Gene Gene information from NCBI Gene database.
Entrez ID 84159
Gene name AT-rich interaction domain 5B
Gene symbol ARID5B
Synonyms (NCBI Gene)
DESRTMRF-2MRF2
Chromosome 10
Chromosome location 10q21.2
Summary This gene encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded protein forms a histone H3K9Me2 demethylase complex with PHD finger protein 2 and regulates the transcription of target genes involved in adipo
miRNA miRNA information provided by mirtarbase database.
1664
miRTarBase ID miRNA Experiments Reference
MIRT022013 hsa-miR-128-3p Sequencing 20371350
MIRT027302 hsa-miR-101-3p Sequencing 20371350
MIRT030642 hsa-miR-22-3p Sequencing 20371350
MIRT549305 hsa-miR-140-3p HITS-CLIP 21572407
MIRT056754 hsa-miR-1277-5p HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
33
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 8649988
GO:0000976 Function Transcription cis-regulatory region binding IBA
GO:0000976 Function Transcription cis-regulatory region binding IDA 21532585
GO:0001822 Process Kidney development IEA
GO:0001889 Process Liver development TAS 21532585
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608538 17362 ENSG00000150347
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q14865
Protein name AT-rich interactive domain-containing protein 5B (ARID domain-containing protein 5B) (MRF1-like protein) (Modulator recognition factor 2) (MRF-2)
Protein function Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target t
PDB 1IG6 , 2OEH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01388 ARID 320 406 ARID/BRIGHT DNA binding domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed, including in liver (at protein level). {ECO:0000269|PubMed:21532585}.
Sequence
MEPNSLQWVGSPCGLHGPYIFYKAFQFHLEGKPRILSLGDFFFVRCTPKDPICIAELQLL
WEERTSRQLLSSSKLYFLPEDTPQGRNSDHGEDEVIAVSEKVIVKLEDLVKWVHSDFSKW
RCGFHAGPVKTEALGRNGQKEALLKYRQSTLNSGLNFKDVLKEKADLGEDEEETNVIVLS
YPQYCRYRSMLKRIQDKPSSILTDQFALALGGIAVVSRNPQILYCRDTFDHPTLIENESI
CDEFAPNLKGRPRKKKPCPQRRDSFSGVKDSNNNSDGKAVAKVKCEARSALTKPKNNHNC
KKVSNEEKPKVAIGEECRADEQAFLVALYKYMKERKTPIERIPYLGFKQINLWTMFQAAQ
KLGGYETITARRQWKHIYDELGGNPGSTSAATCTRRHYERLILPYE
RFIKGEEDKPLPPI
KPRKQENSSQENENKTKVSGTKRIKHEIPKSKKEKENAPKPQDAAEVSSEQEKEQETLIS
QKSIPEPLPAADMKKKIEGYQEFSAKPLASRVDPEKDNETDQGSNSEKVAEEAGEKGPTP
PLPSAPLAPEKDSALVPGASKQPLTSPSALVDSKQESKLCCFTESPESEPQEASFPSFPT
TQPPLANQNETEDDKLPAMADYIANCTVKVDQLGSDDIHNALKQTPKVLVVQSFDMFKDK
DLTGPMNENHGLNYTPLLYSRGNPGIMSPLAKKKLLSQVSGASLSSSYPYGSPPPLISKK
KLIARDDLCSSLSQTHHGQSTDHMAVSRPSVIQHVQSFRSKPSEERKTINDIFKHEKLSR
SDPHRCSFSKHHLNPLADSYVLKQEIQEGKDKLLEKRALPHSHMPSFLADFYSSPHLHSL
YRHTEHHLHNEQTSKYPSRDMYRESENSSFPSHRHQEKLHVNYLTSLHLQDKKSAAAEAP
TDDQPTDLSLPKNPHKPTGKVLGLAHSTTGPQESKGISQFQVLGSQSRDCHPKACRVSPM
TMSGPKKYPESLSRSGKPHHVRLENFRKMEGMVHPILHRKMSPQNIGAARPIKRSLEDLD
LVIAGKKARAVSPLDPSKEVSGKEKASEQESEGSKAAHGGHSGGGSEGHKLPLSSPIFPG
LYSGSLCNSGLNSRLPAGYSHSLQYLKNQTVLSPLMQPLAFHSLVMQRGIFTSPTNSQQL
YRHLAAATPVGSSYGDLLHNSIYPLAAINPQAAFPSSQLSSVHPSTKL
Sequence length 1188
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    HDMs demethylate histones
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
17
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
ARID5B-related disorder Uncertain significance; Likely benign; Benign rs1053149301, rs145088760, rs535896705, rs935409875, rs1477130085, rs144809623, rs368575697, rs368683439, rs117297247, rs143074852, rs1478787856, rs761751447, rs140716429, rs150105654, rs370446097
View all (2 more)
RCV003410567
RCV003921456
RCV003912015
RCV003899424
RCV003899429
RCV003939805
RCV003954929
RCV003971974
RCV003917063
RCV003927078
RCV003941586
RCV003941607
RCV003922056
RCV003914745
RCV003956762
RCV003969484
RCV003935993
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acromegaly Associate 36435867
Acute Disease Associate 24712521
Adenocarcinoma Associate 34725203
Alzheimer Disease Associate 30898171
Arthritis Rheumatoid Associate 23118423, 23577190
Atherosclerosis Associate 28855511, 32107839
Autoimmune Diseases Associate 32231389
Breast Neoplasms Associate 33592583
Carcinoma Hepatocellular Associate 36177006
Carcinoma Squamous Cell Associate 34725203