MIEN1 (migration and invasion enhancer 1)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
84299
Gene name Gene Name - the full gene name approved by the HGNC.
Migration and invasion enhancer 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MIEN1
Synonyms (NCBI Gene) Gene synonyms aliases
C17orf37, C35, ORB3, RDX12, XTP4
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q12
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(4)
miRTarBase ID miRNA Experiments Reference
MIRT051901 hsa-let-7b-5p CLASH 23622248
MIRT046933 hsa-miR-221-3p CLASH 23622248
MIRT731265 hsa-miR-26b-5p Luciferase reporter assay 26827826
MIRT731265 hsa-miR-26b-5p Luciferase reporter assay 26827826
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(16)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956, 29721183, 31694235, 32296183, 32867128
GO:0005737 Component Cytoplasm IEA
GO:0005739 Component Mitochondrion HTP 34800366
GO:0005829 Component Cytosol IBA
GO:0005829 Component Cytosol IDA 21628459
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
611802 28230 ENSG00000141741
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q9BRT3
Protein name Migration and invasion enhancer 1 (HBV X-transactivated gene 4 protein) (HBV XAg-transactivated protein 4) (Protein C35)
Protein function Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process. {ECO:0000269|PubMed:19503095
PDB 2LJK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10262 Rdx 24 → 95 Rdx family Family
Tissue specificity TISSUE SPECIFICITY: Among normal tissues, present only in Leydig cells. Strongly up-regulated in breast cancers and in brain cancer distant metastasis (at protein level). Up-regulated in prostate cancer cells and in the higher grades of prostate adenocarc
Sequence
Sequence length 115
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Unknown Diseases (3)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Inflammatory Bowel Disease Inflammatory bowel disease (MTAG) N/A N/A GWAS
Systemic lupus erythematosus Systemic lupus erythematosus N/A N/A GWAS
Ulcerative colitis Ulcerative colitis N/A N/A GWAS
Show/Hide Text Mining Associations (22)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Alzheimer Disease Associate 37762058
Breast Neoplasms Associate 19503095, 20628393, 21068479, 26173296, 26781796, 27462783, 28198505, 29033401, 30286132
Breast Neoplasms Stimulate 28859163
Carcinoma Ductal Breast Associate 28859163
Carcinoma Non Small Cell Lung Associate 37075843
Carcinoma Ovarian Epithelial Associate 34839022, 37525498
Colorectal Neoplasms Associate 26173296, 27194589
Inflammation Associate 26484354
Lung Neoplasms Associate 37075843
Lymphatic Metastasis Associate 26781796