Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein
Entrez ID	8412
Gene name	BCAR3 adaptor protein, NSP family member
Gene symbol	BCAR3
Synonyms (NCBI Gene)	AND-34MIG7NSP2SH2D3B
Chromosome	1
Chromosome location	1p22.1
Summary	Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was i

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miRTarBase ID	miRNA	Experiments	Reference
MIRT042690	hsa-miR-196b-5p	CLASH	23622248
MIRT817512	hsa-miR-1237	CLIP-seq
MIRT817513	hsa-miR-1914	CLIP-seq
MIRT817514	hsa-miR-19a	CLIP-seq
MIRT817515	hsa-miR-19b	CLIP-seq
MIRT817516	hsa-miR-203	CLIP-seq
MIRT817517	hsa-miR-3140-3p	CLIP-seq
MIRT817518	hsa-miR-3194-3p	CLIP-seq
MIRT817519	hsa-miR-3200-5p	CLIP-seq
MIRT817520	hsa-miR-3660	CLIP-seq
MIRT817521	hsa-miR-3662	CLIP-seq
MIRT817522	hsa-miR-3671	CLIP-seq
MIRT817523	hsa-miR-3691-5p	CLIP-seq
MIRT817524	hsa-miR-4526	CLIP-seq
MIRT817525	hsa-miR-4699-3p	CLIP-seq
MIRT817526	hsa-miR-4724-3p	CLIP-seq
MIRT817527	hsa-miR-4752	CLIP-seq
MIRT817528	hsa-miR-4766-5p	CLIP-seq
MIRT817529	hsa-miR-4802-3p	CLIP-seq
MIRT817530	hsa-miR-522	CLIP-seq
MIRT817531	hsa-miR-548a-3p	CLIP-seq
MIRT817532	hsa-miR-548e	CLIP-seq
MIRT817533	hsa-miR-548f	CLIP-seq
MIRT817534	hsa-miR-568	CLIP-seq
MIRT817535	hsa-miR-643	CLIP-seq
MIRT817536	hsa-miR-889	CLIP-seq
MIRT1545707	hsa-miR-199a-3p	CLIP-seq
MIRT1545708	hsa-miR-199b-3p	CLIP-seq
MIRT1545709	hsa-miR-3129-5p	CLIP-seq
MIRT1545710	hsa-miR-4668-3p	CLIP-seq
MIRT1545711	hsa-miR-4760-3p	CLIP-seq
MIRT1545712	hsa-miR-802	CLIP-seq
MIRT1545713	hsa-miR-936	CLIP-seq
MIRT1545707	hsa-miR-199a-3p	CLIP-seq
MIRT1545708	hsa-miR-199b-3p	CLIP-seq
MIRT1545709	hsa-miR-3129-5p	CLIP-seq
MIRT1941722	hsa-miR-628-5p	CLIP-seq
MIRT817514	hsa-miR-19a	CLIP-seq
MIRT817515	hsa-miR-19b	CLIP-seq
MIRT817518	hsa-miR-3194-3p	CLIP-seq
MIRT2180553	hsa-miR-595	CLIP-seq
MIRT2180554	hsa-miR-648	CLIP-seq
MIRT817512	hsa-miR-1237	CLIP-seq
MIRT2483907	hsa-miR-1244	CLIP-seq
MIRT1545707	hsa-miR-199a-3p	CLIP-seq
MIRT1545708	hsa-miR-199b-3p	CLIP-seq
MIRT817516	hsa-miR-203	CLIP-seq
MIRT1545709	hsa-miR-3129-5p	CLIP-seq
MIRT817517	hsa-miR-3140-3p	CLIP-seq
MIRT817519	hsa-miR-3200-5p	CLIP-seq
MIRT817520	hsa-miR-3660	CLIP-seq
MIRT817521	hsa-miR-3662	CLIP-seq
MIRT817522	hsa-miR-3671	CLIP-seq
MIRT2483908	hsa-miR-4274	CLIP-seq
MIRT2483909	hsa-miR-4519	CLIP-seq
MIRT2483910	hsa-miR-4524	CLIP-seq
MIRT817524	hsa-miR-4526	CLIP-seq
MIRT817525	hsa-miR-4699-3p	CLIP-seq
MIRT817526	hsa-miR-4724-3p	CLIP-seq
MIRT2483911	hsa-miR-4753-3p	CLIP-seq
MIRT817528	hsa-miR-4766-5p	CLIP-seq
MIRT817529	hsa-miR-4802-3p	CLIP-seq
MIRT2483912	hsa-miR-513a-3p	CLIP-seq
MIRT817530	hsa-miR-522	CLIP-seq
MIRT817531	hsa-miR-548a-3p	CLIP-seq
MIRT817532	hsa-miR-548e	CLIP-seq
MIRT817533	hsa-miR-548f	CLIP-seq
MIRT1941722	hsa-miR-628-5p	CLIP-seq
MIRT2483913	hsa-miR-942	CLIP-seq
MIRT817521	hsa-miR-3662	CLIP-seq
MIRT817522	hsa-miR-3671	CLIP-seq
MIRT2483911	hsa-miR-4753-3p	CLIP-seq
MIRT817529	hsa-miR-4802-3p	CLIP-seq
MIRT2483912	hsa-miR-513a-3p	CLIP-seq
MIRT817530	hsa-miR-522	CLIP-seq
MIRT817531	hsa-miR-548a-3p	CLIP-seq
MIRT817532	hsa-miR-548e	CLIP-seq
MIRT817533	hsa-miR-548f	CLIP-seq
MIRT1941722	hsa-miR-628-5p	CLIP-seq
MIRT2483913	hsa-miR-942	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001784	Function	Phosphotyrosine residue binding	IEA
GO:0001784	Function	Phosphotyrosine residue binding	IMP	24216110
GO:0002089	Process	Lens morphogenesis in camera-type eye	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005515	Function	Protein binding	IPI	16273093, 18722344, 19086031, 22081014, 24728074, 25416956, 25640309, 25814554, 28514442, 32296183, 32814053, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005925	Component	Focal adhesion	IEA
GO:0005925	Component	Focal adhesion	ISS
GO:0007165	Process	Signal transduction	TAS	9582273
GO:0007173	Process	Epidermal growth factor receptor signaling pathway	IBA
GO:0007173	Process	Epidermal growth factor receptor signaling pathway	IMP	18722344
GO:0007264	Process	Small GTPase-mediated signal transduction	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	18722344
GO:0008286	Process	Insulin receptor signaling pathway	IBA
GO:0008286	Process	Insulin receptor signaling pathway	IMP	24216110
GO:0009410	Process	Response to xenobiotic stimulus	TAS	9582273
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	ISS
GO:0019900	Function	Kinase binding	IPI	18722344
GO:0043410	Process	Positive regulation of MAPK cascade	IBA
GO:0043410	Process	Positive regulation of MAPK cascade	IMP	24216110
GO:0043547	Process	Positive regulation of GTPase activity	IMP	19086031
GO:0070161	Component	Anchoring junction	IEA
GO:0086100	Process	Endothelin receptor signaling pathway	IBA
GO:0086100	Process	Endothelin receptor signaling pathway	IMP	19086031

MIM	HGNC	e!Ensembl
604704	973	ENSG00000137936

O75815

Protein name

Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B)

Protein function

Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers (PubMed:24216110). Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ER

PDB

3T6A

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00017	SH2	154 → 234	SH2 domain	Domain
PF00617	RasGEF	545 → 737	RasGEF domain	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. Found in several cancer cell lines, but not in nonmalignant breast tissue. {ECO:0000269|PubMed:10187783, ECO:0000269|PubMed:9582273}.

Sequence

MAAGKFASLPRNMPVNHQFPLASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPP
IRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKF
SKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSL
SSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRP
ISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQARE
QNLPRGNLLRNKEKSGSQPACLDHMQDRRALSLKAHQSESYLPIGCKLPPQSSGVDTSPC
PNSPVFRTGSEPALSPAVVRRVSSDARAGEALRGSDSQLCPKPPPKPCKVPFLKVPSSPS
AWLNSEANYCELNPAFATGCGRGAKLPSCAQGSHTELLTAKQNEAPGPRNSGVNYLILDD
DDRERPWEPAAAQMEKGQWDKGEFVTPLLETVSSFRPNEFESKFLPPENKPLETAMLKRA
KELFTNNDPKVIAQHVLSMDCRVARILGVSEEMRRNMGVSSGLELITLPHGHQLRLDIIE
RHNTMAIGIAVDILGCTGTLEDRAATLSKIIQVAVELKDSMGDLYSFSALMKALEMPQIT
RLEKTWTALRHQYTQTAILYEKQLKPFSKLLHEGRESTCVPPNNVSVPLLMPLVTLMERQ
AVTFEGTDMWEKNDQSCEIMLNHLATARFMAEAADSYRMNAERILAGFQPDEEMNEICKT
EFQMRLLWGSKGAQVNQTERYEKFNQILTALSRKLEPPPVKQAEL

Sequence length

825

Interactions

View interactions

BCAR3 (BCAR3 adaptor protein, NSP family member)