Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	84107
Gene name	Zic family zinc finger 4
Gene symbol	ZIC4
Synonyms (NCBI Gene)	-
Chromosome	3
Chromosome location	3q24
Summary	This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development, and have been associated with X-linked visceral heterotaxy and holoprosencephaly type 5. This gene is closely linked t

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miRTarBase ID	miRNA	Experiments	Reference
MIRT627179	hsa-miR-892a	HITS-CLIP	23824327
MIRT627178	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT640634	hsa-miR-1208	HITS-CLIP	23824327
MIRT627177	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT627176	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT627175	hsa-miR-4420	HITS-CLIP	23824327
MIRT627174	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT627173	hsa-miR-5096	HITS-CLIP	23824327
MIRT627172	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT627179	hsa-miR-892a	HITS-CLIP	23824327
MIRT627178	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT627177	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT627176	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT627175	hsa-miR-4420	HITS-CLIP	23824327
MIRT627174	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT627173	hsa-miR-5096	HITS-CLIP	23824327
MIRT627172	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT441707	hsa-miR-105-5p	PAR-CLIP	22100165
MIRT441704	hsa-miR-7853-5p	PAR-CLIP	22100165
MIRT441705	hsa-miR-4662a-5p	PAR-CLIP	22100165
MIRT627179	hsa-miR-892a	HITS-CLIP	23824327
MIRT627178	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT640634	hsa-miR-1208	HITS-CLIP	23824327
MIRT627177	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT627176	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT627175	hsa-miR-4420	HITS-CLIP	23824327
MIRT627174	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT627173	hsa-miR-5096	HITS-CLIP	23824327
MIRT627172	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT627179	hsa-miR-892a	HITS-CLIP	23824327
MIRT627178	hsa-miR-6760-3p	HITS-CLIP	23824327
MIRT627177	hsa-miR-181b-2-3p	HITS-CLIP	23824327
MIRT627176	hsa-miR-181b-3p	HITS-CLIP	23824327
MIRT627175	hsa-miR-4420	HITS-CLIP	23824327
MIRT627174	hsa-miR-653-3p	HITS-CLIP	23824327
MIRT627173	hsa-miR-5096	HITS-CLIP	23824327
MIRT627172	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT441707	hsa-miR-105-5p	PAR-CLIP	22100165
MIRT441704	hsa-miR-7853-5p	PAR-CLIP	22100165
MIRT441705	hsa-miR-4662a-5p	PAR-CLIP	22100165
MIRT1513468	hsa-miR-103a	CLIP-seq
MIRT1513469	hsa-miR-107	CLIP-seq
MIRT1513470	hsa-miR-1301	CLIP-seq
MIRT1513471	hsa-miR-2278	CLIP-seq
MIRT1513472	hsa-miR-369-3p	CLIP-seq
MIRT1513473	hsa-miR-374a	CLIP-seq
MIRT1513474	hsa-miR-374b	CLIP-seq
MIRT1513475	hsa-miR-4468	CLIP-seq
MIRT1513476	hsa-miR-450b-5p	CLIP-seq
MIRT1513477	hsa-miR-5047	CLIP-seq
MIRT1513478	hsa-miR-507	CLIP-seq
MIRT1513479	hsa-miR-557	CLIP-seq
MIRT1513480	hsa-miR-140-3p	CLIP-seq
MIRT1513481	hsa-miR-1587	CLIP-seq
MIRT1513482	hsa-miR-205	CLIP-seq
MIRT1513483	hsa-miR-2467-3p	CLIP-seq
MIRT1513484	hsa-miR-3119	CLIP-seq
MIRT1513485	hsa-miR-3163	CLIP-seq
MIRT1513486	hsa-miR-329	CLIP-seq
MIRT1513487	hsa-miR-3620	CLIP-seq
MIRT1513488	hsa-miR-362-3p	CLIP-seq
MIRT1513489	hsa-miR-3675-3p	CLIP-seq
MIRT1513490	hsa-miR-4257	CLIP-seq
MIRT1513491	hsa-miR-4492	CLIP-seq
MIRT1513492	hsa-miR-4498	CLIP-seq
MIRT1513493	hsa-miR-4524	CLIP-seq
MIRT1513494	hsa-miR-4656	CLIP-seq
MIRT1513495	hsa-miR-4674	CLIP-seq
MIRT1513496	hsa-miR-4675	CLIP-seq
MIRT1513497	hsa-miR-4741	CLIP-seq
MIRT1513498	hsa-miR-635	CLIP-seq
MIRT1513499	hsa-miR-762	CLIP-seq
MIRT1513500	hsa-miR-1243	CLIP-seq
MIRT1513501	hsa-miR-144	CLIP-seq
MIRT1513502	hsa-miR-185	CLIP-seq
MIRT1513503	hsa-miR-3654	CLIP-seq
MIRT1513504	hsa-miR-4306	CLIP-seq
MIRT1513505	hsa-miR-4644	CLIP-seq
MIRT1513506	hsa-miR-4645-3p	CLIP-seq
MIRT1513507	hsa-miR-542-3p	CLIP-seq
MIRT2154751	hsa-miR-4260	CLIP-seq
MIRT2154752	hsa-miR-4744	CLIP-seq
MIRT2441794	hsa-miR-296-5p	CLIP-seq
MIRT2441795	hsa-miR-544	CLIP-seq
MIRT2667364	hsa-miR-1245b-3p	CLIP-seq
MIRT2667365	hsa-miR-1276	CLIP-seq
MIRT2667366	hsa-miR-1305	CLIP-seq
MIRT2667367	hsa-miR-147	CLIP-seq
MIRT2667368	hsa-miR-3133	CLIP-seq
MIRT2667369	hsa-miR-3201	CLIP-seq
MIRT2667370	hsa-miR-3682-3p	CLIP-seq
MIRT2667371	hsa-miR-3684	CLIP-seq
MIRT2667372	hsa-miR-3691-5p	CLIP-seq
MIRT2667373	hsa-miR-3911	CLIP-seq
MIRT2667374	hsa-miR-3924	CLIP-seq
MIRT2667375	hsa-miR-4302	CLIP-seq
MIRT2667376	hsa-miR-4311	CLIP-seq
MIRT2667377	hsa-miR-4431	CLIP-seq
MIRT2667378	hsa-miR-4432	CLIP-seq
MIRT2667379	hsa-miR-452	CLIP-seq
MIRT2667380	hsa-miR-4676-3p	CLIP-seq
MIRT2154752	hsa-miR-4744	CLIP-seq
MIRT2667381	hsa-miR-4752	CLIP-seq
MIRT2667382	hsa-miR-4791	CLIP-seq
MIRT2667383	hsa-miR-548b-3p	CLIP-seq
MIRT2667384	hsa-miR-561	CLIP-seq
MIRT2667385	hsa-miR-583	CLIP-seq
MIRT2667386	hsa-miR-644	CLIP-seq
MIRT2667378	hsa-miR-4432	CLIP-seq
MIRT2667379	hsa-miR-452	CLIP-seq
MIRT2667380	hsa-miR-4676-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0003677	Function	DNA binding	ISS
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0007417	Process	Central nervous system development	IBA
GO:0008270	Function	Zinc ion binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
608948	20393	ENSG00000174963

Q8N9L1

Protein name

Zinc finger protein ZIC 4 (Zinc finger protein of the cerebellum 4)

Protein function

Binds to DNA.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF18366	zf_ZIC	121 → 166	Zic proteins zinc finger domain	Domain
PF00096	zf-C2H2	204 → 228	Zinc finger, C2H2 type	Domain
PF00096	zf-C2H2	264 → 288	Zinc finger, C2H2 type	Domain

Sequence

MRYKTSLVMRKRLRLYRNTLKESSSSSGHHGPQLTAASSPSVFPGLHEEPPQASPSRPLN
GLLRLGLPGDMYARPEPFPPGPAARSDALAAAAALHGYGGMNLTVNLAAPHGPGAFFRYM
RQPIKQELICKWLAADGTATPSLCSKTFSTMHELVTHVTVEHVGGPEQANHICFWEECPR
QGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFRCEFEG
CERRFANSSDRKKHSHVHTSDKPYTCKVRGCDKCYTHPSSLRKHMKVHGRSPPPSSGYDS
ATPSALVSPSSDCGHKSQVASSAAVAARTADLSE

Sequence length

334

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Hepatocellular carcinoma	Benign	rs6766244	RCV005898423

Show/Hide Text Mining Associations (25)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Brain Diseases	Associate	31396565
Carnitine palmitoyl transferase 1A deficiency	Associate	39266576
Cerebellar Ataxia	Associate	32943444
Cerebellar Diseases	Stimulate	15007130
Cerebellar Diseases	Associate	32943444, 35997131
Choroid Plexus Neoplasms	Associate	39266576
Dandy Walker Syndrome	Associate	34238780
Glioma	Associate	34475426
Head and Neck Neoplasms	Associate	24786473, 27553089
Laryngeal Neoplasms	Associate	27553089
Mouth Neoplasms	Associate	27553089
Multiple System Atrophy	Associate	35997131
Neoplasms	Associate	25394776, 27548314, 27553089, 39969322
Neoplasms	Inhibit	39266576
Neurologic Manifestations	Associate	15007130
Olivopontocerebellar Atrophies	Inhibit	35997131
Oropharyngeal Neoplasms	Associate	27553089
Ovarian Neoplasms	Associate	23202957
Papilloma Choroid Plexus	Associate	39266576
Paraneoplastic Syndromes	Associate	35997131
Paraneoplastic Syndromes Nervous System	Associate	15007130
Small Cell Lung Carcinoma	Associate	15007130
Squamous Cell Carcinoma of Head and Neck	Associate	27553089
Striatonigral Degeneration	Associate	35997131
Tertiary Lymphoid Structures	Associate	27553089

ZIC4 (Zic family zinc finger 4)