ESYT3 (extended synaptotagmin 3)

Gene

• Entrez ID: 83850
• Gene name: Extended synaptotagmin 3
• Gene symbol: ESYT3
• Synonyms (NCBI Gene): CHR3SYT, E-Syt3, FAM62C
• Chromosome: 3
• Chromosome location: 3q22.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT971352	hsa-miR-34a	CLIP-seq
MIRT971353	hsa-miR-34c-5p	CLIP-seq
MIRT971354	hsa-miR-3977	CLIP-seq
MIRT971355	hsa-miR-410	CLIP-seq
MIRT971356	hsa-miR-4434	CLIP-seq
MIRT971357	hsa-miR-4493	CLIP-seq
MIRT971358	hsa-miR-449a	CLIP-seq
MIRT971359	hsa-miR-449b	CLIP-seq
MIRT971360	hsa-miR-4516	CLIP-seq
MIRT971361	hsa-miR-4531	CLIP-seq
MIRT971362	hsa-miR-4796-3p	CLIP-seq
MIRT971363	hsa-miR-548t	CLIP-seq
MIRT2222157	hsa-miR-3164	CLIP-seq
MIRT2222158	hsa-miR-3609	CLIP-seq
MIRT2222159	hsa-miR-548ah	CLIP-seq
MIRT971363	hsa-miR-548t	CLIP-seq
MIRT2222160	hsa-miR-587	CLIP-seq
MIRT2222161	hsa-miR-617	CLIP-seq
MIRT2680316	hsa-miR-1271	CLIP-seq
MIRT2680317	hsa-miR-182	CLIP-seq
MIRT2680318	hsa-miR-3152-3p	CLIP-seq
MIRT2680319	hsa-miR-3154	CLIP-seq
MIRT2680320	hsa-miR-3158-3p	CLIP-seq
MIRT971352	hsa-miR-34a	CLIP-seq
MIRT971353	hsa-miR-34c-5p	CLIP-seq
MIRT971358	hsa-miR-449a	CLIP-seq
MIRT971359	hsa-miR-449b	CLIP-seq
MIRT2680321	hsa-miR-96	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IBA
GO:0005515	Function	Protein binding	IPI	23791178, 27065097
GO:0005544	Function	Calcium-dependent phospholipid binding	IBA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	23791178
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0005886	Component	Plasma membrane	IDA	17360437
GO:0005886	Component	Plasma membrane	IEA
GO:0006869	Process	Lipid transport	IEA
GO:0008289	Function	Lipid binding	IEA
GO:0008429	Function	Phosphatidylethanolamine binding	IBA
GO:0009898	Component	Cytoplasmic side of plasma membrane	IDA	23791178
GO:0016020	Component	Membrane	IEA
GO:0031210	Function	Phosphatidylcholine binding	IBA
GO:0035091	Function	Phosphatidylinositol binding	IBA
GO:0044232	Component	Organelle membrane contact site	IDA	23791178
GO:0046872	Function	Metal ion binding	IEA
GO:0061817	Process	Endoplasmic reticulum-plasma membrane tethering	IEA
GO:0140268	Component	Endoplasmic reticulum-plasma membrane contact site	IDA	30220461

Other IDs

• MIM: 616692
• HGNC: 24295
• e!Ensembl: ENSG00000158220

Protein

• UniProt ID: A0FGR9
• Protein name: Extended synaptotagmin-3 (E-Syt3) (Chr3Syt)
• Protein function: Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulu
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF17047	SMP_LBD	114 → 291	Synaptotagmin-like mitochondrial-lipid-binding domain	Domain
  PF00168	C2	306 → 410	C2 domain	Domain
  PF00168	C2	445 → 564	C2 domain	Domain
  PF00168	C2	769 → 878	C2 domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed with high level in cerebellum and skin. {ECO:0000269|PubMed:17360437}.
• Sequence:

  MRAEEPCAPGAPSALGAQRTPGPELRLSSQLLPELCTFVVRVLFYLGPVYLAGYLGLSIT
  WLLLGALLWMWWRRNRRGKLGRLAAAFEFLDNEREFISRELRGQHLPAWIHFPDVERVEW
  ANKIISQTWPYLSMIMESKFREKLEPKIREKSIHLRTFTFTKLYFGQKCPRVNGVKAHTN
  TCNRRRVTVDLQICYIGDCEISVELQKIQAGVNGIQLQGTLRVILEPLLVDKPFVGAVTV
  FFLQKPHLQINWTGLTNLLDAPGINDVSDSLLEDLIATHLVLPNRVTVPVKKGLDLTNLR
  FPLPCGVIRVHLLEAEQLAQKDNFLGLRGKSDPYAKVSIGLQHFRSRTIYRNLNPTWNEV
  FEFMVYEVPGQDLEVDLYDEDTDRDDFLGSLQICLGDVMTNRVVDEWFVLNDTTSGRLHL
  RLEWLSLLTDQEVLTEDHGGLSTAILVVFLESACNLPRNPFDYLNGEYRAKKLSRFARNK
  VSKDPSSYVKLSVGKKTHTSKTCPHNKDPVWSQVFSFFVHNVATERLHLKVLDDDQECAL
  GMLEVPLCQILPYADLTLEQRFQLDHSGLDSLISMRLVLRFLQVEERELGSPYTGPEALK
  KGPLLIKKVATNQGPKAQPQEEGPTDLPCPPDPASDTKDVSRSTTTTTSATTVATEPTSQ
  ETGPEPKGKDSAKRFCEPIGEKKSPATIFLTVPGPHSPGPIKSPRPMKCPASPFAWPPKR
  LAPSMSSLNSLASSCFDLADISLNIEGGDLRRRQLGEIQLTVRYVCLRRCLSVLINGCRN
  LTPCTSSGADPYVRVYLLPERKWACRKKTSVKRKTLEPLFDETFEFFVPMEEVKKRSLDV
  AVKNSRPLGSHRRKELGKVLIDLSKEDLIKGFSQWYELTPNGQPRS

• Sequence length: 886

Pathways

Reactome:

Glycosphingolipid metabolism

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Cholangiocarcinoma	Uncertain significance	rs764669605	RCV005928936

Associations from Text Mining
Disease Name	Relationship Type	References
Adenocarcinoma of Lung	Inhibit	37657044
Adenocarcinoma of Lung	Associate	38111060
Esophageal Achalasia	Associate	34197731
Leukemia Lymphocytic Chronic B Cell	Associate	20484983