Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
83743
Gene name Gene Name - the full gene name approved by the HGNC.
Glutamate rich WD repeat containing 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GRWD1
Synonyms (NCBI Gene) Gene synonyms aliases
CDW4, DIAR14, GRWD, RRB1, WDR28
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.33
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase. [p
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT028689 hsa-miR-27a-3p Sequencing 20371350
MIRT028900 hsa-miR-26b-5p Microarray 19088304
MIRT031380 hsa-miR-16-5p Proteomics 18668040
MIRT044657 hsa-miR-320a CLASH 23622248
MIRT633969 hsa-miR-514a-5p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003682 Function Chromatin binding IDA 25990725
GO:0003688 Function DNA replication origin binding IDA 25990725
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0005515 Function Protein binding IPI 17041588, 18832067, 23349634, 25990725
GO:0005634 Component Nucleus IDA 25990725
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
610597 21270 ENSG00000105447
Protein
UniProt ID Q9BQ67
Protein name Glutamate-rich WD repeat-containing protein 1
Protein function Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness (PubMed:25990725).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12265 CAF1C_H4-bd 44 112 Histone-binding protein RBBP4 or subunit C of CAF1 complex Family
PF00400 WD40 252 290 WD domain, G-beta repeat Repeat
PF00400 WD40 298 336 WD domain, G-beta repeat Repeat
PF00400 WD40 343 382 WD domain, G-beta repeat Repeat
Sequence
MAARKGRRRTCETGEPMEAESGDTSSEGPAQVYLPGRGPPLREGEELVMDEEAYVLYHRA
QTGAPCLSFDIVRDHLGDNRTELPLTLYLCAGTQAESAQSNRLMMLRMHNLH
GTKPPPSE
GSDEEEEEEDEEDEEERKPQLELAMVPHYGGINRVRVSWLGEEPVAGVWSEKGQVEVFAL
RRLLQVVEEPQALAAFLRDEQAQMKPIFSFAGHMGEGFALDWSPRVTGRLLTGDCQKNIH
LWTPTDGGSWHVDQRPFVGHTRSVEDLQWSPTENTVFASCSADASIRIWDIRAAPSKACM
LTTATAHDGDVNVISWSRREPFLLSGGDDGALKIWD
LRQFKSGSPVATFKQHVAPVTSVE
WHPQDSGVFAASGADHQITQWD
LAVERDPEAGDVEADPGLADLPQQLLFVHQGETELKEL
HWHPQCPGLLVSTALSGFTIFRTISV
Sequence length 446
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Lung adenocarcinoma Adenocarcinoma of lung (disorder) rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370
View all (5 more)
27602772
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Renal Cell Associate 34616846
Cerebral Infarction Associate 39290696
Chromosomal Instability Associate 34616846
Diabetes Mellitus Type 2 Associate 35601016
Kidney Diseases Associate 34616846
Neoplasms Associate 34616846
Precancerous Conditions Associate 34616846
Urinary Bladder Neoplasms Associate 33287884
Uterine Cervical Neoplasms Associate 32806782