SYDE2 (synapse defective Rho GTPase homolog 2)

Gene

• Entrez ID: 84144
• Gene name: Synapse defective Rho GTPase homolog 2
• Gene symbol: SYDE2
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1p22.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT046326	hsa-miR-23b-3p	CLASH	23622248
MIRT043965	hsa-miR-378a-5p	CLASH	23622248
MIRT714036	hsa-miR-3529-3p	HITS-CLIP	19536157
MIRT714035	hsa-miR-3664-5p	HITS-CLIP	19536157
MIRT714034	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT714033	hsa-miR-3065-5p	HITS-CLIP	19536157
MIRT714032	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT714031	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT714030	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT714029	hsa-miR-371a-5p	HITS-CLIP	19536157
MIRT714028	hsa-miR-372-5p	HITS-CLIP	19536157
MIRT714027	hsa-miR-3120-5p	HITS-CLIP	19536157
MIRT714026	hsa-miR-4522	HITS-CLIP	19536157
MIRT714025	hsa-miR-6888-3p	HITS-CLIP	19536157
MIRT714024	hsa-miR-6510-3p	HITS-CLIP	19536157
MIRT553858	hsa-miR-31-5p	PAR-CLIP	21572407
MIRT553857	hsa-miR-4715-5p	PAR-CLIP	21572407
MIRT553856	hsa-miR-4733-5p	PAR-CLIP	21572407
MIRT553855	hsa-miR-6814-5p	PAR-CLIP	21572407
MIRT553854	hsa-miR-136-5p	PAR-CLIP	21572407
MIRT553853	hsa-miR-571	PAR-CLIP	21572407
MIRT553852	hsa-miR-6809-5p	PAR-CLIP	21572407
MIRT553851	hsa-miR-182-5p	PAR-CLIP	21572407
MIRT714036	hsa-miR-3529-3p	HITS-CLIP	19536157
MIRT714035	hsa-miR-3664-5p	HITS-CLIP	19536157
MIRT714034	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT714033	hsa-miR-3065-5p	HITS-CLIP	19536157
MIRT714032	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT714031	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT714030	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT714029	hsa-miR-371a-5p	HITS-CLIP	19536157
MIRT714028	hsa-miR-372-5p	HITS-CLIP	19536157
MIRT714027	hsa-miR-3120-5p	HITS-CLIP	19536157
MIRT714026	hsa-miR-4522	HITS-CLIP	19536157
MIRT714025	hsa-miR-6888-3p	HITS-CLIP	19536157
MIRT714024	hsa-miR-6510-3p	HITS-CLIP	19536157
MIRT553858	hsa-miR-31-5p	PAR-CLIP	21572407
MIRT553857	hsa-miR-4715-5p	PAR-CLIP	21572407
MIRT553856	hsa-miR-4733-5p	PAR-CLIP	21572407
MIRT553855	hsa-miR-6814-5p	PAR-CLIP	21572407
MIRT553854	hsa-miR-136-5p	PAR-CLIP	21572407
MIRT553853	hsa-miR-571	PAR-CLIP	21572407
MIRT553852	hsa-miR-6809-5p	PAR-CLIP	21572407
MIRT553851	hsa-miR-182-5p	PAR-CLIP	21572407
MIRT1405167	hsa-miR-103a	CLIP-seq
MIRT1405168	hsa-miR-107	CLIP-seq
MIRT1405169	hsa-miR-1207-5p	CLIP-seq
MIRT1405170	hsa-miR-1245b-3p	CLIP-seq
MIRT1405171	hsa-miR-1283	CLIP-seq
MIRT1405172	hsa-miR-1297	CLIP-seq
MIRT1405173	hsa-miR-15a	CLIP-seq
MIRT1405174	hsa-miR-15b	CLIP-seq
MIRT1405175	hsa-miR-16	CLIP-seq
MIRT1405176	hsa-miR-195	CLIP-seq
MIRT1405177	hsa-miR-24	CLIP-seq
MIRT1405178	hsa-miR-26a	CLIP-seq
MIRT1405179	hsa-miR-26b	CLIP-seq
MIRT1405180	hsa-miR-3122	CLIP-seq
MIRT1405181	hsa-miR-3133	CLIP-seq
MIRT1405182	hsa-miR-3200-5p	CLIP-seq
MIRT1405183	hsa-miR-338-5p	CLIP-seq
MIRT1405184	hsa-miR-33a	CLIP-seq
MIRT1405185	hsa-miR-33b	CLIP-seq
MIRT1405186	hsa-miR-3607-5p	CLIP-seq
MIRT1405187	hsa-miR-3688-5p	CLIP-seq
MIRT1405188	hsa-miR-3689a-3p	CLIP-seq
MIRT1405189	hsa-miR-3689c	CLIP-seq
MIRT1405190	hsa-miR-3691-3p	CLIP-seq
MIRT1405191	hsa-miR-380	CLIP-seq
MIRT1405192	hsa-miR-3913-5p	CLIP-seq
MIRT1405193	hsa-miR-3924	CLIP-seq
MIRT1405194	hsa-miR-424	CLIP-seq
MIRT1405195	hsa-miR-4251	CLIP-seq
MIRT1405196	hsa-miR-4284	CLIP-seq
MIRT1405197	hsa-miR-4310	CLIP-seq
MIRT1405198	hsa-miR-4326	CLIP-seq
MIRT1405199	hsa-miR-4329	CLIP-seq
MIRT1405200	hsa-miR-4465	CLIP-seq
MIRT1405201	hsa-miR-4468	CLIP-seq
MIRT1405202	hsa-miR-4495	CLIP-seq
MIRT1405203	hsa-miR-4524	CLIP-seq
MIRT1405204	hsa-miR-4666-5p	CLIP-seq
MIRT1405205	hsa-miR-4679	CLIP-seq
MIRT1405206	hsa-miR-4722-5p	CLIP-seq
MIRT1405207	hsa-miR-4728-5p	CLIP-seq
MIRT1405208	hsa-miR-4736	CLIP-seq
MIRT1405209	hsa-miR-4755-3p	CLIP-seq
MIRT1405210	hsa-miR-4761-5p	CLIP-seq
MIRT1405211	hsa-miR-4763-3p	CLIP-seq
MIRT1405212	hsa-miR-4768-3p	CLIP-seq
MIRT1405213	hsa-miR-4777-5p	CLIP-seq
MIRT1405214	hsa-miR-4795-3p	CLIP-seq
MIRT1405215	hsa-miR-485-5p	CLIP-seq
MIRT1405216	hsa-miR-496	CLIP-seq
MIRT1405217	hsa-miR-497	CLIP-seq
MIRT1405218	hsa-miR-503	CLIP-seq
MIRT1405219	hsa-miR-518d-5p	CLIP-seq
MIRT1405220	hsa-miR-519b-5p	CLIP-seq
MIRT1405221	hsa-miR-519c-5p	CLIP-seq
MIRT1405222	hsa-miR-520c-5p	CLIP-seq
MIRT1405223	hsa-miR-520d-5p	CLIP-seq
MIRT1405224	hsa-miR-524-5p	CLIP-seq
MIRT1405225	hsa-miR-526a	CLIP-seq
MIRT1405226	hsa-miR-541	CLIP-seq
MIRT1405227	hsa-miR-548c-3p	CLIP-seq
MIRT1405228	hsa-miR-646	CLIP-seq
MIRT1405229	hsa-miR-654-5p	CLIP-seq
MIRT1405182	hsa-miR-3200-5p	CLIP-seq
MIRT1405195	hsa-miR-4251	CLIP-seq
MIRT1405199	hsa-miR-4329	CLIP-seq
MIRT1405180	hsa-miR-3122	CLIP-seq
MIRT1405182	hsa-miR-3200-5p	CLIP-seq
MIRT1405188	hsa-miR-3689a-3p	CLIP-seq
MIRT1405189	hsa-miR-3689c	CLIP-seq
MIRT2121556	hsa-miR-374c	CLIP-seq
MIRT1405192	hsa-miR-3913-5p	CLIP-seq
MIRT2121557	hsa-miR-3926	CLIP-seq
MIRT1405195	hsa-miR-4251	CLIP-seq
MIRT1405199	hsa-miR-4329	CLIP-seq
MIRT2121558	hsa-miR-4433	CLIP-seq
MIRT2121559	hsa-miR-4459	CLIP-seq
MIRT1405207	hsa-miR-4728-5p	CLIP-seq
MIRT1405210	hsa-miR-4761-5p	CLIP-seq
MIRT1405212	hsa-miR-4768-3p	CLIP-seq
MIRT2121560	hsa-miR-4772-5p	CLIP-seq
MIRT2121561	hsa-miR-4786-5p	CLIP-seq
MIRT1405226	hsa-miR-541	CLIP-seq
MIRT2121562	hsa-miR-548s	CLIP-seq
MIRT1405229	hsa-miR-654-5p	CLIP-seq
MIRT2121563	hsa-miR-655	CLIP-seq
MIRT1405169	hsa-miR-1207-5p	CLIP-seq
MIRT2343600	hsa-miR-1273	CLIP-seq
MIRT2343601	hsa-miR-1321	CLIP-seq
MIRT1405180	hsa-miR-3122	CLIP-seq
MIRT1405182	hsa-miR-3200-5p	CLIP-seq
MIRT2343602	hsa-miR-34b	CLIP-seq
MIRT2343603	hsa-miR-3614-5p	CLIP-seq
MIRT2343604	hsa-miR-3661	CLIP-seq
MIRT2343605	hsa-miR-3672	CLIP-seq
MIRT1405187	hsa-miR-3688-5p	CLIP-seq
MIRT1405188	hsa-miR-3689a-3p	CLIP-seq
MIRT1405189	hsa-miR-3689c	CLIP-seq
MIRT2343606	hsa-miR-3689d	CLIP-seq
MIRT1405192	hsa-miR-3913-5p	CLIP-seq
MIRT2343607	hsa-miR-4270	CLIP-seq
MIRT2343608	hsa-miR-4324	CLIP-seq
MIRT2343609	hsa-miR-4441	CLIP-seq
MIRT2343610	hsa-miR-4486	CLIP-seq
MIRT2343611	hsa-miR-4649-5p	CLIP-seq
MIRT1405206	hsa-miR-4722-5p	CLIP-seq
MIRT1405207	hsa-miR-4728-5p	CLIP-seq
MIRT1405208	hsa-miR-4736	CLIP-seq
MIRT2343612	hsa-miR-4739	CLIP-seq
MIRT1405209	hsa-miR-4755-3p	CLIP-seq
MIRT2343613	hsa-miR-4756-5p	CLIP-seq
MIRT1405210	hsa-miR-4761-5p	CLIP-seq
MIRT1405211	hsa-miR-4763-3p	CLIP-seq
MIRT1405212	hsa-miR-4768-3p	CLIP-seq
MIRT2343614	hsa-miR-4797-5p	CLIP-seq
MIRT1405215	hsa-miR-485-5p	CLIP-seq
MIRT2343615	hsa-miR-488	CLIP-seq
MIRT2343616	hsa-miR-508-5p	CLIP-seq
MIRT1405226	hsa-miR-541	CLIP-seq
MIRT2343617	hsa-miR-631	CLIP-seq
MIRT1405229	hsa-miR-654-5p	CLIP-seq
MIRT2343618	hsa-miR-661	CLIP-seq
MIRT2343619	hsa-miR-759	CLIP-seq
MIRT2343620	hsa-miR-766	CLIP-seq
MIRT1405191	hsa-miR-380	CLIP-seq
MIRT1405193	hsa-miR-3924	CLIP-seq
MIRT1405202	hsa-miR-4495	CLIP-seq
MIRT2395452	hsa-miR-4691-5p	CLIP-seq
MIRT2395453	hsa-miR-4775	CLIP-seq
MIRT2433755	hsa-miR-182	CLIP-seq
MIRT2433756	hsa-miR-31	CLIP-seq
MIRT2433755	hsa-miR-182	CLIP-seq
MIRT2433756	hsa-miR-31	CLIP-seq
MIRT1405180	hsa-miR-3122	CLIP-seq
MIRT1405188	hsa-miR-3689a-3p	CLIP-seq
MIRT1405189	hsa-miR-3689c	CLIP-seq
MIRT1405192	hsa-miR-3913-5p	CLIP-seq
MIRT1405207	hsa-miR-4728-5p	CLIP-seq
MIRT1405210	hsa-miR-4761-5p	CLIP-seq
MIRT1405226	hsa-miR-541	CLIP-seq
MIRT1405229	hsa-miR-654-5p	CLIP-seq
MIRT1405169	hsa-miR-1207-5p	CLIP-seq
MIRT2343600	hsa-miR-1273	CLIP-seq
MIRT2343601	hsa-miR-1321	CLIP-seq
MIRT2637249	hsa-miR-148a	CLIP-seq
MIRT2637250	hsa-miR-148b	CLIP-seq
MIRT2637251	hsa-miR-152	CLIP-seq
MIRT2637252	hsa-miR-1825	CLIP-seq
MIRT1405180	hsa-miR-3122	CLIP-seq
MIRT1405182	hsa-miR-3200-5p	CLIP-seq
MIRT1405183	hsa-miR-338-5p	CLIP-seq
MIRT2343602	hsa-miR-34b	CLIP-seq
MIRT2343603	hsa-miR-3614-5p	CLIP-seq
MIRT2343605	hsa-miR-3672	CLIP-seq
MIRT1405187	hsa-miR-3688-5p	CLIP-seq
MIRT1405188	hsa-miR-3689a-3p	CLIP-seq
MIRT1405189	hsa-miR-3689c	CLIP-seq
MIRT2343606	hsa-miR-3689d	CLIP-seq
MIRT2637253	hsa-miR-371-5p	CLIP-seq
MIRT1405192	hsa-miR-3913-5p	CLIP-seq
MIRT1405195	hsa-miR-4251	CLIP-seq
MIRT2343607	hsa-miR-4270	CLIP-seq
MIRT1405199	hsa-miR-4329	CLIP-seq
MIRT2343609	hsa-miR-4441	CLIP-seq
MIRT2343610	hsa-miR-4486	CLIP-seq
MIRT2343611	hsa-miR-4649-5p	CLIP-seq
MIRT2637254	hsa-miR-4666-3p	CLIP-seq
MIRT1405206	hsa-miR-4722-5p	CLIP-seq
MIRT1405207	hsa-miR-4728-5p	CLIP-seq
MIRT1405208	hsa-miR-4736	CLIP-seq
MIRT2343612	hsa-miR-4739	CLIP-seq
MIRT2343613	hsa-miR-4756-5p	CLIP-seq
MIRT1405210	hsa-miR-4761-5p	CLIP-seq
MIRT1405211	hsa-miR-4763-3p	CLIP-seq
MIRT1405212	hsa-miR-4768-3p	CLIP-seq
MIRT2343614	hsa-miR-4797-5p	CLIP-seq
MIRT2343616	hsa-miR-508-5p	CLIP-seq
MIRT1405226	hsa-miR-541	CLIP-seq
MIRT1405227	hsa-miR-548c-3p	CLIP-seq
MIRT1405229	hsa-miR-654-5p	CLIP-seq
MIRT2343618	hsa-miR-661	CLIP-seq
MIRT2343619	hsa-miR-759	CLIP-seq
MIRT2343620	hsa-miR-766	CLIP-seq
MIRT1405169	hsa-miR-1207-5p	CLIP-seq
MIRT2343600	hsa-miR-1273	CLIP-seq
MIRT2343601	hsa-miR-1321	CLIP-seq
MIRT2637249	hsa-miR-148a	CLIP-seq
MIRT2637250	hsa-miR-148b	CLIP-seq
MIRT2637251	hsa-miR-152	CLIP-seq
MIRT2637252	hsa-miR-1825	CLIP-seq
MIRT1405180	hsa-miR-3122	CLIP-seq
MIRT1405182	hsa-miR-3200-5p	CLIP-seq
MIRT1405183	hsa-miR-338-5p	CLIP-seq
MIRT2343602	hsa-miR-34b	CLIP-seq
MIRT2343603	hsa-miR-3614-5p	CLIP-seq
MIRT2343605	hsa-miR-3672	CLIP-seq
MIRT1405187	hsa-miR-3688-5p	CLIP-seq
MIRT1405188	hsa-miR-3689a-3p	CLIP-seq
MIRT1405189	hsa-miR-3689c	CLIP-seq
MIRT2343606	hsa-miR-3689d	CLIP-seq
MIRT2637253	hsa-miR-371-5p	CLIP-seq
MIRT1405192	hsa-miR-3913-5p	CLIP-seq
MIRT1405195	hsa-miR-4251	CLIP-seq
MIRT2343607	hsa-miR-4270	CLIP-seq
MIRT1405199	hsa-miR-4329	CLIP-seq
MIRT2343609	hsa-miR-4441	CLIP-seq
MIRT2343610	hsa-miR-4486	CLIP-seq
MIRT2343611	hsa-miR-4649-5p	CLIP-seq
MIRT2637254	hsa-miR-4666-3p	CLIP-seq
MIRT1405206	hsa-miR-4722-5p	CLIP-seq
MIRT1405207	hsa-miR-4728-5p	CLIP-seq
MIRT1405208	hsa-miR-4736	CLIP-seq
MIRT2343612	hsa-miR-4739	CLIP-seq
MIRT2343613	hsa-miR-4756-5p	CLIP-seq
MIRT1405210	hsa-miR-4761-5p	CLIP-seq
MIRT1405211	hsa-miR-4763-3p	CLIP-seq
MIRT1405212	hsa-miR-4768-3p	CLIP-seq
MIRT2343614	hsa-miR-4797-5p	CLIP-seq
MIRT2343616	hsa-miR-508-5p	CLIP-seq
MIRT1405226	hsa-miR-541	CLIP-seq
MIRT1405227	hsa-miR-548c-3p	CLIP-seq
MIRT1405229	hsa-miR-654-5p	CLIP-seq
MIRT2343618	hsa-miR-661	CLIP-seq
MIRT2343619	hsa-miR-759	CLIP-seq
MIRT2343620	hsa-miR-766	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005096	Function	GTPase activator activity	ISS
GO:0005096	Function	GTPase activator activity	TAS
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0016477	Process	Cell migration	IBA
GO:0016477	Process	Cell migration	IDA	27917469
GO:0046578	Process	Regulation of Ras protein signal transduction	IBA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:0090630	Process	Activation of GTPase activity	ISS
GO:0097060	Component	Synaptic membrane	IBA

Other IDs

• MIM: 620834
• HGNC: 25841
• e!Ensembl: ENSG00000097096

Protein

• UniProt ID: Q5VT97
• Protein name: Rho GTPase-activating protein SYDE2 (Synapse defective protein 1 homolog 2) (Protein syd-1 homolog 2)
• Protein function: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00620	RhoGAP	832 → 996	RhoGAP domain	Domain

• Sequence:

  MHDLPPDSGARRGGRGLADHSFPAGARAPGQPPSRGAAYRRACPRDGERGGGGRPRQQVS
  PPRSPQREPRGGQLRTPRMRPSCSRSLESLRVGAKPPPFQRWPSDSWIRCGAHRDWDEPP
  PRGGRMDGWSGDRARAAAPTGLQPPGCKDHGCSSGSPFRDPAGSSVIRSGKGDRQEGPSF
  LRPPAVTVKKLQKWMYKGRLLSLGMKGRARGTAPKVTGTQAASPNVGALKVRENRVLSVP
  PDQRITLTDLFENAYGSSMKGRELEELKDNIEFRGHKPLNSITVSKKRNWLYQSTLRPLN
  LEEENKKCQDRSHLSISPVSLPKHQLSQSFLKSSKEYCTYVVCNATNSSLSKNCALDFNE
  ENDADDEGEIWYNPIPEDDDLGISSALSFGEADSAVLKLPAVNLSMLSGSDLMKAERHTE
  DSLCSSEHAGDIQTTRSNGMNPIHPAHSTEFVQQYKQKLGHKTQEGIMVEDSPMLKSPFA
  GSGILAATNSTELGIMEPSSPNPSPVKKGSSINWSLPDKIKSPRTVRKLSMKMKKLPEFS
  RKLSVKGTLNYINSPDNTPSLSKYNCREVHHTDILPSGNTTTAAKRNVISRYHLDTSVSS
  QQSYQKKNSMSSKYSCKGGYLSDGDSPELTTKASKHGSENKFGKGKEIISNSCSKNEIDI
  DAFRHYSFSDQPKCSQYISGLMSVHFYGAEDLKPPRIDSKDVFCAIQVDSVNKARTALLT
  CRTTFLDMDHTFNIEIENAQHLKLVVFSWEPTPRKNRVCCHGTVVLPTLFRVTKTHQLAV
  KLEPRGLIYVKVTLMEQWENSLHGLDINQEPIIFGVDIQKVVEKENIGLMVPLLIQKCIM
  EIEKRGCQVVGLYRLCGSAAVKKELREAFERDSKAVGLCENQYPDINVITGVLKDYLREL
  PSPLITKQLYEAVLDAMAKSPLKMSSNGCENDPGDSKYTVDLLDCLPEIEKATLKMLLDH
  LKLVASYHEVNKMTCQNLAVCFGPVLLSQRQEPSTHNNRVFTDSEELASALDFKKHIEVL
  HYLLQLWPVQRLTVKKSTDNLFPEQKSSLNYLRQKKERPHMLNLSGTDSSGVLRPRQNRL
  DSPLSNRYAGDWSSCGENYFLNTKENLNDVDYDDVPSEDRKIGENYSKMDGPEVMIEQPI
  PMSKECTFQTYLTMQTVESTVDRKNNLKDLQESIDTLIGNLERELNKNKLNMSF

• Sequence length: 1194

Pathways

Reactome:

Rho GTPase cycle

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
MULTIPLE SCLEROSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROGRESSIVE SUPRANUCLEAR PALSY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations