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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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8428
|
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Serine/threonine kinase 24 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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STK24 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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HEL-S-95, MST3, MST3B, STE20, STK3 |
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Chromosome
Chromosome number
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13 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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13q32.2 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and |
| UniProt ID |
Q9Y6E0
|
| Protein name |
Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/ |
| Protein function |
Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 |
| PDB |
3A7F
,
3A7G
,
3A7H
,
3A7I
,
3A7J
,
3CKW
,
3CKX
,
3ZHP
,
4O27
,
4QML
,
4QMM
,
4QMN
,
4QMO
,
4QMP
,
4QMQ
,
4QMS
,
4QMT
,
4QMU
,
4QMV
,
4QMW
,
4QMX
,
4QMY
,
4QMZ
,
4QNA
,
4QO9
,
4U8Z
,
4W8D
,
4W8E
,
7B30
,
7B31
,
7B32
,
7B33
,
7B34
,
7B35
,
8BZI
,
8BZJ
,
8QLQ
,
8QLR
,
8QLS
,
8QLT
|
| Family and domains |
Pfam
| Accession |
ID |
Position in sequence |
Description |
Type |
|
PF00069
|
Pkinase |
36 → 286 |
Protein kinase domain |
Domain |
|
| Tissue specificity |
TISSUE SPECIFICITY: Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex. |
| Sequence |
|
| Sequence length |
443 |
| Interactions |
View interactions
|