Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
8428
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Serine/threonine kinase 24 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
STK24 |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
HEL-S-95, MST3, MST3B, STE20, STK3 |
Chromosome
Chromosome number
|
13 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
13q32.2 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and |
UniProt ID |
Q9Y6E0
|
Protein name |
Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/ |
Protein function |
Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 |
PDB |
3A7F
,
3A7G
,
3A7H
,
3A7I
,
3A7J
,
3CKW
,
3CKX
,
3ZHP
,
4O27
,
4QML
,
4QMM
,
4QMN
,
4QMO
,
4QMP
,
4QMQ
,
4QMS
,
4QMT
,
4QMU
,
4QMV
,
4QMW
,
4QMX
,
4QMY
,
4QMZ
,
4QNA
,
4QO9
,
4U8Z
,
4W8D
,
4W8E
,
7B30
,
7B31
,
7B32
,
7B33
,
7B34
,
7B35
,
8BZI
,
8BZJ
,
8QLQ
,
8QLR
,
8QLS
,
8QLT
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00069
|
Pkinase |
36 → 286 |
Protein kinase domain |
Domain |
|
Tissue specificity |
TISSUE SPECIFICITY: Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex. |
Sequence |
|
Sequence length |
443 |
Interactions |
View interactions
|
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Schizophrenia |
Schizophrenia |
rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 View all (12 more) |
31374203 |
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Mental depression |
Major Depressive Disorder |
|
30718901 |
ClinVar |
Neuroticism |
Neuroticism |
|
|
GWAS |
Mental Depression |
Mental Depression |
|
|
GWAS |
Gastroesophageal Reflux Disease |
Gastroesophageal Reflux Disease |
|
|
GWAS |
Metabolic Syndrome |
Metabolic Syndrome |
|
|
GWAS |
Diabetes |
Diabetes |
|
|
GWAS |
Insomnia |
Insomnia |
|
|
GWAS |
|
Associations from Text Mining |
Disease Name |
Relationship Type |
References |
Adenocarcinoma of Lung |
Stimulate
|
37181807 |
Bone Neoplasms |
Associate
|
30281149 |
Colorectal Neoplasms |
Associate
|
22095101 |
Inflammation |
Associate
|
17321610 |
Keratoconus |
Associate
|
28159702 |
Lung Neoplasms |
Associate
|
37181807 |
Neoplasms |
Associate
|
30281149, 37181807 |
Sarcoma Clear Cell |
Associate
|
12966428 |
Small Cell Lung Carcinoma |
Associate
|
31199602 |
Supratentorial Neoplasms |
Associate
|
30514397 |
|