Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	8395
Gene name Gene Name - the full gene name approved by the HGNC.	Phosphatidylinositol-4-phosphate 5-kinase type 1 beta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PIP5K1B
Synonyms (NCBI Gene) Gene synonyms aliases	MSS4, STM7
Chromosome Chromosome number	9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	9q21.11

Show/Hide all(36)

miRTarBase ID	miRNA	Experiments
MIRT2069424	hsa-miR-1206	CLIP-seq
MIRT2069425	hsa-miR-128	CLIP-seq
MIRT2069426	hsa-miR-27a	CLIP-seq
MIRT2069427	hsa-miR-27b	CLIP-seq
MIRT2069428	hsa-miR-412	CLIP-seq
MIRT2069429	hsa-miR-4277	CLIP-seq
MIRT2069430	hsa-miR-4291	CLIP-seq
MIRT2069431	hsa-miR-513a-5p	CLIP-seq
MIRT2069432	hsa-miR-545	CLIP-seq
MIRT2069424	hsa-miR-1206	CLIP-seq
MIRT2069425	hsa-miR-128	CLIP-seq
MIRT2069426	hsa-miR-27a	CLIP-seq
MIRT2069427	hsa-miR-27b	CLIP-seq
MIRT2069428	hsa-miR-412	CLIP-seq
MIRT2069429	hsa-miR-4277	CLIP-seq
MIRT2069431	hsa-miR-513a-5p	CLIP-seq
MIRT2594237	hsa-miR-24	CLIP-seq
MIRT2594238	hsa-miR-3151	CLIP-seq
MIRT2594239	hsa-miR-3157-5p	CLIP-seq
MIRT2594240	hsa-miR-3691-5p	CLIP-seq
MIRT2594241	hsa-miR-4283	CLIP-seq
MIRT2594242	hsa-miR-4437	CLIP-seq
MIRT2594243	hsa-miR-4480	CLIP-seq
MIRT2594244	hsa-miR-4489	CLIP-seq
MIRT2594245	hsa-miR-4691-3p	CLIP-seq
MIRT2594246	hsa-miR-4752	CLIP-seq
MIRT2594237	hsa-miR-24	CLIP-seq
MIRT2594238	hsa-miR-3151	CLIP-seq
MIRT2594239	hsa-miR-3157-5p	CLIP-seq
MIRT2594240	hsa-miR-3691-5p	CLIP-seq
MIRT2594241	hsa-miR-4283	CLIP-seq
MIRT2594242	hsa-miR-4437	CLIP-seq
MIRT2594243	hsa-miR-4480	CLIP-seq
MIRT2594244	hsa-miR-4489	CLIP-seq
MIRT2594245	hsa-miR-4691-3p	CLIP-seq
MIRT2594246	hsa-miR-4752	CLIP-seq

Show/Hide all(30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000285	Function	1-phosphatidylinositol-3-phosphate 5-kinase activity	TAS
GO:0001931	Component	Uropod	IDA	20442317
GO:0005515	Function	Protein binding	IPI	20442317
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006661	Process	Phosphatidylinositol biosynthetic process	IEA
GO:0006661	Process	Phosphatidylinositol biosynthetic process	TAS
GO:0012505	Component	Endomembrane system	IEA
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016308	Function	1-phosphatidylinositol-4-phosphate 5-kinase activity	IBA
GO:0016308	Function	1-phosphatidylinositol-4-phosphate 5-kinase activity	IEA
GO:0016308	Function	1-phosphatidylinositol-4-phosphate 5-kinase activity	ISS
GO:0016308	Function	1-phosphatidylinositol-4-phosphate 5-kinase activity	NAS	8955136
GO:0016308	Function	1-phosphatidylinositol-4-phosphate 5-kinase activity	TAS
GO:0016740	Function	Transferase activity	IEA
GO:0046488	Process	Phosphatidylinositol metabolic process	IEA
GO:0046488	Process	Phosphatidylinositol metabolic process	IEA
GO:0046854	Process	Phosphatidylinositol phosphate biosynthetic process	IBA
GO:0051896	Process	Regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA
GO:0051896	Process	Regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	TAS
GO:0052742	Function	Phosphatidylinositol kinase activity	IEA
GO:0052742	Function	Phosphatidylinositol kinase activity	TAS
GO:0052810	Function	1-phosphatidylinositol-5-kinase activity	TAS

MIM	HGNC	e!Ensembl
602745	8995	ENSG00000107242

Protein

UniProt ID

O14986

Protein name

Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1-beta) (PtdIns(4)P-5-kinase 1 beta) (EC 2.7.1.68) (Phosphatidylinositol 4-phosphate 5-kinase type I beta) (PIP5KIbeta) (Protein STM-7) (Type I phosphatidylinositol 4-phosphate 5-kinase beta)

Protein function

Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transductio

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01504	PIP5K	110 → 394	Phosphatidylinositol-4-phosphate 5-Kinase	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in heart, pancreas, brain, kidney, skeletal muscle and lung. {ECO:0000269|PubMed:8955136}.

Sequence

MSSAAENGEAAPGKQNEEKTYKKTASSAIKGAIQLGIGYTVGNLTSKPERDVLMQDFYVV
ESVFLPSEGSNLTPAHHYPDFRFKTYAPLAFRYFRELFGIKPDDYLYSICSEPLIELSNP
GASGSLFFVTSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCMQSGG
INIRIVVMNNVLPRSMRMHFTYDLKGSTYKRRASRKEREKSNPTFKDLDFLQDMHEGLYF
DTETYNALMKTLQRDCRVLESFKIMDYSLLLGIHFLDHSLKEKEEETPQNVPDAKRTGMQ
KVLYSTAMESIQGPGKSGDGIITENPDTMGGIPAKSHRGEKLLLFMGIIDILQSYRLMKK
LEHSWKALVYDGDTVSVHRPSFYADRFLKFMNSRVFKKIQALKASPSKKRCNSIAALKAT
SQEIVSSISQEWKDEKRDLLTEGQSFSSLDEEALGSRHRPDLVPSTPSLFEAASLATTIS
SSSLYVNEHYPHDRPTLYSNSKGLPSSSTFTLEEGTIYLTAEPNTLEVQDDNASVLDVYL

Sequence length

540

Interactions

View interactions

	KEGG		Reactome
	Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system Phospholipase D signaling pathway Endocytosis Focal adhesion Fc gamma R-mediated phagocytosis Regulation of actin cytoskeleton Yersinia infection Choline metabolism in cancer		Synthesis of PIPs at the plasma membrane WNT mediated activation of DVL PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Gout	Gout	N/A	N/A	GWAS
Kidney Disease	Chronic kidney disease	N/A	N/A	GWAS

Show/Hide Text Mining Associations (7)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	26840709
Adenoma	Stimulate	35260162
Disorders of Sex Development	Stimulate	24055526
Gonadal Dysgenesis 46 XY	Associate	24055526
Hodgkin Disease	Associate	30347596
Renal Insufficiency Chronic	Associate	20383146, 29016630
Tuberculosis Multidrug Resistant	Associate	30347596

PIP5K1B (phosphatidylinositol-4-phosphate 5-kinase type 1 beta)