SPARCL1 (SPARC like 1)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
8404
Gene name Gene Name - the full gene name approved by the HGNC.
SPARC like 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SPARCL1
Synonyms (NCBI Gene) Gene synonyms aliases
MAST 9, MAST9, PIG33, SC1
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q22.1
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(12)
miRTarBase ID miRNA Experiments Reference
MIRT027605 hsa-miR-98-5p Microarray 19088304
MIRT755960 hsa-miR-1290 Luciferase reporter assay, Western blotting, qRT-PCR, RNA pull down assay 35549806
MIRT1381922 hsa-miR-101 CLIP-seq
MIRT1381923 hsa-miR-144 CLIP-seq
MIRT1381924 hsa-miR-153 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(15)
GO ID Ontology Definition Evidence Reference
GO:0005509 Function Calcium ion binding IBA 21873635
GO:0005515 Function Protein binding IPI 20926826
GO:0005518 Function Collagen binding IBA 21873635
GO:0005576 Component Extracellular region HDA 27068509
GO:0005615 Component Extracellular space HDA 16502470
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
606041 11220 ENSG00000152583
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q14515
Protein name SPARC-like protein 1 (High endothelial venule protein) (Hevin) (MAST 9)
PDB 7KBU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09289 FOLN 433 → 454 Follistatin/Osteonectin-like EGF domain Domain
PF00050 Kazal_1 456 → 509 Kazal-type serine protease inhibitor domain Domain
PF10591 SPARC_Ca_bdg 512 → 650 Secreted protein acidic and rich in cysteine Ca binding region Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in lymph node, brain, heart, lung, skeletal muscle, ovary, small intestine, and colon, with lower levels in placenta, pancreas, testis, spleen, and thymus, and no expression in kidney, liver, and peripheral blood leuko
Sequence 
MKTGLFFLCLLGTAAAIPTNARLLSDHSKPTAETVAPDNTAIPSLRAEAEENEKETAVST
EDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTL
DIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSK
HSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPREHANSKQEEDNTQS
DDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKT
GLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDD
YFIPSQAFLEAERAQSIAYHLKIEEQREKVHENENIGTTEPGEHQEAKKAENSSNEEETS
SEGNMRVHAVDSCMSFQCKRGHICKADQQGKPHCVCQDPVTCPPTKPLDQVCGTDNQTYA
SSCHLFATKCRLEGTKKGHQLQLDYFGACKSIPTCTDFEVIQFPLRMRDWLKNILMQLYE
ANSEHAGYLNEKQRNKVKKIYLDEKRLLAGDHPIDLLLRDFKKNYHMYVYPVHWQFSELD
QHPMDRVLTHSELAPLRASLVPMEHCITRFFEECDPNKDKHITLKEWGHCFGIKEEDIDE
NLLF
Sequence length 664
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Epilepsy Epilepsy, Epilepsy, Cryptogenic, Awakening Epilepsy rs113994140, rs28937874, rs1589762127, rs104894166, rs28939075, rs2134001459, rs104894167, rs119488099, rs119488100, rs387906420, rs121917752, rs121918622, rs281865564, rs387907313, rs397514670
View all (165 more)		 18488994
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Endometriosis Endometriosis 20864642 ClinVar
Corneal Dystrophy stromal corneal dystrophy GenCC
Show/Hide Text Mining Associations (46)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 24921089
Adenocarcinoma of Lung Inhibit 28178989
Alzheimer Disease Associate 29154276, 40471493
Amyotrophic Lateral Sclerosis Associate 26401960
Breast Neoplasms Inhibit 23534723
Breast Neoplasms Associate 37180578
Carcinogenesis Associate 23534723
Carcinoma Hepatocellular Associate 34238253
Carcinoma Ovarian Epithelial Associate 30964161
Carcinoma Pancreatic Ductal Stimulate 17325739