Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
84288
Gene name Gene Name - the full gene name approved by the HGNC.
Dynein regulatory complex subunit 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DRC8
Synonyms (NCBI Gene) Gene synonyms aliases
CFAP200, EFCAB2
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q44
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT607856 hsa-miR-431-5p HITS-CLIP 23824327
MIRT607855 hsa-miR-4711-3p HITS-CLIP 23824327
MIRT607854 hsa-miR-6867-5p HITS-CLIP 23824327
MIRT607853 hsa-miR-574-5p HITS-CLIP 23824327
MIRT607856 hsa-miR-431-5p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005509 Function Calcium ion binding IEA
GO:0005737 Component Cytoplasm IEA
GO:0005856 Component Cytoskeleton IEA
GO:0031514 Component Motile cilium IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
619617 28166 ENSG00000203666
Protein
UniProt ID Q5VUJ9
Protein name Dynein regulatory complex protein 8 (EF-hand calcium-binding domain-containing protein 2)
Protein function Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. {ECO:0000250|UniProtK
PDB 8J07
Family and domains
Sequence
MLGPGQVRLRPRVWRDKAGGRVADGASGLPPARGSWRETGTGRALGASSPPRPAQGSSSP
GIQSGPSSRPGSPRGAEQAGTPRPRLSLGISQATGSAARWRTRRTGKGLGYNSDEIRPRT
LLIEHLMEGGRRDHHTMTVLWGTQEIIVAEFHKKIKEAFEVFDHESNNTVDVREIGTIIR
SLGCCPTEGELHDLIAEVEEEEPTGYIRFEKFLPVMTEILLERKYRPIPEDVLLRAFEVL
DSAKRGFLTKDELIKYMTEEDGVSLRRPG
Sequence length 269
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colonic neoplasms Malignant tumor of colon rs267607789, rs774277300, rs781222233, rs1060502734, rs1060503333, rs1339238483 30529582
Colorectal cancer Colorectal Carcinoma, Adenocarcinoma of large intestine rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
30529582
Colorectal neoplasms Colorectal Neoplasms, Malignant neoplasm of large intestine rs28929483, rs63751108, rs28929484, rs63749831, rs63750047, rs63751207, rs63749811, rs1553350126, rs63750875, rs63750955, rs587776706, rs63750871, rs587776715, rs63751466, rs63750049
View all (1682 more)
30529582