Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
84376
Gene name Gene Name - the full gene name approved by the HGNC.
Hook microtubule tethering protein 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
HOOK3
Synonyms (NCBI Gene) Gene synonyms aliases
HK3
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8p11.21
Summary Summary of gene provided in NCBI Entrez Gene.
Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocyt
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs747141054 G>A Likely-pathogenic Missense variant, coding sequence variant
rs1563293555 T>G Likely-pathogenic Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT026745 hsa-miR-192-5p Microarray 19074876
MIRT047303 hsa-miR-181a-5p CLASH 23622248
MIRT046999 hsa-miR-181a-3p CLASH 23622248
MIRT039786 hsa-miR-615-3p CLASH 23622248
MIRT718763 hsa-miR-556-5p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000242 Component Pericentriolar material ISS
GO:0005515 Function Protein binding IPI 17237231, 18799622, 28514442, 32296183
GO:0005737 Component Cytoplasm IBA 21873635
GO:0005801 Component Cis-Golgi network IDA 11238449
GO:0005813 Component Centrosome IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607825 23576 ENSG00000168172
Protein
UniProt ID Q86VS8
Protein name Protein Hook homolog 3 (h-hook3) (hHK3)
Protein function Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activat
PDB 5J8E , 6B9H , 8QAT , 9KNS , 9KO8
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF19047 HOOK_N 11 161 HOOK domain Domain
PF05622 HOOK 184 709 HOOK protein coiled-coil region Coiled-coil
Sequence
Sequence length 718
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Motor proteins  
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Unknown
Disease term Disease name Evidence References Source
Alzheimer disease Alzheimer disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Neoplasms Associate 23676460, 26230842, 27974047
Obesity Associate 34638758
Polycystic Ovary Syndrome Associate 37547318
Prostatic Neoplasms Associate 26230842