Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	84444
Gene name Gene Name - the full gene name approved by the HGNC.	DOT1 like histone lysine methyltransferase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	DOT1L
Synonyms (NCBI Gene) Gene synonyms aliases	DOT1, KMT4, NDNS
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19p13.3
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes. [provided by RefSeq, Aug 2011

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miRTarBase ID	miRNA	Experiments	Reference
MIRT051846	hsa-let-7c-5p	CLASH	23622248
MIRT049038	hsa-miR-92a-3p	CLASH	23622248
MIRT440783	hsa-miR-485-5p	HITS-CLIP	24374217
MIRT440782	hsa-miR-541-5p	HITS-CLIP	24374217
MIRT440781	hsa-miR-412-3p	HITS-CLIP	24374217
MIRT440783	hsa-miR-485-5p	HITS-CLIP	24374217
MIRT440782	hsa-miR-541-5p	HITS-CLIP	24374217
MIRT440781	hsa-miR-412-3p	HITS-CLIP	24374217
MIRT943451	hsa-let-7a	CLIP-seq
MIRT943452	hsa-let-7b	CLIP-seq
MIRT943453	hsa-let-7c	CLIP-seq
MIRT943454	hsa-let-7d	CLIP-seq
MIRT943455	hsa-let-7e	CLIP-seq
MIRT943456	hsa-let-7f	CLIP-seq
MIRT943457	hsa-let-7g	CLIP-seq
MIRT943458	hsa-let-7i	CLIP-seq
MIRT943459	hsa-miR-101	CLIP-seq
MIRT943460	hsa-miR-1184	CLIP-seq
MIRT943461	hsa-miR-1207-5p	CLIP-seq
MIRT943462	hsa-miR-1227	CLIP-seq
MIRT943463	hsa-miR-1285	CLIP-seq
MIRT943464	hsa-miR-1296	CLIP-seq
MIRT943465	hsa-miR-134	CLIP-seq
MIRT943466	hsa-miR-1343	CLIP-seq
MIRT943467	hsa-miR-148a	CLIP-seq
MIRT943468	hsa-miR-148b	CLIP-seq
MIRT943469	hsa-miR-152	CLIP-seq
MIRT943470	hsa-miR-153	CLIP-seq
MIRT943471	hsa-miR-1539	CLIP-seq
MIRT943472	hsa-miR-1587	CLIP-seq
MIRT943473	hsa-miR-15a	CLIP-seq
MIRT943474	hsa-miR-15b	CLIP-seq
MIRT943475	hsa-miR-16	CLIP-seq
MIRT943476	hsa-miR-1909	CLIP-seq
MIRT943477	hsa-miR-1915	CLIP-seq
MIRT943478	hsa-miR-195	CLIP-seq
MIRT943479	hsa-miR-1976	CLIP-seq
MIRT943480	hsa-miR-200b	CLIP-seq
MIRT943481	hsa-miR-200c	CLIP-seq
MIRT943482	hsa-miR-202	CLIP-seq
MIRT943483	hsa-miR-214	CLIP-seq
MIRT943484	hsa-miR-24	CLIP-seq
MIRT943485	hsa-miR-2909	CLIP-seq
MIRT943486	hsa-miR-296-3p	CLIP-seq
MIRT943487	hsa-miR-298	CLIP-seq
MIRT943488	hsa-miR-299-3p	CLIP-seq
MIRT943489	hsa-miR-3064-3p	CLIP-seq
MIRT943490	hsa-miR-3118	CLIP-seq
MIRT943491	hsa-miR-3125	CLIP-seq
MIRT943492	hsa-miR-3135	CLIP-seq
MIRT943493	hsa-miR-3147	CLIP-seq
MIRT943494	hsa-miR-3151	CLIP-seq
MIRT943495	hsa-miR-3163	CLIP-seq
MIRT943496	hsa-miR-3164	CLIP-seq
MIRT943497	hsa-miR-3179	CLIP-seq
MIRT943498	hsa-miR-3187-5p	CLIP-seq
MIRT943499	hsa-miR-3192	CLIP-seq
MIRT943500	hsa-miR-3193	CLIP-seq
MIRT943501	hsa-miR-3202	CLIP-seq
MIRT943502	hsa-miR-329	CLIP-seq
MIRT943503	hsa-miR-342-5p	CLIP-seq
MIRT943504	hsa-miR-3591-5p	CLIP-seq
MIRT943505	hsa-miR-3619-3p	CLIP-seq
MIRT943506	hsa-miR-3619-5p	CLIP-seq
MIRT943507	hsa-miR-3620	CLIP-seq
MIRT943508	hsa-miR-362-3p	CLIP-seq
MIRT943509	hsa-miR-3654	CLIP-seq
MIRT943510	hsa-miR-3675-3p	CLIP-seq
MIRT943511	hsa-miR-3689a-3p	CLIP-seq
MIRT943512	hsa-miR-3689c	CLIP-seq
MIRT943513	hsa-miR-378g	CLIP-seq
MIRT943514	hsa-miR-3916	CLIP-seq
MIRT943515	hsa-miR-3918	CLIP-seq
MIRT943516	hsa-miR-3927	CLIP-seq
MIRT943517	hsa-miR-3929	CLIP-seq
MIRT943518	hsa-miR-3936	CLIP-seq
MIRT943519	hsa-miR-3960	CLIP-seq
MIRT943520	hsa-miR-424	CLIP-seq
MIRT943521	hsa-miR-4252	CLIP-seq
MIRT943522	hsa-miR-4256	CLIP-seq
MIRT943523	hsa-miR-4258	CLIP-seq
MIRT943524	hsa-miR-429	CLIP-seq
MIRT943525	hsa-miR-4291	CLIP-seq
MIRT943526	hsa-miR-4292	CLIP-seq
MIRT943527	hsa-miR-4300	CLIP-seq
MIRT943528	hsa-miR-4417	CLIP-seq
MIRT943529	hsa-miR-4419b	CLIP-seq
MIRT943530	hsa-miR-4425	CLIP-seq
MIRT943531	hsa-miR-4437	CLIP-seq
MIRT943532	hsa-miR-4450	CLIP-seq
MIRT943533	hsa-miR-4458	CLIP-seq
MIRT943534	hsa-miR-4462	CLIP-seq
MIRT943535	hsa-miR-4476	CLIP-seq
MIRT943536	hsa-miR-4478	CLIP-seq
MIRT943537	hsa-miR-4486	CLIP-seq
MIRT943538	hsa-miR-4488	CLIP-seq
MIRT943539	hsa-miR-4492	CLIP-seq
MIRT943540	hsa-miR-4498	CLIP-seq
MIRT943541	hsa-miR-4500	CLIP-seq
MIRT943542	hsa-miR-4512	CLIP-seq
MIRT943543	hsa-miR-4514	CLIP-seq
MIRT943544	hsa-miR-4519	CLIP-seq
MIRT943545	hsa-miR-4522	CLIP-seq
MIRT943546	hsa-miR-4530	CLIP-seq
MIRT943547	hsa-miR-4632	CLIP-seq
MIRT943548	hsa-miR-4640-5p	CLIP-seq
MIRT943549	hsa-miR-4645-3p	CLIP-seq
MIRT943550	hsa-miR-4650-3p	CLIP-seq
MIRT943551	hsa-miR-4656	CLIP-seq
MIRT943552	hsa-miR-4664-5p	CLIP-seq
MIRT943553	hsa-miR-4674	CLIP-seq
MIRT943554	hsa-miR-4675	CLIP-seq
MIRT943555	hsa-miR-4685-5p	CLIP-seq
MIRT943556	hsa-miR-4690-3p	CLIP-seq
MIRT943557	hsa-miR-4692	CLIP-seq
MIRT943558	hsa-miR-4697-5p	CLIP-seq
MIRT943559	hsa-miR-4706	CLIP-seq
MIRT943560	hsa-miR-4707-3p	CLIP-seq
MIRT943561	hsa-miR-4715-3p	CLIP-seq
MIRT943562	hsa-miR-4722-3p	CLIP-seq
MIRT943563	hsa-miR-4726-5p	CLIP-seq
MIRT943564	hsa-miR-4728-5p	CLIP-seq
MIRT943565	hsa-miR-4731-5p	CLIP-seq
MIRT943566	hsa-miR-4741	CLIP-seq
MIRT943567	hsa-miR-4749-5p	CLIP-seq
MIRT943568	hsa-miR-4763-3p	CLIP-seq
MIRT943569	hsa-miR-4764-5p	CLIP-seq
MIRT943570	hsa-miR-4772-3p	CLIP-seq
MIRT943571	hsa-miR-4776-5p	CLIP-seq
MIRT943572	hsa-miR-4793-5p	CLIP-seq
MIRT943573	hsa-miR-486-3p	CLIP-seq
MIRT943574	hsa-miR-491-5p	CLIP-seq
MIRT943575	hsa-miR-497	CLIP-seq
MIRT943576	hsa-miR-503	CLIP-seq
MIRT943577	hsa-miR-518d-5p	CLIP-seq
MIRT943578	hsa-miR-519b-5p	CLIP-seq
MIRT943579	hsa-miR-519c-5p	CLIP-seq
MIRT943580	hsa-miR-520c-5p	CLIP-seq
MIRT943581	hsa-miR-520d-5p	CLIP-seq
MIRT943582	hsa-miR-524-5p	CLIP-seq
MIRT943583	hsa-miR-526a	CLIP-seq
MIRT943584	hsa-miR-532-3p	CLIP-seq
MIRT943585	hsa-miR-541	CLIP-seq
MIRT943586	hsa-miR-545	CLIP-seq
MIRT943587	hsa-miR-548a-3p	CLIP-seq
MIRT943588	hsa-miR-548e	CLIP-seq
MIRT943589	hsa-miR-548f	CLIP-seq
MIRT943590	hsa-miR-558	CLIP-seq
MIRT943591	hsa-miR-566	CLIP-seq
MIRT943592	hsa-miR-577	CLIP-seq
MIRT943593	hsa-miR-582-5p	CLIP-seq
MIRT943594	hsa-miR-612	CLIP-seq
MIRT943595	hsa-miR-634	CLIP-seq
MIRT943596	hsa-miR-637	CLIP-seq
MIRT943597	hsa-miR-642b	CLIP-seq
MIRT943598	hsa-miR-648	CLIP-seq
MIRT943599	hsa-miR-654-5p	CLIP-seq
MIRT943600	hsa-miR-662	CLIP-seq
MIRT943601	hsa-miR-7	CLIP-seq
MIRT943602	hsa-miR-744	CLIP-seq
MIRT943603	hsa-miR-761	CLIP-seq
MIRT943604	hsa-miR-762	CLIP-seq
MIRT943605	hsa-miR-891b	CLIP-seq
MIRT943606	hsa-miR-920	CLIP-seq
MIRT943607	hsa-miR-922	CLIP-seq
MIRT943608	hsa-miR-940	CLIP-seq
MIRT943609	hsa-miR-98	CLIP-seq
MIRT1556236	hsa-miR-4650-5p	CLIP-seq
MIRT943459	hsa-miR-101	CLIP-seq
MIRT943460	hsa-miR-1184	CLIP-seq
MIRT1979376	hsa-miR-1200	CLIP-seq
MIRT1979377	hsa-miR-1247	CLIP-seq
MIRT1979378	hsa-miR-1264	CLIP-seq
MIRT1979379	hsa-miR-128	CLIP-seq
MIRT1979380	hsa-miR-1321	CLIP-seq
MIRT1979381	hsa-miR-1324	CLIP-seq
MIRT943466	hsa-miR-1343	CLIP-seq
MIRT1979382	hsa-miR-151-5p	CLIP-seq
MIRT1979383	hsa-miR-151b	CLIP-seq
MIRT943473	hsa-miR-15a	CLIP-seq
MIRT943474	hsa-miR-15b	CLIP-seq
MIRT943475	hsa-miR-16	CLIP-seq
MIRT1979384	hsa-miR-1827	CLIP-seq
MIRT1979385	hsa-miR-186	CLIP-seq
MIRT1979386	hsa-miR-187	CLIP-seq
MIRT1979387	hsa-miR-1908	CLIP-seq
MIRT943476	hsa-miR-1909	CLIP-seq
MIRT943477	hsa-miR-1915	CLIP-seq
MIRT943478	hsa-miR-195	CLIP-seq
MIRT1979388	hsa-miR-210	CLIP-seq
MIRT943483	hsa-miR-214	CLIP-seq
MIRT1979389	hsa-miR-224	CLIP-seq
MIRT1979390	hsa-miR-27a	CLIP-seq
MIRT1979391	hsa-miR-27b	CLIP-seq
MIRT943485	hsa-miR-2909	CLIP-seq
MIRT943486	hsa-miR-296-3p	CLIP-seq
MIRT943487	hsa-miR-298	CLIP-seq
MIRT1979392	hsa-miR-29a	CLIP-seq
MIRT1979393	hsa-miR-29b	CLIP-seq
MIRT1979394	hsa-miR-29c	CLIP-seq
MIRT1979395	hsa-miR-3133	CLIP-seq
MIRT943493	hsa-miR-3147	CLIP-seq
MIRT1979396	hsa-miR-3150a-3p	CLIP-seq
MIRT1979397	hsa-miR-3152-5p	CLIP-seq
MIRT1979398	hsa-miR-3158-5p	CLIP-seq
MIRT943495	hsa-miR-3163	CLIP-seq
MIRT1979399	hsa-miR-3175	CLIP-seq
MIRT943502	hsa-miR-329	CLIP-seq
MIRT1979400	hsa-miR-337-3p	CLIP-seq
MIRT943503	hsa-miR-342-5p	CLIP-seq
MIRT1979401	hsa-miR-3612	CLIP-seq
MIRT1979402	hsa-miR-3616-3p	CLIP-seq
MIRT943506	hsa-miR-3619-5p	CLIP-seq
MIRT943508	hsa-miR-362-3p	CLIP-seq
MIRT943509	hsa-miR-3654	CLIP-seq
MIRT1979403	hsa-miR-3670	CLIP-seq
MIRT943511	hsa-miR-3689a-3p	CLIP-seq
MIRT943512	hsa-miR-3689c	CLIP-seq
MIRT1979404	hsa-miR-374c	CLIP-seq
MIRT943518	hsa-miR-3936	CLIP-seq
MIRT1979405	hsa-miR-3940-3p	CLIP-seq
MIRT943520	hsa-miR-424	CLIP-seq
MIRT943521	hsa-miR-4252	CLIP-seq
MIRT943523	hsa-miR-4258	CLIP-seq
MIRT1979406	hsa-miR-4269	CLIP-seq
MIRT1979407	hsa-miR-4271	CLIP-seq
MIRT1979408	hsa-miR-4273	CLIP-seq
MIRT943525	hsa-miR-4291	CLIP-seq
MIRT943527	hsa-miR-4300	CLIP-seq
MIRT1979409	hsa-miR-4305	CLIP-seq
MIRT1979410	hsa-miR-431	CLIP-seq
MIRT1979411	hsa-miR-4324	CLIP-seq
MIRT1979412	hsa-miR-4419a	CLIP-seq
MIRT943530	hsa-miR-4425	CLIP-seq
MIRT1979413	hsa-miR-4435	CLIP-seq
MIRT1979414	hsa-miR-4436b-3p	CLIP-seq
MIRT943538	hsa-miR-4488	CLIP-seq
MIRT1979415	hsa-miR-4494	CLIP-seq
MIRT1979416	hsa-miR-4510	CLIP-seq
MIRT943546	hsa-miR-4530	CLIP-seq
MIRT943547	hsa-miR-4632	CLIP-seq
MIRT1979417	hsa-miR-4633-3p	CLIP-seq
MIRT943549	hsa-miR-4645-3p	CLIP-seq
MIRT1979418	hsa-miR-4645-5p	CLIP-seq
MIRT1979419	hsa-miR-4651	CLIP-seq
MIRT943552	hsa-miR-4664-5p	CLIP-seq
MIRT1979420	hsa-miR-4673	CLIP-seq
MIRT1979421	hsa-miR-4677-5p	CLIP-seq
MIRT943555	hsa-miR-4685-5p	CLIP-seq
MIRT943558	hsa-miR-4697-5p	CLIP-seq
MIRT943560	hsa-miR-4707-3p	CLIP-seq
MIRT1979422	hsa-miR-4711-3p	CLIP-seq
MIRT943561	hsa-miR-4715-3p	CLIP-seq
MIRT1979423	hsa-miR-4716-3p	CLIP-seq
MIRT1979424	hsa-miR-4717-3p	CLIP-seq
MIRT943562	hsa-miR-4722-3p	CLIP-seq
MIRT1979425	hsa-miR-4725-3p	CLIP-seq
MIRT1979426	hsa-miR-4726-3p	CLIP-seq
MIRT943564	hsa-miR-4728-5p	CLIP-seq
MIRT943565	hsa-miR-4731-5p	CLIP-seq
MIRT1979427	hsa-miR-4739	CLIP-seq
MIRT1979428	hsa-miR-4756-5p	CLIP-seq
MIRT1979429	hsa-miR-4777-5p	CLIP-seq
MIRT1979430	hsa-miR-4779	CLIP-seq
MIRT943572	hsa-miR-4793-5p	CLIP-seq
MIRT943573	hsa-miR-486-3p	CLIP-seq
MIRT943574	hsa-miR-491-5p	CLIP-seq
MIRT943575	hsa-miR-497	CLIP-seq
MIRT1979431	hsa-miR-499a-5p	CLIP-seq
MIRT1979432	hsa-miR-502-5p	CLIP-seq
MIRT943576	hsa-miR-503	CLIP-seq
MIRT1979433	hsa-miR-513a-5p	CLIP-seq
MIRT943577	hsa-miR-518d-5p	CLIP-seq
MIRT943578	hsa-miR-519b-5p	CLIP-seq
MIRT943579	hsa-miR-519c-5p	CLIP-seq
MIRT943580	hsa-miR-520c-5p	CLIP-seq
MIRT943583	hsa-miR-526a	CLIP-seq
MIRT1979434	hsa-miR-544b	CLIP-seq
MIRT943587	hsa-miR-548a-3p	CLIP-seq
MIRT943588	hsa-miR-548e	CLIP-seq
MIRT943589	hsa-miR-548f	CLIP-seq
MIRT943592	hsa-miR-577	CLIP-seq
MIRT1979435	hsa-miR-608	CLIP-seq
MIRT943595	hsa-miR-634	CLIP-seq
MIRT943596	hsa-miR-637	CLIP-seq
MIRT943597	hsa-miR-642b	CLIP-seq
MIRT1979436	hsa-miR-650	CLIP-seq
MIRT1979437	hsa-miR-655	CLIP-seq
MIRT1979438	hsa-miR-663	CLIP-seq
MIRT943603	hsa-miR-761	CLIP-seq
MIRT1979439	hsa-miR-767-3p	CLIP-seq
MIRT943606	hsa-miR-920	CLIP-seq
MIRT943607	hsa-miR-922	CLIP-seq
MIRT1979440	hsa-miR-939	CLIP-seq
MIRT943451	hsa-let-7a	CLIP-seq
MIRT943452	hsa-let-7b	CLIP-seq
MIRT943453	hsa-let-7c	CLIP-seq
MIRT943454	hsa-let-7d	CLIP-seq
MIRT943455	hsa-let-7e	CLIP-seq
MIRT943456	hsa-let-7f	CLIP-seq
MIRT943457	hsa-let-7g	CLIP-seq
MIRT943458	hsa-let-7i	CLIP-seq
MIRT2214526	hsa-miR-1204	CLIP-seq
MIRT2214527	hsa-miR-1207-3p	CLIP-seq
MIRT1979378	hsa-miR-1264	CLIP-seq
MIRT1979379	hsa-miR-128	CLIP-seq
MIRT943463	hsa-miR-1285	CLIP-seq
MIRT2214528	hsa-miR-1291	CLIP-seq
MIRT2214529	hsa-miR-132	CLIP-seq
MIRT1979380	hsa-miR-1321	CLIP-seq
MIRT943465	hsa-miR-134	CLIP-seq
MIRT943466	hsa-miR-1343	CLIP-seq
MIRT1979382	hsa-miR-151-5p	CLIP-seq
MIRT1979383	hsa-miR-151b	CLIP-seq
MIRT943470	hsa-miR-153	CLIP-seq
MIRT943473	hsa-miR-15a	CLIP-seq
MIRT943474	hsa-miR-15b	CLIP-seq
MIRT943475	hsa-miR-16	CLIP-seq
MIRT1979384	hsa-miR-1827	CLIP-seq
MIRT943478	hsa-miR-195	CLIP-seq
MIRT943479	hsa-miR-1976	CLIP-seq
MIRT943480	hsa-miR-200b	CLIP-seq
MIRT943481	hsa-miR-200c	CLIP-seq
MIRT943482	hsa-miR-202	CLIP-seq
MIRT2214530	hsa-miR-212	CLIP-seq
MIRT943483	hsa-miR-214	CLIP-seq
MIRT1979389	hsa-miR-224	CLIP-seq
MIRT943484	hsa-miR-24	CLIP-seq
MIRT1979390	hsa-miR-27a	CLIP-seq
MIRT1979391	hsa-miR-27b	CLIP-seq
MIRT943485	hsa-miR-2909	CLIP-seq
MIRT943486	hsa-miR-296-3p	CLIP-seq
MIRT943487	hsa-miR-298	CLIP-seq
MIRT1979392	hsa-miR-29a	CLIP-seq
MIRT1979393	hsa-miR-29b	CLIP-seq
MIRT1979394	hsa-miR-29c	CLIP-seq
MIRT2214531	hsa-miR-3065-3p	CLIP-seq
MIRT943490	hsa-miR-3118	CLIP-seq
MIRT943493	hsa-miR-3147	CLIP-seq
MIRT1979396	hsa-miR-3150a-3p	CLIP-seq
MIRT943495	hsa-miR-3163	CLIP-seq
MIRT943496	hsa-miR-3164	CLIP-seq
MIRT1979399	hsa-miR-3175	CLIP-seq
MIRT943498	hsa-miR-3187-5p	CLIP-seq
MIRT943499	hsa-miR-3192	CLIP-seq
MIRT2214532	hsa-miR-328	CLIP-seq
MIRT943502	hsa-miR-329	CLIP-seq
MIRT1979400	hsa-miR-337-3p	CLIP-seq
MIRT943504	hsa-miR-3591-5p	CLIP-seq
MIRT1979401	hsa-miR-3612	CLIP-seq
MIRT1979402	hsa-miR-3616-3p	CLIP-seq
MIRT943505	hsa-miR-3619-3p	CLIP-seq
MIRT943506	hsa-miR-3619-5p	CLIP-seq
MIRT943507	hsa-miR-3620	CLIP-seq
MIRT943508	hsa-miR-362-3p	CLIP-seq
MIRT943509	hsa-miR-3654	CLIP-seq
MIRT2214533	hsa-miR-3656	CLIP-seq
MIRT943510	hsa-miR-3675-3p	CLIP-seq
MIRT943511	hsa-miR-3689a-3p	CLIP-seq
MIRT943512	hsa-miR-3689c	CLIP-seq
MIRT943516	hsa-miR-3927	CLIP-seq
MIRT943518	hsa-miR-3936	CLIP-seq
MIRT943520	hsa-miR-424	CLIP-seq
MIRT943521	hsa-miR-4252	CLIP-seq
MIRT943522	hsa-miR-4256	CLIP-seq
MIRT943523	hsa-miR-4258	CLIP-seq
MIRT2214534	hsa-miR-4264	CLIP-seq
MIRT1979407	hsa-miR-4271	CLIP-seq
MIRT943524	hsa-miR-429	CLIP-seq
MIRT943525	hsa-miR-4291	CLIP-seq
MIRT943528	hsa-miR-4417	CLIP-seq
MIRT1979412	hsa-miR-4419a	CLIP-seq
MIRT943530	hsa-miR-4425	CLIP-seq
MIRT943531	hsa-miR-4437	CLIP-seq
MIRT943533	hsa-miR-4458	CLIP-seq
MIRT2214535	hsa-miR-448	CLIP-seq
MIRT943538	hsa-miR-4488	CLIP-seq
MIRT943539	hsa-miR-4492	CLIP-seq
MIRT943540	hsa-miR-4498	CLIP-seq
MIRT943541	hsa-miR-4500	CLIP-seq
MIRT1979416	hsa-miR-4510	CLIP-seq
MIRT943543	hsa-miR-4514	CLIP-seq
MIRT943545	hsa-miR-4522	CLIP-seq
MIRT943546	hsa-miR-4530	CLIP-seq
MIRT943550	hsa-miR-4650-3p	CLIP-seq
MIRT943553	hsa-miR-4674	CLIP-seq
MIRT2214536	hsa-miR-4691-3p	CLIP-seq
MIRT943557	hsa-miR-4692	CLIP-seq
MIRT943558	hsa-miR-4697-5p	CLIP-seq
MIRT943560	hsa-miR-4707-3p	CLIP-seq
MIRT943561	hsa-miR-4715-3p	CLIP-seq
MIRT1979423	hsa-miR-4716-3p	CLIP-seq
MIRT943562	hsa-miR-4722-3p	CLIP-seq
MIRT2214537	hsa-miR-4723-5p	CLIP-seq
MIRT1979425	hsa-miR-4725-3p	CLIP-seq
MIRT943564	hsa-miR-4728-5p	CLIP-seq
MIRT943565	hsa-miR-4731-5p	CLIP-seq
MIRT1979427	hsa-miR-4739	CLIP-seq
MIRT2214538	hsa-miR-4755-3p	CLIP-seq
MIRT1979428	hsa-miR-4756-5p	CLIP-seq
MIRT943571	hsa-miR-4776-5p	CLIP-seq
MIRT1979430	hsa-miR-4779	CLIP-seq
MIRT943572	hsa-miR-4793-5p	CLIP-seq
MIRT943573	hsa-miR-486-3p	CLIP-seq
MIRT2214539	hsa-miR-486-5p	CLIP-seq
MIRT943574	hsa-miR-491-5p	CLIP-seq
MIRT943575	hsa-miR-497	CLIP-seq
MIRT1979432	hsa-miR-502-5p	CLIP-seq
MIRT943576	hsa-miR-503	CLIP-seq
MIRT1979433	hsa-miR-513a-5p	CLIP-seq
MIRT943577	hsa-miR-518d-5p	CLIP-seq
MIRT943578	hsa-miR-519b-5p	CLIP-seq
MIRT943579	hsa-miR-519c-5p	CLIP-seq
MIRT943580	hsa-miR-520c-5p	CLIP-seq
MIRT943583	hsa-miR-526a	CLIP-seq
MIRT943586	hsa-miR-545	CLIP-seq
MIRT2214540	hsa-miR-554	CLIP-seq
MIRT2214541	hsa-miR-556-3p	CLIP-seq
MIRT2214542	hsa-miR-570	CLIP-seq
MIRT943592	hsa-miR-577	CLIP-seq
MIRT2214543	hsa-miR-589	CLIP-seq
MIRT943594	hsa-miR-612	CLIP-seq
MIRT2214544	hsa-miR-622	CLIP-seq
MIRT2214545	hsa-miR-625	CLIP-seq
MIRT943595	hsa-miR-634	CLIP-seq
MIRT943596	hsa-miR-637	CLIP-seq
MIRT943597	hsa-miR-642b	CLIP-seq
MIRT2214546	hsa-miR-646	CLIP-seq
MIRT943598	hsa-miR-648	CLIP-seq
MIRT1979436	hsa-miR-650	CLIP-seq
MIRT2214547	hsa-miR-663b	CLIP-seq
MIRT943603	hsa-miR-761	CLIP-seq
MIRT943604	hsa-miR-762	CLIP-seq
MIRT943607	hsa-miR-922	CLIP-seq
MIRT1979440	hsa-miR-939	CLIP-seq
MIRT943609	hsa-miR-98	CLIP-seq
MIRT1979378	hsa-miR-1264	CLIP-seq
MIRT943466	hsa-miR-1343	CLIP-seq
MIRT2387087	hsa-miR-1469	CLIP-seq
MIRT1979384	hsa-miR-1827	CLIP-seq
MIRT943477	hsa-miR-1915	CLIP-seq
MIRT2387088	hsa-miR-2277-5p	CLIP-seq
MIRT1979392	hsa-miR-29a	CLIP-seq
MIRT1979393	hsa-miR-29b	CLIP-seq
MIRT1979394	hsa-miR-29c	CLIP-seq
MIRT2214531	hsa-miR-3065-3p	CLIP-seq
MIRT943502	hsa-miR-329	CLIP-seq
MIRT1979401	hsa-miR-3612	CLIP-seq
MIRT943508	hsa-miR-362-3p	CLIP-seq
MIRT2214533	hsa-miR-3656	CLIP-seq
MIRT943518	hsa-miR-3936	CLIP-seq
MIRT943523	hsa-miR-4258	CLIP-seq
MIRT1979407	hsa-miR-4271	CLIP-seq
MIRT943538	hsa-miR-4488	CLIP-seq
MIRT943539	hsa-miR-4492	CLIP-seq
MIRT943540	hsa-miR-4498	CLIP-seq
MIRT943556	hsa-miR-4690-3p	CLIP-seq
MIRT943558	hsa-miR-4697-5p	CLIP-seq
MIRT943561	hsa-miR-4715-3p	CLIP-seq
MIRT1979423	hsa-miR-4716-3p	CLIP-seq
MIRT1979425	hsa-miR-4725-3p	CLIP-seq
MIRT943565	hsa-miR-4731-5p	CLIP-seq
MIRT943569	hsa-miR-4764-5p	CLIP-seq
MIRT943572	hsa-miR-4793-5p	CLIP-seq
MIRT943573	hsa-miR-486-3p	CLIP-seq
MIRT2214540	hsa-miR-554	CLIP-seq
MIRT943592	hsa-miR-577	CLIP-seq
MIRT2214544	hsa-miR-622	CLIP-seq
MIRT2214545	hsa-miR-625	CLIP-seq
MIRT943595	hsa-miR-634	CLIP-seq
MIRT943596	hsa-miR-637	CLIP-seq
MIRT1979436	hsa-miR-650	CLIP-seq
MIRT943604	hsa-miR-762	CLIP-seq
MIRT943608	hsa-miR-940	CLIP-seq
MIRT2448496	hsa-miR-3591-3p	CLIP-seq
MIRT2448497	hsa-miR-4475	CLIP-seq
MIRT2214539	hsa-miR-486-5p	CLIP-seq
MIRT2448498	hsa-miR-711	CLIP-seq
MIRT2518820	hsa-miR-1254	CLIP-seq
MIRT2518821	hsa-miR-3116	CLIP-seq
MIRT943548	hsa-miR-4640-5p	CLIP-seq
MIRT943563	hsa-miR-4726-5p	CLIP-seq
MIRT2518822	hsa-miR-4727-5p	CLIP-seq
MIRT2518823	hsa-miR-661	CLIP-seq
MIRT2518824	hsa-miR-760	CLIP-seq

Show/Hide all(24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000077	Process	DNA damage checkpoint	IBA	21873635
GO:0000781	Component	Chromosome, telomeric region	IEA
GO:0003677	Function	DNA binding	IEA
GO:0005515	Function	Protein binding	IPI	20153263, 20203130, 23260655, 26496610
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	15851025
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006281	Process	DNA repair	IBA	21873635
GO:0006348	Process	Chromatin silencing at telomere	IBA	21873635
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	15851025
GO:0010467	Process	Gene expression	IEA
GO:0018024	Function	Histone-lysine N-methyltransferase activity	IDA	17707234
GO:0018024	Function	Histone-lysine N-methyltransferase activity	TAS
GO:0031151	Function	Histone methyltransferase activity (H3-K79 specific)	IBA	21873635
GO:0032200	Process	Telomere organization	TAS	17675446
GO:0032991	Component	Protein-containing complex	IDA	15851025
GO:0034729	Process	Histone H3-K79 methylation	IDA	15851025
GO:0042054	Function	Histone methyltransferase activity	IDA	15851025
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	15851025
GO:0046425	Process	Regulation of receptor signaling pathway via JAK-STAT	IDA	22002246
GO:2000677	Process	Regulation of transcription regulatory region DNA binding	IBA	21873635
GO:2000677	Process	Regulation of transcription regulatory region DNA binding	IMP	22002246

MIM	HGNC	e!Ensembl
607375	24948	ENSG00000104885

Protein

UniProt ID

Q8TEK3

Protein name

Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.360) (DOT1-like protein) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (Lysine N-methyltransferase 4)

Protein function

Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190).

PDB

1NW3 , 2MV7 , 3QOW , 3QOX , 3SR4 , 3SX0 , 3UWP , 4EK9 , 4EKG , 4EKI , 4EQZ , 4ER0 , 4ER3 , 4ER5 , 4ER6 , 4ER7 , 4HRA , 4WVL , 5DRT , 5DRY , 5DSX , 5DT2 , 5DTM , 5DTQ , 5DTR , 5JUW , 5MVS , 5MW3 , 5MW4 , 6IN3 , 6J99 , 6JM9 , 6JMA , 6JN2 , 6NJ9 , 6NN6 , 6NOG , 6NQA , 6O96 , 6TE6 , 6TEL , 6TEN , 7BWD , 7EDP , 7S7E , 7S7F , 7XCR , 7XCT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08123	DOT1	115 → 317	Histone methylation protein DOT1	Domain

Sequence

MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNAATPTKGP
EGKVAGPADAPMDSGAEEEKAGAATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMNTA
NPERKPKKNQTALDALHAQTVSQTAASSPQDAYRSPHSPFYQLPPSVQRHSPNPLLVAPT
PPALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGQEKEKNAQLLGAAQQLLSHCQAQK
EEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEQDNRALRGQSLQLL
KARCEELQLDWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLK
SCVPPDDALSLHLRGKGALGRELEPDASRLHLELDCTKFSLPHLSSMSPELSMNGQAAGY
ELCGVLSRPSSKQNTPQYLASPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRLSPAKIV
LRRHLSQDHTVPGRPAASELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQL
AGEKSSEKGLRERAYGSSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARST
PSPVLQPRDPSSTLEKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGA
EPATLDESSSSGSLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGAAQGPL
PEASKGDLPSDSGFSDPESEAKRRIVFTITTGAGSAKQSPSSKHSPLTASARGDCVPSHG
QDSRRRGRRKRASAGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEI
TAISSPETSLKSSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARI
ERKIATISLESKSPPKTLENGGGLAGRKPAPAGEPVNSSKWKSTFSPISDIGLAKSADSP
LQASSALSQNSLFTFRPALEEPSADAKLAAHPRKGFPGSLSGADGLSPGTNPANGCTFGG
GLAADLSLHSFSDGASLPHKGPEAAGLSSPLSFPSQRGKEGSDANPFLSKRQLDGLAGLK
GEGSRGKEAGEGGLPLCGPTDKTPLLSGKAAKARDREVDLKNGHNLFISAAAVPPGSLLS
GPGLAPAASSAGGAASSAQTHRSFLGPFPPGPQFALGPMSLQANLGSVAGSSVLQSLFSS
VPAAAGLVHVSSAATRLTNSHAMGSFSGVAGGTVGGN

Sequence length

1537

Interactions

View interactions

	KEGG		Reactome
	Lysine degradation Metabolic pathways Transcriptional misregulation in cancer		PKMTs methylate histone lysines

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Arthritis	Degenerative polyarthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	22566624
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370 View all (5 more)	27158780

Show/Hide Unknown Diseases (3)

Disease term	Disease name	Evidence	Source
Unknown
Systemic lupus erythematosus	Systemic lupus erythematosus		GWAS
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients	GWAS, CBGDA
Atrial Fibrillation	Atrial Fibrillation		GWAS

Show/Hide Text Mining Associations (42)

Disease Name	Relationship Type	References
Associations from Text Mining
Acute Lung Injury	Associate	37595582
Adenocarcinoma of Lung	Associate	27158780
Atherosclerosis	Associate	24916648
Bone Diseases	Associate	38072145
Bone Neoplasms	Associate	30281149
Brain Injuries	Associate	37595582
Breast Neoplasms	Associate	35135840, 35850772
Carcinoma	Associate	30281149
Carcinoma Renal Cell	Associate	27713173, 37365941
Cell Transformation Viral	Associate	29563185
Colorectal Neoplasms	Associate	30616689
Congenital Abnormalities	Associate	37827158
Developmental Disabilities	Associate	37827158
Drug Related Side Effects and Adverse Reactions	Inhibit	31717699
Gastrointestinal Stromal Tumors	Associate	35499757
Genetic Diseases Inborn	Associate	37827158
Genital Diseases Female	Associate	28114995
Infections	Associate	31727944
Influenza Human	Associate	32188146
Intellectual Disability	Associate	37827158
Internal Hernia	Associate	28114995
Kidney Neoplasms	Associate	37365941
Leukemia	Associate	20854876, 22924785, 24858818, 25987043, 26345285, 26439302, 28076791, 29724899, 30616689, 30759380, 30981630, 31253180, 31717699, 31727944, 32437908 View all (6 more)
Leukemia	Inhibit	27535106
Leukemia Biphenotypic Acute	Associate	22924785, 23433670, 24858818, 25987043, 31717699, 34187895, 35172132, 39307938
Leukemia Myeloid Acute	Associate	22924785, 24858818, 25397901, 27535106, 27698101, 27760321, 30374167, 32634241, 34016956
Lung Neoplasms	Associate	22190683, 37256945
Lymphatic Metastasis	Associate	28114995
Lymphoma	Stimulate	39307938
Lymphoma B Cell	Associate	39307938
Myocardial Infarction	Associate	24916648
Neoplasms	Associate	25987043, 26439302, 27002147, 27713173, 28114995, 30616689, 35135840, 36318113, 39307938
Oncogene Addiction	Associate	30374167
Osteoporosis	Inhibit	38072145
Ovarian Diseases	Associate	36318113
Ovarian Neoplasms	Associate	28114995, 36318113
Pancreatic Neoplasms	Associate	35350907
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	23433670, 26345285, 27683039
Rectal Neoplasms	Associate	30616689
Squamous Cell Carcinoma of Head and Neck	Associate	27002147
Triple Negative Breast Neoplasms	Associate	32244385
Triple Negative Breast Neoplasms	Stimulate	35135840

DOT1L (DOT1 like histone lysine methyltransferase)