Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	83989
Gene name Gene Name - the full gene name approved by the HGNC.	ARB2 cotranscriptional regulator A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ARB2A
Synonyms (NCBI Gene) Gene synonyms aliases	C5orf21, FAM172A, Toupee
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q15

Show/Hide all(218)

miRTarBase ID	miRNA	Experiments	Reference
MIRT039397	hsa-miR-421	CLASH	23622248
MIRT527521	hsa-miR-6835-3p	PAR-CLIP	22012620
MIRT527520	hsa-miR-1910-3p	PAR-CLIP	22012620
MIRT527519	hsa-miR-6511a-5p	PAR-CLIP	22012620
MIRT401439	hsa-miR-330-3p	PAR-CLIP	22012620
MIRT527518	hsa-miR-1827	PAR-CLIP	22012620
MIRT440683	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440683	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT527521	hsa-miR-6835-3p	PAR-CLIP	22012620
MIRT527520	hsa-miR-1910-3p	PAR-CLIP	22012620
MIRT527519	hsa-miR-6511a-5p	PAR-CLIP	22012620
MIRT401439	hsa-miR-330-3p	PAR-CLIP	22012620
MIRT527518	hsa-miR-1827	PAR-CLIP	22012620
MIRT981975	hsa-miR-1207-5p	CLIP-seq
MIRT981976	hsa-miR-1236	CLIP-seq
MIRT981977	hsa-miR-1252	CLIP-seq
MIRT981978	hsa-miR-1273d	CLIP-seq
MIRT981979	hsa-miR-1279	CLIP-seq
MIRT981980	hsa-miR-1299	CLIP-seq
MIRT981981	hsa-miR-132	CLIP-seq
MIRT981982	hsa-miR-137	CLIP-seq
MIRT981983	hsa-miR-147	CLIP-seq
MIRT981984	hsa-miR-2053	CLIP-seq
MIRT981985	hsa-miR-212	CLIP-seq
MIRT981986	hsa-miR-23a	CLIP-seq
MIRT981987	hsa-miR-23b	CLIP-seq
MIRT981988	hsa-miR-23c	CLIP-seq
MIRT981989	hsa-miR-3065-5p	CLIP-seq
MIRT981990	hsa-miR-3074-3p	CLIP-seq
MIRT981991	hsa-miR-30a	CLIP-seq
MIRT981992	hsa-miR-30b	CLIP-seq
MIRT981993	hsa-miR-30c	CLIP-seq
MIRT981994	hsa-miR-30d	CLIP-seq
MIRT981995	hsa-miR-30e	CLIP-seq
MIRT981996	hsa-miR-3143	CLIP-seq
MIRT981997	hsa-miR-3145-5p	CLIP-seq
MIRT981998	hsa-miR-3148	CLIP-seq
MIRT981999	hsa-miR-3159	CLIP-seq
MIRT982000	hsa-miR-3182	CLIP-seq
MIRT982001	hsa-miR-3190	CLIP-seq
MIRT982002	hsa-miR-3192	CLIP-seq
MIRT982003	hsa-miR-323-5p	CLIP-seq
MIRT982004	hsa-miR-323b-5p	CLIP-seq
MIRT982005	hsa-miR-326	CLIP-seq
MIRT982006	hsa-miR-330-5p	CLIP-seq
MIRT982007	hsa-miR-3606	CLIP-seq
MIRT982008	hsa-miR-361-5p	CLIP-seq
MIRT982009	hsa-miR-3647-3p	CLIP-seq
MIRT982010	hsa-miR-3688-3p	CLIP-seq
MIRT982011	hsa-miR-378g	CLIP-seq
MIRT982012	hsa-miR-3911	CLIP-seq
MIRT982013	hsa-miR-3919	CLIP-seq
MIRT982014	hsa-miR-3942-3p	CLIP-seq
MIRT982015	hsa-miR-3978	CLIP-seq
MIRT982016	hsa-miR-4272	CLIP-seq
MIRT982017	hsa-miR-4274	CLIP-seq
MIRT982018	hsa-miR-4292	CLIP-seq
MIRT982019	hsa-miR-4303	CLIP-seq
MIRT982020	hsa-miR-4314	CLIP-seq
MIRT982021	hsa-miR-4325	CLIP-seq
MIRT982022	hsa-miR-4422	CLIP-seq
MIRT982023	hsa-miR-4437	CLIP-seq
MIRT982024	hsa-miR-4514	CLIP-seq
MIRT982025	hsa-miR-4519	CLIP-seq
MIRT982026	hsa-miR-4527	CLIP-seq
MIRT982027	hsa-miR-4635	CLIP-seq
MIRT982028	hsa-miR-4645-3p	CLIP-seq
MIRT982029	hsa-miR-4645-5p	CLIP-seq
MIRT982030	hsa-miR-4646-5p	CLIP-seq
MIRT982031	hsa-miR-4649-3p	CLIP-seq
MIRT982032	hsa-miR-4673	CLIP-seq
MIRT982033	hsa-miR-4674	CLIP-seq
MIRT982034	hsa-miR-4690-3p	CLIP-seq
MIRT982035	hsa-miR-4692	CLIP-seq
MIRT982036	hsa-miR-4694-3p	CLIP-seq
MIRT982037	hsa-miR-4725-5p	CLIP-seq
MIRT982038	hsa-miR-4729	CLIP-seq
MIRT982039	hsa-miR-4747-5p	CLIP-seq
MIRT982040	hsa-miR-4755-3p	CLIP-seq
MIRT982041	hsa-miR-4756-3p	CLIP-seq
MIRT982042	hsa-miR-4762-3p	CLIP-seq
MIRT982043	hsa-miR-4763-3p	CLIP-seq
MIRT982044	hsa-miR-4766-5p	CLIP-seq
MIRT982045	hsa-miR-4778-3p	CLIP-seq
MIRT982046	hsa-miR-4782-5p	CLIP-seq
MIRT982047	hsa-miR-495	CLIP-seq
MIRT982048	hsa-miR-504	CLIP-seq
MIRT982049	hsa-miR-508-5p	CLIP-seq
MIRT982050	hsa-miR-514	CLIP-seq
MIRT982051	hsa-miR-514b-3p	CLIP-seq
MIRT982052	hsa-miR-516b	CLIP-seq
MIRT982053	hsa-miR-526b	CLIP-seq
MIRT982054	hsa-miR-545	CLIP-seq
MIRT982055	hsa-miR-548ac	CLIP-seq
MIRT982056	hsa-miR-548d-3p	CLIP-seq
MIRT982057	hsa-miR-548n	CLIP-seq
MIRT982058	hsa-miR-548p	CLIP-seq
MIRT982059	hsa-miR-548t	CLIP-seq
MIRT982060	hsa-miR-548z	CLIP-seq
MIRT982061	hsa-miR-556-3p	CLIP-seq
MIRT982062	hsa-miR-578	CLIP-seq
MIRT982063	hsa-miR-581	CLIP-seq
MIRT982064	hsa-miR-615-3p	CLIP-seq
MIRT982065	hsa-miR-644	CLIP-seq
MIRT982066	hsa-miR-665	CLIP-seq
MIRT982067	hsa-miR-760	CLIP-seq
MIRT982068	hsa-miR-875-3p	CLIP-seq
MIRT982069	hsa-miR-876-3p	CLIP-seq
MIRT982070	hsa-miR-885-3p	CLIP-seq
MIRT982071	hsa-miR-940	CLIP-seq
MIRT982034	hsa-miR-4690-3p	CLIP-seq
MIRT982070	hsa-miR-885-3p	CLIP-seq
MIRT982034	hsa-miR-4690-3p	CLIP-seq
MIRT982070	hsa-miR-885-3p	CLIP-seq
MIRT981975	hsa-miR-1207-5p	CLIP-seq
MIRT981977	hsa-miR-1252	CLIP-seq
MIRT981979	hsa-miR-1279	CLIP-seq
MIRT981982	hsa-miR-137	CLIP-seq
MIRT1991071	hsa-miR-141	CLIP-seq
MIRT1991072	hsa-miR-200a	CLIP-seq
MIRT981984	hsa-miR-2053	CLIP-seq
MIRT982005	hsa-miR-326	CLIP-seq
MIRT982006	hsa-miR-330-5p	CLIP-seq
MIRT982011	hsa-miR-378g	CLIP-seq
MIRT982013	hsa-miR-3919	CLIP-seq
MIRT982014	hsa-miR-3942-3p	CLIP-seq
MIRT1991073	hsa-miR-3943	CLIP-seq
MIRT1991074	hsa-miR-4286	CLIP-seq
MIRT1991075	hsa-miR-4323	CLIP-seq
MIRT982021	hsa-miR-4325	CLIP-seq
MIRT982024	hsa-miR-4514	CLIP-seq
MIRT982028	hsa-miR-4645-3p	CLIP-seq
MIRT982029	hsa-miR-4645-5p	CLIP-seq
MIRT982032	hsa-miR-4673	CLIP-seq
MIRT982035	hsa-miR-4692	CLIP-seq
MIRT982040	hsa-miR-4755-3p	CLIP-seq
MIRT982041	hsa-miR-4756-3p	CLIP-seq
MIRT1991076	hsa-miR-4758-3p	CLIP-seq
MIRT982043	hsa-miR-4763-3p	CLIP-seq
MIRT1991077	hsa-miR-4775	CLIP-seq
MIRT982050	hsa-miR-514	CLIP-seq
MIRT982051	hsa-miR-514b-3p	CLIP-seq
MIRT982055	hsa-miR-548ac	CLIP-seq
MIRT1991078	hsa-miR-548ae	CLIP-seq
MIRT1991079	hsa-miR-548aj	CLIP-seq
MIRT1991080	hsa-miR-548am	CLIP-seq
MIRT982056	hsa-miR-548d-3p	CLIP-seq
MIRT1991081	hsa-miR-548x	CLIP-seq
MIRT982060	hsa-miR-548z	CLIP-seq
MIRT1991082	hsa-miR-590-3p	CLIP-seq
MIRT982064	hsa-miR-615-3p	CLIP-seq
MIRT982071	hsa-miR-940	CLIP-seq
MIRT981975	hsa-miR-1207-5p	CLIP-seq
MIRT982002	hsa-miR-3192	CLIP-seq
MIRT982024	hsa-miR-4514	CLIP-seq
MIRT982029	hsa-miR-4645-5p	CLIP-seq
MIRT982032	hsa-miR-4673	CLIP-seq
MIRT982035	hsa-miR-4692	CLIP-seq
MIRT982040	hsa-miR-4755-3p	CLIP-seq
MIRT982043	hsa-miR-4763-3p	CLIP-seq
MIRT2225180	hsa-miR-4799-5p	CLIP-seq
MIRT982064	hsa-miR-615-3p	CLIP-seq
MIRT982071	hsa-miR-940	CLIP-seq
MIRT981975	hsa-miR-1207-5p	CLIP-seq
MIRT981980	hsa-miR-1299	CLIP-seq
MIRT1991071	hsa-miR-141	CLIP-seq
MIRT2387764	hsa-miR-193a-3p	CLIP-seq
MIRT2387765	hsa-miR-193b	CLIP-seq
MIRT1991072	hsa-miR-200a	CLIP-seq
MIRT981984	hsa-miR-2053	CLIP-seq
MIRT982003	hsa-miR-323-5p	CLIP-seq
MIRT982008	hsa-miR-361-5p	CLIP-seq
MIRT982024	hsa-miR-4514	CLIP-seq
MIRT982026	hsa-miR-4527	CLIP-seq
MIRT982029	hsa-miR-4645-5p	CLIP-seq
MIRT982032	hsa-miR-4673	CLIP-seq
MIRT982035	hsa-miR-4692	CLIP-seq
MIRT982040	hsa-miR-4755-3p	CLIP-seq
MIRT982043	hsa-miR-4763-3p	CLIP-seq
MIRT982064	hsa-miR-615-3p	CLIP-seq
MIRT982068	hsa-miR-875-3p	CLIP-seq
MIRT982069	hsa-miR-876-3p	CLIP-seq
MIRT982071	hsa-miR-940	CLIP-seq
MIRT982034	hsa-miR-4690-3p	CLIP-seq
MIRT982070	hsa-miR-885-3p	CLIP-seq
MIRT982034	hsa-miR-4690-3p	CLIP-seq
MIRT982070	hsa-miR-885-3p	CLIP-seq
MIRT2449225	hsa-miR-410	CLIP-seq
MIRT2449226	hsa-miR-4717-5p	CLIP-seq
MIRT2449227	hsa-miR-4753-5p	CLIP-seq
MIRT2528669	hsa-miR-1179	CLIP-seq
MIRT981978	hsa-miR-1273d	CLIP-seq
MIRT2528670	hsa-miR-1273e	CLIP-seq
MIRT981979	hsa-miR-1279	CLIP-seq
MIRT981982	hsa-miR-137	CLIP-seq
MIRT2528671	hsa-miR-218	CLIP-seq
MIRT2528672	hsa-miR-25	CLIP-seq
MIRT2528673	hsa-miR-299-5p	CLIP-seq
MIRT2528674	hsa-miR-3147	CLIP-seq
MIRT2528675	hsa-miR-3170	CLIP-seq
MIRT2528676	hsa-miR-32	CLIP-seq
MIRT2528677	hsa-miR-363	CLIP-seq
MIRT2528678	hsa-miR-367	CLIP-seq
MIRT982021	hsa-miR-4325	CLIP-seq
MIRT2528679	hsa-miR-4425	CLIP-seq
MIRT982028	hsa-miR-4645-3p	CLIP-seq
MIRT982034	hsa-miR-4690-3p	CLIP-seq
MIRT982050	hsa-miR-514	CLIP-seq
MIRT982051	hsa-miR-514b-3p	CLIP-seq
MIRT2528680	hsa-miR-629	CLIP-seq
MIRT2528681	hsa-miR-636	CLIP-seq
MIRT982070	hsa-miR-885-3p	CLIP-seq
MIRT2528682	hsa-miR-92a	CLIP-seq
MIRT2528683	hsa-miR-92b	CLIP-seq
MIRT2680583	hsa-miR-3163	CLIP-seq
MIRT2680584	hsa-miR-4427	CLIP-seq
MIRT2680585	hsa-miR-4490	CLIP-seq
MIRT2680586	hsa-miR-4774-5p	CLIP-seq

Show/Hide all(15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000381	Process	Regulation of alternative mRNA splicing, via spliceosome	IEA
GO:0000381	Process	Regulation of alternative mRNA splicing, via spliceosome	ISS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0014032	Process	Neural crest cell development	IEA
GO:0014032	Process	Neural crest cell development	ISS
GO:0031048	Process	Regulatory ncRNA-mediated heterochromatin formation	IBA
GO:0035197	Function	SiRNA binding	IBA

MIM	HGNC	e!Ensembl
621249	25365	ENSG00000113391

Protein

UniProt ID

Q8WUF8

Protein name

Cotranscriptional regulator ARB2A (ARB2 cotranscriptional regulator A) (Cotranscriptional regulator FAM172A) (Protein FAM172A)

Protein function

Plays a role in the regulation of alternative splicing, by interacting with AGO2 and CHD7. Seems to be required for stabilizing protein-protein interactions at the chromatin-spliceosome interface. May have hydrolase activity. {ECO:0000250|UniPro

Family and domains

Sequence

MSISLSSLILLPIWINMAQIQQGGPDEKEKTTALKDLLSRIDLDELMKKDEPPLDFPDTL
EGFEYAFNEKGQLRHIKTGEPFVFNYREDLHRWNQKRYEALGEIITKYVYELLEKDCNLK
KVSIPVDATESEPKSFIFMSEDALTNPQKLMVLIHGSGVVRAGQWARRLIINEDLDSGTQ
IPFIKRAVAEGYGVIVLNPNENYIEVEKPKIHVQSSSDSSDEPAEKRERKDKVSKETKKR
RDFYEKYRNPQREKEMMQLYIRENGSPEEHAIYVWDHFIAQAAAENVFFVAHSYGGLAFV
ELMIQREADVKNKVTAVALTDSVHNVWHQEAGKTIREWMRENCCNWVSSSEPLDTSVESM
LPDCPRVSAGTDRHELTSWKSFPSIFKFFTEASEAKTSSLKPAVTRRSHRIKHEEL

Sequence length

416

Interactions

View interactions

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Insomnia	Insomnia	N/A	N/A	GWAS
Mental Depression	Major depressive disorder	N/A	N/A	GWAS
Neuroticism	Neuroticism	N/A	N/A	GWAS