Gene Gene information from NCBI Gene database.
Entrez ID 8408
Gene name Unc-51 like autophagy activating kinase 1
Gene symbol ULK1
Synonyms (NCBI Gene)
ATG1ATG1AUNC51Unc51.1hATG1
Chromosome 12
Chromosome location 12q24.33
miRNA miRNA information provided by mirtarbase database.
760
miRTarBase ID miRNA Experiments Reference
MIRT017081 hsa-miR-335-5p Microarray 18185580
MIRT051250 hsa-miR-16-5p CLASH 23622248
MIRT045246 hsa-miR-186-5p CLASH 23622248
MIRT044753 hsa-miR-320a CLASH 23622248
MIRT038087 hsa-miR-423-5p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
E2F1 Activation 18408756
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
85
GO ID Ontology Definition Evidence Reference
GO:0000045 Process Autophagosome assembly IBA
GO:0000045 Process Autophagosome assembly IDA 20713597, 23202584, 23392225, 23524951, 25891078, 33637724
GO:0000045 Process Autophagosome assembly IDA 19225151, 28890335
GO:0000045 Process Autophagosome assembly IMP 30778222
GO:0000166 Function Nucleotide binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603168 12558 ENSG00000177169
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O75385
Protein name Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1)
Protein function Serine/threonine-protein kinase involved in autophagy in response to starvation (PubMed:18936157, PubMed:21460634, PubMed:21795849, PubMed:23524951, PubMed:25040165, PubMed:29487085, PubMed:31123703). Acts upstream of phosphatidylinositol 3-kina
PDB 4WNO , 4WNP , 5CI7 , 6HYO , 6MNH , 6QAS , 8P5G , 8P5H , 8P5I , 8P5J , 8P5K , 8P5L , 8SOI , 8SQZ , 8SRM , 8SV9 , 9C82 , 9F32
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 16 278 Protein kinase domain Domain
PF12063 DUF3543 842 1048 Domain of unknown function (DUF3543) Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.
Sequence
MEPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLL
GKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQ
QIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAAT
LCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLV
PTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFL
DASPSVRKSPPVPVPSYPSSGS
GSSSSSSSTSHLASPPSLGEMQQLQKTLASPADTAGFLHSSRDSGGSKDSSCDTDDFVMV
PAQFPGDLVAEAPSAKPPPDSLMCSGSSLVASAGLESHGRTPSPSPPCSSSPSPSGRAGP
FSSSRCGASVPIPVPTQVQNYQRIERNLQSPTQFQTPRSSAIRRSGSTSPLGFARASPSP
PAHAEHGGVLARKMSLGGGRPYTPSPQVGTIPERPGWSGTPSPQGAEMRGGRSPRPGSSA
PEHSPRTSGLGCRLHSAPNLSDLHVVRPKLPKPPTDPLGAVFSPPQASPPQPSHGLQSCR
NLRGSPKLPDFLQRNPLPPILGSPTKAVPSFDFPKTPSSQNLLALLARQGVVMTPPRNRT
LPDLSEVGPFHGQPLGPGLRPGEDPKGPFGRSFSTSRLTDLLLKAAFGTQAPDPGSTESL
QEKPMEIAPSAGFGGSLHPGARAGGTSSPSPVVFTVGSPPSGSTPPQGPRTRMFSAGPTG
SASSSARHLVPGPCSEAPAPELPAPGHGCSFADPITANLEGAVTFEAPDLPEETLMEQEH
TEILRGLRFTLLFVQHVLEIAALKGSASEAAGGPEYQLQESVVADQISLLSREWGFAEQL
VLYLKVAELLSSGLQSAIDQIRAGKLCLSSTVKQVVRRLNELYKASVVSCQGLSLRLQRF
FLDKQRLLDRIHSITAERLIFSHAVQMVQSAALDEMFQHREGCVPRYHKALLLLEGLQHM
LSDQADIENVTKCKLCIERRLSALLTGI
CA
Sequence length 1050
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Mitophagy - animal
Autophagy - animal
mTOR signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Alzheimer disease
Amyotrophic lateral sclerosis
Huntington disease
Spinocerebellar ataxia
Pathways of neurodegeneration - multiple diseases
  Macroautophagy
TBC/RABGAPs
RAB GEFs exchange GTP for GDP on RABs
Receptor Mediated Mitophagy
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
3
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
ULK1-related disorder Likely benign rs145451295, rs200169540, rs148651967 RCV003942015
RCV003943844
RCV003932912
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 25404012
Anodontia Associate 28844109
Autoimmune Diseases Associate 25792739
beta Thalassemia Associate 37339583, 37894732, 40655320
Breast Neoplasms Associate 28351329, 31409895, 32705220, 33213267, 33632157, 34870550
Carcinogenesis Associate 28844109
Carcinoma Endometrioid Associate 34162658
Carcinoma Hepatocellular Associate 23573318, 35565977, 35953761
Carcinoma Non Small Cell Lung Associate 28614291, 28639909, 34957997, 36281945
Carcinoma Ovarian Epithelial Associate 34162658, 36805591, 38286802