TOMM40L (translocase of outer mitochondrial membrane 40 like)

Gene

• Entrez ID: 84134
• Gene name: Translocase of outer mitochondrial membrane 40 like
• Gene symbol: TOMM40L
• Synonyms (NCBI Gene): TOMM40B
• Chromosome: 1
• Chromosome location: 1q23.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT533583	hsa-miR-27a-3p	PAR-CLIP	22012620
MIRT533582	hsa-miR-27b-3p	PAR-CLIP	22012620
MIRT533581	hsa-miR-6895-5p	PAR-CLIP	22012620
MIRT533580	hsa-miR-7160-3p	PAR-CLIP	22012620
MIRT533579	hsa-miR-4512	PAR-CLIP	22012620
MIRT533578	hsa-miR-330-3p	PAR-CLIP	22012620
MIRT533577	hsa-miR-128-3p	PAR-CLIP	22012620
MIRT533576	hsa-miR-216a-3p	PAR-CLIP	22012620
MIRT533575	hsa-miR-3681-3p	PAR-CLIP	22012620
MIRT533574	hsa-miR-6508-3p	PAR-CLIP	22012620
MIRT533573	hsa-miR-1296-5p	PAR-CLIP	22012620
MIRT533572	hsa-miR-513a-5p	PAR-CLIP	22012620
MIRT533571	hsa-miR-2909	PAR-CLIP	22012620
MIRT533583	hsa-miR-27a-3p	PAR-CLIP	22012620
MIRT533582	hsa-miR-27b-3p	PAR-CLIP	22012620
MIRT533581	hsa-miR-6895-5p	PAR-CLIP	22012620
MIRT533580	hsa-miR-7160-3p	PAR-CLIP	22012620
MIRT533579	hsa-miR-4512	PAR-CLIP	22012620
MIRT533578	hsa-miR-330-3p	PAR-CLIP	22012620
MIRT533577	hsa-miR-128-3p	PAR-CLIP	22012620
MIRT533576	hsa-miR-216a-3p	PAR-CLIP	22012620
MIRT533575	hsa-miR-3681-3p	PAR-CLIP	22012620
MIRT533574	hsa-miR-6508-3p	PAR-CLIP	22012620
MIRT533573	hsa-miR-1296-5p	PAR-CLIP	22012620
MIRT533572	hsa-miR-513a-5p	PAR-CLIP	22012620
MIRT533571	hsa-miR-2909	PAR-CLIP	22012620
MIRT1446698	hsa-miR-1193	CLIP-seq
MIRT1446699	hsa-miR-1236	CLIP-seq
MIRT1446700	hsa-miR-2392	CLIP-seq
MIRT1446701	hsa-miR-335	CLIP-seq
MIRT1446702	hsa-miR-3912	CLIP-seq
MIRT1446703	hsa-miR-3914	CLIP-seq
MIRT1446704	hsa-miR-3925-3p	CLIP-seq
MIRT1446705	hsa-miR-4286	CLIP-seq
MIRT1446706	hsa-miR-4301	CLIP-seq
MIRT1446707	hsa-miR-4447	CLIP-seq
MIRT1446708	hsa-miR-4450	CLIP-seq
MIRT1446709	hsa-miR-4472	CLIP-seq
MIRT1446710	hsa-miR-4540	CLIP-seq
MIRT1446711	hsa-miR-4691-3p	CLIP-seq
MIRT1446712	hsa-miR-4691-5p	CLIP-seq
MIRT1446713	hsa-miR-4727-3p	CLIP-seq
MIRT1446714	hsa-miR-4753-3p	CLIP-seq
MIRT1446715	hsa-miR-4768-5p	CLIP-seq
MIRT1446716	hsa-miR-4771	CLIP-seq
MIRT1446717	hsa-miR-499a-5p	CLIP-seq
MIRT1446718	hsa-miR-515-5p	CLIP-seq
MIRT1446719	hsa-miR-570	CLIP-seq
MIRT1446720	hsa-miR-591	CLIP-seq
MIRT1446721	hsa-miR-766	CLIP-seq
MIRT2133592	hsa-miR-128	CLIP-seq
MIRT2133593	hsa-miR-1296	CLIP-seq
MIRT2133594	hsa-miR-150	CLIP-seq
MIRT2133595	hsa-miR-204	CLIP-seq
MIRT2133596	hsa-miR-211	CLIP-seq
MIRT2133597	hsa-miR-27a	CLIP-seq
MIRT2133598	hsa-miR-27b	CLIP-seq
MIRT2133599	hsa-miR-3127-5p	CLIP-seq
MIRT2133600	hsa-miR-3176	CLIP-seq
MIRT2133601	hsa-miR-3198	CLIP-seq
MIRT2133602	hsa-miR-326	CLIP-seq
MIRT2133603	hsa-miR-330-5p	CLIP-seq
MIRT2133604	hsa-miR-3616-5p	CLIP-seq
MIRT2133605	hsa-miR-3647-5p	CLIP-seq
MIRT2133606	hsa-miR-3691-3p	CLIP-seq
MIRT1446702	hsa-miR-3912	CLIP-seq
MIRT2133607	hsa-miR-3918	CLIP-seq
MIRT2133608	hsa-miR-3922-3p	CLIP-seq
MIRT1446704	hsa-miR-3925-3p	CLIP-seq
MIRT2133609	hsa-miR-3926	CLIP-seq
MIRT2133610	hsa-miR-4309	CLIP-seq
MIRT2133611	hsa-miR-4314	CLIP-seq
MIRT2133612	hsa-miR-4330	CLIP-seq
MIRT2133613	hsa-miR-4432	CLIP-seq
MIRT2133614	hsa-miR-4446-5p	CLIP-seq
MIRT2133615	hsa-miR-4480	CLIP-seq
MIRT2133616	hsa-miR-4635	CLIP-seq
MIRT2133617	hsa-miR-4646-5p	CLIP-seq
MIRT2133618	hsa-miR-4653-3p	CLIP-seq
MIRT2133619	hsa-miR-4670-3p	CLIP-seq
MIRT2133620	hsa-miR-4676-5p	CLIP-seq
MIRT2133621	hsa-miR-4717-3p	CLIP-seq
MIRT2133622	hsa-miR-4755-5p	CLIP-seq
MIRT2133623	hsa-miR-4780	CLIP-seq
MIRT2133624	hsa-miR-548s	CLIP-seq
MIRT2133625	hsa-miR-573	CLIP-seq
MIRT2133626	hsa-miR-575	CLIP-seq
MIRT2133627	hsa-miR-623	CLIP-seq
MIRT2133599	hsa-miR-3127-5p	CLIP-seq
MIRT2354819	hsa-miR-3160-5p	CLIP-seq
MIRT2354820	hsa-miR-377	CLIP-seq
MIRT2133607	hsa-miR-3918	CLIP-seq
MIRT2354821	hsa-miR-412	CLIP-seq
MIRT2354822	hsa-miR-4659a-3p	CLIP-seq
MIRT2354823	hsa-miR-4659b-3p	CLIP-seq
MIRT2354824	hsa-miR-4772-5p	CLIP-seq
MIRT1446698	hsa-miR-1193	CLIP-seq
MIRT2648570	hsa-miR-1252	CLIP-seq
MIRT2133592	hsa-miR-128	CLIP-seq
MIRT2648571	hsa-miR-1286	CLIP-seq
MIRT2648572	hsa-miR-129-3p	CLIP-seq
MIRT2133593	hsa-miR-1296	CLIP-seq
MIRT2133595	hsa-miR-204	CLIP-seq
MIRT2133596	hsa-miR-211	CLIP-seq
MIRT1446700	hsa-miR-2392	CLIP-seq
MIRT2648573	hsa-miR-2467-5p	CLIP-seq
MIRT2133597	hsa-miR-27a	CLIP-seq
MIRT2133598	hsa-miR-27b	CLIP-seq
MIRT2648574	hsa-miR-3148	CLIP-seq
MIRT2648575	hsa-miR-3153	CLIP-seq
MIRT2648576	hsa-miR-3157-5p	CLIP-seq
MIRT2648577	hsa-miR-3159	CLIP-seq
MIRT2648578	hsa-miR-3185	CLIP-seq
MIRT2648579	hsa-miR-3189-3p	CLIP-seq
MIRT2648580	hsa-miR-3192	CLIP-seq
MIRT2133602	hsa-miR-326	CLIP-seq
MIRT2133603	hsa-miR-330-5p	CLIP-seq
MIRT2648581	hsa-miR-3616-3p	CLIP-seq
MIRT2133604	hsa-miR-3616-5p	CLIP-seq
MIRT2133605	hsa-miR-3647-5p	CLIP-seq
MIRT2648582	hsa-miR-3688-3p	CLIP-seq
MIRT2648583	hsa-miR-3689a-3p	CLIP-seq
MIRT2648584	hsa-miR-3689c	CLIP-seq
MIRT1446703	hsa-miR-3914	CLIP-seq
MIRT2648585	hsa-miR-4293	CLIP-seq
MIRT2133611	hsa-miR-4314	CLIP-seq
MIRT2133614	hsa-miR-4446-5p	CLIP-seq
MIRT1446707	hsa-miR-4447	CLIP-seq
MIRT1446708	hsa-miR-4450	CLIP-seq
MIRT1446709	hsa-miR-4472	CLIP-seq
MIRT2133616	hsa-miR-4635	CLIP-seq
MIRT2133617	hsa-miR-4646-5p	CLIP-seq
MIRT2133619	hsa-miR-4670-3p	CLIP-seq
MIRT2133620	hsa-miR-4676-5p	CLIP-seq
MIRT2648586	hsa-miR-4687-5p	CLIP-seq
MIRT2648587	hsa-miR-4690-3p	CLIP-seq
MIRT2648588	hsa-miR-4721	CLIP-seq
MIRT2648589	hsa-miR-4722-5p	CLIP-seq
MIRT1446713	hsa-miR-4727-3p	CLIP-seq
MIRT2648590	hsa-miR-4728-5p	CLIP-seq
MIRT2133622	hsa-miR-4755-5p	CLIP-seq
MIRT2133623	hsa-miR-4780	CLIP-seq
MIRT2648591	hsa-miR-4786-5p	CLIP-seq
MIRT2648592	hsa-miR-544b	CLIP-seq
MIRT1446719	hsa-miR-570	CLIP-seq
MIRT2133625	hsa-miR-573	CLIP-seq
MIRT2133626	hsa-miR-575	CLIP-seq
MIRT1446720	hsa-miR-591	CLIP-seq
MIRT2133627	hsa-miR-623	CLIP-seq
MIRT2648593	hsa-miR-671-5p	CLIP-seq
MIRT2648594	hsa-miR-769-5p	CLIP-seq
MIRT1446698	hsa-miR-1193	CLIP-seq
MIRT2648571	hsa-miR-1286	CLIP-seq
MIRT2648572	hsa-miR-129-3p	CLIP-seq
MIRT2133593	hsa-miR-1296	CLIP-seq
MIRT2693899	hsa-miR-1299	CLIP-seq
MIRT2133595	hsa-miR-204	CLIP-seq
MIRT2133596	hsa-miR-211	CLIP-seq
MIRT2693900	hsa-miR-2117	CLIP-seq
MIRT1446700	hsa-miR-2392	CLIP-seq
MIRT2693901	hsa-miR-2467-3p	CLIP-seq
MIRT2648573	hsa-miR-2467-5p	CLIP-seq
MIRT2648574	hsa-miR-3148	CLIP-seq
MIRT2648575	hsa-miR-3153	CLIP-seq
MIRT2648576	hsa-miR-3157-5p	CLIP-seq
MIRT2648577	hsa-miR-3159	CLIP-seq
MIRT2693902	hsa-miR-3173-3p	CLIP-seq
MIRT2648579	hsa-miR-3189-3p	CLIP-seq
MIRT2648580	hsa-miR-3192	CLIP-seq
MIRT2133602	hsa-miR-326	CLIP-seq
MIRT2133603	hsa-miR-330-5p	CLIP-seq
MIRT2133604	hsa-miR-3616-5p	CLIP-seq
MIRT2133605	hsa-miR-3647-5p	CLIP-seq
MIRT2648582	hsa-miR-3688-3p	CLIP-seq
MIRT2648583	hsa-miR-3689a-3p	CLIP-seq
MIRT2648584	hsa-miR-3689c	CLIP-seq
MIRT2693903	hsa-miR-382	CLIP-seq
MIRT1446703	hsa-miR-3914	CLIP-seq
MIRT2693904	hsa-miR-4273	CLIP-seq
MIRT2693905	hsa-miR-4283	CLIP-seq
MIRT2133611	hsa-miR-4314	CLIP-seq
MIRT2693906	hsa-miR-4426	CLIP-seq
MIRT2133614	hsa-miR-4446-5p	CLIP-seq
MIRT1446707	hsa-miR-4447	CLIP-seq
MIRT1446708	hsa-miR-4450	CLIP-seq
MIRT1446709	hsa-miR-4472	CLIP-seq
MIRT2693907	hsa-miR-4489	CLIP-seq
MIRT2693908	hsa-miR-4492	CLIP-seq
MIRT2693909	hsa-miR-4496	CLIP-seq
MIRT2693910	hsa-miR-4498	CLIP-seq
MIRT2693911	hsa-miR-4525	CLIP-seq
MIRT2693912	hsa-miR-4533	CLIP-seq
MIRT2133616	hsa-miR-4635	CLIP-seq
MIRT2133617	hsa-miR-4646-5p	CLIP-seq
MIRT2693913	hsa-miR-4647	CLIP-seq
MIRT2693914	hsa-miR-4662b	CLIP-seq
MIRT2133619	hsa-miR-4670-3p	CLIP-seq
MIRT2693915	hsa-miR-4677-5p	CLIP-seq
MIRT2648586	hsa-miR-4687-5p	CLIP-seq
MIRT2648587	hsa-miR-4690-3p	CLIP-seq
MIRT2648589	hsa-miR-4722-5p	CLIP-seq
MIRT1446713	hsa-miR-4727-3p	CLIP-seq
MIRT2648590	hsa-miR-4728-5p	CLIP-seq
MIRT2693916	hsa-miR-4747-5p	CLIP-seq
MIRT2133622	hsa-miR-4755-5p	CLIP-seq
MIRT2133623	hsa-miR-4780	CLIP-seq
MIRT2648591	hsa-miR-4786-5p	CLIP-seq
MIRT1446719	hsa-miR-570	CLIP-seq
MIRT2133625	hsa-miR-573	CLIP-seq
MIRT1446720	hsa-miR-591	CLIP-seq
MIRT2133627	hsa-miR-623	CLIP-seq
MIRT2648593	hsa-miR-671-5p	CLIP-seq
MIRT2693917	hsa-miR-762	CLIP-seq
MIRT2648594	hsa-miR-769-5p	CLIP-seq
MIRT2693918	hsa-miR-875-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005742	Component	Mitochondrial outer membrane translocase complex	IBA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0008150	Process	Biological_process	ND
GO:0008320	Function	Protein transmembrane transporter activity	IBA
GO:0008320	Function	Protein transmembrane transporter activity	IEA
GO:0015031	Process	Protein transport	IEA
GO:0015288	Function	Porin activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0030150	Process	Protein import into mitochondrial matrix	IBA
GO:0030150	Process	Protein import into mitochondrial matrix	IEA
GO:0032991	Component	Protein-containing complex	IDA
GO:0046930	Component	Pore complex	IEA
GO:0055085	Process	Transmembrane transport	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q969M1
• Protein name: Mitochondrial import receptor subunit TOM40B (Protein TOMM40-like)
• Protein function: Potential channel-forming protein implicated in import of protein precursors into mitochondria.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01459	Porin_3	26 → 302	Eukaryotic porin	Family

• Sequence:

  MGNTLGLAPMGTLPRRSPRREEPLPNPGSFDELHRLCKDVFPAQMEGVKLVVNKVLSSHF
  QVAHTIHMSALGLPGYHLHAAYAGDWQLSPTEVFPTVVGDMDSSGSLNAQVLLLLAERLR
  AKAVFQTQQAKFLTWQFDGEYRGDDYTATLTLGNPDLIGESVIMVAHFLQSLTHRLVLGG
  ELVYHRRPGEEGAILTLAGKYSAVHWVATLNVGSGGAHASYYHRANEQVQVGVEFEANTR
  LQDTTFSFGYHLTLPQANMVFRGLVDSNWCVGAVLEKKMPPLPVTLALGAFLNHWRNRFH
  CGFSITVG

• Sequence length: 308

Pathways

KEGG:

Mitophagy - animal
Amyotrophic lateral sclerosis
Pathways of neurodegeneration - multiple diseases

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
IGA GLOMERULONEPHRITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TOMM40L-related disorder	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations