Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	84254
Gene name	Calcium/calmodulin dependent protein kinase kinase 1
Gene symbol	CAMKK1
Synonyms (NCBI Gene)	CAMKKA
Chromosome	17
Chromosome location	17p13.2
Summary	The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants

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miRTarBase ID	miRNA	Experiments	Reference
MIRT053703	hsa-miR-221-3p	Microarray	22942087
MIRT860413	hsa-miR-3688-5p	CLIP-seq
MIRT860414	hsa-miR-4633-5p	CLIP-seq
MIRT860415	hsa-miR-4650-5p	CLIP-seq
MIRT860416	hsa-miR-4663	CLIP-seq
MIRT860417	hsa-miR-4755-3p	CLIP-seq
MIRT860418	hsa-miR-532-5p	CLIP-seq
MIRT860419	hsa-miR-885-3p	CLIP-seq
MIRT860420	hsa-miR-106a	CLIP-seq
MIRT860421	hsa-miR-106b	CLIP-seq
MIRT860422	hsa-miR-1294	CLIP-seq
MIRT860423	hsa-miR-132	CLIP-seq
MIRT860424	hsa-miR-17	CLIP-seq
MIRT860425	hsa-miR-20a	CLIP-seq
MIRT860426	hsa-miR-20b	CLIP-seq
MIRT860427	hsa-miR-2114	CLIP-seq
MIRT860428	hsa-miR-212	CLIP-seq
MIRT860429	hsa-miR-2278	CLIP-seq
MIRT860430	hsa-miR-302a	CLIP-seq
MIRT860431	hsa-miR-302b	CLIP-seq
MIRT860432	hsa-miR-302c	CLIP-seq
MIRT860433	hsa-miR-302d	CLIP-seq
MIRT860434	hsa-miR-302e	CLIP-seq
MIRT860435	hsa-miR-3120-5p	CLIP-seq
MIRT860436	hsa-miR-3136-3p	CLIP-seq
MIRT860437	hsa-miR-346	CLIP-seq
MIRT860438	hsa-miR-3614-5p	CLIP-seq
MIRT860439	hsa-miR-3689a-3p	CLIP-seq
MIRT860440	hsa-miR-3689c	CLIP-seq
MIRT860441	hsa-miR-371b-3p	CLIP-seq
MIRT860442	hsa-miR-372	CLIP-seq
MIRT860443	hsa-miR-373	CLIP-seq
MIRT860444	hsa-miR-4270	CLIP-seq
MIRT860445	hsa-miR-4286	CLIP-seq
MIRT860446	hsa-miR-4288	CLIP-seq
MIRT860447	hsa-miR-4292	CLIP-seq
MIRT860448	hsa-miR-4308	CLIP-seq
MIRT860449	hsa-miR-4316	CLIP-seq
MIRT860450	hsa-miR-4421	CLIP-seq
MIRT860451	hsa-miR-4441	CLIP-seq
MIRT860452	hsa-miR-4685-5p	CLIP-seq
MIRT860453	hsa-miR-4709-5p	CLIP-seq
MIRT860454	hsa-miR-4719	CLIP-seq
MIRT860455	hsa-miR-4724-5p	CLIP-seq
MIRT860456	hsa-miR-4786-3p	CLIP-seq
MIRT860457	hsa-miR-508-5p	CLIP-seq
MIRT860458	hsa-miR-512-3p	CLIP-seq
MIRT860459	hsa-miR-519d	CLIP-seq
MIRT860460	hsa-miR-520a-3p	CLIP-seq
MIRT860461	hsa-miR-520b	CLIP-seq
MIRT860462	hsa-miR-520c-3p	CLIP-seq
MIRT860463	hsa-miR-520d-3p	CLIP-seq
MIRT860464	hsa-miR-520e	CLIP-seq
MIRT860465	hsa-miR-520g	CLIP-seq
MIRT860466	hsa-miR-520h	CLIP-seq
MIRT860467	hsa-miR-595	CLIP-seq
MIRT860468	hsa-miR-632	CLIP-seq
MIRT860469	hsa-miR-671-5p	CLIP-seq
MIRT860470	hsa-miR-93	CLIP-seq
MIRT860435	hsa-miR-3120-5p	CLIP-seq
MIRT860437	hsa-miR-346	CLIP-seq
MIRT860446	hsa-miR-4288	CLIP-seq
MIRT860450	hsa-miR-4421	CLIP-seq
MIRT860456	hsa-miR-4786-3p	CLIP-seq
MIRT860468	hsa-miR-632	CLIP-seq
MIRT860469	hsa-miR-671-5p	CLIP-seq
MIRT2193079	hsa-miR-515-5p	CLIP-seq
MIRT2193080	hsa-miR-2110	CLIP-seq
MIRT860435	hsa-miR-3120-5p	CLIP-seq
MIRT2193081	hsa-miR-3140-3p	CLIP-seq
MIRT2193082	hsa-miR-3150a-3p	CLIP-seq
MIRT2193083	hsa-miR-3175	CLIP-seq
MIRT860437	hsa-miR-346	CLIP-seq
MIRT860446	hsa-miR-4288	CLIP-seq
MIRT2193084	hsa-miR-4300	CLIP-seq
MIRT860450	hsa-miR-4421	CLIP-seq
MIRT2193085	hsa-miR-4438	CLIP-seq
MIRT860456	hsa-miR-4786-3p	CLIP-seq
MIRT2193086	hsa-miR-558	CLIP-seq
MIRT860468	hsa-miR-632	CLIP-seq
MIRT860469	hsa-miR-671-5p	CLIP-seq
MIRT2193087	hsa-miR-920	CLIP-seq
MIRT2193088	hsa-miR-939	CLIP-seq
MIRT2385513	hsa-miR-3184	CLIP-seq
MIRT2385514	hsa-miR-423-5p	CLIP-seq
MIRT2385515	hsa-miR-4728-5p	CLIP-seq
MIRT2496165	hsa-miR-1277	CLIP-seq
MIRT2496166	hsa-miR-3121-3p	CLIP-seq
MIRT2496167	hsa-miR-4738-3p	CLIP-seq
MIRT2496168	hsa-miR-4742-3p	CLIP-seq
MIRT2496169	hsa-miR-548g	CLIP-seq
MIRT2677332	hsa-miR-1205	CLIP-seq
MIRT2677333	hsa-miR-1225-3p	CLIP-seq
MIRT2677334	hsa-miR-3908	CLIP-seq
MIRT2677335	hsa-miR-4323	CLIP-seq
MIRT2677336	hsa-miR-4514	CLIP-seq
MIRT2677337	hsa-miR-4692	CLIP-seq
MIRT2677338	hsa-miR-604	CLIP-seq
MIRT2677339	hsa-miR-647	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004683	Function	Calcium/calmodulin-dependent protein kinase activity	IBA
GO:0004683	Function	Calcium/calmodulin-dependent protein kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	18242179, 28514442, 32707033, 32814053, 33961781, 36931259
GO:0005516	Function	Calmodulin binding	IBA
GO:0005516	Function	Calmodulin binding	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0106310	Function	Protein serine kinase activity	IEA

MIM	HGNC	e!Ensembl
611411	1469	ENSG00000004660

Q8N5S9

Protein name

Calcium/calmodulin-dependent protein kinase kinase 1 (CaM-KK 1) (CaM-kinase kinase 1) (CaMKK 1) (EC 2.7.11.17) (CaM-kinase IV kinase) (Calcium/calmodulin-dependent protein kinase kinase alpha) (CaM-KK alpha) (CaM-kinase kinase alpha) (CaMKK alpha)

Protein function

Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promote

PDB

6CCF , 6CD6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	128 → 409	Protein kinase domain	Domain

Sequence

MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR
LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE
DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ
AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME
VPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF
EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA
LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSE
EEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNL
LVKEGFGEGGKSPELPGVQEDEAAS

Sequence length

505

Interactions

View interactions

	KEGG		Reactome
	Alcoholism		CaMK IV-mediated phosphorylation of CREB CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Activation of RAC1 downstream of NMDARs

CAMKK1 (calcium/calmodulin dependent protein kinase kinase 1)