Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	83939
Gene name	Eukaryotic translation initiation factor 2A
Gene symbol	EIF2A
Synonyms (NCBI Gene)	CDA02EIF-2AMST089MSTP004MSTP089
Chromosome	3
Chromosome location	3q25.1
Summary	This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrations of Mg2+. This gene should not be co

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miRTarBase ID	miRNA	Experiments	Reference
MIRT031752	hsa-miR-16-5p	Proteomics	18668040
MIRT048013	hsa-miR-30c-5p	CLASH	23622248
MIRT044991	hsa-miR-186-5p	CLASH	23622248
MIRT678090	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT678089	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT678088	hsa-miR-764	HITS-CLIP	23824327
MIRT678087	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT678086	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT678085	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT678084	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678082	hsa-miR-4635	HITS-CLIP	23824327
MIRT678081	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT678080	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT678079	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT678077	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT678076	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT678075	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT678074	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT678073	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT678072	hsa-miR-640	HITS-CLIP	23824327
MIRT678071	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT678090	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT678089	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT678088	hsa-miR-764	HITS-CLIP	23824327
MIRT678087	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT678086	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT678085	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT678084	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678083	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT678082	hsa-miR-4635	HITS-CLIP	23824327
MIRT678081	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT678080	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT678079	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT678078	hsa-miR-6131	HITS-CLIP	23824327
MIRT678077	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT678076	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT678075	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT678074	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT678073	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT678072	hsa-miR-640	HITS-CLIP	23824327
MIRT678071	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT444534	hsa-miR-320a	PAR-CLIP	22100165
MIRT444533	hsa-miR-320b	PAR-CLIP	22100165
MIRT444532	hsa-miR-320c	PAR-CLIP	22100165
MIRT444531	hsa-miR-320d	PAR-CLIP	22100165
MIRT444530	hsa-miR-4429	PAR-CLIP	22100165
MIRT444529	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT444528	hsa-miR-142-5p	PAR-CLIP	22100165
MIRT444527	hsa-miR-5590-3p	PAR-CLIP	22100165
MIRT444526	hsa-miR-9-3p	PAR-CLIP	22100165
MIRT208659	hsa-miR-340-5p	PAR-CLIP	22100165
MIRT440742	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440742	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT736852	hsa-miR-26a-5p	Western blottingqRT-PCR	32567701
MIRT678090	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT678089	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT678088	hsa-miR-764	HITS-CLIP	23824327
MIRT678087	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT678086	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT678085	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT678084	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678082	hsa-miR-4635	HITS-CLIP	23824327
MIRT678081	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT678080	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT678079	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT678077	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT678076	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT678075	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT678074	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT678073	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT678072	hsa-miR-640	HITS-CLIP	23824327
MIRT678071	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT678090	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT678089	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT678088	hsa-miR-764	HITS-CLIP	23824327
MIRT678087	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT678086	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT678085	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT678084	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT678083	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT678082	hsa-miR-4635	HITS-CLIP	23824327
MIRT678081	hsa-miR-4680-5p	HITS-CLIP	23824327
MIRT678080	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT678079	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT678078	hsa-miR-6131	HITS-CLIP	23824327
MIRT678077	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT678076	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT678075	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT678074	hsa-miR-7158-3p	HITS-CLIP	23824327
MIRT678073	hsa-miR-203b-3p	HITS-CLIP	23824327
MIRT678072	hsa-miR-640	HITS-CLIP	23824327
MIRT678071	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT444534	hsa-miR-320a	PAR-CLIP	22100165
MIRT444533	hsa-miR-320b	PAR-CLIP	22100165
MIRT444532	hsa-miR-320c	PAR-CLIP	22100165
MIRT444531	hsa-miR-320d	PAR-CLIP	22100165
MIRT444530	hsa-miR-4429	PAR-CLIP	22100165
MIRT444529	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT444528	hsa-miR-142-5p	PAR-CLIP	22100165
MIRT444527	hsa-miR-5590-3p	PAR-CLIP	22100165
MIRT444526	hsa-miR-9-3p	PAR-CLIP	22100165
MIRT208659	hsa-miR-340-5p	PAR-CLIP	22100165
MIRT956329	hsa-miR-10a	CLIP-seq
MIRT956330	hsa-miR-10b	CLIP-seq
MIRT956331	hsa-miR-1245	CLIP-seq
MIRT956332	hsa-miR-1254	CLIP-seq
MIRT956333	hsa-miR-1285	CLIP-seq
MIRT956334	hsa-miR-1827	CLIP-seq
MIRT956335	hsa-miR-3116	CLIP-seq
MIRT956336	hsa-miR-3176	CLIP-seq
MIRT956337	hsa-miR-3180-5p	CLIP-seq
MIRT956338	hsa-miR-3187-5p	CLIP-seq
MIRT956339	hsa-miR-320e	CLIP-seq
MIRT956340	hsa-miR-330-3p	CLIP-seq
MIRT956341	hsa-miR-339-5p	CLIP-seq
MIRT956342	hsa-miR-3612	CLIP-seq
MIRT956343	hsa-miR-3672	CLIP-seq
MIRT956344	hsa-miR-3685	CLIP-seq
MIRT956345	hsa-miR-384	CLIP-seq
MIRT956346	hsa-miR-3919	CLIP-seq
MIRT956347	hsa-miR-3922-3p	CLIP-seq
MIRT956348	hsa-miR-3945	CLIP-seq
MIRT956349	hsa-miR-4253	CLIP-seq
MIRT956350	hsa-miR-4477b	CLIP-seq
MIRT956351	hsa-miR-4725-5p	CLIP-seq
MIRT956352	hsa-miR-4786-5p	CLIP-seq
MIRT956353	hsa-miR-495	CLIP-seq
MIRT956354	hsa-miR-504	CLIP-seq
MIRT956355	hsa-miR-513a-3p	CLIP-seq
MIRT956356	hsa-miR-520a-5p	CLIP-seq
MIRT956357	hsa-miR-525-5p	CLIP-seq
MIRT956358	hsa-miR-607	CLIP-seq
MIRT956359	hsa-miR-612	CLIP-seq
MIRT956360	hsa-miR-650	CLIP-seq
MIRT956361	hsa-miR-661	CLIP-seq
MIRT956362	hsa-miR-759	CLIP-seq
MIRT956363	hsa-miR-769-5p	CLIP-seq
MIRT1548258	hsa-miR-150	CLIP-seq
MIRT1548259	hsa-miR-511	CLIP-seq
MIRT1983215	hsa-miR-1271	CLIP-seq
MIRT1548258	hsa-miR-150	CLIP-seq
MIRT1983216	hsa-miR-182	CLIP-seq
MIRT1983217	hsa-miR-18a	CLIP-seq
MIRT1983218	hsa-miR-18b	CLIP-seq
MIRT1983219	hsa-miR-3155	CLIP-seq
MIRT1983220	hsa-miR-3155b	CLIP-seq
MIRT1983221	hsa-miR-34a	CLIP-seq
MIRT1983222	hsa-miR-34c-5p	CLIP-seq
MIRT1983223	hsa-miR-3545-3p	CLIP-seq
MIRT1983224	hsa-miR-3653	CLIP-seq
MIRT1983225	hsa-miR-3658	CLIP-seq
MIRT1983226	hsa-miR-3934	CLIP-seq
MIRT1983227	hsa-miR-4325	CLIP-seq
MIRT1983228	hsa-miR-449a	CLIP-seq
MIRT1983229	hsa-miR-449b	CLIP-seq
MIRT1983230	hsa-miR-4506	CLIP-seq
MIRT1983231	hsa-miR-4729	CLIP-seq
MIRT1983232	hsa-miR-4731-5p	CLIP-seq
MIRT1983233	hsa-miR-4735-3p	CLIP-seq
MIRT1983234	hsa-miR-4761-5p	CLIP-seq
MIRT1983235	hsa-miR-4772-5p	CLIP-seq
MIRT1983236	hsa-miR-484	CLIP-seq
MIRT1983237	hsa-miR-507	CLIP-seq
MIRT1983238	hsa-miR-5095	CLIP-seq
MIRT1548259	hsa-miR-511	CLIP-seq
MIRT1983239	hsa-miR-552	CLIP-seq
MIRT1983240	hsa-miR-557	CLIP-seq
MIRT1983241	hsa-miR-576-3p	CLIP-seq
MIRT1983242	hsa-miR-579	CLIP-seq
MIRT1983243	hsa-miR-629	CLIP-seq
MIRT1983244	hsa-miR-96	CLIP-seq
MIRT2218463	hsa-miR-1238	CLIP-seq
MIRT2218464	hsa-miR-129-5p	CLIP-seq
MIRT2218465	hsa-miR-132	CLIP-seq
MIRT2218466	hsa-miR-139-3p	CLIP-seq
MIRT2218467	hsa-miR-147	CLIP-seq
MIRT1548258	hsa-miR-150	CLIP-seq
MIRT1983217	hsa-miR-18a	CLIP-seq
MIRT1983218	hsa-miR-18b	CLIP-seq
MIRT2218468	hsa-miR-2113	CLIP-seq
MIRT2218469	hsa-miR-212	CLIP-seq
MIRT2218470	hsa-miR-3120-5p	CLIP-seq
MIRT2218471	hsa-miR-3160-5p	CLIP-seq
MIRT2218472	hsa-miR-338-3p	CLIP-seq
MIRT2218473	hsa-miR-340	CLIP-seq
MIRT2218474	hsa-miR-346	CLIP-seq
MIRT2218475	hsa-miR-3689d	CLIP-seq
MIRT1983226	hsa-miR-3934	CLIP-seq
MIRT2218476	hsa-miR-4284	CLIP-seq
MIRT2218477	hsa-miR-4288	CLIP-seq
MIRT1983232	hsa-miR-4731-5p	CLIP-seq
MIRT1983233	hsa-miR-4735-3p	CLIP-seq
MIRT1983234	hsa-miR-4761-5p	CLIP-seq
MIRT2218478	hsa-miR-4772-3p	CLIP-seq
MIRT956353	hsa-miR-495	CLIP-seq
MIRT1983238	hsa-miR-5095	CLIP-seq
MIRT1983239	hsa-miR-552	CLIP-seq
MIRT2218479	hsa-miR-562	CLIP-seq
MIRT2218480	hsa-miR-599	CLIP-seq
MIRT2218481	hsa-miR-632	CLIP-seq
MIRT2218482	hsa-miR-802	CLIP-seq
MIRT2387315	hsa-miR-3591-5p	CLIP-seq
MIRT2218475	hsa-miR-3689d	CLIP-seq
MIRT2387316	hsa-miR-4255	CLIP-seq
MIRT956332	hsa-miR-1254	CLIP-seq
MIRT2521946	hsa-miR-1265	CLIP-seq
MIRT2521947	hsa-miR-1279	CLIP-seq
MIRT2521948	hsa-miR-2392	CLIP-seq
MIRT2521949	hsa-miR-3074-3p	CLIP-seq
MIRT956335	hsa-miR-3116	CLIP-seq
MIRT2521950	hsa-miR-3117-5p	CLIP-seq
MIRT2218471	hsa-miR-3160-5p	CLIP-seq
MIRT956336	hsa-miR-3176	CLIP-seq
MIRT2218472	hsa-miR-338-3p	CLIP-seq
MIRT2521951	hsa-miR-3675-3p	CLIP-seq
MIRT956347	hsa-miR-3922-3p	CLIP-seq
MIRT1983226	hsa-miR-3934	CLIP-seq
MIRT2521952	hsa-miR-4265	CLIP-seq
MIRT2521953	hsa-miR-4296	CLIP-seq
MIRT2521954	hsa-miR-4322	CLIP-seq
MIRT1983227	hsa-miR-4325	CLIP-seq
MIRT2521955	hsa-miR-4417	CLIP-seq
MIRT1983230	hsa-miR-4506	CLIP-seq
MIRT2521956	hsa-miR-4696	CLIP-seq
MIRT2521957	hsa-miR-4753-3p	CLIP-seq
MIRT2521958	hsa-miR-4778-5p	CLIP-seq
MIRT2521959	hsa-miR-489	CLIP-seq
MIRT1983237	hsa-miR-507	CLIP-seq
MIRT1548259	hsa-miR-511	CLIP-seq
MIRT1983240	hsa-miR-557	CLIP-seq
MIRT1983241	hsa-miR-576-3p	CLIP-seq
MIRT2521960	hsa-miR-595	CLIP-seq
MIRT1983243	hsa-miR-629	CLIP-seq
MIRT2521961	hsa-miR-633	CLIP-seq
MIRT956361	hsa-miR-661	CLIP-seq
MIRT956332	hsa-miR-1254	CLIP-seq
MIRT2521946	hsa-miR-1265	CLIP-seq
MIRT2521947	hsa-miR-1279	CLIP-seq
MIRT2521948	hsa-miR-2392	CLIP-seq
MIRT2521949	hsa-miR-3074-3p	CLIP-seq
MIRT956335	hsa-miR-3116	CLIP-seq
MIRT2521950	hsa-miR-3117-5p	CLIP-seq
MIRT2218471	hsa-miR-3160-5p	CLIP-seq
MIRT956336	hsa-miR-3176	CLIP-seq
MIRT2218472	hsa-miR-338-3p	CLIP-seq
MIRT2521951	hsa-miR-3675-3p	CLIP-seq
MIRT956347	hsa-miR-3922-3p	CLIP-seq
MIRT1983226	hsa-miR-3934	CLIP-seq
MIRT2521952	hsa-miR-4265	CLIP-seq
MIRT2521953	hsa-miR-4296	CLIP-seq
MIRT2521954	hsa-miR-4322	CLIP-seq
MIRT1983227	hsa-miR-4325	CLIP-seq
MIRT2521955	hsa-miR-4417	CLIP-seq
MIRT1983230	hsa-miR-4506	CLIP-seq
MIRT2521956	hsa-miR-4696	CLIP-seq
MIRT2521957	hsa-miR-4753-3p	CLIP-seq
MIRT2521958	hsa-miR-4778-5p	CLIP-seq
MIRT2521959	hsa-miR-489	CLIP-seq
MIRT1983237	hsa-miR-507	CLIP-seq
MIRT1548259	hsa-miR-511	CLIP-seq
MIRT1983240	hsa-miR-557	CLIP-seq
MIRT1983241	hsa-miR-576-3p	CLIP-seq
MIRT2521960	hsa-miR-595	CLIP-seq
MIRT1983243	hsa-miR-629	CLIP-seq
MIRT956361	hsa-miR-661	CLIP-seq

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000049	Function	TRNA binding	IBA
GO:0000049	Function	TRNA binding	IMP	12133843
GO:0003729	Function	MRNA binding	IBA
GO:0003743	Function	Translation initiation factor activity	IBA
GO:0003743	Function	Translation initiation factor activity	IDA	10563826
GO:0003743	Function	Translation initiation factor activity	IEA
GO:0003743	Function	Translation initiation factor activity	IMP	12133843
GO:0005515	Function	Protein binding	IPI
GO:0005615	Component	Extracellular space	HDA	22664934
GO:0005737	Component	Cytoplasm	IDA	12133843
GO:0005850	Component	Eukaryotic translation initiation factor 2 complex	IDA	12133843
GO:0006412	Process	Translation	IEA
GO:0006412	Process	Translation	IEA
GO:0006413	Process	Translational initiation	IDA	10563826
GO:0006413	Process	Translational initiation	IDA	12133843
GO:0006413	Process	Translational initiation	IEA
GO:0006417	Process	Regulation of translation	IEA
GO:0006417	Process	Regulation of translation	IMP	12133843
GO:0009967	Process	Positive regulation of signal transduction	IEA
GO:0032933	Process	SREBP signaling pathway	IEA
GO:0042255	Process	Ribosome assembly	IMP	12133843
GO:0043022	Function	Ribosome binding	IBA
GO:0043022	Function	Ribosome binding	IMP	12133843
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0072562	Component	Blood microparticle	HDA	22516433
GO:1990928	Process	Response to amino acid starvation	IEA

MIM	HGNC	e!Ensembl
609234	3254	ENSG00000144895

Q9BY44

Protein name

Eukaryotic translation initiation factor 2A (eIF-2A) (65 kDa eukaryotic translation initiation factor 2A) [Cleaved into: Eukaryotic translation initiation factor 2A, N-terminally processed]

Protein function

Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a co

PDB

8DYS

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08662	eIF2A	216 → 411	Eukaryotic translation initiation factor eIF2A	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Expressed at higher level in pancreas, heart, brain and placenta. {ECO:0000269|PubMed:12133843}.

Sequence

MAPSTPLLTVRGSEGLYMVNGPPHFTESTVFPRESGKNCKVCIFSKDGTLFAWGNGEKVN
IISVTNKGLLHSFDLLKAVCLEFSPKNTVLATWQPYTTSKDGTAGIPNLQLYDVKTGTCL
KSFIQKKMQNWCPSWSEDETLCARNVNNEVHFFENNNFNTIANKLHLQKINDFVLSPGPQ
PYKVAVYVPGSKGAPSFVRLYQYPNFAGPHAALANKSFFKADKVTMLWNKKATAVLVIAS
TDVDKTGASYYGEQTLHYIATNGESAVVQLPKNGPIYDVVWNSSSTEFCAVYGFMPAKAT
IFNLKCDPVFDFGTGPRNAAYYSPHGHILVLAGFGNLRGQMEVWDVKNYKLISKPVASDS
TYFAWCPDGEHILTATCAPRLRVNNGYKIWHYTGSILHKYDVPSNAELWQVSWQPFLDGI
FPAKTITYQAVPSEVPNEEPKVATAYRPPALRNKPITNSKLHEEEPPQNMKPQSGNDKPL
SKTALKNQRKHEAKKAAKQEARSDKSPDLAPTPAPQSTPRNTVSQSISGDPEIDKKIKNL
KKKLKAIEQLKEQAATGKQLEKNQLEKIQKETALLQELEDLELGI

Sequence length

585

Interactions

View interactions

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
EIF2A-related disorder	Likely benign	rs199994540	RCV003969112
Hepatocellular carcinoma	Uncertain significance	rs372635613	RCV005937462
Malignant lymphoma, large B-cell, diffuse	Uncertain significance	rs372635613	RCV005937463
Malignant tumor of urinary bladder	Uncertain significance	rs781322944	RCV005932521
	Uncertain significance	rs1187477899	RCV004515813

Show/Hide Text Mining Associations (93)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Acidosis	Stimulate	28134810
Adenocarcinoma of Lung	Associate	29676829, 31551255, 36226539
Adrenocortical Carcinoma	Associate	27631436
Alzheimer Disease	Associate	20463975, 26512942, 32665027, 34153352
Angiomyolipoma	Associate	22791333
Arthritis Rheumatoid	Associate	37862122
Arthritis Rheumatoid	Stimulate	40141133
Atherosclerosis	Associate	24205197, 28081747
Brain Neoplasms	Associate	19188486
Breast Neoplasms	Associate	18559534, 23029376, 24204783, 25590579, 27109102, 30655322, 31211507, 32427827, 39187325
Breast Neoplasms	Stimulate	28294178
Burkitt Lymphoma	Associate	14747531
Carcinogenesis	Associate	33749640
Carcinoma Hepatocellular	Associate	23973991, 24525736, 35724265
Carcinoma Non Small Cell Lung	Associate	22102852, 33819860
Carcinoma Pancreatic Ductal	Associate	30747823
Cardiovascular Diseases	Associate	36012132
Cataract	Associate	26091066
Cell Transformation Neoplastic	Associate	12942578
Cholangiocarcinoma	Associate	24587347, 35683032
Colitis Ulcerative	Associate	35185383
Colonic Neoplasms	Associate	12942578
Colorectal Neoplasms	Associate	28300830, 31199053, 31243264, 32323831, 33749640, 34663797
Crohn Disease	Associate	26986695
Depressive Disorder Major	Associate	40015617
Diabetes Mellitus	Associate	26159176, 31615341
Disease	Associate	30617154
Drug Related Side Effects and Adverse Reactions	Associate	23706161
Dyskinesia Drug Induced	Associate	28193519
Dystonia	Associate	33049316, 33144327
Enterovirus Infections	Associate	31941779
Epilepsy	Associate	33144327
Escherichia coli Infections	Associate	26986695
Glomerulonephritis IGA	Associate	30415257
Heart Failure	Associate	26055788
Hemoglobinopathies	Associate	23690448
Hepatitis C	Associate	24486950
Hypoxia	Associate	17488873, 18268023
Hypoxia Brain	Associate	17488873
Infections	Associate	14747531, 2555543
Inflammation	Associate	26040555, 30089253, 35185383, 36012132
Inflammatory Bowel Diseases	Stimulate	22028783
Insulinoma	Associate	26159176
Keratoconus	Associate	30029277
Leukemia	Associate	19129918, 26542945
Leukemia Promyelocytic Acute	Inhibit	34201614
Leukoencephalopathies	Associate	29632131
Lung Neoplasms	Associate	18694499, 30305853, 36521248
Lupus Erythematosus Systemic	Associate	11120763, 26090483
Lymphoma Non Hodgkin	Associate	10393856
Malnutrition	Associate	31398886
Melanoma	Associate	20022965, 25759478
Melanoma Cutaneous Malignant	Associate	30634982
Mesothelioma Malignant	Associate	29921948
Mitochondrial Diseases	Associate	26787461, 27708226, 32132706, 32132707
Mitochondrial Diseases	Stimulate	30380689
Mouth Neoplasms	Associate	34318593
Multiple Myeloma	Associate	19190324, 28119225
Muscle Hypotonia	Associate	33144327
Myopia	Stimulate	26091066
Myopia	Associate	26351848
Myotonic Dystrophy	Associate	20479119, 33856033
Necrosis	Associate	15699214
Neoplasm Metastasis	Associate	37834012
Neoplasms	Stimulate	12942578
Neoplasms	Associate	17113348, 18087277, 19188486, 20709751, 24204783, 26039820, 26542945, 27958308, 30305853, 30424508, 31211507, 31699971
Neoplasms	Inhibit	22429849
Neoplasms Glandular and Epithelial	Associate	12942578
Neuroblastoma	Associate	19122239, 20022965
Neurodegenerative Diseases	Associate	11238455, 20463975
Neurologic Disease Infantile Multisystem with Osseous Fragility	Associate	26159176
Neurotoxicity Syndromes	Associate	20463975
Obesity	Stimulate	27481183
Obesity Maternal	Stimulate	30006153
Oropharyngeal Neoplasms	Associate	28418119, 30414263
Osteoporosis	Stimulate	26091066
Osteosarcoma	Associate	22429849
Overweight	Stimulate	27481183
Pancreatic Neoplasms	Associate	29720726
Papillomavirus Infections	Associate	15060162
Parkinson Disease	Stimulate	40015617
Polycythemia Vera	Associate	17113348
Pre Eclampsia	Stimulate	25675914
Prostatic Neoplasms	Associate	27587023
Renal Insufficiency	Associate	26159176
Severe Acute Respiratory Syndrome	Associate	20361218
Sleep Deprivation	Associate	21555338
Stomach Neoplasms	Associate	27708226, 29587440
Triple Negative Breast Neoplasms	Associate	28294178, 37834012
Uveal melanoma	Associate	34201614
Virus Diseases	Associate	15060162, 22926522
Weight Loss	Stimulate	18087277
Wolcott Rallison syndrome	Associate	26159176

EIF2A (eukaryotic translation initiation factor 2A)