Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	84166
Gene name	NLR family CARD domain containing 5
Gene symbol	NLRC5
Synonyms (NCBI Gene)	CLR16.1NOD27NOD4
Chromosome	16
Chromosome location	16q13
Summary	This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling p

164

Show/Hide all (164)

miRTarBase ID	miRNA	Experiments	Reference
MIRT725318	hsa-miR-149-5p	HITS-CLIP	19536157
MIRT725317	hsa-miR-6808-5p	HITS-CLIP	19536157
MIRT725316	hsa-miR-6893-5p	HITS-CLIP	19536157
MIRT725315	hsa-miR-940	HITS-CLIP	19536157
MIRT725314	hsa-miR-3126-3p	HITS-CLIP	19536157
MIRT725313	hsa-miR-4514	HITS-CLIP	19536157
MIRT725312	hsa-miR-4692	HITS-CLIP	19536157
MIRT725311	hsa-miR-3158-5p	HITS-CLIP	19536157
MIRT725310	hsa-miR-1184	HITS-CLIP	19536157
MIRT725309	hsa-miR-1205	HITS-CLIP	19536157
MIRT725308	hsa-miR-17-3p	HITS-CLIP	19536157
MIRT725307	hsa-miR-4794	HITS-CLIP	19536157
MIRT725306	hsa-miR-664a-5p	HITS-CLIP	19536157
MIRT725305	hsa-miR-3064-5p	HITS-CLIP	19536157
MIRT725303	hsa-miR-6504-5p	HITS-CLIP	19536157
MIRT725304	hsa-miR-4736	HITS-CLIP	19536157
MIRT725302	hsa-miR-452-3p	HITS-CLIP	19536157
MIRT725301	hsa-miR-6511b-5p	HITS-CLIP	19536157
MIRT725300	hsa-miR-6811-5p	HITS-CLIP	19536157
MIRT725299	hsa-miR-216b-5p	HITS-CLIP	19536157
MIRT440105	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440105	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT725318	hsa-miR-149-5p	HITS-CLIP	19536157
MIRT725317	hsa-miR-6808-5p	HITS-CLIP	19536157
MIRT725316	hsa-miR-6893-5p	HITS-CLIP	19536157
MIRT725315	hsa-miR-940	HITS-CLIP	19536157
MIRT725314	hsa-miR-3126-3p	HITS-CLIP	19536157
MIRT725313	hsa-miR-4514	HITS-CLIP	19536157
MIRT725312	hsa-miR-4692	HITS-CLIP	19536157
MIRT725311	hsa-miR-3158-5p	HITS-CLIP	19536157
MIRT725310	hsa-miR-1184	HITS-CLIP	19536157
MIRT725309	hsa-miR-1205	HITS-CLIP	19536157
MIRT725308	hsa-miR-17-3p	HITS-CLIP	19536157
MIRT725307	hsa-miR-4794	HITS-CLIP	19536157
MIRT725306	hsa-miR-664a-5p	HITS-CLIP	19536157
MIRT725305	hsa-miR-3064-5p	HITS-CLIP	19536157
MIRT725303	hsa-miR-6504-5p	HITS-CLIP	19536157
MIRT725304	hsa-miR-4736	HITS-CLIP	19536157
MIRT725302	hsa-miR-452-3p	HITS-CLIP	19536157
MIRT725301	hsa-miR-6511b-5p	HITS-CLIP	19536157
MIRT725300	hsa-miR-6811-5p	HITS-CLIP	19536157
MIRT725299	hsa-miR-216b-5p	HITS-CLIP	19536157
MIRT1187203	hsa-miR-1262	CLIP-seq
MIRT1187204	hsa-miR-1293	CLIP-seq
MIRT1187205	hsa-miR-1343	CLIP-seq
MIRT1187206	hsa-miR-147	CLIP-seq
MIRT1187207	hsa-miR-3165	CLIP-seq
MIRT1187208	hsa-miR-362-5p	CLIP-seq
MIRT1187209	hsa-miR-3667-3p	CLIP-seq
MIRT1187210	hsa-miR-378g	CLIP-seq
MIRT1187211	hsa-miR-425	CLIP-seq
MIRT1187212	hsa-miR-4258	CLIP-seq
MIRT1187213	hsa-miR-4289	CLIP-seq
MIRT1187214	hsa-miR-4483	CLIP-seq
MIRT1187215	hsa-miR-4691-5p	CLIP-seq
MIRT1187216	hsa-miR-4701-3p	CLIP-seq
MIRT1187217	hsa-miR-4755-3p	CLIP-seq
MIRT1187218	hsa-miR-500b	CLIP-seq
MIRT1187219	hsa-miR-501-5p	CLIP-seq
MIRT1187220	hsa-miR-515-5p	CLIP-seq
MIRT1187221	hsa-miR-579	CLIP-seq
MIRT2054217	hsa-miR-103a	CLIP-seq
MIRT2054218	hsa-miR-107	CLIP-seq
MIRT2054219	hsa-miR-1197	CLIP-seq
MIRT2054220	hsa-miR-1224-5p	CLIP-seq
MIRT2054221	hsa-miR-125a-5p	CLIP-seq
MIRT2054222	hsa-miR-125b	CLIP-seq
MIRT2054223	hsa-miR-1286	CLIP-seq
MIRT2054224	hsa-miR-1288	CLIP-seq
MIRT2054225	hsa-miR-214	CLIP-seq
MIRT2054226	hsa-miR-3169	CLIP-seq
MIRT2054227	hsa-miR-3619-5p	CLIP-seq
MIRT2054228	hsa-miR-4287	CLIP-seq
MIRT2054229	hsa-miR-4319	CLIP-seq
MIRT2054230	hsa-miR-4418	CLIP-seq
MIRT2054231	hsa-miR-4436a	CLIP-seq
MIRT2054232	hsa-miR-4469	CLIP-seq
MIRT2054233	hsa-miR-4685-3p	CLIP-seq
MIRT2054234	hsa-miR-4732-3p	CLIP-seq
MIRT2054235	hsa-miR-4751	CLIP-seq
MIRT2054236	hsa-miR-509-3-5p	CLIP-seq
MIRT2054237	hsa-miR-509-5p	CLIP-seq
MIRT2054238	hsa-miR-544b	CLIP-seq
MIRT2054239	hsa-miR-670	CLIP-seq
MIRT2054240	hsa-miR-761	CLIP-seq
MIRT2054238	hsa-miR-544b	CLIP-seq
MIRT2054217	hsa-miR-103a	CLIP-seq
MIRT2054218	hsa-miR-107	CLIP-seq
MIRT2054219	hsa-miR-1197	CLIP-seq
MIRT2054220	hsa-miR-1224-5p	CLIP-seq
MIRT2054221	hsa-miR-125a-5p	CLIP-seq
MIRT2054222	hsa-miR-125b	CLIP-seq
MIRT2054223	hsa-miR-1286	CLIP-seq
MIRT2054224	hsa-miR-1288	CLIP-seq
MIRT1187206	hsa-miR-147	CLIP-seq
MIRT2581589	hsa-miR-1909	CLIP-seq
MIRT2581590	hsa-miR-198	CLIP-seq
MIRT2054225	hsa-miR-214	CLIP-seq
MIRT2581591	hsa-miR-2355-3p	CLIP-seq
MIRT2581592	hsa-miR-3064-3p	CLIP-seq
MIRT2581593	hsa-miR-3121-5p	CLIP-seq
MIRT2054226	hsa-miR-3169	CLIP-seq
MIRT2581594	hsa-miR-33a	CLIP-seq
MIRT2581595	hsa-miR-33b	CLIP-seq
MIRT2581596	hsa-miR-3613-3p	CLIP-seq
MIRT2054227	hsa-miR-3619-5p	CLIP-seq
MIRT2581597	hsa-miR-377	CLIP-seq
MIRT2581598	hsa-miR-410	CLIP-seq
MIRT2581599	hsa-miR-4267	CLIP-seq
MIRT2054228	hsa-miR-4287	CLIP-seq
MIRT1187213	hsa-miR-4289	CLIP-seq
MIRT2054229	hsa-miR-4319	CLIP-seq
MIRT2054230	hsa-miR-4418	CLIP-seq
MIRT2054231	hsa-miR-4436a	CLIP-seq
MIRT2054232	hsa-miR-4469	CLIP-seq
MIRT2581600	hsa-miR-451	CLIP-seq
MIRT2581601	hsa-miR-4646-3p	CLIP-seq
MIRT2054233	hsa-miR-4685-3p	CLIP-seq
MIRT2581602	hsa-miR-4713-5p	CLIP-seq
MIRT2054234	hsa-miR-4732-3p	CLIP-seq
MIRT2581603	hsa-miR-4733-5p	CLIP-seq
MIRT2054235	hsa-miR-4751	CLIP-seq
MIRT2581604	hsa-miR-4789-3p	CLIP-seq
MIRT2054236	hsa-miR-509-3-5p	CLIP-seq
MIRT2054237	hsa-miR-509-5p	CLIP-seq
MIRT2054238	hsa-miR-544b	CLIP-seq
MIRT2581605	hsa-miR-586	CLIP-seq
MIRT2581606	hsa-miR-662	CLIP-seq
MIRT2054239	hsa-miR-670	CLIP-seq
MIRT2054240	hsa-miR-761	CLIP-seq
MIRT2054220	hsa-miR-1224-5p	CLIP-seq
MIRT2054221	hsa-miR-125a-5p	CLIP-seq
MIRT2054222	hsa-miR-125b	CLIP-seq
MIRT2054224	hsa-miR-1288	CLIP-seq
MIRT1187206	hsa-miR-147	CLIP-seq
MIRT2581589	hsa-miR-1909	CLIP-seq
MIRT2581590	hsa-miR-198	CLIP-seq
MIRT2581591	hsa-miR-2355-3p	CLIP-seq
MIRT2581592	hsa-miR-3064-3p	CLIP-seq
MIRT2581593	hsa-miR-3121-5p	CLIP-seq
MIRT2054226	hsa-miR-3169	CLIP-seq
MIRT2581596	hsa-miR-3613-3p	CLIP-seq
MIRT2581597	hsa-miR-377	CLIP-seq
MIRT2581598	hsa-miR-410	CLIP-seq
MIRT2581599	hsa-miR-4267	CLIP-seq
MIRT2054228	hsa-miR-4287	CLIP-seq
MIRT1187213	hsa-miR-4289	CLIP-seq
MIRT2054229	hsa-miR-4319	CLIP-seq
MIRT2054230	hsa-miR-4418	CLIP-seq
MIRT2054232	hsa-miR-4469	CLIP-seq
MIRT2581600	hsa-miR-451	CLIP-seq
MIRT2581601	hsa-miR-4646-3p	CLIP-seq
MIRT2054233	hsa-miR-4685-3p	CLIP-seq
MIRT2581602	hsa-miR-4713-5p	CLIP-seq
MIRT2054234	hsa-miR-4732-3p	CLIP-seq
MIRT2581603	hsa-miR-4733-5p	CLIP-seq
MIRT2054235	hsa-miR-4751	CLIP-seq
MIRT2581604	hsa-miR-4789-3p	CLIP-seq
MIRT2054236	hsa-miR-509-3-5p	CLIP-seq
MIRT2054237	hsa-miR-509-5p	CLIP-seq
MIRT2054238	hsa-miR-544b	CLIP-seq
MIRT2581605	hsa-miR-586	CLIP-seq
MIRT2581606	hsa-miR-662	CLIP-seq
MIRT2054239	hsa-miR-670	CLIP-seq

Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	20639463
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	20434986
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	20639463
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	20061403, 20434986
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA
GO:0005829	Component	Cytosol	IDA	20639463
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0009617	Process	Response to bacterium	IEA
GO:0032088	Process	Negative regulation of NF-kappaB transcription factor activity	IDA	20434986
GO:0043549	Process	Regulation of kinase activity	IDA	20434986
GO:0045087	Process	Innate immune response	IEA
GO:0045087	Process	Innate immune response	IMP	20434986
GO:0045345	Process	Positive regulation of MHC class I biosynthetic process	IBA
GO:0045345	Process	Positive regulation of MHC class I biosynthetic process	IDA	20639463
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	20639463
GO:0051607	Process	Defense response to virus	IEP	20061403
GO:0060335	Process	Positive regulation of type II interferon-mediated signaling pathway	IDA	20061403
GO:0060335	Process	Positive regulation of type II interferon-mediated signaling pathway	IMP	20639463
GO:0060339	Process	Negative regulation of type I interferon-mediated signaling pathway	IBA
GO:0060339	Process	Negative regulation of type I interferon-mediated signaling pathway	IDA	20434986
GO:0060339	Process	Negative regulation of type I interferon-mediated signaling pathway	IEA
GO:0060340	Process	Positive regulation of type I interferon-mediated signaling pathway	IDA	20061403

MIM	HGNC	e!Ensembl
613537	29933	ENSG00000140853

Q86WI3

Protein name

Protein NLRC5 (Caterpiller protein 16.1) (CLR16.1) (Nucleotide-binding oligomerization domain protein 27) (Nucleotide-binding oligomerization domain protein 4)

Protein function

Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. {ECO:0000269|P

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF18461	Atypical_Card	1 → 95	Atypical caspase recruitment domain	Domain
PF05729	NACHT	222 → 383	NACHT domain	Domain
PF17776	NLRC4_HD2	514 → 629	NLRC4 helical domain HD2	Domain
PF13516	LRR_6	869 → 891	Leucine Rich repeat	Repeat
PF13516	LRR_6	1006 → 1025	Leucine Rich repeat	Repeat
PF13516	LRR_6	1604 → 1627	Leucine Rich repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Expressed in spleen, thymus, lung, brain, tonsil, heart and prostate. {ECO:0000269|PubMed:20061403, ECO:0000269|PubMed:20434986}.

Sequence

MDPVGLQLGNKNLWSCLVRLLTKDPEWLNAKMKFFLPNTDLDSRNETLDPEQRVILQLNK
LHVQGSDTWQSFIHCVCMQLEVPLDLEVLLLSTFGYDDGFTSQLGAEGKSQPESQLHHGL
KRPHQSCGSSPRRKQCKKQQLELAKKYLQLLRTSAQQRYRSQIPGSGQPHAFHQVYVPPI
LRRATASLDTPEGAIMGDVKVEDGADVSISDLFNTRVNKGPRVTVLLGKAGMGKTTLAHR
LCQKWAEGHLNCFQALFLFEFRQLNLITRFLTPSELLFDLYLSPESDHDTVFQYLEKNAD
QVLLIFDGLDEALQPMGPDGPGPVLTLFSHLCNGTLLPGCRVMATSRPGKLPACLPAEAA
MVHMLGFDGPRVEEYVNHFFSAQPSREGALVELQTNGRLRSLCAVPALCQVACLCLHHLL
PDHAPGQSVALLPNMTQLYMQMVLALSPPGHLPTSSLLDLGEVALRGLETGKVIFYAKDI
APPLIAFGATHSLLTSFCVCTGPGHQQTGYAFTHLSLQEFLAALHLMASPKVNKDTLTQY
VTLHSRWVQRTKARLGLSDHLPTFLAGLASCTCRPFLSHLAQGNEDCVGAKQAAVVQVLK
KLATRKLTGPKVVELCHCVDETQEPELASLTAQSLPYQLPFHNFPLTCTDLATLTNILEH
REAPIHLDFDGCPLEPHCPEALVGCGQIENLSFKSRKCGDAFAEALSRSLPTMGRLQMLG
LAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSN
SICVSTLLCLARVAVTCPTVRMLQAREADLIFLLSPPTETTAELQRAPDLQESDGQRKGA
QSRSLTLRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIA
RKLDLSNNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQEPEEQKGPQERAAF
LDSLMLQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEG
AARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDK
TSRDMWATGSLPDFPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLEL
QLSCEFLSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDLRS
LHHATLHFRSNEEEEGVCCGRFTGCSLSQEHVESLCWLLSKCKDLSQVDLSANLLGDSGL
RCLLECLPQVPISGLLDLSHNSISQESALYLLETLPSCPRVREASVNLGSEQSFRIHFSR
EDQAGKTLRLSECSFRPEHVSRLATGLSKSLQLTELTLTQCCLGQKQLAILLSLVGRPAG
LFSLRVQEPWADRARVLSLLEVCAQASGSVTEISISETQQQLCVQLEFPRQEENPEAVAL
RLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFR
LTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHL
LLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGD
AGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTAL
GLAQELPQHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLAGGVLRFCMELP
LLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKR
VDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPIPCDMAQHLKSQEPRLDFAFFDNQP
QAPWGT

Sequence length

1866

Interactions

View interactions

	Reactome
			DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Likely benign	rs377644369	RCV005939351
Cervical cancer	Likely benign	rs377644369	RCV005939352
Clear cell carcinoma of kidney	Benign; Likely benign	rs190737526	RCV005910062
Familial cancer of breast	Benign; Likely benign	rs190737526	RCV005910061
Ovarian serous cystadenocarcinoma	Uncertain significance; Benign; Likely benign	rs779319734, rs190737526	RCV005939350 RCV005910063
Sarcoma	Uncertain significance	rs201051347	RCV005939349
Uterine corpus endometrial carcinoma	Benign	rs191379199	RCV005907588

Show/Hide Text Mining Associations (25)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Abdominal Injuries	Associate	28947923
Anti Neutrophil Cytoplasmic Antibody Associated Vasculitis	Associate	31186034
Carcinoma Non Small Cell Lung	Associate	36194200, 36694434
Colorectal Neoplasms	Associate	26378020, 29408916
Diabetes Mellitus Type 1	Associate	36898736
Dyslipidemias	Associate	29327327
Endometrial Neoplasms	Inhibit	32431202
Endometrial Neoplasms	Associate	35174769, 35880269
Glomerulonephritis Membranous	Associate	40018947
Head and Neck Neoplasms	Associate	38231444
Hypoxia	Associate	36694434
Inflammation	Associate	29327327, 30453994
Kidney Diseases	Associate	31186034
Lupus Erythematosus Systemic	Associate	28085900
Lupus Nephritis	Associate	31186034
Melanoma	Associate	33547395
Nasopharyngeal Carcinoma	Associate	28098136
Neoplasms	Associate	26611618, 27162338, 32431202, 32959881, 33547395, 35174769, 35745070, 36194200, 36694434, 36898736
Neoplasms Adipose Tissue	Associate	28947923
Nephritis	Associate	30453994
Obesity	Associate	28947923
Osteoporosis	Associate	29327327
Rectal Neoplasms	Associate	29408916
Squamous Cell Carcinoma of Head and Neck	Associate	38231444
Vasculitis	Stimulate	31186034

NLRC5 (NLR family CARD domain containing 5)