Gene Gene information from NCBI Gene database.
Entrez ID 8396
Gene name Phosphatidylinositol-5-phosphate 4-kinase type 2 beta
Gene symbol PIP4K2B
Synonyms (NCBI Gene)
PI5P4KBPIP5K2BPIP5KIIBPIP5KIIbetaPIP5P4KB
Chromosome 17
Chromosome location 17q12
Summary The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate
miRNA miRNA information provided by mirtarbase database.
1206
miRTarBase ID miRNA Experiments Reference
MIRT021118 hsa-miR-186-5p Sequencing 20371350
MIRT024431 hsa-miR-215-5p Microarray 19074876
MIRT026451 hsa-miR-192-5p Microarray 19074876
MIRT051101 hsa-miR-16-5p CLASH 23622248
MIRT044592 hsa-miR-320a CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
44
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0005515 Function Protein binding IPI 25416956, 28514442, 32296183, 33961781
GO:0005524 Function ATP binding IDA 26774281
GO:0005524 Function ATP binding IEA
GO:0005525 Function GTP binding IDA 26774281
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603261 8998 ENSG00000276293
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P78356
Protein name Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-b
Protein function Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate (PubMed:26774281, PubMed:9038203). Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the p
PDB 1BO1 , 3WZZ , 3X01 , 3X02 , 3X03 , 3X04 , 3X05 , 3X06 , 3X07 , 3X08 , 3X09 , 3X0A , 3X0B , 3X0C , 6K4G , 6K4H , 7EM1 , 7EM2 , 7EM3 , 7EM4 , 7EM5 , 7EM6 , 7EM7 , 7EM8 , 7N80 , 7N81
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01504 PIP5K 122 414 Phosphatidylinositol-4-phosphate 5-Kinase Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver. {ECO:0000269|PubMed:9038203}.
Sequence
Sequence length 416
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Inositol phosphate metabolism
Metabolic pathways
Phosphatidylinositol signaling system
Regulation of actin cytoskeleton
  Synthesis of PIPs at the plasma membrane
PI5P Regulates TP53 Acetylation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Synthesis of PIPs in the nucleus
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BREAST CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenocarcinoma of Lung Associate 26840709
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 24127122, 33176066
★☆☆☆☆
Found in Text Mining only
Hereditary Breast and Ovarian Cancer Syndrome Associate 24127122
★☆☆☆☆
Found in Text Mining only
Neoplasm Metastasis Inhibit 24127122
★☆☆☆☆
Found in Text Mining only
Neoplasms Associate 24127122, 33176066, 36918565
★☆☆☆☆
Found in Text Mining only