Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	84311
Gene name	Mitochondrial ribosomal protein L45
Gene symbol	MRPL45
Synonyms (NCBI Gene)	L45mtMRP-L45Mba1mL45
Chromosome	17
Chromosome location	17q12
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% prot

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miRTarBase ID	miRNA	Experiments	Reference
MIRT048023	hsa-miR-148a-3p	CLASH	23622248
MIRT044951	hsa-miR-186-5p	CLASH	23622248
MIRT710945	hsa-miR-500b-3p	HITS-CLIP	19536157
MIRT710943	hsa-miR-4530	HITS-CLIP	19536157
MIRT710944	hsa-miR-338-3p	HITS-CLIP	19536157
MIRT710942	hsa-miR-6072	HITS-CLIP	19536157
MIRT710941	hsa-miR-6891-3p	HITS-CLIP	19536157
MIRT710939	hsa-miR-2115-5p	HITS-CLIP	19536157
MIRT710940	hsa-miR-6512-3p	HITS-CLIP	19536157
MIRT710938	hsa-miR-6720-5p	HITS-CLIP	19536157
MIRT710945	hsa-miR-500b-3p	HITS-CLIP	19536157
MIRT710943	hsa-miR-4530	HITS-CLIP	19536157
MIRT710944	hsa-miR-338-3p	HITS-CLIP	19536157
MIRT710942	hsa-miR-6072	HITS-CLIP	19536157
MIRT710941	hsa-miR-6891-3p	HITS-CLIP	19536157
MIRT710939	hsa-miR-2115-5p	HITS-CLIP	19536157
MIRT710940	hsa-miR-6512-3p	HITS-CLIP	19536157
MIRT710938	hsa-miR-6720-5p	HITS-CLIP	19536157
MIRT1159437	hsa-miR-1272	CLIP-seq
MIRT1159438	hsa-miR-185	CLIP-seq
MIRT1159439	hsa-miR-196a	CLIP-seq
MIRT1159440	hsa-miR-196b	CLIP-seq
MIRT1159441	hsa-miR-2115	CLIP-seq
MIRT1159442	hsa-miR-2392	CLIP-seq
MIRT1159443	hsa-miR-298	CLIP-seq
MIRT1159444	hsa-miR-3174	CLIP-seq
MIRT1159445	hsa-miR-3682-3p	CLIP-seq
MIRT1159446	hsa-miR-3925-5p	CLIP-seq
MIRT1159447	hsa-miR-3944-5p	CLIP-seq
MIRT1159448	hsa-miR-4276	CLIP-seq
MIRT1159449	hsa-miR-4293	CLIP-seq
MIRT1159450	hsa-miR-4306	CLIP-seq
MIRT1159451	hsa-miR-4436b-5p	CLIP-seq
MIRT1159452	hsa-miR-4493	CLIP-seq
MIRT1159453	hsa-miR-4502	CLIP-seq
MIRT1159454	hsa-miR-4644	CLIP-seq
MIRT1159455	hsa-miR-4704-3p	CLIP-seq
MIRT1159456	hsa-miR-4727-5p	CLIP-seq
MIRT1159457	hsa-miR-4769-3p	CLIP-seq
MIRT1159458	hsa-miR-548m	CLIP-seq
MIRT1159459	hsa-miR-628-5p	CLIP-seq
MIRT1159444	hsa-miR-3174	CLIP-seq
MIRT2045749	hsa-miR-3672	CLIP-seq
MIRT1159448	hsa-miR-4276	CLIP-seq
MIRT1159449	hsa-miR-4293	CLIP-seq
MIRT1159451	hsa-miR-4436b-5p	CLIP-seq
MIRT2045750	hsa-miR-4512	CLIP-seq
MIRT2274714	hsa-miR-105	CLIP-seq
MIRT2274715	hsa-miR-128	CLIP-seq
MIRT2274716	hsa-miR-1296	CLIP-seq
MIRT2274717	hsa-miR-138	CLIP-seq
MIRT1159438	hsa-miR-185	CLIP-seq
MIRT1159439	hsa-miR-196a	CLIP-seq
MIRT1159440	hsa-miR-196b	CLIP-seq
MIRT2274718	hsa-miR-2114	CLIP-seq
MIRT1159441	hsa-miR-2115	CLIP-seq
MIRT2274719	hsa-miR-2117	CLIP-seq
MIRT2274720	hsa-miR-224	CLIP-seq
MIRT2274721	hsa-miR-2355-5p	CLIP-seq
MIRT1159442	hsa-miR-2392	CLIP-seq
MIRT2274722	hsa-miR-27a	CLIP-seq
MIRT2274723	hsa-miR-27b	CLIP-seq
MIRT1159443	hsa-miR-298	CLIP-seq
MIRT2274724	hsa-miR-3144-3p	CLIP-seq
MIRT2274725	hsa-miR-3148	CLIP-seq
MIRT2274726	hsa-miR-3153	CLIP-seq
MIRT2274727	hsa-miR-3163	CLIP-seq
MIRT2274728	hsa-miR-3168	CLIP-seq
MIRT1159444	hsa-miR-3174	CLIP-seq
MIRT2274729	hsa-miR-323b-5p	CLIP-seq
MIRT2274730	hsa-miR-340	CLIP-seq
MIRT2274731	hsa-miR-342-3p	CLIP-seq
MIRT2274732	hsa-miR-3620	CLIP-seq
MIRT2274733	hsa-miR-3662	CLIP-seq
MIRT2045749	hsa-miR-3672	CLIP-seq
MIRT2274734	hsa-miR-370	CLIP-seq
MIRT2274735	hsa-miR-3921	CLIP-seq
MIRT1159446	hsa-miR-3925-5p	CLIP-seq
MIRT1159447	hsa-miR-3944-5p	CLIP-seq
MIRT2274736	hsa-miR-412	CLIP-seq
MIRT2274737	hsa-miR-4273	CLIP-seq
MIRT1159448	hsa-miR-4276	CLIP-seq
MIRT2274738	hsa-miR-4282	CLIP-seq
MIRT1159449	hsa-miR-4293	CLIP-seq
MIRT1159450	hsa-miR-4306	CLIP-seq
MIRT1159451	hsa-miR-4436b-5p	CLIP-seq
MIRT2274739	hsa-miR-4457	CLIP-seq
MIRT2274740	hsa-miR-4468	CLIP-seq
MIRT1159452	hsa-miR-4493	CLIP-seq
MIRT2045750	hsa-miR-4512	CLIP-seq
MIRT1159454	hsa-miR-4644	CLIP-seq
MIRT2274741	hsa-miR-4648	CLIP-seq
MIRT2274742	hsa-miR-4653-5p	CLIP-seq
MIRT2274743	hsa-miR-4654	CLIP-seq
MIRT2274744	hsa-miR-4668-5p	CLIP-seq
MIRT1159455	hsa-miR-4704-3p	CLIP-seq
MIRT2274745	hsa-miR-4715-3p	CLIP-seq
MIRT2274746	hsa-miR-4722-3p	CLIP-seq
MIRT1159456	hsa-miR-4727-5p	CLIP-seq
MIRT2274747	hsa-miR-4728-3p	CLIP-seq
MIRT2274748	hsa-miR-4732-3p	CLIP-seq
MIRT2274749	hsa-miR-4766-5p	CLIP-seq
MIRT1159457	hsa-miR-4769-3p	CLIP-seq
MIRT2274750	hsa-miR-4769-5p	CLIP-seq
MIRT2274751	hsa-miR-494	CLIP-seq
MIRT2274752	hsa-miR-513b	CLIP-seq
MIRT2274753	hsa-miR-548a-3p	CLIP-seq
MIRT2274754	hsa-miR-548ae	CLIP-seq
MIRT2274755	hsa-miR-548aj	CLIP-seq
MIRT2274756	hsa-miR-548am	CLIP-seq
MIRT2274757	hsa-miR-548e	CLIP-seq
MIRT2274758	hsa-miR-548f	CLIP-seq
MIRT1159458	hsa-miR-548m	CLIP-seq
MIRT2274759	hsa-miR-548x	CLIP-seq
MIRT2274760	hsa-miR-549	CLIP-seq
MIRT2274761	hsa-miR-579	CLIP-seq
MIRT2274762	hsa-miR-587	CLIP-seq
MIRT2274763	hsa-miR-593	CLIP-seq
MIRT2274764	hsa-miR-607	CLIP-seq
MIRT2274765	hsa-miR-875-5p	CLIP-seq
MIRT2274766	hsa-miR-944	CLIP-seq
MIRT1159437	hsa-miR-1272	CLIP-seq
MIRT2274720	hsa-miR-224	CLIP-seq
MIRT1159445	hsa-miR-3682-3p	CLIP-seq
MIRT1159451	hsa-miR-4436b-5p	CLIP-seq
MIRT2274739	hsa-miR-4457	CLIP-seq
MIRT1159452	hsa-miR-4493	CLIP-seq
MIRT1159453	hsa-miR-4502	CLIP-seq
MIRT1159456	hsa-miR-4727-5p	CLIP-seq
MIRT1159457	hsa-miR-4769-3p	CLIP-seq
MIRT2274752	hsa-miR-513b	CLIP-seq
MIRT1159459	hsa-miR-628-5p	CLIP-seq
MIRT1159437	hsa-miR-1272	CLIP-seq
MIRT2274716	hsa-miR-1296	CLIP-seq
MIRT2274717	hsa-miR-138	CLIP-seq
MIRT2573667	hsa-miR-146b-3p	CLIP-seq
MIRT1159438	hsa-miR-185	CLIP-seq
MIRT1159439	hsa-miR-196a	CLIP-seq
MIRT1159440	hsa-miR-196b	CLIP-seq
MIRT1159441	hsa-miR-2115	CLIP-seq
MIRT1159442	hsa-miR-2392	CLIP-seq
MIRT2274724	hsa-miR-3144-3p	CLIP-seq
MIRT2274727	hsa-miR-3163	CLIP-seq
MIRT2274728	hsa-miR-3168	CLIP-seq
MIRT2573668	hsa-miR-3173-5p	CLIP-seq
MIRT2573669	hsa-miR-3184	CLIP-seq
MIRT2573670	hsa-miR-3187-3p	CLIP-seq
MIRT2274729	hsa-miR-323b-5p	CLIP-seq
MIRT2573671	hsa-miR-330-3p	CLIP-seq
MIRT2573672	hsa-miR-3605-5p	CLIP-seq
MIRT2274732	hsa-miR-3620	CLIP-seq
MIRT2045749	hsa-miR-3672	CLIP-seq
MIRT1159445	hsa-miR-3682-3p	CLIP-seq
MIRT1159446	hsa-miR-3925-5p	CLIP-seq
MIRT2274736	hsa-miR-412	CLIP-seq
MIRT2573673	hsa-miR-423-5p	CLIP-seq
MIRT2274738	hsa-miR-4282	CLIP-seq
MIRT2573674	hsa-miR-4305	CLIP-seq
MIRT1159450	hsa-miR-4306	CLIP-seq
MIRT2274740	hsa-miR-4468	CLIP-seq
MIRT1159453	hsa-miR-4502	CLIP-seq
MIRT2045750	hsa-miR-4512	CLIP-seq
MIRT2573675	hsa-miR-4529-5p	CLIP-seq
MIRT1159454	hsa-miR-4644	CLIP-seq
MIRT2573676	hsa-miR-4679	CLIP-seq
MIRT1159455	hsa-miR-4704-3p	CLIP-seq
MIRT2573677	hsa-miR-4714-5p	CLIP-seq
MIRT2274745	hsa-miR-4715-3p	CLIP-seq
MIRT2573678	hsa-miR-4716-5p	CLIP-seq
MIRT2274751	hsa-miR-494	CLIP-seq
MIRT2573679	hsa-miR-511	CLIP-seq
MIRT2573680	hsa-miR-520d-5p	CLIP-seq
MIRT2573681	hsa-miR-524-5p	CLIP-seq
MIRT1159458	hsa-miR-548m	CLIP-seq
MIRT2274760	hsa-miR-549	CLIP-seq
MIRT2274761	hsa-miR-579	CLIP-seq
MIRT2573682	hsa-miR-583	CLIP-seq
MIRT2274764	hsa-miR-607	CLIP-seq
MIRT1159459	hsa-miR-628-5p	CLIP-seq
MIRT2573683	hsa-miR-874	CLIP-seq
MIRT2274765	hsa-miR-875-5p	CLIP-seq
MIRT1159437	hsa-miR-1272	CLIP-seq
MIRT2274716	hsa-miR-1296	CLIP-seq
MIRT2274717	hsa-miR-138	CLIP-seq
MIRT2573667	hsa-miR-146b-3p	CLIP-seq
MIRT1159438	hsa-miR-185	CLIP-seq
MIRT1159439	hsa-miR-196a	CLIP-seq
MIRT1159440	hsa-miR-196b	CLIP-seq
MIRT1159441	hsa-miR-2115	CLIP-seq
MIRT1159442	hsa-miR-2392	CLIP-seq
MIRT2274727	hsa-miR-3163	CLIP-seq
MIRT2274728	hsa-miR-3168	CLIP-seq
MIRT2573668	hsa-miR-3173-5p	CLIP-seq
MIRT2573669	hsa-miR-3184	CLIP-seq
MIRT2274729	hsa-miR-323b-5p	CLIP-seq
MIRT2573671	hsa-miR-330-3p	CLIP-seq
MIRT2573672	hsa-miR-3605-5p	CLIP-seq
MIRT2274732	hsa-miR-3620	CLIP-seq
MIRT2045749	hsa-miR-3672	CLIP-seq
MIRT1159445	hsa-miR-3682-3p	CLIP-seq
MIRT1159446	hsa-miR-3925-5p	CLIP-seq
MIRT2274736	hsa-miR-412	CLIP-seq
MIRT2573673	hsa-miR-423-5p	CLIP-seq
MIRT2274738	hsa-miR-4282	CLIP-seq
MIRT1159450	hsa-miR-4306	CLIP-seq
MIRT2274740	hsa-miR-4468	CLIP-seq
MIRT1159453	hsa-miR-4502	CLIP-seq
MIRT2045750	hsa-miR-4512	CLIP-seq
MIRT1159454	hsa-miR-4644	CLIP-seq
MIRT2573676	hsa-miR-4679	CLIP-seq
MIRT1159455	hsa-miR-4704-3p	CLIP-seq
MIRT2573677	hsa-miR-4714-5p	CLIP-seq
MIRT2274745	hsa-miR-4715-3p	CLIP-seq
MIRT2573680	hsa-miR-520d-5p	CLIP-seq
MIRT2573681	hsa-miR-524-5p	CLIP-seq
MIRT1159458	hsa-miR-548m	CLIP-seq
MIRT2274760	hsa-miR-549	CLIP-seq
MIRT2274761	hsa-miR-579	CLIP-seq
MIRT2573682	hsa-miR-583	CLIP-seq
MIRT2274763	hsa-miR-593	CLIP-seq
MIRT2274764	hsa-miR-607	CLIP-seq
MIRT1159459	hsa-miR-628-5p	CLIP-seq
MIRT2573683	hsa-miR-874	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003735	Function	Structural constituent of ribosome	IDA	33602856
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	33602856
GO:0005739	Component	Mitochondrion	IDA	28892042
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	NAS	27023846
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005762	Component	Mitochondrial large ribosomal subunit	IDA	25278503, 28892042, 33602856
GO:0005762	Component	Mitochondrial large ribosomal subunit	NAS	25278503
GO:0005840	Component	Ribosome	IEA
GO:0032543	Process	Mitochondrial translation	IDA	33602856
GO:0032543	Process	Mitochondrial translation	NAS	27023846
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
611850	16651	ENSG00000278845

Q9BRJ2

Protein name

Large ribosomal subunit protein mL45 (39S ribosomal protein L45, mitochondrial) (L45mt) (MRP-L45)

Protein function

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:25278503, PubMed:25838379, PubMed:28892042, PubMed:33602856, PubMed:35177605). Within the mitochondrial ribosomes, required to direct the nascent polypeptide toward the tunn

PDB

3J7Y , 3J9M , 5OOL , 5OOM , 6I9R , 6NU2 , 6NU3 , 6VLZ , 6VMI , 6ZM5 , 6ZM6 , 6ZS9 , 6ZSA , 6ZSB , 6ZSC , 6ZSD , 6ZSE , 6ZSG , 7A5F , 7A5G , 7A5H , 7A5I , 7A5J , 7A5K , 7L08 , 7L20 , 7O9K , 7O9M , 7ODR , 7ODS , 7ODT , 7OF0 , 7OF2 , 7OF3 , 7OF4 , 7OF5 , 7OF6 , 7OF7 , 7OG4 , 7OI6 , 7OI7 , 7OI8 , 7OI9 , 7OIA , 7OIB , 7OIC , 7OID , 7OIE , 7PD3 , 7PO4 , 7QH6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04280	Tim44	118 → 266	Tim44-like domain	Domain

Sequence

MAAPIPQGFSCLSRFLGWWFRQPVLVTQSAAIVPVRTKKRFTPPIYQPKFKTEKEFMQHA
RKAGLVIPPEKSDRSIHLACTAGIFDAYVPPEGDARISSLSKEGLIERTERMKKTMASQV
SIRRIKDYDANFKIKDFPEKAKDIFIEAHLCLNNSDHDRLHTLVTEHCFPDMTWDIKYKT
VRWSFVESLEPSHVVQVRCSSMMNQGNVYGQITVRMHTRQTLAIYDRFGRLMYGQEDVPK
DVLEYVVFEKQLTNPYGSWRMHTKIVPPWAPPKQPILKTVMIPGPQLKPEEEYEEAQGEA
QKPQLA

Sequence length

306

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
GASTRIC ULCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LATE-ONSET ALZHEIMER'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

MRPL45 (mitochondrial ribosomal protein L45)