ANKRD27 (ankyrin repeat domain 27)

Gene

• Entrez ID: 84079
• Gene name: Ankyrin repeat domain 27
• Gene symbol: ANKRD27
• Synonyms (NCBI Gene): PP12899, VARP
• Chromosome: 19
• Chromosome location: 19q13.11

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT002637	hsa-miR-124-3p	Microarray	15685193
MIRT002637	hsa-miR-124-3p	Microarray	18668037
MIRT002637	hsa-miR-124-3p	Microarray	15685193
MIRT050984	hsa-miR-17-5p	CLASH	23622248
MIRT042819	hsa-miR-324-3p	CLASH	23622248
MIRT041158	hsa-miR-500a-3p	CLASH	23622248
MIRT038857	hsa-miR-93-3p	CLASH	23622248
MIRT409697	hsa-miR-218-5p	PAR-CLIP	21572407
MIRT559592	hsa-miR-4750-3p	PAR-CLIP	21572407
MIRT559591	hsa-miR-29b-1-5p	PAR-CLIP	21572407
MIRT559590	hsa-miR-15b-3p	PAR-CLIP	21572407
MIRT559589	hsa-miR-3661	PAR-CLIP	21572407
MIRT559588	hsa-miR-631	PAR-CLIP	21572407
MIRT559587	hsa-miR-5087	PAR-CLIP	21572407
MIRT559586	hsa-miR-2052	PAR-CLIP	21572407
MIRT559584	hsa-miR-4256	PAR-CLIP	21572407
MIRT559585	hsa-miR-183-3p	PAR-CLIP	21572407
MIRT559583	hsa-miR-4452	PAR-CLIP	21572407
MIRT559582	hsa-miR-2113	PAR-CLIP	21572407
MIRT409697	hsa-miR-218-5p	PAR-CLIP	21572407
MIRT559592	hsa-miR-4750-3p	PAR-CLIP	21572407
MIRT559591	hsa-miR-29b-1-5p	PAR-CLIP	21572407
MIRT559590	hsa-miR-15b-3p	PAR-CLIP	21572407
MIRT559589	hsa-miR-3661	PAR-CLIP	21572407
MIRT559588	hsa-miR-631	PAR-CLIP	21572407
MIRT559587	hsa-miR-5087	PAR-CLIP	21572407
MIRT559586	hsa-miR-2052	PAR-CLIP	21572407
MIRT559584	hsa-miR-4256	PAR-CLIP	21572407
MIRT559585	hsa-miR-183-3p	PAR-CLIP	21572407
MIRT559583	hsa-miR-4452	PAR-CLIP	21572407
MIRT559582	hsa-miR-2113	PAR-CLIP	21572407
MIRT783274	hsa-miR-124	CLIP-seq
MIRT783275	hsa-miR-1245b-3p	CLIP-seq
MIRT783276	hsa-miR-1257	CLIP-seq
MIRT783277	hsa-miR-1271	CLIP-seq
MIRT783278	hsa-miR-1273d	CLIP-seq
MIRT783279	hsa-miR-1321	CLIP-seq
MIRT783280	hsa-miR-142-5p	CLIP-seq
MIRT783281	hsa-miR-181a	CLIP-seq
MIRT783282	hsa-miR-181b	CLIP-seq
MIRT783283	hsa-miR-181c	CLIP-seq
MIRT783284	hsa-miR-181d	CLIP-seq
MIRT783285	hsa-miR-182	CLIP-seq
MIRT783286	hsa-miR-29a	CLIP-seq
MIRT783287	hsa-miR-29b	CLIP-seq
MIRT783288	hsa-miR-29c	CLIP-seq
MIRT783289	hsa-miR-3065-5p	CLIP-seq
MIRT783290	hsa-miR-3122	CLIP-seq
MIRT783291	hsa-miR-3168	CLIP-seq
MIRT783292	hsa-miR-3647-3p	CLIP-seq
MIRT783293	hsa-miR-3664-3p	CLIP-seq
MIRT783294	hsa-miR-3689a-3p	CLIP-seq
MIRT783295	hsa-miR-3689c	CLIP-seq
MIRT783296	hsa-miR-3913-5p	CLIP-seq
MIRT783297	hsa-miR-3919	CLIP-seq
MIRT783298	hsa-miR-3974	CLIP-seq
MIRT783299	hsa-miR-4262	CLIP-seq
MIRT783300	hsa-miR-4310	CLIP-seq
MIRT783301	hsa-miR-4330	CLIP-seq
MIRT783302	hsa-miR-4436a	CLIP-seq
MIRT783303	hsa-miR-4446-5p	CLIP-seq
MIRT783304	hsa-miR-4457	CLIP-seq
MIRT783305	hsa-miR-452	CLIP-seq
MIRT783306	hsa-miR-4672	CLIP-seq
MIRT783307	hsa-miR-4676-3p	CLIP-seq
MIRT783308	hsa-miR-4676-5p	CLIP-seq
MIRT783309	hsa-miR-4693-5p	CLIP-seq
MIRT783310	hsa-miR-4728-5p	CLIP-seq
MIRT783311	hsa-miR-4739	CLIP-seq
MIRT783312	hsa-miR-4746-3p	CLIP-seq
MIRT783313	hsa-miR-4755-5p	CLIP-seq
MIRT783314	hsa-miR-4756-3p	CLIP-seq
MIRT783315	hsa-miR-4756-5p	CLIP-seq
MIRT783316	hsa-miR-4777-5p	CLIP-seq
MIRT783317	hsa-miR-4802-3p	CLIP-seq
MIRT783318	hsa-miR-490-5p	CLIP-seq
MIRT783319	hsa-miR-506	CLIP-seq
MIRT783320	hsa-miR-510	CLIP-seq
MIRT783321	hsa-miR-513b	CLIP-seq
MIRT783322	hsa-miR-513c	CLIP-seq
MIRT783323	hsa-miR-514b-5p	CLIP-seq
MIRT783324	hsa-miR-518d-5p	CLIP-seq
MIRT783325	hsa-miR-519b-5p	CLIP-seq
MIRT783326	hsa-miR-519c-5p	CLIP-seq
MIRT783327	hsa-miR-520c-5p	CLIP-seq
MIRT783328	hsa-miR-526a	CLIP-seq
MIRT783329	hsa-miR-548aa	CLIP-seq
MIRT783330	hsa-miR-561	CLIP-seq
MIRT783331	hsa-miR-570	CLIP-seq
MIRT783332	hsa-miR-574-3p	CLIP-seq
MIRT783333	hsa-miR-575	CLIP-seq
MIRT783334	hsa-miR-576-3p	CLIP-seq
MIRT783335	hsa-miR-579	CLIP-seq
MIRT783336	hsa-miR-587	CLIP-seq
MIRT783337	hsa-miR-624	CLIP-seq
MIRT783338	hsa-miR-671-5p	CLIP-seq
MIRT783339	hsa-miR-765	CLIP-seq
MIRT783340	hsa-miR-96	CLIP-seq
MIRT783277	hsa-miR-1271	CLIP-seq
MIRT783285	hsa-miR-182	CLIP-seq
MIRT783335	hsa-miR-579	CLIP-seq
MIRT783336	hsa-miR-587	CLIP-seq
MIRT783340	hsa-miR-96	CLIP-seq
MIRT783277	hsa-miR-1271	CLIP-seq
MIRT783285	hsa-miR-182	CLIP-seq
MIRT783335	hsa-miR-579	CLIP-seq
MIRT783336	hsa-miR-587	CLIP-seq
MIRT783340	hsa-miR-96	CLIP-seq
MIRT783274	hsa-miR-124	CLIP-seq
MIRT783275	hsa-miR-1245b-3p	CLIP-seq
MIRT783276	hsa-miR-1257	CLIP-seq
MIRT783277	hsa-miR-1271	CLIP-seq
MIRT1931086	hsa-miR-1273g	CLIP-seq
MIRT783280	hsa-miR-142-5p	CLIP-seq
MIRT783285	hsa-miR-182	CLIP-seq
MIRT783286	hsa-miR-29a	CLIP-seq
MIRT783287	hsa-miR-29b	CLIP-seq
MIRT783288	hsa-miR-29c	CLIP-seq
MIRT783289	hsa-miR-3065-5p	CLIP-seq
MIRT1931087	hsa-miR-3611	CLIP-seq
MIRT783292	hsa-miR-3647-3p	CLIP-seq
MIRT1931088	hsa-miR-3682-5p	CLIP-seq
MIRT783297	hsa-miR-3919	CLIP-seq
MIRT1931089	hsa-miR-3925-3p	CLIP-seq
MIRT1931090	hsa-miR-425	CLIP-seq
MIRT1931091	hsa-miR-4267	CLIP-seq
MIRT783300	hsa-miR-4310	CLIP-seq
MIRT783301	hsa-miR-4330	CLIP-seq
MIRT783305	hsa-miR-452	CLIP-seq
MIRT783306	hsa-miR-4672	CLIP-seq
MIRT783307	hsa-miR-4676-3p	CLIP-seq
MIRT783309	hsa-miR-4693-5p	CLIP-seq
MIRT783314	hsa-miR-4756-3p	CLIP-seq
MIRT1931092	hsa-miR-4768-5p	CLIP-seq
MIRT783319	hsa-miR-506	CLIP-seq
MIRT783322	hsa-miR-513c	CLIP-seq
MIRT783323	hsa-miR-514b-5p	CLIP-seq
MIRT783330	hsa-miR-561	CLIP-seq
MIRT783332	hsa-miR-574-3p	CLIP-seq
MIRT783334	hsa-miR-576-3p	CLIP-seq
MIRT783335	hsa-miR-579	CLIP-seq
MIRT783336	hsa-miR-587	CLIP-seq
MIRT1931093	hsa-miR-758	CLIP-seq
MIRT1931094	hsa-miR-766	CLIP-seq
MIRT1931095	hsa-miR-942	CLIP-seq
MIRT783340	hsa-miR-96	CLIP-seq
MIRT2171723	hsa-miR-1237	CLIP-seq
MIRT783274	hsa-miR-124	CLIP-seq
MIRT2171724	hsa-miR-1243	CLIP-seq
MIRT783275	hsa-miR-1245b-3p	CLIP-seq
MIRT2171725	hsa-miR-1248	CLIP-seq
MIRT783276	hsa-miR-1257	CLIP-seq
MIRT783277	hsa-miR-1271	CLIP-seq
MIRT783278	hsa-miR-1273d	CLIP-seq
MIRT1931086	hsa-miR-1273g	CLIP-seq
MIRT783280	hsa-miR-142-5p	CLIP-seq
MIRT783285	hsa-miR-182	CLIP-seq
MIRT783289	hsa-miR-3065-5p	CLIP-seq
MIRT783291	hsa-miR-3168	CLIP-seq
MIRT2171726	hsa-miR-3182	CLIP-seq
MIRT1931087	hsa-miR-3611	CLIP-seq
MIRT783292	hsa-miR-3647-3p	CLIP-seq
MIRT2171727	hsa-miR-3654	CLIP-seq
MIRT783293	hsa-miR-3664-3p	CLIP-seq
MIRT2171728	hsa-miR-3667-3p	CLIP-seq
MIRT1931088	hsa-miR-3682-5p	CLIP-seq
MIRT2171729	hsa-miR-3686	CLIP-seq
MIRT2171730	hsa-miR-3907	CLIP-seq
MIRT1931089	hsa-miR-3925-3p	CLIP-seq
MIRT783298	hsa-miR-3974	CLIP-seq
MIRT1931091	hsa-miR-4267	CLIP-seq
MIRT783300	hsa-miR-4310	CLIP-seq
MIRT783301	hsa-miR-4330	CLIP-seq
MIRT783302	hsa-miR-4436a	CLIP-seq
MIRT783304	hsa-miR-4457	CLIP-seq
MIRT2171731	hsa-miR-4477b	CLIP-seq
MIRT783305	hsa-miR-452	CLIP-seq
MIRT783307	hsa-miR-4676-3p	CLIP-seq
MIRT783308	hsa-miR-4676-5p	CLIP-seq
MIRT2171732	hsa-miR-4684-3p	CLIP-seq
MIRT783309	hsa-miR-4693-5p	CLIP-seq
MIRT2171733	hsa-miR-4731-3p	CLIP-seq
MIRT1931092	hsa-miR-4768-5p	CLIP-seq
MIRT783316	hsa-miR-4777-5p	CLIP-seq
MIRT2171734	hsa-miR-4782-5p	CLIP-seq
MIRT2171735	hsa-miR-4801	CLIP-seq
MIRT783318	hsa-miR-490-5p	CLIP-seq
MIRT2171736	hsa-miR-500a	CLIP-seq
MIRT783319	hsa-miR-506	CLIP-seq
MIRT783320	hsa-miR-510	CLIP-seq
MIRT783321	hsa-miR-513b	CLIP-seq
MIRT783322	hsa-miR-513c	CLIP-seq
MIRT783323	hsa-miR-514b-5p	CLIP-seq
MIRT783324	hsa-miR-518d-5p	CLIP-seq
MIRT783325	hsa-miR-519b-5p	CLIP-seq
MIRT783326	hsa-miR-519c-5p	CLIP-seq
MIRT783327	hsa-miR-520c-5p	CLIP-seq
MIRT783328	hsa-miR-526a	CLIP-seq
MIRT783330	hsa-miR-561	CLIP-seq
MIRT783331	hsa-miR-570	CLIP-seq
MIRT783332	hsa-miR-574-3p	CLIP-seq
MIRT783333	hsa-miR-575	CLIP-seq
MIRT783334	hsa-miR-576-3p	CLIP-seq
MIRT783335	hsa-miR-579	CLIP-seq
MIRT783336	hsa-miR-587	CLIP-seq
MIRT783337	hsa-miR-624	CLIP-seq
MIRT783338	hsa-miR-671-5p	CLIP-seq
MIRT1931093	hsa-miR-758	CLIP-seq
MIRT783339	hsa-miR-765	CLIP-seq
MIRT1931094	hsa-miR-766	CLIP-seq
MIRT2171737	hsa-miR-873	CLIP-seq
MIRT1931095	hsa-miR-942	CLIP-seq
MIRT783340	hsa-miR-96	CLIP-seq
MIRT783274	hsa-miR-124	CLIP-seq
MIRT2171724	hsa-miR-1243	CLIP-seq
MIRT783277	hsa-miR-1271	CLIP-seq
MIRT783285	hsa-miR-182	CLIP-seq
MIRT2171727	hsa-miR-3654	CLIP-seq
MIRT2171731	hsa-miR-4477b	CLIP-seq
MIRT783305	hsa-miR-452	CLIP-seq
MIRT783307	hsa-miR-4676-3p	CLIP-seq
MIRT783309	hsa-miR-4693-5p	CLIP-seq
MIRT2171734	hsa-miR-4782-5p	CLIP-seq
MIRT783319	hsa-miR-506	CLIP-seq
MIRT783335	hsa-miR-579	CLIP-seq
MIRT783336	hsa-miR-587	CLIP-seq
MIRT783340	hsa-miR-96	CLIP-seq
MIRT2443666	hsa-miR-3064-3p	CLIP-seq
MIRT783275	hsa-miR-1245b-3p	CLIP-seq
MIRT2474771	hsa-miR-1252	CLIP-seq
MIRT783279	hsa-miR-1321	CLIP-seq
MIRT783281	hsa-miR-181a	CLIP-seq
MIRT783282	hsa-miR-181b	CLIP-seq
MIRT783283	hsa-miR-181c	CLIP-seq
MIRT783284	hsa-miR-181d	CLIP-seq
MIRT2474772	hsa-miR-200b	CLIP-seq
MIRT2474773	hsa-miR-200c	CLIP-seq
MIRT2474774	hsa-miR-221	CLIP-seq
MIRT2474775	hsa-miR-222	CLIP-seq
MIRT2443666	hsa-miR-3064-3p	CLIP-seq
MIRT783289	hsa-miR-3065-5p	CLIP-seq
MIRT2474776	hsa-miR-3154	CLIP-seq
MIRT783291	hsa-miR-3168	CLIP-seq
MIRT2474777	hsa-miR-3662	CLIP-seq
MIRT2171730	hsa-miR-3907	CLIP-seq
MIRT783299	hsa-miR-4262	CLIP-seq
MIRT2474778	hsa-miR-429	CLIP-seq
MIRT783300	hsa-miR-4310	CLIP-seq
MIRT783301	hsa-miR-4330	CLIP-seq
MIRT783308	hsa-miR-4676-5p	CLIP-seq
MIRT2171732	hsa-miR-4684-3p	CLIP-seq
MIRT783311	hsa-miR-4739	CLIP-seq
MIRT783315	hsa-miR-4756-5p	CLIP-seq
MIRT783316	hsa-miR-4777-5p	CLIP-seq
MIRT783318	hsa-miR-490-5p	CLIP-seq
MIRT783322	hsa-miR-513c	CLIP-seq
MIRT783323	hsa-miR-514b-5p	CLIP-seq
MIRT783324	hsa-miR-518d-5p	CLIP-seq
MIRT783325	hsa-miR-519b-5p	CLIP-seq
MIRT783326	hsa-miR-519c-5p	CLIP-seq
MIRT783327	hsa-miR-520c-5p	CLIP-seq
MIRT783328	hsa-miR-526a	CLIP-seq
MIRT2474779	hsa-miR-548v	CLIP-seq
MIRT2474780	hsa-miR-552	CLIP-seq
MIRT783332	hsa-miR-574-3p	CLIP-seq
MIRT783333	hsa-miR-575	CLIP-seq
MIRT783334	hsa-miR-576-3p	CLIP-seq
MIRT783338	hsa-miR-671-5p	CLIP-seq
MIRT2474781	hsa-miR-764	CLIP-seq
MIRT2474782	hsa-miR-802	CLIP-seq
MIRT2171737	hsa-miR-873	CLIP-seq
MIRT2474771	hsa-miR-1252	CLIP-seq
MIRT783278	hsa-miR-1273d	CLIP-seq
MIRT783279	hsa-miR-1321	CLIP-seq
MIRT783281	hsa-miR-181a	CLIP-seq
MIRT783282	hsa-miR-181b	CLIP-seq
MIRT783283	hsa-miR-181c	CLIP-seq
MIRT783284	hsa-miR-181d	CLIP-seq
MIRT2474772	hsa-miR-200b	CLIP-seq
MIRT2474773	hsa-miR-200c	CLIP-seq
MIRT2474774	hsa-miR-221	CLIP-seq
MIRT2474775	hsa-miR-222	CLIP-seq
MIRT2443666	hsa-miR-3064-3p	CLIP-seq
MIRT783289	hsa-miR-3065-5p	CLIP-seq
MIRT2474776	hsa-miR-3154	CLIP-seq
MIRT2474777	hsa-miR-3662	CLIP-seq
MIRT783293	hsa-miR-3664-3p	CLIP-seq
MIRT783299	hsa-miR-4262	CLIP-seq
MIRT2474778	hsa-miR-429	CLIP-seq
MIRT783302	hsa-miR-4436a	CLIP-seq
MIRT783311	hsa-miR-4739	CLIP-seq
MIRT783315	hsa-miR-4756-5p	CLIP-seq
MIRT783316	hsa-miR-4777-5p	CLIP-seq
MIRT783320	hsa-miR-510	CLIP-seq
MIRT783322	hsa-miR-513c	CLIP-seq
MIRT783323	hsa-miR-514b-5p	CLIP-seq
MIRT783324	hsa-miR-518d-5p	CLIP-seq
MIRT783325	hsa-miR-519b-5p	CLIP-seq
MIRT783326	hsa-miR-519c-5p	CLIP-seq
MIRT783327	hsa-miR-520c-5p	CLIP-seq
MIRT783328	hsa-miR-526a	CLIP-seq
MIRT2474779	hsa-miR-548v	CLIP-seq
MIRT2474780	hsa-miR-552	CLIP-seq
MIRT2474781	hsa-miR-764	CLIP-seq
MIRT2474782	hsa-miR-802	CLIP-seq
MIRT2171737	hsa-miR-873	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000149	Function	SNARE binding	IBA
GO:0000149	Function	SNARE binding	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	16525121
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	16525121, 19745841, 22705394, 23104059
GO:0005764	Component	Lysosome	IDA	24856514
GO:0005764	Component	Lysosome	IEA
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IBA
GO:0005769	Component	Early endosome	IDA	16525121, 24856514
GO:0005769	Component	Early endosome	IEA
GO:0005770	Component	Late endosome	IBA
GO:0005770	Component	Late endosome	IDA	24856514
GO:0005770	Component	Late endosome	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	24856514
GO:0005886	Component	Plasma membrane	IEA
GO:0010976	Process	Positive regulation of neuron projection development	IEA
GO:0012505	Component	Endomembrane system	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0030133	Component	Transport vesicle	IBA
GO:0030133	Component	Transport vesicle	IEA
GO:0030659	Component	Cytoplasmic vesicle membrane	IEA
GO:0031267	Function	Small GTPase binding	IDA	16525121
GO:0031267	Function	Small GTPase binding	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032456	Process	Endocytic recycling	IMP	24856514
GO:0035544	Process	Negative regulation of SNARE complex assembly	IDA	24856514
GO:0035646	Process	Endosome to melanosome transport	IEA
GO:0042470	Component	Melanosome	IEA
GO:0043005	Component	Neuron projection	IBA
GO:0043005	Component	Neuron projection	IEA
GO:0045022	Process	Early endosome to late endosome transport	IBA
GO:0045022	Process	Early endosome to late endosome transport	IDA	16525121
GO:0048812	Process	Neuron projection morphogenesis	IBA
GO:0048812	Process	Neuron projection morphogenesis	IEA
GO:0050775	Process	Positive regulation of dendrite morphogenesis	IEA
GO:0097422	Component	Tubular endosome	IBA
GO:0097422	Component	Tubular endosome	IDA	24856514

Other IDs

• MIM: 618957
• HGNC: 25310
• e!Ensembl: ENSG00000105186

Protein

• UniProt ID: Q96NW4
• Protein name: Ankyrin repeat domain-containing protein 27 (VPS9 domain-containing protein)
• Protein function: May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics (PubMed:16525121, PubMed:18477474). May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE comple
• PDB: 4B93, 4CYM, 4CZ2, 6TL0
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02204	VPS9	264 → 367	Vacuolar sorting protein 9 (VPS9) domain	Family
  PF12796	Ank_2	401 → 526	Ankyrin repeats (3 copies)	Repeat
  PF12796	Ank_2	500 → 595	Ankyrin repeats (3 copies)	Repeat
  PF12796	Ank_2	673 → 807	Ankyrin repeats (3 copies)	Repeat
  PF12796	Ank_2	781 → 873	Ankyrin repeats (3 copies)	Repeat

• Sequence:

  MALYDEDLLKNPFYLALQKCRPDLCSKVAQIHGIVLVPCKGSLSSSIQSTCQFESYILIP
  VEEHFQTLNGKDVFIQGNRIKLGAGFACLLSVPILFEETFYNEKEESFSILCIAHPLEKR
  ESSEEPLAPSDPFSLKTIEDVREFLGRHSERFDRNIASFHRTFRECERKSLRHHIDSANA
  LYTKCLQQLLRDSHLKMLAKQEAQMNLMKQAVEIYVHHEIYNLIFKYVGTMEASEDAAFN
  KITRSLQDLQQKDIGVKPEFSFNIPRAKRELAQLNKCTSPQQKLVCLRKVVQLITQSPSQ
  RVNLETMCADDLLSVLLYLLVKTEIPNWMANLSYIKNFRFSSLAKDELGYCLTSFEAAIE
  YIRQGSLSAKPPESEGFGDRLFLKQRMSLLSQMTSSPTDCLFKHIASGNQKEVERLLSQE
  DHDKDTVQKMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLID
  LLVSKGAMVNATDYHGATPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYG
  HEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKET
  PLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQ
  EETKKDYREVEKLLRAVADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKC
  APAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVP
  LHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASN
  NKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCV
  ASLDDVAETDRKEYVTVKIRKKWNSKLYDLPDEPFTRQFYFVHSAGQFKGKTSREIMARD
  RSVPNLTEGSLHEPGRQSVTLRQNNLPAQSGSHAAEKGNSDWPERPGLTQTGPGHRRMLR
  RHTVEDAVVSQGPEAAGPLSTPQEVSASRS

• Sequence length: 1050

Pathways

Reactome:

RAB GEFs exchange GTP for GDP on RABs