STK24 (serine/threonine kinase 24)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 8428 |
| Gene name | Serine/threonine kinase 24 |
| Gene symbol | STK24 |
| Synonyms (NCBI Gene) |
HEL-S-95MST3MST3BSTE20STK3
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| Chromosome | 13 |
| Chromosome location | 13q32.2 |
| Summary | This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and |
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miRNA
miRNA information provided by mirtarbase database.
409
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9Y6E0 | ||||||||||
| Protein name | Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/ | ||||||||||
| Protein function | Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 | ||||||||||
| PDB | 3A7F , 3A7G , 3A7H , 3A7I , 3A7J , 3CKW , 3CKX , 3ZHP , 4O27 , 4QML , 4QMM , 4QMN , 4QMO , 4QMP , 4QMQ , 4QMS , 4QMT , 4QMU , 4QMV , 4QMW , 4QMX , 4QMY , 4QMZ , 4QNA , 4QO9 , 4U8Z , 4W8D , 4W8E , 7B30 , 7B31 , 7B32 , 7B33 , 7B34 , 7B35 , 8BZI , 8BZJ , 8QLQ , 8QLR , 8QLS , 8QLT | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex. | ||||||||||
| Sequence |
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| Sequence length | 443 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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