsa-miR-3119	CLIP-seq
MIRT1124540	hsa-miR-3126-3p	CLIP-seq
MIRT1124541	hsa-miR-3160-5p	CLIP-seq
MIRT1124542	hsa-miR-3170	CLIP-seq
MIRT1124543	hsa-miR-3179	CLIP-seq
MIRT1124544	hsa-miR-326	CLIP-seq
MIRT1124545	hsa-miR-330-5p	CLIP-seq
MIRT1124546	hsa-miR-3613-3p	CLIP-seq
MIRT1124547	hsa-miR-3652	CLIP-seq
MIRT1124548	hsa-miR-381	CLIP-seq
MIRT1124549	hsa-miR-3940-5p	CLIP-seq
MIRT1124550	hsa-miR-4260	CLIP-seq
MIRT1124551	hsa-miR-4265	CLIP-seq
MIRT1124552	hsa-miR-4269	CLIP-seq
MIRT1124553	hsa-miR-4282	CLIP-seq
MIRT1124554	hsa-miR-4296	CLIP-seq
MIRT1124555	hsa-miR-4302	CLIP-seq
MIRT1124556	hsa-miR-4322	CLIP-seq
MIRT1124557	hsa-miR-4417	CLIP-seq
MIRT1124558	hsa-miR-4430	CLIP-seq
MIRT1124559	hsa-miR-4492	CLIP-seq
MIRT1124560	hsa-miR-4498	CLIP-seq
MIRT1124561	hsa-miR-4507	CLIP-seq
MIRT1124562	hsa-miR-4656	CLIP-seq
MIRT1124563	hsa-miR-4666-3p	CLIP-seq
MIRT1124564	hsa-miR-4675	CLIP-seq
MIRT1124565	hsa-miR-4701-3p	CLIP-seq
MIRT1124566	hsa-miR-4719	CLIP-seq
MIRT1124567	hsa-miR-4741	CLIP-seq
MIRT1124568	hsa-miR-4768-5p	CLIP-seq
MIRT1124569	hsa-miR-4775	CLIP-seq
MIRT1124570	hsa-miR-4794	CLIP-seq
MIRT1124571	hsa-miR-485-5p	CLIP-seq
MIRT1124572	hsa-miR-490-3p	CLIP-seq
MIRT1124573	hsa-miR-548ad	CLIP-seq
MIRT1124574	hsa-miR-548q	CLIP-seq
MIRT1124575	hsa-miR-570	CLIP-seq
MIRT1124576	hsa-miR-582-5p	CLIP-seq
MIRT1124577	hsa-miR-590-3p	CLIP-seq
MIRT1124578	hsa-miR-615-5p	CLIP-seq
MIRT1124579	hsa-miR-629	CLIP-seq
MIRT1124580	hsa-miR-646	CLIP-seq
MIRT1124581	hsa-miR-671-5p	CLIP-seq
MIRT1124582	hsa-miR-762	CLIP-seq
MIRT1124583	hsa-miR-9	CLIP-seq
MIRT1124530	hsa-miR-1203	CLIP-seq
MIRT2035198	hsa-miR-132	CLIP-seq
MIRT1124534	hsa-miR-149	CLIP-seq
MIRT2035199	hsa-miR-194	CLIP-seq
MIRT2035200	hsa-miR-2110	CLIP-seq
MIRT2035201	hsa-miR-212	CLIP-seq
MIRT1124536	hsa-miR-299-3p	CLIP-seq
MIRT1124538	hsa-miR-3064-5p	CLIP-seq
MIRT2035202	hsa-miR-3132	CLIP-seq
MIRT2035203	hsa-miR-3144-5p	CLIP-seq
MIRT1124544	hsa-miR-326	CLIP-seq
MIRT1124545	hsa-miR-330-5p	CLIP-seq
MIRT2035204	hsa-miR-335	CLIP-seq
MIRT2035205	hsa-miR-3616-5p	CLIP-seq
MIRT2035206	hsa-miR-3647-5p	CLIP-seq
MIRT2035207	hsa-miR-3649	CLIP-seq
MIRT1124551	hsa-miR-4265	CLIP-seq
MIRT1124552	hsa-miR-4269	CLIP-seq
MIRT2035208	hsa-miR-4271	CLIP-seq
MIRT1124554	hsa-miR-4296	CLIP-seq
MIRT1124556	hsa-miR-4322	CLIP-seq
MIRT1124557	hsa-miR-4417	CLIP-seq
MIRT2035209	hsa-miR-4682	CLIP-seq
MIRT1124566	hsa-miR-4719	CLIP-seq
MIRT2035210	hsa-miR-4725-3p	CLIP-seq
MIRT1124570	hsa-miR-4794	CLIP-seq
MIRT2035211	hsa-miR-4795-5p	CLIP-seq
MIRT2035212	hsa-miR-491-5p	CLIP-seq
MIRT2035213	hsa-miR-555	CLIP-seq
MIRT2035214	hsa-miR-573	CLIP-seq
MIRT2035215	hsa-miR-602	CLIP-seq
MIRT2035216	hsa-miR-802	CLIP-seq
MIRT2035217	hsa-miR-885-3p	CLIP-seq
MIRT2035198	hsa-miR-132	CLIP-seq
MIRT1124534	hsa-miR-149	CLIP-seq
MIRT2035199	hsa-miR-194	CLIP-seq
MIRT2035200	hsa-miR-2110	CLIP-seq
MIRT2035201	hsa-miR-212	CLIP-seq
MIRT1124538	hsa-miR-3064-5p	CLIP-seq
MIRT2035202	hsa-miR-3132	CLIP-seq
MIRT2035203	hsa-miR-3144-5p	CLIP-seq
MIRT1124544	hsa-miR-326	CLIP-seq
MIRT1124545	hsa-miR-330-5p	CLIP-seq
MIRT2035204	hsa-miR-335	CLIP-seq
MIRT2035205	hsa-miR-3616-5p	CLIP-seq
MIRT2035206	hsa-miR-3647-5p	CLIP-seq
MIRT2035207	hsa-miR-3649	CLIP-seq
MIRT2035208	hsa-miR-4271	CLIP-seq
MIRT2035210	hsa-miR-4725-3p	CLIP-seq
MIRT1124570	hsa-miR-4794	CLIP-seq
MIRT2035211	hsa-miR-4795-5p	CLIP-seq
MIRT1124571	hsa-miR-485-5p	CLIP-seq
MIRT2035212	hsa-miR-491-5p	CLIP-seq
MIRT2035213	hsa-miR-555	CLIP-seq
MIRT2035214	hsa-miR-573	CLIP-seq
MIRT2035215	hsa-miR-602	CLIP-seq
MIRT2035216	hsa-miR-802	CLIP-seq
MIRT2035217	hsa-miR-885-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000281	Process	Mitotic cytokinesis	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 21516116, 22458338, 23602568, 24722188, 25416956, 25910212, 26871637, 26949739, 28514442, 31515488, 31980649, 32296183, 32814053
GO:0005813	Component	Centrosome	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005874	Component	Microtubule	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0030496	Component	Midbody	IEA
GO:0031982	Component	Vesicle	IDA	25468996
GO:0051013	Process	Microtubule severing	IEA
GO:0051168	Process	Nuclear export	IEA
GO:0051255	Process	Spindle midzone assembly	IEA
GO:0060682	Process	Primary ureteric bud growth	IEA
GO:0072197	Process	Ureter morphogenesis	IEA
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IBA	21873635
GO:1900181	Process	Negative regulation of protein localization to nucleus	IEA

Other IDs

• MIM: 610454
• HGNC: 29381
• e!Ensembl: ENSG00000107816

Protein

• UniProt ID: Q9BRK4
• Protein name: Leucine zipper putative tumor suppressor 2 (hLZTS2) (Protein LAPSER1)
• Protein function: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microt
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06818	Fez1	439 → 636		Coiled-coil

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon. {ECO:0000269|PubMed:11709705}.
• Sequence:

  MAIVQTLPVPLEPAPEAATAPQAPVMGSVSSLISGRPCPGGPAPPRHHGPPGPTFFRQQD
  GLLRGGYEAQEPLCPAVPPRKAVPVTSFTYINEDFRTESPPSPSSDVEDAREQRAHNAHL
  RGPPPKLIPVSGKLEKNMEKILIRPTAFKPVLPKPRGAPSLPSFMGPRATGLSGSQGSLT
  QLFGGPASSSSSSSSSSAADKPLAFSGWASGCPSGTLSDSGRNSLSSLPTYSTGGAEPTT
  SSPGGHLPSHGSGRGALPGPARGVPTGPSHSDSGRSSSSKSTGSLGGRVAGGLLGSGTRA
  SPDSSSCGERSPPPPPPPPSDEALLHCVLEGKLRDREAELQQLRDSLDENEATMCQAYEE
  RQRHWQREREALREDCAAQAQRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLER
  RCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALRE
  ARATLRVSEGRARGLQEAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREP
  PVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGER
  LAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQAPCIC
  LEEITATEI

• Sequence length: 669

Pathways

KEGG:

Wnt signaling pathway

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800, rs63750198, rs63751109, rs863223312, rs63750710, rs63751615, rs63750206, rs63750781, rs63750899, rs63750691, rs63750217, rs121912965, rs63749939, rs63751194, rs63750693, rs63750540, rs63751221, rs193922370, rs80359596, rs397514632, rs483352909, rs200495564, rs397514684, rs397516436, rs398122386, rs79512956, rs74953290, rs587779001, rs63750677, rs63749837, rs267607816, rs63751715, rs267607819, rs267607815, rs267607822, rs63749906, rs587778883, rs63750472, rs63751012, rs63750715, rs63750580, rs267607706, rs267607709, rs267607710, rs587778894, rs63750749, rs63750483, rs63751015, rs63751153, rs63751094, rs63751118, rs63750316, rs63749981, rs587778906, rs267607821, rs587778908, rs63750020, rs587778909, rs63750713, rs267607825, rs63751592, rs281864936, rs587778913, rs587778914, rs63749795, rs63750855, rs63749916, rs63749923, rs63751472, rs63751689, rs267607832, rs267607837, rs267607836, rs587778923, rs63750028, rs587778928, rs587778929, rs587778930, rs63751277, rs587778933, rs267607842, rs267607843, rs63750192, rs587778934, rs63750193, rs587778937, rs587778938, rs267607845, rs63751244, rs63751393, rs63751460, rs267607849, rs267607853, rs267607856, rs267607850, rs63751657, rs267607854, rs267607852, rs587778942, rs63750309, rs63750587, rs63749863, rs63751486, rs63750016, rs63749868, rs63750375, rs63750035, rs63750604, rs63750386, rs63750150, rs63750486, rs63751428, rs267607866, rs63749986, rs63751594, rs63750152, rs63750850, rs267607867, rs267607868, rs63751632, rs267607871, rs63751892, rs587778956, rs63750469, rs587778958, rs63749792, rs267607875, rs63751255, rs281864938, rs63751202, rs63750726, rs63751310, rs63749900, rs587778964, rs267607879, rs267607878, rs587778966, rs267607883, rs267607887, rs63750061, rs63750663, rs587778968, rs587778971, rs63750809, rs63749867, rs63750864, rs587778972, rs63751275, rs267607718, rs267607722, rs63750769, rs267607717, rs587778973, rs267607716, rs267607720, rs63749995, rs63750859, rs587778975, rs63750114, rs587778976, rs63750603, rs267607889, rs267607723, rs63750561, rs63750499, rs63751642, rs63751022, rs587778981, rs63750971, rs267607898, rs267607906, rs267607903, rs587778989, rs587778992, rs267607894, rs267607901, rs267607892, rs63750437, rs587778997, rs587778998, rs63750005, rs63750641, rs63751421, rs11541859, rs63750266, rs111052004, rs267607726, rs267607727, rs63750453, rs267607734, rs267607735, rs63751665, rs267607736, rs267607732, rs63749816, rs63750539, rs267607739, rs587779006, rs587779008, rs267607745, rs267607742, rs63751595, rs267607743, rs587779010, rs587779012, rs63750057, rs63749818, rs63751124, rs587779014, rs587779015, rs63749820, rs63751302, rs267607750, rs267607751, rs267607749, rs63750891, rs63749959, rs63749804, rs267607765, rs267607760, rs587779021, rs267607759, rs63750515, rs587779023, rs63751021, rs63751480, rs267607772, rs267607773, rs587779024, rs63751653, rs587779027, rs267607767, rs587779029, rs63750706, rs63750385, rs267607774, rs267607778, rs267607780, rs587779034, rs63751711, rs267607784, rs587779035, rs63750823, rs63750822, rs267607787, rs63750303, rs63749839, rs63749827, rs267607789, rs267607790, rs267607791, rs267607786, rs267607771, rs267607795, rs267607794, rs267607788, rs267607799, rs267607801, rs587779045, rs63750034, rs587779047, rs63750216, rs63751707, rs63751598, rs267607803, rs267607777, rs63750144, rs267607805, rs63750547, rs63750489, rs63750993, rs587779054, rs63751259, rs63749926, rs63750796, rs587779058, rs63750745, rs63750582, rs180177084, rs587779866, rs200389141, rs587779950, rs587780104, rs587780183, rs587778536, rs587780683, rs587781554, rs267607712, rs587777627, rs587783057, rs730881734, rs41542214, rs730881273, rs786203456, rs786201990, rs786202767, rs748005072, rs786204317, rs786204318, rs797045117, rs63750549, rs863225383, rs863225384, rs863225373, rs863225376, rs863225377, rs863225378, rs863225379, rs863225380, rs863225381, rs63750059, rs267607823, rs864622457, rs869312767, rs869312753, rs876661059, rs876658915, rs876658923, rs876660860, rs876660822, rs876660458, rs876660214, rs876658657, rs876658247, rs876659226, rs876658821, rs876660589, rs876659068, rs876659681, rs876659608, rs878853794, rs878853778, rs878853780, rs878853785, rs886039423, rs886039424, rs1057517543, rs1057517541, rs756843954, rs1057517617, rs1057517558, rs1057519256, rs1060500689, rs764085979, rs1060500707, rs1060500699, rs1060500706, rs1060500703, rs1064795341, rs1064793607, rs1064794348, rs1064795441, rs1064794373, rs1064793172, rs1064794122, rs1064795515, rs1064794331, rs63750978, rs1114167435, rs1553641362, rs63751448, rs1553648029, rs1553648058, rs587778903, rs1553653237, rs1553664353, rs267607744, rs1553647995, rs1553648047, rs1553653084, rs1553663750, rs1553664436, rs1553488015, rs1553637293, rs63750310, rs63750443, rs63751596, rs1553646681, rs550890395, rs1064796057, rs1553642079, rs1553648023, rs587782087, rs746536721, rs1553653037, rs1248251121, rs1553646602, rs1434898623, rs1553665683, rs1553648068, rs1553645331, rs1553644123, rs1553658246, rs1553651299, rs1553648149, rs1553663159, rs1302248679, rs1553664119, rs1553658009, rs1553665977, rs1416171624, rs1553663834, rs1553664617, rs1553664702, rs1553647969, rs1553648040, rs1437454428, rs1553641273, rs63751101, rs1553646764, rs1553648225, rs1554082118, rs1553648201, rs1553638868, rs1553665866, rs376736188, rs1553642707, rs1553645226, rs1553652883, rs63751435, rs1553653115, rs1553653195, rs63750300, rs1553662622, rs1553658104, rs1553648220, rs1559544064, rs63750584, rs267608083, rs1559551570, rs1559575107, rs1559553501, rs1565986506, rs1559524405, rs1559553492, rs1559554339, rs1559588540, rs1559558071, rs761329565, rs1559521039, rs1559574795, rs1567221417, rs1559578422, rs1481129490, rs1570714352, rs779783209, rs1575376830, rs1575469070, rs1575537843, rs1575620443, rs1575621506, rs587779022, rs1575414904, rs1575449093, rs1575469505, rs1575536254, rs1575537933, rs1575632112, rs1575639851, rs1575441094, rs1575449402, rs267607831, rs2081922847, rs2083403132, rs2085415927, rs2085469647, rs2043913790, rs147542208

Associations from Text Mining
Disease Name	Relationship Type	References
Breast Neoplasms	Associate	18242184
Carcinogenesis	Associate	29499699
Carcinoma Non Small Cell Lung	Inhibit	23761130
Colorectal Neoplasms	Associate	36750557
Glioma	Associate	18242184
Leukemia Myeloid Acute	Associate	28222251, 35148810
Lung Neoplasms	Associate	23761130
Lymphatic Metastasis	Stimulate	29499699
Neoplasms	Associate	18242184
Neoplasms	Inhibit	23761130, 29499699
Squamous Cell Carcinoma of Head and Neck	Associate	29499699