AKAP19 (A-kinase anchoring protein 19)

Gene

• Entrez ID: 84281
• Gene name: A-kinase anchoring protein 19
• Gene symbol: AKAP19
• Synonyms (NCBI Gene): C2orf88, smAKAP
• Chromosome: 2
• Chromosome location: 2q32.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT045898	hsa-miR-125b-5p	CLASH	23622248
MIRT846516	hsa-miR-3616-5p	CLIP-seq
MIRT846517	hsa-miR-3647-5p	CLIP-seq
MIRT846518	hsa-miR-3671	CLIP-seq
MIRT846519	hsa-miR-573	CLIP-seq
MIRT846520	hsa-miR-607	CLIP-seq
MIRT846521	hsa-miR-218	CLIP-seq
MIRT846522	hsa-miR-302a	CLIP-seq
MIRT846523	hsa-miR-302b	CLIP-seq
MIRT846524	hsa-miR-302c	CLIP-seq
MIRT846525	hsa-miR-302d	CLIP-seq
MIRT846526	hsa-miR-302e	CLIP-seq
MIRT846527	hsa-miR-3661	CLIP-seq
MIRT846528	hsa-miR-372	CLIP-seq
MIRT846529	hsa-miR-373	CLIP-seq
MIRT846530	hsa-miR-4307	CLIP-seq
MIRT738146	hsa-miR-433	CLIP-seq
MIRT846531	hsa-miR-4659a-3p	CLIP-seq
MIRT846532	hsa-miR-4659b-3p	CLIP-seq
MIRT846533	hsa-miR-4713-5p	CLIP-seq
MIRT846534	hsa-miR-4775	CLIP-seq
MIRT846535	hsa-miR-4778-3p	CLIP-seq
MIRT846536	hsa-miR-512-3p	CLIP-seq
MIRT846537	hsa-miR-519a	CLIP-seq
MIRT846538	hsa-miR-519b-3p	CLIP-seq
MIRT846539	hsa-miR-519c-3p	CLIP-seq
MIRT846540	hsa-miR-520a-3p	CLIP-seq
MIRT846541	hsa-miR-520b	CLIP-seq
MIRT846542	hsa-miR-520c-3p	CLIP-seq
MIRT846543	hsa-miR-520d-3p	CLIP-seq
MIRT846544	hsa-miR-520e	CLIP-seq
MIRT846545	hsa-miR-605	CLIP-seq
MIRT846546	hsa-miR-619	CLIP-seq
MIRT846547	hsa-miR-631	CLIP-seq
MIRT846548	hsa-miR-636	CLIP-seq
MIRT846549	hsa-miR-875-3p	CLIP-seq
MIRT846550	hsa-miR-942	CLIP-seq
MIRT1951246	hsa-miR-23a	CLIP-seq
MIRT1951247	hsa-miR-23b	CLIP-seq
MIRT1951248	hsa-miR-23c	CLIP-seq
MIRT1951249	hsa-miR-3140-3p	CLIP-seq
MIRT1951250	hsa-miR-3714	CLIP-seq
MIRT1951251	hsa-miR-4272	CLIP-seq
MIRT1951252	hsa-miR-4729	CLIP-seq
MIRT2445638	hsa-let-7a	CLIP-seq
MIRT2445639	hsa-let-7b	CLIP-seq
MIRT2445640	hsa-let-7c	CLIP-seq
MIRT2445641	hsa-let-7d	CLIP-seq
MIRT2445642	hsa-let-7e	CLIP-seq
MIRT2445643	hsa-let-7f	CLIP-seq
MIRT2445644	hsa-let-7g	CLIP-seq
MIRT2445645	hsa-let-7i	CLIP-seq
MIRT2445646	hsa-miR-3591-5p	CLIP-seq
MIRT2445647	hsa-miR-3927	CLIP-seq
MIRT2445648	hsa-miR-4255	CLIP-seq
MIRT2445649	hsa-miR-4282	CLIP-seq
MIRT2445650	hsa-miR-4458	CLIP-seq
MIRT2445651	hsa-miR-4500	CLIP-seq
MIRT2445652	hsa-miR-548an	CLIP-seq
MIRT2445653	hsa-miR-570	CLIP-seq
MIRT2445654	hsa-miR-877	CLIP-seq
MIRT2445655	hsa-miR-891a	CLIP-seq
MIRT2445656	hsa-miR-98	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 25416956, 31515488, 32296183
GO:0005886	Component	Plasma membrane	IEA
GO:0034237	Function	Protein kinase A regulatory subunit binding	IEA

Other IDs

• MIM: 615117
• HGNC: 28191
• e!Ensembl: ENSG00000187699

Protein

• UniProt ID: Q9BSF0
• Protein name: Small membrane A-kinase anchor protein (Small membrane AKAP) (smAKAP)
• Protein function: Binds to type I regulatory subunits of protein kinase A (PKA-RI) and may anchor/target them to the plasma membrane.
• PDB: 5HVZ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15127	SmAKAP	1 → 94	Small membrane A-kinase anchor protein	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in heart (at protein level). {ECO:0000269|PubMed:23115245}.
• Sequence:

  MGCMKSKQTFPFPTIYEGEKQHESEEPFMPEERCLPRMASPVNVKEEVKEPPGTNTVILE
  YAHRLSQDILCDALQQWACNNIKYHDIPYIESEGP

• Sequence length: 95

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Arthritis	Juvenile arthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	19565504
Myostatin-related muscle hypertrophy	Myostatin-related muscle hypertrophy	rs397515373