Gene Gene information from NCBI Gene database.
Entrez ID 8428
Gene name Serine/threonine kinase 24
Gene symbol STK24
Synonyms (NCBI Gene)
HEL-S-95MST3MST3BSTE20STK3
Chromosome 13
Chromosome location 13q32.2
Summary This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and
miRNA miRNA information provided by mirtarbase database.
409
miRTarBase ID miRNA Experiments Reference
MIRT020540 hsa-miR-155-5p Proteomics 18668040
MIRT023521 hsa-miR-1-3p Proteomics 18668040
MIRT045062 hsa-miR-186-5p CLASH 23622248
MIRT036877 hsa-miR-877-3p CLASH 23622248
MIRT720090 hsa-miR-140-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
46
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0004672 Function Protein kinase activity IEA
GO:0004672 Function Protein kinase activity TAS 9353338
GO:0004674 Function Protein serine/threonine kinase activity IBA
GO:0004674 Function Protein serine/threonine kinase activity IDA 16314523, 17046825
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604984 11403 ENSG00000102572
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9Y6E0
Protein name Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/
Protein function Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2
PDB 3A7F , 3A7G , 3A7H , 3A7I , 3A7J , 3CKW , 3CKX , 3ZHP , 4O27 , 4QML , 4QMM , 4QMN , 4QMO , 4QMP , 4QMQ , 4QMS , 4QMT , 4QMU , 4QMV , 4QMW , 4QMX , 4QMY , 4QMZ , 4QNA , 4QO9 , 4U8Z , 4W8D , 4W8E , 7B30 , 7B31 , 7B32 , 7B33 , 7B34 , 7B35 , 8BZI , 8BZJ , 8QLQ , 8QLR , 8QLS , 8QLT
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 36 286 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex.
Sequence
MDSRAQLWGLALNKRRATLPHPGGSTNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQK
VVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSAL
DLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQ
LTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVL
FLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI
LRNAKKTSYLTELI
DRYKRWKAEQSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDLD
RNKMKDIPKRPFSQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISD
TMVAQLVQRLQRYSLSGGGTSSH
Sequence length 443
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
11
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ANXIETY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DYSLEXIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GASTROESOPHAGEAL REFLUX DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenocarcinoma of Lung Stimulate 37181807
★☆☆☆☆
Found in Text Mining only
Bone Neoplasms Associate 30281149
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Associate 22095101
★☆☆☆☆
Found in Text Mining only
Inflammation Associate 17321610
★☆☆☆☆
Found in Text Mining only
Keratoconus Associate 28159702
★☆☆☆☆
Found in Text Mining only
Lung Neoplasms Associate 37181807
★☆☆☆☆
Found in Text Mining only
Neoplasms Associate 30281149, 37181807
★☆☆☆☆
Found in Text Mining only
Sarcoma Clear Cell Associate 12966428
★☆☆☆☆
Found in Text Mining only
Small Cell Lung Carcinoma Associate 31199602
★☆☆☆☆
Found in Text Mining only
Supratentorial Neoplasms Associate 30514397
★☆☆☆☆
Found in Text Mining only