Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8408
Gene name Gene Name - the full gene name approved by the HGNC.
Unc-51 like autophagy activating kinase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ULK1
Synonyms (NCBI Gene) Gene synonyms aliases
ATG1, ATG1A, UNC51, Unc51.1, hATG1
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q24.33
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT017081 hsa-miR-335-5p Microarray 18185580
MIRT051250 hsa-miR-16-5p CLASH 23622248
MIRT045246 hsa-miR-186-5p CLASH 23622248
MIRT044753 hsa-miR-320a CLASH 23622248
MIRT038087 hsa-miR-423-5p CLASH 23622248
Transcription factors
Transcription factor Regulation Reference
E2F1 Activation 18408756
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004674 Function Protein serine/threonine kinase activity IDA 18936157, 25126726, 27103069
GO:0004674 Function Protein serine/threonine kinase activity NAS 9693035
GO:0004674 Function Protein serine/threonine kinase activity TAS
GO:0005515 Function Protein binding IPI 11146101, 17389358, 18936157, 19211835, 19597335, 20562859, 21072212, 22354037, 22613832, 23392225, 23524951, 24290141, 24603492, 25126726, 25127057, 25438055, 25686248, 25891078, 26347139, 26593251, 27334615, 28195531, 28561066, 29950492, 31806350
GO:0005524 Function ATP binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603168 12558 ENSG00000177169
Protein
UniProt ID O75385
Protein name Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1)
Protein function Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kina
PDB 4WNO , 4WNP , 5CI7 , 6HYO , 6MNH , 6QAS , 8P5G , 8P5H , 8P5I , 8P5J , 8P5K , 8P5L , 8SOI , 8SQZ , 8SRM , 8SV9 , 9C82 , 9F32
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 16 278 Protein kinase domain Domain
PF12063 DUF3543 842 1048 Domain of unknown function (DUF3543) Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.
Sequence
MEPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLL
GKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQ
QIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAAT
LCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLV
PTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFL
DASPSVRKSPPVPVPSYPSSGS
GSSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMV
PAQFPGDLVAEAPSAKPPPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSSPSPSGRAGP
FSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAIRRSGSTSPLGFARASPSP
PAHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSA
PEHSPRTSGLGCRLHSAPNLSDLHVVRPKLPKPPTDPLGAVFSPPQASPPQPSHGLQSCR
NLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVVMTPPRNRT
LPDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPDPGSTESL
QEKPMEIAPSAGFGGSLHPGARAGGTSSPSPVVFTVGSPPSGSTPPQGPRTRMFSAGPTG
SASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGAVTFEAPDLPEETLMEQEH
TEILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGFAEQL
VLYLKVAELLSSGLQSAIDQIRAGKLCLSSTVKQVVRRLNELYKASVVSCQGLSLRLQRF
FLDKQRLLDRIHSITAERLIFSHAVQMVQSAALDEMFQHREGCVPRYHKALLLLEGLQHM
LSDQADIENVTKCKLCIERRLSALLTGI
CA
Sequence length 1050
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Mitophagy - animal
Autophagy - animal
mTOR signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Alzheimer disease
Amyotrophic lateral sclerosis
Huntington disease
Spinocerebellar ataxia
Pathways of neurodegeneration - multiple diseases
  Macroautophagy
TBC/RABGAPs
RAB GEFs exchange GTP for GDP on RABs
Receptor Mediated Mitophagy
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Lung adenocarcinoma Adenocarcinoma of lung (disorder) rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370
View all (5 more)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 25404012
Anodontia Associate 28844109
Autoimmune Diseases Associate 25792739
beta Thalassemia Associate 37339583, 37894732, 40655320
Breast Neoplasms Associate 28351329, 31409895, 32705220, 33213267, 33632157, 34870550
Carcinogenesis Associate 28844109
Carcinoma Endometrioid Associate 34162658
Carcinoma Hepatocellular Associate 23573318, 35565977, 35953761
Carcinoma Non Small Cell Lung Associate 28614291, 28639909, 34957997, 36281945
Carcinoma Ovarian Epithelial Associate 34162658, 36805591, 38286802