Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
84223
Gene name Gene Name - the full gene name approved by the HGNC.
Dynein regulatory complex subunit 9
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DRC9
Synonyms (NCBI Gene) Gene synonyms aliases
CFAP122, IQCG
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q29
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019420 hsa-miR-148b-3p Microarray 17612493
MIRT025135 hsa-miR-181a-5p Microarray 17612493
MIRT442472 hsa-miR-548e-5p PAR-CLIP 22100165
MIRT025135 hsa-miR-181a-5p PAR-CLIP 22100165
MIRT442471 hsa-miR-181b-5p PAR-CLIP 22100165
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002177 Component Manchette ISS
GO:0005516 Function Calmodulin binding IDA 24787902
GO:0005737 Component Cytoplasm IBA 21873635
GO:0005737 Component Cytoplasm IDA 24787902
GO:0005829 Component Cytosol IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
612477 25251 ENSG00000114473
Protein
UniProt ID Q9H095
Protein name Dynein regulatory complex protein 9 (IQ domain-containing protein G)
Protein function Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when
PDB 4LZX , 4M1L , 8J07
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00612 IQ 394 413 IQ calmodulin-binding motif Motif
Sequence
MEEDSLEDSNLPPKVWHSEMTVSVTGEPPSTVEEEGIPKETDIEIIPEIPETLEPLSLPD
VLRISAVLEDTTDQLSILNYIMPVQYEGRQSICVKSREMNLEGTNLDKLPMASTITKIPS
PLITEEGPNLPEIRHRGRFAVEFNKMQDLVFKKPTRQTIMTTETLKKIQIDRQFFSDVIA
DTIKELQDSATYNSLLQALSKERENKMHFYDIIAREEKGRKQIISLQKQLINVKKEWQFE
VQSQNEYIANLKDQLQEMKAKSNLENRYMKTNTELQIAQTQKKCNRTEELLVEEIEKLRM
KTEEEARTHTEIEMFLRKEQQKLEERLEFWMEKYDKDTEMKQNELNALKATKASDLAHLQ
DLAKMIREYEQVIIEDRIEKERSKKKVKQDLLELKSVIKLQAWWRGTMIRREIGGFKMPK
DKVDSKDSKGKGKGKDKRRGKKK
Sequence length 443
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Anemia Anemia, Diamond-Blackfan rs118204044, rs118204045, rs118204046, rs121918330, rs869320719, rs869312029, rs121918332, rs869320724, rs767094129, rs786205058, rs786205059, rs137853119, rs137853120, rs137853121, rs1384933966
View all (89 more)
Diamond-blackfan anemia Diamond-Blackfan Anemia 5 rs121434389, rs1570566590, rs151155897, rs143951267, rs267607023, rs786200892, rs148622862, rs397507554, rs121434405, rs1571026775, rs142156224, rs267607021, rs1581931541, rs267607022, rs61762293
View all (76 more)
25946618, 18535205