Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
83734
Gene name Gene Name - the full gene name approved by the HGNC.
Autophagy related 10
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ATG10
Synonyms (NCBI Gene) Gene synonyms aliases
APG10, APG10L, pp12616
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q14.1-q14.2
Summary Summary of gene provided in NCBI Entrez Gene.
Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modif
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT021335 hsa-miR-9-5p Microarray 17612493
MIRT024684 hsa-miR-215-5p Microarray 19074876
MIRT025071 hsa-miR-181a-5p Microarray 17612493
MIRT026156 hsa-miR-192-5p Microarray 19074876
MIRT540702 hsa-miR-8485 HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000045 Process Autophagosome assembly IBA
GO:0000045 Process Autophagosome assembly IDA 23202584
GO:0000045 Process Autophagosome assembly IDA 16963840
GO:0000423 Process Mitophagy IBA
GO:0005515 Function Protein binding IPI 32296183, 32814053
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
610800 20315 ENSG00000152348
Protein
UniProt ID Q9H0Y0
Protein name Ubiquitin-like-conjugating enzyme ATG10 (EC 2.3.2.-) (Autophagy-related protein 10) (APG10-like)
Protein function E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugatio
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03987 Autophagy_act_C 11 207 Autophagocytosis associated protein, active-site domain Domain
Sequence
Sequence length 220
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Autophagy - other
Autophagy - animal
  Macroautophagy
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Breast cancer Breast cancer N/A N/A GWAS
Hypertension Hypertension N/A N/A GWAS
Prostate cancer Prostate cancer N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 29259263, 32873769, 35029906
Alzheimer Disease Associate 22273362, 29039784
Anti Neutrophil Cytoplasmic Antibody Associated Vasculitis Associate 34961976
Breast Neoplasms Associate 29727689
Carcinoma Hepatocellular Associate 34116652, 34746309, 37077914
Colitis Ulcerative Associate 33904657
Colorectal Neoplasms Stimulate 23285162
Drug Related Side Effects and Adverse Reactions Associate 31692259
Ehlers Danlos syndrome type 1 Associate 30716086
Gastrointestinal Stromal Tumors Associate 36204881