Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8395
Gene name Gene Name - the full gene name approved by the HGNC.	Phosphatidylinositol-4-phosphate 5-kinase type 1 beta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PIP5K1B
Synonyms (NCBI Gene) Gene synonyms aliases	MSS4, STM7
Chromosome Chromosome number	9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	9q21.11

Show/Hide all(36)

miRTarBase ID	miRNA	Experiments
MIRT2069424	hsa-miR-1206	CLIP-seq
MIRT2069425	hsa-miR-128	CLIP-seq
MIRT2069426	hsa-miR-27a	CLIP-seq
MIRT2069427	hsa-miR-27b	CLIP-seq
MIRT2069428	hsa-miR-412	CLIP-seq
MIRT2069429	hsa-miR-4277	CLIP-seq
MIRT2069430	hsa-miR-4291	CLIP-seq
MIRT2069431	hsa-miR-513a-5p	CLIP-seq
MIRT2069432	hsa-miR-545	CLIP-seq
MIRT2069424	hsa-miR-1206	CLIP-seq
MIRT2069425	hsa-miR-128	CLIP-seq
MIRT2069426	hsa-miR-27a	CLIP-seq
MIRT2069427	hsa-miR-27b	CLIP-seq
MIRT2069428	hsa-miR-412	CLIP-seq
MIRT2069429	hsa-miR-4277	CLIP-seq
MIRT2069431	hsa-miR-513a-5p	CLIP-seq
MIRT2594237	hsa-miR-24	CLIP-seq
MIRT2594238	hsa-miR-3151	CLIP-seq
MIRT2594239	hsa-miR-3157-5p	CLIP-seq
MIRT2594240	hsa-miR-3691-5p	CLIP-seq
MIRT2594241	hsa-miR-4283	CLIP-seq
MIRT2594242	hsa-miR-4437	CLIP-seq
MIRT2594243	hsa-miR-4480	CLIP-seq
MIRT2594244	hsa-miR-4489	CLIP-seq
MIRT2594245	hsa-miR-4691-3p	CLIP-seq
MIRT2594246	hsa-miR-4752	CLIP-seq
MIRT2594237	hsa-miR-24	CLIP-seq
MIRT2594238	hsa-miR-3151	CLIP-seq
MIRT2594239	hsa-miR-3157-5p	CLIP-seq
MIRT2594240	hsa-miR-3691-5p	CLIP-seq
MIRT2594241	hsa-miR-4283	CLIP-seq
MIRT2594242	hsa-miR-4437	CLIP-seq
MIRT2594243	hsa-miR-4480	CLIP-seq
MIRT2594244	hsa-miR-4489	CLIP-seq
MIRT2594245	hsa-miR-4691-3p	CLIP-seq
MIRT2594246	hsa-miR-4752	CLIP-seq

Show/Hide all(11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001931	Component	Uropod	IDA	20442317
GO:0005515	Function	Protein binding	IPI	20442317
GO:0005524	Function	ATP binding	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0006661	Process	Phosphatidylinositol biosynthetic process	TAS
GO:0012505	Component	Endomembrane system	IEA
GO:0014066	Process	Regulation of phosphatidylinositol 3-kinase signaling	TAS
GO:0016308	Function	1-phosphatidylinositol-4-phosphate 5-kinase activity	ISS
GO:0016308	Function	1-phosphatidylinositol-4-phosphate 5-kinase activity	NAS	8955136
GO:0046854	Process	Phosphatidylinositol phosphorylation	IEA

MIM	HGNC	e!Ensembl
602745	8995	ENSG00000107242

Protein

UniProt ID

O14986

Protein name

Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1-beta) (PtdIns(4)P-5-kinase 1 beta) (EC 2.7.1.68) (Phosphatidylinositol 4-phosphate 5-kinase type I beta) (PIP5KIbeta) (Protein STM-7) (Type I phosphatidylinositol 4-phosphate 5-kinase beta)

Protein function

Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transductio

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01504	PIP5K	110 → 394	Phosphatidylinositol-4-phosphate 5-Kinase	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in heart, pancreas, brain, kidney, skeletal muscle and lung. {ECO:0000269|PubMed:8955136}.

Sequence

MSSAAENGEAAPGKQNEEKTYKKTASSAIKGAIQLGIGYTVGNLTSKPERDVLMQDFYVV
ESVFLPSEGSNLTPAHHYPDFRFKTYAPLAFRYFRELFGIKPDDYLYSICSEPLIELSNP
GASGSLFFVTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCMQSGG
INIRIVVMNNVLPRSMRMHFTYDLKGSTYKRRASRKEREKSNPTFKDLDFLQDMHEGLYF
DTETYNALMKTLQRDCRVLESFKIMDYSLLLGIHFLDHSLKEKEEETPQNVPDAKRTGMQ
KVLYSTAMESIQGPGKSGDGIITENPDTMGGIPAKSHRGEKLLLFMGIIDILQSYRLMKK
LEHSWKALVYDGDTVSVHRPSFYADRFLKFMNSRVFKKIQALKASPSKKRCNSIAALKAT
SQEIVSSISQEWKDEKRDLLTEGQSFSSLDEEALGSRHRPDLVPSTPSLFEAASLATTIS
SSSLYVNEHYPHDRPTLYSNSKGLPSSSTFTLEEGTIYLTAEPNTLEVQDDNASVLDVYL

Sequence length

540

Interactions

View interactions

	KEGG		Reactome
	Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system Phospholipase D signaling pathway Endocytosis Focal adhesion Fc gamma R-mediated phagocytosis Regulation of actin cytoskeleton Yersinia infection Choline metabolism in cancer		Synthesis of PIPs at the plasma membrane WNT mediated activation of DVL PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Show/Hide Causal Diseases (3)

Disease term	Disease name	dbSNP ID	References
Causal
Diabetes	Diabetes	rs80356611	31451708
Diabetes mellitus	Diabetes Mellitus	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237 View all (293 more)	31451708
Kidney disease	Chronic Kidney Diseases	rs74315342, rs749740335, rs757649673, rs112417755, rs35138315	22479191, 20383146

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Kidney Disease	Kidney Disease	GWAS
Gout	Gout	GWAS

Show/Hide Text Mining Associations (7)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	26840709
Adenoma	Stimulate	35260162
Disorders of Sex Development	Stimulate	24055526
Gonadal Dysgenesis 46 XY	Associate	24055526
Hodgkin Disease	Associate	30347596
Renal Insufficiency Chronic	Associate	20383146, 29016630
Tuberculosis Multidrug Resistant	Associate	30347596

PIP5K1B (phosphatidylinositol-4-phosphate 5-kinase type 1 beta)