Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8428
Gene name Gene Name - the full gene name approved by the HGNC.
Serine/threonine kinase 24
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
STK24
Synonyms (NCBI Gene) Gene synonyms aliases
HEL-S-95, MST3, MST3B, STE20, STK3
Chromosome Chromosome number
13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
13q32.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020540 hsa-miR-155-5p Proteomics 18668040
MIRT023521 hsa-miR-1-3p Proteomics 18668040
MIRT045062 hsa-miR-186-5p CLASH 23622248
MIRT036877 hsa-miR-877-3p CLASH 23622248
MIRT720090 hsa-miR-140-5p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004672 Function Protein kinase activity TAS 9353338
GO:0004674 Function Protein serine/threonine kinase activity IDA 16314523, 17046825
GO:0005515 Function Protein binding IPI 16189514, 17657516, 18782753, 20332113, 21516116, 23455922, 23541896, 25531779, 27807006, 28169274, 31515488
GO:0005524 Function ATP binding IEA
GO:0005634 Component Nucleus IDA 12107159
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604984 11403 ENSG00000102572
Protein
UniProt ID Q9Y6E0
Protein name Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/
Protein function Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2
PDB 3A7F , 3A7G , 3A7H , 3A7I , 3A7J , 3CKW , 3CKX , 3ZHP , 4O27 , 4QML , 4QMM , 4QMN , 4QMO , 4QMP , 4QMQ , 4QMS , 4QMT , 4QMU , 4QMV , 4QMW , 4QMX , 4QMY , 4QMZ , 4QNA , 4QO9 , 4U8Z , 4W8D , 4W8E , 7B30 , 7B31 , 7B32 , 7B33 , 7B34 , 7B35 , 8BZI , 8BZJ , 8QLQ , 8QLR , 8QLS , 8QLT
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 36 286 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex.
Sequence
MDSRAQLWGLALNKRRATLPHPGGSTNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQK
VVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSAL
DLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQ
LTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVL
FLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI
LRNAKKTSYLTELI
DRYKRWKAEQSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDLD
RNKMKDIPKRPFSQCLSTIISPLFAELKEKSQACGGNLGSIEELRGAIYLAEEACPGISD
TMVAQLVQRLQRYSLSGGGTSSH
Sequence length 443
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
31374203
Unknown
Disease term Disease name Evidence References Source
Mental depression Major Depressive Disorder 30718901 ClinVar
Neuroticism Neuroticism GWAS
Mental Depression Mental Depression GWAS
Gastroesophageal Reflux Disease Gastroesophageal Reflux Disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Stimulate 37181807
Bone Neoplasms Associate 30281149
Colorectal Neoplasms Associate 22095101
Inflammation Associate 17321610
Keratoconus Associate 28159702
Lung Neoplasms Associate 37181807
Neoplasms Associate 30281149, 37181807
Sarcoma Clear Cell Associate 12966428
Small Cell Lung Carcinoma Associate 31199602
Supratentorial Neoplasms Associate 30514397