HSDL2 (hydroxysteroid dehydrogenase like 2)

Gene

• Entrez ID: 84263
• Gene name: Hydroxysteroid dehydrogenase like 2
• Gene symbol: HSDL2
• Synonyms (NCBI Gene): C9orf99, SDR13C1
• Chromosome: 9
• Chromosome location: 9q32

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT000865	hsa-miR-15a-5p	Microarray	18362358
MIRT000864	hsa-miR-16-5p	Microarray	18362358
MIRT043745	hsa-miR-328-3p	CLASH	23622248
MIRT756041	hsa-miR-26a-5p	Luciferase reporter assay, Western blotting, qRT-PCR, Immunohistochemistry (IHC), Flow cytometry	35948893
MIRT1055674	hsa-miR-2467-3p	CLIP-seq
MIRT1055675	hsa-miR-4422	CLIP-seq
MIRT1055676	hsa-miR-516a-3p	CLIP-seq
MIRT1055677	hsa-miR-103a	CLIP-seq
MIRT1055678	hsa-miR-107	CLIP-seq
MIRT1055679	hsa-miR-1182	CLIP-seq
MIRT1055680	hsa-miR-1323	CLIP-seq
MIRT1055681	hsa-miR-138	CLIP-seq
MIRT1055682	hsa-miR-183	CLIP-seq
MIRT1055683	hsa-miR-193a-5p	CLIP-seq
MIRT1055684	hsa-miR-2053	CLIP-seq
MIRT1055685	hsa-miR-224	CLIP-seq
MIRT1055686	hsa-miR-300	CLIP-seq
MIRT1055687	hsa-miR-302f	CLIP-seq
MIRT1055688	hsa-miR-3132	CLIP-seq
MIRT1055689	hsa-miR-3182	CLIP-seq
MIRT1055690	hsa-miR-3183	CLIP-seq
MIRT1055691	hsa-miR-338-5p	CLIP-seq
MIRT1055692	hsa-miR-3545-3p	CLIP-seq
MIRT1055693	hsa-miR-375	CLIP-seq
MIRT1055694	hsa-miR-381	CLIP-seq
MIRT1055695	hsa-miR-4273	CLIP-seq
MIRT1055696	hsa-miR-4278	CLIP-seq
MIRT1055697	hsa-miR-4451	CLIP-seq
MIRT1055698	hsa-miR-4484	CLIP-seq
MIRT1055699	hsa-miR-4659a-3p	CLIP-seq
MIRT1055700	hsa-miR-4659b-3p	CLIP-seq
MIRT1055701	hsa-miR-4666-3p	CLIP-seq
MIRT1055702	hsa-miR-4677-5p	CLIP-seq
MIRT1055703	hsa-miR-4716-3p	CLIP-seq
MIRT1055704	hsa-miR-4720-3p	CLIP-seq
MIRT1055705	hsa-miR-4723-3p	CLIP-seq
MIRT1055706	hsa-miR-4781-3p	CLIP-seq
MIRT1055707	hsa-miR-4786-3p	CLIP-seq
MIRT1055708	hsa-miR-4804-3p	CLIP-seq
MIRT1055709	hsa-miR-548an	CLIP-seq
MIRT1055710	hsa-miR-548o	CLIP-seq
MIRT1055711	hsa-miR-550b	CLIP-seq
MIRT2012777	hsa-miR-1267	CLIP-seq
MIRT2012778	hsa-miR-3180-5p	CLIP-seq
MIRT2012779	hsa-miR-4274	CLIP-seq
MIRT2012780	hsa-miR-4519	CLIP-seq
MIRT2012781	hsa-miR-4661-5p	CLIP-seq
MIRT2012782	hsa-miR-495	CLIP-seq
MIRT2012783	hsa-miR-520a-5p	CLIP-seq
MIRT2012784	hsa-miR-525-5p	CLIP-seq
MIRT2012785	hsa-miR-579	CLIP-seq
MIRT2012786	hsa-miR-944	CLIP-seq
MIRT2245105	hsa-miR-1976	CLIP-seq
MIRT2547977	hsa-miR-181a	CLIP-seq
MIRT2547978	hsa-miR-181b	CLIP-seq
MIRT2547979	hsa-miR-181c	CLIP-seq
MIRT2547980	hsa-miR-181d	CLIP-seq
MIRT2547981	hsa-miR-23a	CLIP-seq
MIRT2547982	hsa-miR-23b	CLIP-seq
MIRT2547983	hsa-miR-23c	CLIP-seq
MIRT2547984	hsa-miR-4262	CLIP-seq
MIRT2547985	hsa-miR-1193	CLIP-seq
MIRT2547986	hsa-miR-1273f	CLIP-seq
MIRT2547987	hsa-miR-127-5p	CLIP-seq
MIRT2547988	hsa-miR-1343	CLIP-seq
MIRT2547989	hsa-miR-136	CLIP-seq
MIRT2547990	hsa-miR-143	CLIP-seq
MIRT2547991	hsa-miR-185	CLIP-seq
MIRT2547992	hsa-miR-203	CLIP-seq
MIRT1055684	hsa-miR-2053	CLIP-seq
MIRT2547993	hsa-miR-21	CLIP-seq
MIRT2547994	hsa-miR-3156-3p	CLIP-seq
MIRT2547995	hsa-miR-3163	CLIP-seq
MIRT2547996	hsa-miR-3198	CLIP-seq
MIRT2547997	hsa-miR-3690	CLIP-seq
MIRT2547998	hsa-miR-421	CLIP-seq
MIRT2547999	hsa-miR-4254	CLIP-seq
MIRT2548000	hsa-miR-4272	CLIP-seq
MIRT2548001	hsa-miR-4301	CLIP-seq
MIRT2548002	hsa-miR-4306	CLIP-seq
MIRT2548003	hsa-miR-4307	CLIP-seq
MIRT2548004	hsa-miR-4309	CLIP-seq
MIRT2548005	hsa-miR-432	CLIP-seq
MIRT2548006	hsa-miR-4453	CLIP-seq
MIRT2548007	hsa-miR-4494	CLIP-seq
MIRT2548008	hsa-miR-4534	CLIP-seq
MIRT2548009	hsa-miR-4538	CLIP-seq
MIRT2548010	hsa-miR-4644	CLIP-seq
MIRT2548011	hsa-miR-4653-3p	CLIP-seq
MIRT2548012	hsa-miR-4659a-5p	CLIP-seq
MIRT2548013	hsa-miR-4659b-5p	CLIP-seq
MIRT2548014	hsa-miR-4666-5p	CLIP-seq
MIRT2548015	hsa-miR-4708-5p	CLIP-seq
MIRT2548016	hsa-miR-4738-3p	CLIP-seq
MIRT2548017	hsa-miR-4770	CLIP-seq
MIRT2548018	hsa-miR-4776-3p	CLIP-seq
MIRT2548019	hsa-miR-4780	CLIP-seq
MIRT2548020	hsa-miR-4802-3p	CLIP-seq
MIRT2548021	hsa-miR-4803	CLIP-seq
MIRT2548022	hsa-miR-548ac	CLIP-seq
MIRT2548023	hsa-miR-548ae	CLIP-seq
MIRT2548024	hsa-miR-548aj	CLIP-seq
MIRT2548025	hsa-miR-548am	CLIP-seq
MIRT2548026	hsa-miR-548d-3p	CLIP-seq
MIRT2548027	hsa-miR-548g	CLIP-seq
MIRT2548028	hsa-miR-548x	CLIP-seq
MIRT2548029	hsa-miR-548z	CLIP-seq
MIRT2548030	hsa-miR-561	CLIP-seq
MIRT2548031	hsa-miR-590-5p	CLIP-seq
MIRT2548032	hsa-miR-676	CLIP-seq
MIRT2548033	hsa-miR-877	CLIP-seq
MIRT2547985	hsa-miR-1193	CLIP-seq
MIRT2547986	hsa-miR-1273f	CLIP-seq
MIRT2547987	hsa-miR-127-5p	CLIP-seq
MIRT2547988	hsa-miR-1343	CLIP-seq
MIRT2547989	hsa-miR-136	CLIP-seq
MIRT2682466	hsa-miR-140-3p	CLIP-seq
MIRT2547990	hsa-miR-143	CLIP-seq
MIRT2547991	hsa-miR-185	CLIP-seq
MIRT2547992	hsa-miR-203	CLIP-seq
MIRT2547993	hsa-miR-21	CLIP-seq
MIRT2547994	hsa-miR-3156-3p	CLIP-seq
MIRT2547995	hsa-miR-3163	CLIP-seq
MIRT2547996	hsa-miR-3198	CLIP-seq
MIRT2547997	hsa-miR-3690	CLIP-seq
MIRT2547998	hsa-miR-421	CLIP-seq
MIRT2547999	hsa-miR-4254	CLIP-seq
MIRT2548000	hsa-miR-4272	CLIP-seq
MIRT2548001	hsa-miR-4301	CLIP-seq
MIRT2548002	hsa-miR-4306	CLIP-seq
MIRT2548003	hsa-miR-4307	CLIP-seq
MIRT2548004	hsa-miR-4309	CLIP-seq
MIRT2548005	hsa-miR-432	CLIP-seq
MIRT2548007	hsa-miR-4494	CLIP-seq
MIRT2548008	hsa-miR-4534	CLIP-seq
MIRT2548010	hsa-miR-4644	CLIP-seq
MIRT2548011	hsa-miR-4653-3p	CLIP-seq
MIRT2548014	hsa-miR-4666-5p	CLIP-seq
MIRT2548015	hsa-miR-4708-5p	CLIP-seq
MIRT2548016	hsa-miR-4738-3p	CLIP-seq
MIRT2682467	hsa-miR-4769-3p	CLIP-seq
MIRT2548017	hsa-miR-4770	CLIP-seq
MIRT2548019	hsa-miR-4780	CLIP-seq
MIRT2548020	hsa-miR-4802-3p	CLIP-seq
MIRT2548021	hsa-miR-4803	CLIP-seq
MIRT2548022	hsa-miR-548ac	CLIP-seq
MIRT2548023	hsa-miR-548ae	CLIP-seq
MIRT2548024	hsa-miR-548aj	CLIP-seq
MIRT2548025	hsa-miR-548am	CLIP-seq
MIRT2548026	hsa-miR-548d-3p	CLIP-seq
MIRT2548027	hsa-miR-548g	CLIP-seq
MIRT2548028	hsa-miR-548x	CLIP-seq
MIRT2548029	hsa-miR-548z	CLIP-seq
MIRT2548030	hsa-miR-561	CLIP-seq
MIRT2548031	hsa-miR-590-5p	CLIP-seq
MIRT2548032	hsa-miR-676	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA	38820148
GO:0005739	Component	Mitochondrion	IEA
GO:0005777	Component	Peroxisome	IDA	19703561
GO:0005777	Component	Peroxisome	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016229	Function	Steroid dehydrogenase activity	IDA	19703561
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0042632	Process	Cholesterol homeostasis	IEA
GO:0042632	Process	Cholesterol homeostasis	IMP	38820148

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q6YN16
• Protein name: Hydroxysteroid dehydrogenase-like protein 2 (EC 1.-.-.-) (Short chain dehydrogenase/reductase family 13C member 1)
• Protein function: Has apparently no steroid dehydrogenase activity (PubMed:19703561). Controls bile acid (BA) and lipid metabolism in response to nutritional cues (PubMed:38820148).
• PDB: 3KVO
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00106	adh_short	11 → 209	short chain dehydrogenase	Domain
  PF02036	SCP2	310 → 412	SCP-2 sterol transfer family	Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:12834046}.
• Sequence:

  MLPNTGRLAGCTVFITGASRGIGKAIALKAAKDGANIVIAAKTAQPHPKLLGTIYTAAEE
  IEAVGGKALPCIVDVRDEQQISAAVEKAIKKFGGIDILVNNASAISLTNTLDTPTKRLDL
  MMNVNTRGTYLASKACIPYLKKSKVAHILNISPPLNLNPVWFKQHCAYTIAKYGMSMYVL
  GMAEEFKGEIAVNALWPKTAIHTAAMDMLGGPGIESQCRKVDIIADAAYSIFQKPKSFTG
  NFVIDENILKEEGIENFDVYAIKPGHPLQPDFFLDEYPEAVSKKVESTGAVPEFKEEKLQ
  LQPKPRSGAVEETFRIVKDSLSDDVVKATQAIYLFELSGEDGGTWFLDLKSKGGNVGYGE
  PSDQADVVMSMTTDDFVKMFSGKLKPTMAFMSGKLKIKGNMALAIKLEKLMNQMNARL

• Sequence length: 418