Gene Gene information from NCBI Gene database.
Entrez ID 84255
Gene name Solute carrier family 37 member 3
Gene symbol SLC37A3
Synonyms (NCBI Gene)
SPX3
Chromosome 7
Chromosome location 7q34
miRNA miRNA information provided by mirtarbase database.
383
miRTarBase ID miRNA Experiments Reference
MIRT021553 hsa-miR-142-3p Microarray 17612493
MIRT025190 hsa-miR-181a-5p Sequencing 20371350
MIRT028288 hsa-miR-32-5p Sequencing 20371350
MIRT534219 hsa-miR-3925-5p PAR-CLIP 20371350
MIRT534218 hsa-miR-3123 PAR-CLIP 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 29745899
GO:0005764 Component Lysosome IEA
GO:0005765 Component Lysosomal membrane IDA 29745899
GO:0005765 Component Lysosomal membrane IEA
GO:0005783 Component Endoplasmic reticulum IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
619137 20651 ENSG00000157800
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8NCC5
Protein name Sugar phosphate exchanger 3 (Solute carrier family 37 member 3)
Protein function Unlike the other SLC37 members, lacks glucose-6-phosphate antiporter activity (PubMed:21949678). In osteoclasts, forms a transporter complex with ATRAID for nitrogen-containing-bisphophonates (N-BPs) required for releasing N-BP molecules that ha
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07690 MFS_1 23 419 Major Facilitator Superfamily Family
Tissue specificity TISSUE SPECIFICITY: Expressed in liver, kidney, intestine and pancreas. {ECO:0000269|PubMed:21949678}.
Sequence
Sequence length 494
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
8
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANDROGENETIC ALOPECIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Cervical cancer Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
EYE DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Carcinoma Hepatocellular Associate 36773462
★☆☆☆☆
Found in Text Mining only
Congenital Hyperinsulinism Associate 23869231
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Type 1 Associate 36773462
★☆☆☆☆
Found in Text Mining only
Neoplasm Metastasis Associate 36773462
★☆☆☆☆
Found in Text Mining only
Retinitis Pigmentosa Associate 35486108
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Tuberculosis Associate 36476775
★☆☆☆☆
Found in Text Mining only