Gene Gene information from NCBI Gene database.
Entrez ID 84376
Gene name Hook microtubule tethering protein 3
Gene symbol HOOK3
Synonyms (NCBI Gene)
HK3
Chromosome 8
Chromosome location 8p11.21
Summary Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocyt
SNPs SNP information provided by dbSNP.
2
SNP ID Visualize variation Clinical significance Consequence
rs747141054 G>A Likely-pathogenic Missense variant, coding sequence variant
rs1563293555 T>G Likely-pathogenic Coding sequence variant, missense variant
miRNA miRNA information provided by mirtarbase database.
1732
miRTarBase ID miRNA Experiments Reference
MIRT026745 hsa-miR-192-5p Microarray 19074876
MIRT047303 hsa-miR-181a-5p CLASH 23622248
MIRT046999 hsa-miR-181a-3p CLASH 23622248
MIRT039786 hsa-miR-615-3p CLASH 23622248
MIRT718763 hsa-miR-556-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
44
GO ID Ontology Definition Evidence Reference
GO:0000242 Component Pericentriolar material IEA
GO:0000242 Component Pericentriolar material ISS
GO:0005515 Function Protein binding IPI 17237231, 18799622, 23414517, 28514442, 32073997, 32296183, 33961781
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607825 23576 ENSG00000168172
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q86VS8
Protein name Protein Hook homolog 3 (h-hook3) (hHK3)
Protein function Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activat
PDB 5J8E , 6B9H , 8QAT , 9KNS , 9KO8
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF19047 HOOK_N 11 161 HOOK domain Domain
PF05622 HOOK 184 709 HOOK protein coiled-coil region Coiled-coil
Sequence
Sequence length 718
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Motor proteins  
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
2
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Short stature Likely pathogenic rs1563293555 RCV000736156
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Neoplasms Associate 23676460, 26230842, 27974047
Obesity Associate 34638758
Polycystic Ovary Syndrome Associate 37547318
Prostatic Neoplasms Associate 26230842