TATDN1 (TatD DNase domain containing 1)

Gene

• Entrez ID: 83940
• Gene name: TatD DNase domain containing 1
• Gene symbol: TATDN1
• Synonyms (NCBI Gene): CDA11
• Chromosome: 8
• Chromosome location: 8q24.13

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004518	Function	Nuclease activity	IEA
GO:0004520	Function	DNA endonuclease activity	IDA	36881763
GO:0005515	Function	Protein binding	IPI	15846844
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0006259	Process	DNA metabolic process	IEA
GO:0008296	Function	3'-5'-DNA exonuclease activity	IBA
GO:0008296	Function	3'-5'-DNA exonuclease activity	IDA	36881763
GO:0016787	Function	Hydrolase activity	IEA
GO:0016788	Function	Hydrolase activity, acting on ester bonds	IEA
GO:0046872	Function	Metal ion binding	IEA

Other IDs

• MIM: 619364
• HGNC: 24220
• e!Ensembl: ENSG00000147687

Protein

• UniProt ID: Q6P1N9
• Protein name: Deoxyribonuclease TATDN1 (EC 3.1.21.-) (Hepatocarcinoma high expression protein)
• Protein function: Deoxyribonuclease which catalyzes (in vitro) the decatenation of kinetoplast DNA, which are circular DNA catenated to each other, producing linear DNA molecules (By similarity). Plays an important role in chromosomal segregation and cell cycle p
• PDB: 2XIO, 8EFG
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01026	TatD_DNase	7 → 294	TatD related DNase	Domain

• Sequence:

  MSRFKFIDIGINLTDPMFRGIYRGVQKHQDDLQDVIGRAVEIGVKKFMITGGNLQDSKDA
  LHLAQTNGMFFSTVGCHPTRCGEFEKNNPDLYLKELLNLAENNKGKVVAIGECGLDFDRL
  QFCPKDTQLKYFEKQFELSEQTKLPMFLHCRNSHAEFLDIMKRNRDRCVGGVVHSFDGTK
  EAAAALIDLDLYIGFNGCSLKTEANLEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYIRT
  AFPTKKKWESGHCLKDRNEPCHIIQILEIMSAVRDEDPLELANTLYNNTIKVFFPGI

• Sequence length: 297