Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	83985
Gene name	SPNS lysolipid transporter 1, lysophospholipid
Gene symbol	SPNS1
Synonyms (NCBI Gene)	HSpin1LATPP2030SLC62A1SLC63A1SPIN1SPINLnrs
Chromosome	16
Chromosome location	16p11.2

103

Show/Hide all (103)

miRTarBase ID	miRNA	Experiments	Reference
MIRT041120	hsa-miR-503-5p	CLASH	23622248
MIRT036406	hsa-miR-1227-3p	CLASH	23622248
MIRT645363	hsa-miR-495-3p	HITS-CLIP	23824327
MIRT645362	hsa-miR-5688	HITS-CLIP	23824327
MIRT645361	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT645360	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT645359	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT645358	hsa-miR-623	HITS-CLIP	23824327
MIRT645357	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT645356	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT645355	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT645353	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT645354	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT645363	hsa-miR-495-3p	HITS-CLIP	23824327
MIRT645362	hsa-miR-5688	HITS-CLIP	23824327
MIRT645361	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT645360	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT645359	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT645358	hsa-miR-623	HITS-CLIP	23824327
MIRT645357	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT645356	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT645355	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT645353	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT645354	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT467300	hsa-miR-224-3p	PAR-CLIP	23592263
MIRT467299	hsa-miR-522-3p	PAR-CLIP	23592263
MIRT467298	hsa-miR-3156-5p	PAR-CLIP	23592263
MIRT467297	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT467296	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT467295	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT467294	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT467293	hsa-miR-1914-3p	PAR-CLIP	23592263
MIRT467292	hsa-miR-5194	PAR-CLIP	23592263
MIRT467291	hsa-miR-6738-5p	PAR-CLIP	23592263
MIRT467290	hsa-miR-6820-5p	PAR-CLIP	23592263
MIRT467289	hsa-miR-4467	PAR-CLIP	23592263
MIRT467288	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT467287	hsa-miR-4710	PAR-CLIP	23592263
MIRT467286	hsa-miR-6734-5p	PAR-CLIP	23592263
MIRT467285	hsa-miR-6770-3p	PAR-CLIP	23592263
MIRT467284	hsa-miR-3662	PAR-CLIP	23592263
MIRT467283	hsa-miR-8066	PAR-CLIP	23592263
MIRT467282	hsa-miR-590-3p	PAR-CLIP	23592263
MIRT467281	hsa-miR-4729	PAR-CLIP	23592263
MIRT467280	hsa-miR-4735-5p	PAR-CLIP	23592263
MIRT467278	hsa-miR-4775	PAR-CLIP	23592263
MIRT467279	hsa-miR-5696	PAR-CLIP	23592263
MIRT645363	hsa-miR-495-3p	HITS-CLIP	23824327
MIRT645362	hsa-miR-5688	HITS-CLIP	23824327
MIRT645361	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT645360	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT645359	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT645358	hsa-miR-623	HITS-CLIP	23824327
MIRT645357	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT645356	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT645355	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT645353	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT645354	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT645363	hsa-miR-495-3p	HITS-CLIP	23824327
MIRT645362	hsa-miR-5688	HITS-CLIP	23824327
MIRT645361	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT645360	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT645359	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT645358	hsa-miR-623	HITS-CLIP	23824327
MIRT645357	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT645356	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT645355	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT645353	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT645354	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT467300	hsa-miR-224-3p	PAR-CLIP	23592263
MIRT467299	hsa-miR-522-3p	PAR-CLIP	23592263
MIRT467298	hsa-miR-3156-5p	PAR-CLIP	23592263
MIRT467297	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT467296	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT467295	hsa-miR-3184-5p	PAR-CLIP	23592263
MIRT467294	hsa-miR-423-5p	PAR-CLIP	23592263
MIRT467293	hsa-miR-1914-3p	PAR-CLIP	23592263
MIRT467292	hsa-miR-5194	PAR-CLIP	23592263
MIRT467291	hsa-miR-6738-5p	PAR-CLIP	23592263
MIRT467290	hsa-miR-6820-5p	PAR-CLIP	23592263
MIRT467289	hsa-miR-4467	PAR-CLIP	23592263
MIRT467288	hsa-miR-625-5p	PAR-CLIP	23592263
MIRT467287	hsa-miR-4710	PAR-CLIP	23592263
MIRT467286	hsa-miR-6734-5p	PAR-CLIP	23592263
MIRT467285	hsa-miR-6770-3p	PAR-CLIP	23592263
MIRT467284	hsa-miR-3662	PAR-CLIP	23592263
MIRT467283	hsa-miR-8066	PAR-CLIP	23592263
MIRT467282	hsa-miR-590-3p	PAR-CLIP	23592263
MIRT467281	hsa-miR-4729	PAR-CLIP	23592263
MIRT467280	hsa-miR-4735-5p	PAR-CLIP	23592263
MIRT467278	hsa-miR-4775	PAR-CLIP	23592263
MIRT467279	hsa-miR-5696	PAR-CLIP	23592263
MIRT2691891	hsa-miR-1299	CLIP-seq
MIRT2691892	hsa-miR-1915	CLIP-seq
MIRT2691893	hsa-miR-1972	CLIP-seq
MIRT2691894	hsa-miR-320e	CLIP-seq
MIRT2691895	hsa-miR-3936	CLIP-seq
MIRT2691896	hsa-miR-4640-5p	CLIP-seq
MIRT2691897	hsa-miR-4726-5p	CLIP-seq
MIRT2691898	hsa-miR-4755-3p	CLIP-seq
MIRT2691899	hsa-miR-642a	CLIP-seq
MIRT2691900	hsa-miR-671-5p	CLIP-seq
MIRT2691901	hsa-miR-875-3p	CLIP-seq

Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	12815463
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005764	Component	Lysosome	IEA
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	HDA	17897319
GO:0005765	Component	Lysosomal membrane	IEA
GO:0006869	Process	Lipid transport	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0022857	Function	Transmembrane transporter activity	IBA
GO:0022857	Function	Transmembrane transporter activity	IEA
GO:0033700	Process	Phospholipid efflux	IBA
GO:0033700	Process	Phospholipid efflux	IEA
GO:0035751	Process	Regulation of lysosomal lumen pH	IEA
GO:0051977	Process	Lysophospholipid transport	IBA
GO:0051977	Process	Lysophospholipid transport	IEA
GO:0055085	Process	Transmembrane transport	IEA

MIM	HGNC	e!Ensembl
612583	30621	ENSG00000169682

Q9H2V7

Protein name

Protein spinster homolog 1 (HSpin1) (SPNS1) (Spinster-like protein 1)

Protein function

Plays a critical role in the phospholipid salvage pathway from lysosomes to the cytosol (PubMed:36161949, PubMed:37075117). Mediates the rate-limiting, proton-dependent, lysosomal efflux of lysophospholipids, which can then be reacylated by acyl

PDB

9BOI

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07690	MFS_1	65 → 433	Major Facilitator Superfamily	Family

Sequence

MAGSDTAPFLSQADDPDDGPVPGTPGLPGSTGNPKSEEPEVPDQEGLQRITGLSPGRSAL
IVAVLCYINLLNYMDRFTVAGVLPDIEQFFNIGDSSSGLIQTVFISSYMVLAPVFGYLGD
RYNRKYLMCGGIAFWSLVTLGSSFIPGEHFWLLLLTRGLVGVGEASYSTIAPTLIADLFV
ADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDMAGDWHWALRVTPGLGVVAVLLLFLVVRE
PPRGAVERHSDLPPLNPTSWWADLRALARNPSFVLSSLGFTAVAFVTGSLALWAPAFLLR
SRVVLGETPPCLPGDSCSSSDSLIFGLITCLTGVLGVGLGVEISRRLRHSNPRADPLVCA
TGLLGSAPFLFLSLACARGSIVATYIFIFIGETLLSMNWAIVADILLYVVIPTRRSTAEA
FQIVLSHLLGDAGSPYLIGLISDRLRRNWPPSFLSEFRALQFSLMLCAFVGALGGAAFLG
TAIFIEADRRRAQLHVQGLLHEAGSTDDRIVVPQRGRSTRVPVASVLI

Sequence length

528

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	26280373	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	32807131	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Associate	38460365	★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma Cutaneous Malignant	Associate	34087900	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	21179495, 34750098	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Associate	26449484	★★★★★ ★☆☆☆☆ Found in Text Mining only

SPNS1 (SPNS lysolipid transporter 1, lysophospholipid)