Gene Gene information from NCBI Gene database.
Entrez ID 84187
Gene name Transmembrane protein 164
Gene symbol TMEM164
Synonyms (NCBI Gene)
bB360B22.3
Chromosome X
Chromosome location Xq23
miRNA miRNA information provided by mirtarbase database.
737
miRTarBase ID miRNA Experiments Reference
MIRT016431 hsa-miR-193b-3p Microarray 20304954
MIRT024394 hsa-miR-215-5p Microarray 19074876
MIRT026233 hsa-miR-192-5p Microarray 19074876
MIRT027458 hsa-miR-98-5p Microarray 19088304
MIRT528467 hsa-miR-4668-3p PAR-CLIP 22012620
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
3
GO ID Ontology Definition Evidence Reference
GO:0016020 Component Membrane IEA
GO:0160020 Process Positive regulation of ferroptosis IBA
GO:0160020 Process Positive regulation of ferroptosis IDA 35947500
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q5U3C3
Protein name Transmembrane protein 164 (Arachidonoyl ether phospholipid synthase)
Protein function Positive regulator of ferroptosis (PubMed:35947500, PubMed:36782012). Involved in the acylation of ether lysophospholipids with the arachidonoyl chain (5Z,8Z,11Z,14Z-eicosatetraenoyl; C20:4) of diacylglycerophospholipids, generating C20:4 ether
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF14808 TMEM164 10 274 TMEM164 family Family
Sequence
Sequence length 297
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
SCOLIOSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1 Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations