Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
83931
Gene name Gene Name - the full gene name approved by the HGNC.
Serine/threonine kinase 40
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
STK40
Synonyms (NCBI Gene) Gene synonyms aliases
SHIK, SgK495
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p34.3
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT007319 hsa-miR-31-5p Luciferase reporter assay 23233723
MIRT007319 hsa-miR-31-5p Luciferase reporter assay 23233723
MIRT007319 hsa-miR-31-5p Luciferase reporter assay 23233723
MIRT007319 hsa-miR-31-5p Luciferase reporter assay 23233723
MIRT025713 hsa-miR-7-5p Sequencing 20371350
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003016 Process Respiratory system process IEA
GO:0005515 Function Protein binding IPI 21784977, 25852190, 28514442, 32296183
GO:0005524 Function ATP binding IEA
GO:0005654 Component Nucleoplasm IDA
GO:0005829 Component Cytosol IDA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
609437 21373 ENSG00000196182
Protein
UniProt ID Q8N2I9
Protein name Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase) (Sugen kinase 495) (SgK495)
Protein function May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
PDB 5L2Q
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 40 328 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Strongly expressed in heart, brain, placenta, lung, skeletal muscle, kidney, spleen, thymus, prostate, liver, pancreas, testis, ovary, small intestine, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:13679039}.
Sequence
Sequence length 435
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colorectal cancer Adenocarcinoma of large intestine rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 37761960
Colorectal Neoplasms Associate 34170070
Neoplasms Associate 34170070
Stomach Neoplasms Associate 37915566